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Despite their significant impact on quality of life, these symptoms are often inadequately addressed. Propolis is a natural bee-derived product, rich in bioactive compounds with anti-inflammatory, antioxidant, immunomodulatory, and neuroprotective properties, which holds potential in PD due to its multitarget and multipathway actions, addressing various underlying mechanisms of non-motor symptom diseases. Preclinical and clinical studies suggest that propolis may influence key pathological mechanisms in PD\u2019s non-motor symptoms. Evidence points to its potential benefits in improving cognition, mood disorders, gastrointestinal health, and alleviating cardiovascular and sleep-related issues. Although research on propolis in non-motor symptoms of PD remains scarce, findings from related conditions suggest its ability to influence mechanisms associated with these symptoms. This review underscores the underexplored therapeutic potential of propolis in non-motor symptoms of PD, drawing on existing evidence and advocating for further research to fully assess its role in addressing these symptoms and improving patient outcomes.<\/jats:p>","DOI":"10.3390\/molecules30081672","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T03:32:53Z","timestamp":1744169573000},"page":"1672","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Nature\u2019s Remedies: Exploring the Potential of Propolis to Alleviate Non-Motor Manifestations of Parkinson\u2019s Disease"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8144-2971","authenticated-orcid":false,"given":"K\u00e9telin Vit\u00f3ria","family":"Matias","sequence":"first","affiliation":[{"name":"Disciplina de Neuroci\u00eancia, Departamento de Neurologia e Neurocirurgia, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo 04039-032, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5536-0308","authenticated-orcid":false,"given":"Valeria de Cassia","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Disciplina de Neuroci\u00eancia, Departamento de Neurologia e Neurocirurgia, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo 04039-032, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulvio Alexandre","family":"Scorza","sequence":"additional","affiliation":[{"name":"Disciplina de Neuroci\u00eancia, Departamento de Neurologia e Neurocirurgia, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo 04039-032, SP, Brazil"},{"name":"Departamento de Pesquisa da BP, A Benefic\u00eancia Portuguesa de S\u00e3o Paulo, S\u00e3o Paulo 01323-001, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2839-7305","authenticated-orcid":false,"given":"Josef","family":"Finsterer","sequence":"additional","affiliation":[{"name":"Neurology and Neurophysiology Center, 1180 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rozana Mesquita","family":"Ciconelli","sequence":"additional","affiliation":[{"name":"Departamento de Pesquisa da BP, A Benefic\u00eancia Portuguesa de S\u00e3o Paulo, S\u00e3o Paulo 01323-001, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7810-4748","authenticated-orcid":false,"given":"Carla Alessandra","family":"Scorza","sequence":"additional","affiliation":[{"name":"Disciplina de Neuroci\u00eancia, Departamento de Neurologia e Neurocirurgia, Universidade Federal de S\u00e3o Paulo (UNIFESP), S\u00e3o Paulo 04039-032, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S1474-4422(18)30295-3","article-title":"Global, regional, and national burden of Parkinson\u2019s disease, 1990\u20132016: A systematic analysis for the Global Burden of Disease Study 2016","volume":"17","author":"Dorsey","year":"2018","journal-title":"Lancet Neurol."},{"key":"ref_2","first-page":"451","article-title":"Parkinson\u2019s Disease Is Predominantly an Environmental Disease","volume":"14","author":"Dorsey","year":"2024","journal-title":"J. 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