{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:57:33Z","timestamp":1782939453015,"version":"3.54.5"},"reference-count":120,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Medicinal plants from the genus Saururus are commonly used to treat inflammatory pathologies. They contain numerous bioactive compounds, notably the polycyclic lignan sauchinone from the species Saururus chinensis. An in-depth analysis of benzoxanthenone lignans related to sauchinone, and the analogous products carpanone and polemannones, has been carried out. The review reports the product\u2019s isolation, biosynthetic pathway, and chemical strategies to synthesize benzoxanthenones via liquid- and solid-phase syntheses. The metabolic and pharmacokinetic properties of sauchinone are discussed. At the pharmacological level, sauchinone is a potent blocker of the production of pro-inflammatory mediators, such as nitric oxide and prostaglandin E2, and an efficient antioxidant agent. The properties of sauchinone can be exploited to combat multiple pathologies, such as liver injuries, renal dysfunction, osteoarthritis, inflammatory bowel disease, ulcerative colitis, and cancers. The capacity of the natural product to inhibit tumor cell proliferation and to reduce migration\/invasion of cancer cells and the development of metastases is underlined, together with the regulation of the epithelial-mesenchymal transition and immune checkpoints. Altogether, the review offers a complete survey of the chemical and biochemical properties of sauchinone-type benzoxanthenones.<\/jats:p>","DOI":"10.3390\/molecules30081696","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T10:47:41Z","timestamp":1744282061000},"page":"1696","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Benzoxanthenone Lignans Related to Carpanone, Polemanone, and Sauchinone: Natural Origin, Chemical Syntheses, and Pharmacological Properties"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2973-9357","authenticated-orcid":false,"given":"Christian","family":"Bailly","sequence":"first","affiliation":[{"name":"UMR9020-U1277-CANTHER\u2014Cancer Heterogeneity Plasticity and Resistance to Therapies, CHU Lille, CNRS, Inserm, OncoLille Institut, University of Lille, 59000 Lille, France"},{"name":"Institute of Pharmaceutical Chemistry Albert Lespagnol (ICPAL), Faculty of Pharmacy, University of Lille, 59006 Lille, France"},{"name":"OncoWitan, Scientific Consulting Office, 59290 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1142\/S0192415X20500032","article-title":"A review of traditional uses, phytochemistry, and pharmacological properties of the genus Saururus","volume":"48","author":"Liu","year":"2020","journal-title":"Am. J. Chin. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e3434","DOI":"10.7717\/peerj.3434","article-title":"Tiny pollen grains: First evidence of Saururaceae from the late Cretaceous of western North America","volume":"5","author":"Grimm","year":"2017","journal-title":"PeerJ"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1111\/tpj.16097","article-title":"The Saururus chinensis genome provides insights into the evolution of pollination strategies and herbaceousness in magnoliids","volume":"113","author":"Xue","year":"2023","journal-title":"Plant J."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Zhao, Y.H., Zhang, X.M., and Li, D.Z. (2021). Development of the petaloid bracts of a paleoherb species, Saururus chinensis. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0255679"},{"key":"ref_5","first-page":"202","article-title":"Saururus\u00a0cernuus","volume":"8","author":"Phares","year":"1867","journal-title":"Atlanta Med. Surg. J."},{"key":"ref_6","first-page":"189","article-title":"Potent cytotoxic activity of Saururus cernuus extract on human colon and breast carcinoma cultures under normoxic conditions","volume":"27","author":"Badisa","year":"2007","journal-title":"Anticancer Res."},{"key":"ref_7","first-page":"1491","article-title":"Manassantin A inhibits tumour growth under hypoxia through the activation of chaperone-mediated autophagy by modulating Hsp90 activity","volume":"128","author":"Byun","year":"2023","journal-title":"Br. J. Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"20989","DOI":"10.1074\/jbc.M117.812925","article-title":"The lignan manassantin is a potent and specific inhibitor of mitochondrial complex I and bioenergetic activity in mammals","volume":"292","author":"Ma","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1021\/acs.jproteome.6b00237","article-title":"Discovery of manassantin A protein targets using large-scale protein folding and stability measurements","volume":"15","author":"Kwon","year":"2016","journal-title":"J. Proteome Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1111\/cbdd.14213","article-title":"Cytotoxic effects of neolignans from Saururus cernuus (Saururaceae) against prostate cancer cells","volume":"101","author":"Toneto","year":"2023","journal-title":"Chem. Biol. Drug Des."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"104251","DOI":"10.1016\/j.fitote.2019.104251","article-title":"Dibenzylbutane neolignans from Saururus cernuus L. (Saururaceae) displayed anti-Trypanosoma cruzi activity via alterations in the mitochondrial membrane potential","volume":"137","author":"Brito","year":"2019","journal-title":"Fitoterapia"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Brito, J.R., Wilairatana, P., Roquini, D.B., Parra, B.C., Gon\u00e7alves, M.M., Souza, D.C.S., Ferreira, E.A., Salvadori, M.C., Teixeira, F.S., and Lago, J.H.G. (2022). Neolignans isolated from Saururus cernuus L. (Saururaceae) exhibit efficacy against Schistosoma mansoni. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-23110-2"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1021\/np50068a006","article-title":"Chemistry of Saururus cernuus, V. sauristolactam and other nitrogenous constituents","volume":"53","author":"Rao","year":"1990","journal-title":"J. Nat. Prod."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1055\/s-2004-818964","article-title":"Aristolactam BII of Saururus chinensis attenuates glutamate-induced neurotoxicity in rat cortical cultures probably by inhibiting nitric oxide production","volume":"70","author":"Kim","year":"2004","journal-title":"Planta Med."},{"key":"ref_15","unstructured":"Dong, Y.K., Huh, H., Choong, K.Y., and Kim, J. (2001, January 29). Two new nitroalkyl indole alkaloids from Saururus chinensis. Proceedings of the PSK Conference, Washington, DC, USA."},{"key":"ref_16","first-page":"479","article-title":"Chemical constituents of Saururus chinensis (Lour.) Bail","volume":"24","author":"Li","year":"1999","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.phytol.2024.11.009","article-title":"A new furanoditerpene from Saururus chinensis aerial parts","volume":"65","author":"Nguyen","year":"2025","journal-title":"Phytochem. Lett."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"969","DOI":"10.3987\/COM-95-7370","article-title":"Studies on constituents of Saururus chinensis","volume":"43","author":"Wang","year":"1996","journal-title":"Heterocycles"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1021\/np990499e","article-title":"Hepatoprotective diastereomeric lignans from Saururus chinensis herbs","volume":"63","author":"Sung","year":"2000","journal-title":"J. Nat. Prod."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1055\/s-0033-1351053","article-title":"Further lignans from Saururus chinensis","volume":"79","author":"Gao","year":"2013","journal-title":"Planta Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1248\/bpb.31.523","article-title":"Protective effect of lignans against sepsis from the roots of Saururus chinensis","volume":"31","author":"Seo","year":"2008","journal-title":"Biol. Pharm. Bull."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.bse.2014.04.002","article-title":"Secondary metabolites from Saururus chinensis and their chemotaxonomic significance","volume":"56","author":"Zhuang","year":"2014","journal-title":"Biochem. Syst. Ecol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Wang, C., Qin, X., Wang, Y., Wang, W., Sun, S., Wang, H., Li, S., Dai, X., Zhu, X., and Gao, X. (2025). Noval selective ligand-extraction of bioactive components in complex natural products applying immobilized multi-target magnetic beads. Biomed. Chromatogr., 39.","DOI":"10.1002\/bmc.6060"},{"key":"ref_24","first-page":"1505","article-title":"Determination in the content of sauchinone from different medicament portions in Saururus chinensis (Lour.) Baill. by HPLC","volume":"35","author":"Wang","year":"2015","journal-title":"Chin. J. Pharm. Anal."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.jpba.2009.11.004","article-title":"Simultaneous determination of eleven bioactive compounds in Saururus chinensis from different harvesting seasons by HPLC-DAD","volume":"51","author":"Chen","year":"2010","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1080\/10826070903320426","article-title":"Simultaneous determination of five active constituents in the aerial parts of Saururus chinensis by HPLC-DAD","volume":"32","author":"Kim","year":"2009","journal-title":"J. Liq. Chromatogr. Relat. Technol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"PC80","DOI":"10.1055\/s-0028-1084598","article-title":"Simultaneous determination of lignans, aristolactam alkaloids and flavonoids in the Saururus chinensis by validated HPLC-DAD-MS\/MS","volume":"74","author":"Lee","year":"2008","journal-title":"Planta Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1177\/1535370215614657","article-title":"Anti-inflammatory effects of Saururus chinensis aerial parts in murine macrophages via induction of heme oxygenase-1","volume":"241","author":"Meng","year":"2016","journal-title":"Exp. Biol. Med."},{"key":"ref_29","first-page":"176","article-title":"Hepatoprotective Constituents of Saururus chinensis roots against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells","volume":"38","author":"Jeong","year":"2007","journal-title":"Korean J. Pharmacogn."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.fitote.2014.12.011","article-title":"Two new lignans from Saururus chinensis and their DGAT inhibitory activity","volume":"101","author":"Li","year":"2015","journal-title":"Fitoterapia"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/S2707-3688(23)00092-4","article-title":"Tissue-specific comparative transcriptome analysis reveals candidate genes involved in lignans biosynthesis in Saururus chinensis","volume":"4","author":"Liang","year":"2023","journal-title":"J. Holist. Integr. Pharm."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1021\/acs.jnatprod.9b00520","article-title":"Lignans from Saururus chinensis with inhibitory effects on nitric oxide production","volume":"82","author":"Jin","year":"2019","journal-title":"J. Nat. Prod."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1016\/S0031-9422(00)84743-3","article-title":"Benzoxanthenone derivatives from Polemannia montana","volume":"26","author":"Jakupovic","year":"1987","journal-title":"Phytochemistry"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"5159","DOI":"10.1016\/S0040-4039(01)88911-5","article-title":"Novel lignans from a Cinnamomum sp. from Bougainville","volume":"59","author":"Brophy","year":"1969","journal-title":"Tetrahedron Lett."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6696","DOI":"10.1021\/ja00753a073","article-title":"Total synthesis of carpanone","volume":"93","author":"Chapman","year":"1971","journal-title":"J. Am. Chem. Soc."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1055\/s-0037-1611196","article-title":"Concise four-step total synthesis of (\u00b1)-carpanone","volume":"15","author":"Carreira","year":"2019","journal-title":"Synfacts"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4437","DOI":"10.1016\/S0040-4039(01)82977-4","article-title":"Transition metal(ii) schiff\u2019s base complexes catalyzed oxidation of trans-2-(1-propenyl)-4,5-methylenedioxyphenol to carpanone by molecular oxygen","volume":"22","author":"Matsumoto","year":"1981","journal-title":"Tetrahedron Lett."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/asia.201901727","article-title":"Diastereoselective synthesis of benzoxanthenones","volume":"15","author":"Neuhaus","year":"2020","journal-title":"Chem. Asian J."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"14286","DOI":"10.1021\/acs.joc.8b01821","article-title":"An autonomous self-optimizing flow reactor for the synthesis of natural product carpanone","volume":"83","author":"Wimmer","year":"2018","journal-title":"J. Org. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"14101","DOI":"10.1021\/acs.joc.9b02263","article-title":"Reconfigurable flow platform for automated reagent screening and autonomous optimization for bioinspired lignans synthesis","volume":"84","author":"Aka","year":"2019","journal-title":"J. Org. Chem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"4378","DOI":"10.1021\/ol9017326","article-title":"A new cross-coupling-based synthesis of carpanone","volume":"11","author":"Liron","year":"2009","journal-title":"Org. Lett."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"4097","DOI":"10.1021\/ol801643t","article-title":"A new catalytic Cu(II)\/sparteine oxidant system for \u03b2,\u03b2-phenolic couplings of styrenyl phenols: Synthesis of carpanone and unnatural analogs","volume":"10","author":"Daniels","year":"2008","journal-title":"Org. Lett."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"A25","DOI":"10.1021\/ed072pA25","article-title":"Microscale synthesis of the natural products carpanone and piperine","volume":"72","author":"Sloop","year":"1995","journal-title":"J. Chem. Educ."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"4528","DOI":"10.1021\/jo300263k","article-title":"Oxidative dimerization of (E)- and (Z)-2-propenylsesamol with O2 in the presence and absence of laccases and other catalysts: Selective formation of carpanones and benzopyrans under different reaction conditions","volume":"77","author":"Constantin","year":"2012","journal-title":"J. Org. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1039\/D1CB00259G","article-title":"Laccase-mediated synthesis of bioactive natural products and their analogues","volume":"3","author":"Cardullo","year":"2022","journal-title":"RSC Chem. Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"100066","DOI":"10.1016\/j.tchem.2024.100066","article-title":"Inverse electron demand Diels-Alder reaction in total synthesis of bioactive natural products","volume":"9","author":"Rashid","year":"2024","journal-title":"Tetrahedron Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1016\/j.tetlet.2009.04.043","article-title":"Total synthesis of polemannones B and C","volume":"50","author":"Fadeyi","year":"2009","journal-title":"Tetrahedron Lett."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1039\/b203388g","article-title":"A concise synthesis of carpanone using solid-supported reagents and scavengers","volume":"1","author":"Baxendale","year":"2002","journal-title":"J. Chem. Soc. Perkin Trans."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1021\/ja993674m","article-title":"Solid-phase biomimetic synthesis of carpanone-like molecules","volume":"122","author":"Lindsley","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"5391","DOI":"10.1021\/ja056338g","article-title":"Synthesis of a 10,000-membered library of molecules resembling carpanone and discovery of vesicular traffic inhibitors","volume":"128","author":"Goess","year":"2006","journal-title":"J. Am. Chem. Soc."},{"key":"ref_51","first-page":"849","article-title":"Diversity-oriented synthesis of a 10,102-membered library of carpanones","volume":"8","author":"Uozumi","year":"2006","journal-title":"Synfacts"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"He, Y.J., Xiao, D., Gong, Q.Z., Zhu, J.X., Jiang, X.Y., Dai, W.Q., Wen, X.D., Feng, F., and Qu, W. (2025). Synthesis, biological evaluation, and molecular docking of ent-sauchinone-based amide derivatives with potential anti-invasion and anti-migration activities. Nat. Prod. Res., ahead of print.","DOI":"10.1080\/14786419.2025.2459804"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"6728","DOI":"10.1080\/07391102.2020.1802341","article-title":"Predictive modeling by deep learning, virtual screening and molecular dynamics study of natural compounds against SARS-CoV-2 main protease","volume":"39","author":"Joshi","year":"2021","journal-title":"J. Biomol. Struct. Dyn."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1002\/bmc.2681","article-title":"Quantitative determination of sauchinone in rat plasma by liquid chromatography-mass spectrometry","volume":"26","author":"Xu","year":"2012","journal-title":"Biomed. Chromatogr."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1248\/bpb.b14-00524","article-title":"Pharmacokinetics, tissue distribution, and tentative metabolite identification of sauchinone in mice by microsampling and HPLC-MS\/MS methods","volume":"38","author":"Kim","year":"2015","journal-title":"Biol. Pharm. Bull."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s13318-016-0381-y","article-title":"Pharmacokinetics and pharmacodynamics of promising arginase inhibitors","volume":"42","author":"Abdelkawy","year":"2017","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"You, B.H., Gong, E.C., and Choi, Y.H. (2018). Inhibitory effect of sauchinone on UDP-glucuronosyltransferase (UGT) 2B7 activity. Molecules, 23.","DOI":"10.3390\/molecules23020366"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Gong, E.C., Chea, S., Balupuri, A., Kang, N.S., Chin, Y.W., and Choi, Y.H. (2018). Enzyme kinetics and molecular docking studies on cytochrome 2B6, 2C19, 2E1, and 3A4 activities by sauchinone. Molecules, 23.","DOI":"10.3390\/molecules23030555"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Ye, T., Xi, H., Juhas, M., and Li, J. (2021). Deep learning driven drug discovery: Tackling severe acute respiratory syndrome coronavirus 2. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.739684"},{"key":"ref_60","unstructured":"De Chiara, D., and Giusepponi, S. (2020). Fighting SARS-CoV-2 using natural compounds: A virtual screening analysis. High Performance Computing on CRESCO Infrastructure: Research Activity and Results 2020, The CRESCO infrastructure Scientific."},{"key":"ref_61","first-page":"242","article-title":"Sauchinone with zinc sulfate significantly inhibits the activity of the SARS-CoV-2 3CL-protease","volume":"2","author":"Saadh","year":"2021","journal-title":"Pharmacologyonline"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Song, J.H., Mun, S.H., Yang, H., Kwon, Y.S., Kim, S.R., Song, M.Y., Ham, Y., Choi, H.J., Baek, W.J., and Cho, S. (2023). Antiviral mechanisms of saucerneol from Saururus chinensis against enterovirus A71, coxsackievirus A16, and coxsackievirus B3: Role of mitochondrial ROS and the STING\/TKB-1\/IRF3 pathway. Viruses, 16.","DOI":"10.3390\/v16010016"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1021\/np400757k","article-title":"Potential antiviral lignans from the roots of Saururus chinensis with activity against Epstein-Barr virus lytic replication","volume":"77","author":"Cui","year":"2014","journal-title":"J. Nat. Prod."},{"key":"ref_64","first-page":"1642","article-title":"Effect and mechanism of Saururus chinensis against herpes dimplex virus","volume":"37","author":"Tian","year":"2012","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.antiviral.2009.11.002","article-title":"Lignan, sesquilignans and dilignans, novel HIV-1 protease and cytopathic effect inhibitors purified from the rhizomes of Saururus chinensis","volume":"85","author":"Lee","year":"2010","journal-title":"Antivir. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.ejphar.2014.01.039","article-title":"Effect of sauchinone, a lignan from Saururus chinensis, on bacterial phagocytosis by macrophages","volume":"728","author":"Jeong","year":"2014","journal-title":"Eur. J. Pharmacol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.phymed.2013.08.009","article-title":"Sauchinone from Saururus chinensis protects vascular inflammation by heme oxygenase-1 induction in human umbilical vein endothelial cells","volume":"21","author":"Li","year":"2014","journal-title":"Phytomedicine"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1248\/bpb.34.1566","article-title":"Sauchinone suppresses pro-inflammatory mediators by inducing heme oxygenase-1 in RAW264.7 macrophages","volume":"34","author":"Li","year":"2011","journal-title":"Biol. Pharm. Bull."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1055\/s-0029-1185906","article-title":"Protective effect of sauchinone by upregulating heme oxygenase-1 via the P38 MAPK and Nrf2\/ARE pathways in HepG2 cells","volume":"76","author":"Jeong","year":"2010","journal-title":"Planta Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1111\/j.1476-5381.2010.01095.x","article-title":"Nrf2-mediated liver protection by sauchinone, an antioxidant lignan, from acetaminophen toxicity through the PKC\u03b4-GSK3\u03b2 pathway","volume":"163","author":"Kay","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"6439","DOI":"10.1007\/s00210-024-03102-x","article-title":"The promising antioxidant effects of lignans: Nrf2 activation comes into view","volume":"397","author":"Hassanein","year":"2024","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1254\/jphs.11207SC","article-title":"Protective effect of sauchinone on methamphetamine-induced neurotoxicity in mice","volume":"118","author":"Jang","year":"2012","journal-title":"J. Pharmacol. Sci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1248\/bpb.26.1428","article-title":"Sauchinone, a lignan from Saururus chinensis, inhibits staurosporine-induced apoptosis in C6 rat glioma cells","volume":"26","author":"Song","year":"2003","journal-title":"Biol. Pharm. Bull."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1248\/bpb.23.666","article-title":"Sauchinone, a lignan from Saururus chinensis, attenuates CCl4-induced toxicity in primary cultures of rat hepatocytes","volume":"23","author":"Sung","year":"2000","journal-title":"Biol. Pharm. Bull."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1248\/bpb.b13-00101","article-title":"Sauchinone, a lignan from Saururus chinensis, protects human skin keratinocytes against ultraviolet B-induced photoaging by regulating the oxidative defense system","volume":"36","author":"Park","year":"2013","journal-title":"Biol. Pharm. Bull."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1248\/bpb.34.575","article-title":"Sauchinone attenuates oxidative stress-induced skeletal muscle myoblast damage through the down-regulation of ceramide","volume":"34","author":"Jung","year":"2011","journal-title":"Biol. Pharm. Bull."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.freeradbiomed.2009.12.006","article-title":"Inhibition of SREBP-1c-mediated hepatic steatosis and oxidative stress by sauchinone, an AMPK-activating lignan in Saururus chinensis","volume":"48","author":"Kim","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1007\/s12272-009-2113-1","article-title":"Sauchinone reduces oxygen-glucose deprivation-evoked neuronal cell death via suppression of intracellular radical production","volume":"32","author":"Choi","year":"2009","journal-title":"Arch. Pharm. Res."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Chae, H.S., You, B.H., Kim, D.Y., Lee, H., Ko, H.W., Ko, H.J., Choi, Y.H., Choi, S.S., and Chin, Y.W. (2018). Sauchinone controls hepatic cholesterol homeostasis by the negative regulation of PCSK9 transcriptional network. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-24935-6"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"155505","DOI":"10.1016\/j.phymed.2024.155505","article-title":"A promising therapy for fatty liver disease: PCSK9 inhibitors","volume":"128","author":"Han","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.cbi.2014.10.005","article-title":"Sauchinone attenuates liver fibrosis and hepatic stellate cell activation through TGF-beta\/Smad signaling pathway","volume":"224","author":"Lee","year":"2014","journal-title":"Chem. Biol. Interact."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.freeradbiomed.2009.07.018","article-title":"Efficacy of sauchinone as a novel AMPK-activating lignan for preventing iron-induced oxidative stress and liver injury","volume":"47","author":"Kim","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Yoon, J.J., Lee, H.K., Kim, H.Y., Han, B.H., Lee, H.S., Lee, Y.J., and Kang, D.G. (2020). Sauchinone protects renal mesangial cell dysfunction against angiotensin II by improving renal fibrosis and inflammation. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21197003"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/1440-1681.13187","article-title":"Sauchinone inhibits angiotensin II-induced proliferation and migration of vascular smooth muscle cells","volume":"47","author":"Wang","year":"2020","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Gao, Y., Zhao, H., and Li, Y. (2018). Sauchinone prevents IL-1beta-induced inflammatory response in human chondrocytes. J. Biochem. Mol. Toxicol., 32.","DOI":"10.1002\/jbt.22033"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.intimp.2018.06.041","article-title":"Sauchinone inhibits IL-1beta induced catabolism and hypertrophy in mouse chondrocytes to attenuate osteoarthritis via Nrf2\/HO-1 and NF-kappaB pathways","volume":"62","author":"Wu","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.bcp.2007.06.044","article-title":"Inhibition of osteoclast differentiation and bone resorption by sauchinone","volume":"74","author":"Han","year":"2007","journal-title":"Biochem. Pharmacol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/j.bbrc.2020.04.038","article-title":"miR-340 affects sauchinone inhibition of Th17 cell differentiation and promotes intestinal inflammation in inflammatory bowel disease","volume":"526","author":"Chen","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.bbrc.2020.05.022","article-title":"Sauchinone attenuates inflammatory responses in dendritic cells via Blimp-1 and ameliorates dextran sulfate sodium (DSS)-induced colitis","volume":"527","author":"Xiu","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.bbrc.2019.11.122","article-title":"Sauchinone ameliorates intestinal inflammation and promotes Th17 cell production of IL-10 via Blimp-1","volume":"522","author":"Xiao","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Wu, K., Liu, X., Meng, X., Cao, L., Li, H., Bi, Y., Wang, M., Wang, M., and Jiang, Y. (2023). Sauchinone alleviates dextran sulfate sodium-induced ulcerative colitis via NAD(P)H dehydrogenase [quinone] 1\/NF-kB pathway and gut microbiota. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.1084257"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.intimp.2013.07.011","article-title":"Sauchinone, a lignan from Saururus chinensis, attenuates neutrophil pro-inflammatory activity and acute lung injury","volume":"17","author":"Han","year":"2013","journal-title":"Int. Immunopharmacol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.intimp.2010.06.001","article-title":"Sauchinone, a lignan from Saururus chinensis, reduces tumor necrosis factor-alpha production through the inhibition of c-raf\/MEK1\/2\/ERK 1\/2 pathway activation","volume":"10","author":"Bae","year":"2010","journal-title":"Int. Immunopharmacol."},{"key":"ref_94","first-page":"3251","article-title":"Sauchinone augments cardiomyocyte viability by enhancing autophagy proteins -PI3K, ERK(1\/2), AMPK and Beclin-1 during early ischemia-reperfusion injury in vitro","volume":"8","author":"Thapalia","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"572","DOI":"10.3346\/jkms.2012.27.5.572","article-title":"Protective effect of sauchinone against regional myocardial ischemia\/reperfusion injury: Inhibition of p38 MAPK and JNK death signaling pathways","volume":"27","author":"Kim","year":"2012","journal-title":"J. Korean Med. Sci."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.bbrc.2009.05.039","article-title":"Suppression of Th2-driven, allergen-induced airway inflammation by sauchinone","volume":"385","author":"Min","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jep.2010.08.002","article-title":"Ethanol extracts of Saururus chinensis suppress ovalbumin-sensitization airway inflammation","volume":"132","author":"Quan","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.intimp.2012.07.002","article-title":"Sauchinone suppresses lipopolysaccharide-induced inflammatory responses through Akt signaling in BV2 cells","volume":"14","author":"Jang","year":"2012","journal-title":"Int. Immunopharmacol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1248\/bpb.32.1870","article-title":"Inhibition of double-stranded RNA-induced inducible nitric oxide synthase expression by fraxinellone and sauchinone in murine microglia","volume":"32","author":"Lee","year":"2009","journal-title":"Biol. Pharm. Bull."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"6670212","DOI":"10.1155\/2021\/6670212","article-title":"Sauchinone blocks ethanol withdrawal-induced anxiety but spares locomotor sensitization: Involvement of nitric oxide in the bed nucleus of the stria terminalis","volume":"2021","author":"Jiao","year":"2021","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"105702","DOI":"10.1016\/j.intimp.2019.105702","article-title":"Sauchinone suppresses FcepsilonRI-mediated mast cell signaling and anaphylaxis through regulation of LKB1\/AMPK axis and SHP-1-Syk signaling module","volume":"74","author":"Deng","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/1742-2094-11-118","article-title":"Inhibitory effect of ent-Sauchinone on amyloidogenesis via inhibition of STAT3-mediated NF-\u03baB activation in cultured astrocytes and microglial BV-2 cells","volume":"11","author":"Song","year":"2014","journal-title":"J. Neuroinflamm."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Gong, Q.Z., Xiao, D., Feng, F., Wen, X.D., and Qu, W. (2018). ent-Sauchinone as potential anticancer agent inhibiting migration and invasion of human liver cancer cells via suppressing the STAT3 signaling pathway. Chem. Biodivers., 15.","DOI":"10.1002\/cbdv.201800024"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.tiv.2010.12.004","article-title":"Sauchinone protects pancreatic beta cells against cytokine-mediated toxicity","volume":"25","author":"Jeong","year":"2011","journal-title":"Toxicol. Vitr."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Kim, N.H., Sung, N.J., Shin, S., Ryu, D.S., Youn, H.S., and Park, S.A. (2021). Sauchinone inhibits the proliferation, migration and invasion of breast cancer cells by suppressing Akt-CREB-MMP13 signaling pathway. Biosci. Rep., 41.","DOI":"10.1042\/BSR20211067"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/sj.bjp.0705231","article-title":"Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2 expression by sauchinone effects on I-kappaBalpha phosphorylation, C\/EBP and AP-1 activation","volume":"139","author":"Lee","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.phymed.2010.10.013","article-title":"A methylene chloride fraction of Saururus chinensis induces apoptosis through the activation of caspase-3 in prostate and breast cancer cells","volume":"18","author":"Kim","year":"2011","journal-title":"Phytomedicine"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.cbi.2016.11.016","article-title":"Sauchinone exerts anticancer effects by targeting AMPK signaling in hepatocellular carcinoma cells","volume":"261","author":"Kim","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.biopha.2018.02.121","article-title":"Sauchinone prevents TGF-beta-induced EMT and metastasis in gastric cancer cells","volume":"101","author":"He","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s11418-020-01435-4","article-title":"Sauchinone: A prospective therapeutic agent-mediated EIF4EBP1 down-regulation suppresses proliferation, invasion and migration of lung adenocarcinoma cells","volume":"74","author":"Li","year":"2020","journal-title":"J. Nat. Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1097\/CAD.0000000000000956","article-title":"Sauchinone inhibits hypoxia-induced epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma cells through the Wnt\/beta-catenin pathway","volume":"31","author":"Qiao","year":"2020","journal-title":"Anticancer Drugs"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/10799893.2021.1881556","article-title":"Sauchinone inhibits hypoxia-induced invasion and epithelial-mesenchymal transition in osteosarcoma cells via inactivation of the sonic hedgehog pathway","volume":"42","author":"Zhou","year":"2022","journal-title":"J. Recept. Signal Transduct. Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1111\/1759-7714.14834","article-title":"Sauchinone inhibits breast cancer cell proliferation through regulating microRNA-148a-3p\/HER-2 axis","volume":"14","author":"Hu","year":"2023","journal-title":"Thorac. Cancer"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.2174\/1871520623666230320125406","article-title":"Sauchinone inhibits the proliferation and immune invasion capacity of colorectal cancer cells through the suppression of PD-L1 and MMP2\/MM9","volume":"23","author":"Lu","year":"2023","journal-title":"Anticancer Agents Med. Chem."},{"key":"ref_115","first-page":"537","article-title":"Study on the apoptosis of PC3 cells induced by sauchinone and its mechanism","volume":"8","author":"Wu","year":"2018","journal-title":"Anti-Tumor Pharm."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"156624","DOI":"10.1016\/j.phymed.2025.156624","article-title":"Sauchinone preserves cardiac function in doxorubicin-induced cardiomyopathy by inhibiting the NLRP3 inflammasome","volume":"140","author":"Xin","year":"2025","journal-title":"Phytomedicine"},{"key":"ref_117","first-page":"273","article-title":"Immune-modulating and anti-vascular activities of two xanthenone acetic acid analogues: A comparative study to DMXAA","volume":"34","author":"Barbera","year":"2009","journal-title":"Int. J. Oncol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2165\/00063030-199708020-00005","article-title":"Immunomodulatory actions of xanthenone anticancer agents","volume":"8","author":"Baguley","year":"1997","journal-title":"BioDrugs"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"100486","DOI":"10.1016\/j.prmcm.2024.100486","article-title":"Sauchinone, an active phytochemical of Saururus chinensis, and its use as therapeutic","volume":"12","author":"Patel","year":"2024","journal-title":"Pharmacol. Res.\u2013Mod. Chin. Med."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Kuk, M.U., Lee, Y.H., Kim, D., Lee, K.S., Park, J.H., Yoon, J.H., Lee, Y.J., So, B., Kim, M., and Kwon, H.W. (2025). Sauchinone ameliorates senescence through reducing mitochondrial ROS production. 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