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The association of these nanoparticles in a single system creates a bimodal entity, allowing the excellent luminescent properties of ZnO quantum dots to be combined with the contrast agent of IO for magnetic resonance imaging (MRI). The present study focuses on the luminescent and MRI properties of a new poly(lactic-co-glycolic acid) (PLGA) nanocarrier system formulation containing ZnO NPs and IO NPs in different nominal ratios. Microscopic analysis (TEM and SEM) reveals a circular morphology with IO and ZnO NPs. The average diameter of the particles was determined to be 220 nm, as measured by DLS. The luminescence results indicate that the PLGA system shows strong emission in the visible range, and the MRI analysis shows a high r2 relaxivity of 171 mM\u22121 s\u22121 at 7T. The optimized formulation, exhibiting a molar ratio of Fe:Zn ranging from 1:10 to 1:13 (mol:mol), demonstrates superior fluorescence and MRI performance, underscoring the significance of nanoparticle composition in bimodal imaging applications. The systems evaluated demonstrate no toxicity in the THP-1 cells for doses of up to 128 \u00b5g mL\u22121, with efficient labeling after 4 h of incubation, yielding images of strong luminescence and T2 contrast. The PLGA:ZnO:IO system demonstrates considerable potential as a bimodal platform for diagnostic imaging.<\/jats:p>","DOI":"10.3390\/molecules30081818","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T03:01:06Z","timestamp":1744945266000},"page":"1818","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bimodal Poly(lactic-co-glycolic acid) Nanocarrier with Zinc Oxide and Iron Oxide for Fluorescence and Magnetic Resonance Imaging"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7249-5880","authenticated-orcid":false,"given":"Th\u00falio Wliandon Lemos","family":"Barbosa","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, S\u00e3o Paulo State University (UNESP), Araraquara 14800-903, SP, Brazil"},{"name":"National Institute of Health and Medical Research (INSERM), National Centre for Scientific Research (CNRS), Materials, Engineering, Nanosciences, and Technologies (MINT), Research and Training System-Interactions, Catalysis, Applications, and Technologies (SFR ICAT), University of Angers, F49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1308-9345","authenticated-orcid":false,"given":"Laurent","family":"Lemaire","sequence":"additional","affiliation":[{"name":"National Institute of Health and Medical Research (INSERM), National Centre for Scientific Research (CNRS), Materials, Engineering, Nanosciences, and Technologies (MINT), Research and Training System-Interactions, Catalysis, Applications, and Technologies (SFR ICAT), University of Angers, F49000 Angers, France"},{"name":"Platform for Research in Imaging and Multimodal Spectroscopy (PRISM), SFR ICAT, University of Angers, F49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4251-4549","authenticated-orcid":false,"given":"Isabelle","family":"Verdu","sequence":"additional","affiliation":[{"name":"National Institute of Health and Medical Research (INSERM), National Centre for Scientific Research (CNRS), Materials, Engineering, Nanosciences, and Technologies (MINT), Research and Training System-Interactions, Catalysis, Applications, and Technologies (SFR ICAT), University of Angers, F49000 Angers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Santos","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, S\u00e3o Paulo State University (UNESP), Araraquara 14800-903, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0831-0225","authenticated-orcid":false,"given":"Nat\u00e1lia Galv\u00e3o","family":"de Freitas","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, S\u00e3o Paulo State University (UNESP), Araraquara 14800-903, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Picchi","family":"Salto","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, S\u00e3o Paulo State University (UNESP), Araraquara 14800-903, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3128-3739","authenticated-orcid":false,"given":"Leila Aparecida","family":"Chiavacci","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, S\u00e3o Paulo State University (UNESP), Araraquara 14800-903, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jmst.2022.10.084","article-title":"Constructing Bimodal Nanoprobe Based on Gd:AgInS2\/ZnS Quantum Dots for Fluorometric\/Magnetic Resonance Imaging in Mesenchymal Stem Cells","volume":"148","author":"Yang","year":"2023","journal-title":"J. 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