{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T01:25:18Z","timestamp":1772587518253,"version":"3.50.1"},"reference-count":27,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key-Area Research and Development Program of Guangdong Province","award":["2024B1111100001"],"award-info":[{"award-number":["2024B1111100001"]}]},{"name":"Key-Area Research and Development Program of Guangdong Province","award":["2023ZDZX2023"],"award-info":[{"award-number":["2023ZDZX2023"]}]},{"name":"Key-Area Research and Development Program of Guangdong Province","award":["2024"],"award-info":[{"award-number":["2024"]}]},{"name":"Research project from Provincial Department of Education, Guangdong Province","award":["2024B1111100001"],"award-info":[{"award-number":["2024B1111100001"]}]},{"name":"Research project from Provincial Department of Education, Guangdong Province","award":["2023ZDZX2023"],"award-info":[{"award-number":["2023ZDZX2023"]}]},{"name":"Research project from Provincial Department of Education, Guangdong Province","award":["2024"],"award-info":[{"award-number":["2024"]}]},{"name":"Scientific Research Innovation Project of Graduate School of South China Normal University","award":["2024B1111100001"],"award-info":[{"award-number":["2024B1111100001"]}]},{"name":"Scientific Research Innovation Project of Graduate School of South China Normal University","award":["2023ZDZX2023"],"award-info":[{"award-number":["2023ZDZX2023"]}]},{"name":"Scientific Research Innovation Project of Graduate School of South China Normal University","award":["2024"],"award-info":[{"award-number":["2024"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>We report the design and biological evaluation of a nanoplatform featuring controllable aggregation-induced emission (AIE) behavior. The free rotation of benzene rings (4-(1,2,2-triphenylvinyl) benzaldehyde) largely suppresses fluorescence in the pure organic phase. However, water-induced molecular aggregation enhances the fluorescence signal. The delivery system follows the membrane\u2013cytoplasm\u2013nucleus route and it leads to apoptosis in two cancer cells (U937 cells and Hela cells). The AIE moiety accumulates in the cytoplasm, emitting a bright-blue signal, but the anticancer drug doxorubicin selectively targets the nucleus with unique red emission. The current noninvasive method with DOX-triggered apoptosis holds promise for tumor diagnosis and real-time imaging.<\/jats:p>","DOI":"10.3390\/molecules30081782","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T04:05:31Z","timestamp":1744776331000},"page":"1782","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Molecular-Based Nanoplatform Leads to the Formation of a Self-Indicating Responsive Drug Delivery System"],"prefix":"10.3390","volume":"30","author":[{"given":"Lingbo","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Xiangya Hospital Central South University, Changsha 410008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhua","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, School of Chemistry, South China Normal University, Guangzhou 510006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihao","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, School of Chemistry, South China Normal University, Guangzhou 510006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijie","family":"Luo","sequence":"additional","affiliation":[{"name":"Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, School of Chemistry, South China Normal University, Guangzhou 510006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhui","family":"Zheng","sequence":"additional","affiliation":[{"name":"Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, School of Chemistry, South China Normal University, Guangzhou 510006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1021\/acs.jmedchem.5b01622","article-title":"Aggregation Induced Emission Mediated Controlled Release by Using a Built-In Functionalized Nanocluster with Theranostic Features","volume":"59","author":"Zhou","year":"2016","journal-title":"J. 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