{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T05:59:00Z","timestamp":1778479140302,"version":"3.51.4"},"reference-count":19,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science &amp; Technology Development Fund of Tianjin Education Commission for Higher Education","award":["2021KJ132"],"award-info":[{"award-number":["2021KJ132"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>To further explore the anti-inflammatory components of the seeds of Dolichos lablab L., a comprehensive phytochemical investigation was conducted using diverse chromatographic and spectrometric technologies, as well as chemical reactions. As a result, ten previously unreported terpenoid glycosides, namely dolilabterpenosides A, B, C1\u2013C3, D, E, and F1\u2013F3 (1\u201310), along with four known analogues (11\u201314), initially identified from Dolichos genus, were obtained. In addition, the lipopolysaccharide (LPS)-induced RAW264.7 cell model was employed to detect the expression levels of nitric oxide (NO), inflammatory cytokines tumour necrosis factor (TNF)-\u03b1 and interleukin (IL)-1\u03b2 to assess the anti-inflammatory activities of the obtained compounds. The results of bioactive assay showed that compounds 1, 4\u20137, and 10\u201312 showed significant inhibitory activity on NO release in RAW264.7 cells in a dose-dependent manner, and all of them were demonstrated to inhibit the increase in TNF-\u03b1 and IL-I\u03b2 levels in the supernatant of RAW264.7 cells stimulated by LPS.<\/jats:p>","DOI":"10.3390\/molecules30081779","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T10:49:54Z","timestamp":1744714194000},"page":"1779","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["In Vitro Anti-Inflammatory Terpenoid Glycosides from the Seeds of Dolichos lablab"],"prefix":"10.3390","volume":"30","author":[{"given":"Wei","family":"Zhang","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Tianjin University of Traditional Chinese Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingya","family":"Ruan","sequence":"additional","affiliation":[{"name":"Institute of Tianjin University of Traditional Chinese, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaming","family":"Cheng","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Tianjin University of Traditional Chinese Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Tianjin University of Traditional Chinese, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinuo","family":"Zheng","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Tianjin University of Traditional Chinese Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2889-699X","authenticated-orcid":false,"given":"Minghao","family":"Lin","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Tianjin University of Traditional Chinese Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Tianjin University of Traditional Chinese Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China"},{"name":"Institute of Tianjin University of Traditional Chinese, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Tianjin University of Traditional Chinese Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China"},{"name":"Institute of Tianjin University of Traditional Chinese, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"130610","DOI":"10.1016\/j.foodchem.2021.130610","article-title":"Ingredients with anti-inflammatory effect from medicine food homology plants","volume":"30","author":"Lu","year":"2022","journal-title":"Food Chem."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s10753-020-01320-y","article-title":"Zingerone mitigates carrageenan-induced inflammation through antioxidant and anti-inflammatory activities","volume":"44","author":"Mehrzadi","year":"2020","journal-title":"Inflammation"},{"key":"ref_3","first-page":"22","article-title":"The pharmacology and medical importance of Dolichos lablab (Lablab purpureus)\u2014A review","volume":"7","year":"2017","journal-title":"IOSR J. 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