{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:58:53Z","timestamp":1790891933875,"version":"4.1.0"},"reference-count":96,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Teacher Professional Development Project: Overseas Visiting Scholarship (Senior Research Scholar) (Xiangguo Meng)","award":["A3-0200-24-311008-12"],"award-info":[{"award-number":["A3-0200-24-311008-12"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide. The difficulty in early diagnosis, combined with the tendency for tumor invasion and metastasis, creates significant challenges for current therapeutic approaches. Additionally, the pharmaceutical agents currently used to treat NSCLC often come with severe side effects and can lead to drug resistance. As a result, there is an urgent need to develop new therapeutic agents with fewer side effects that can effectively overcome resistance mechanisms. Flavonoids, a prominent class of natural compounds, have shown promise in preventing and treating various cancers. By structurally optimizing flavonoids, it is possible to enhance their anticancer activity and improve their pharmacokinetic properties. This article reviews the different mechanisms of action and structure\u2013activity relationships (SARs) of flavonoid derivatives in treating NSCLC, aiming to provide a scientific foundation for developing new therapeutic agents.<\/jats:p>","DOI":"10.3390\/molecules30081827","type":"journal-article","created":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T20:15:06Z","timestamp":1745180106000},"page":"1827","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Research Progress on the Structure\u2013activity Relationship and Mechanism of Flavonoid Derivatives in the Treatment of Lung Cancer"],"prefix":"10.3390","volume":"30","author":[{"given":"Jiacheng","family":"Yao","sequence":"first","affiliation":[{"name":"Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China"},{"name":"Faculty of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Yangzijiang Pharmaceutical Group Shanghai Haini Pharmaceutical Co., Ltd., Shanghai 201318, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yikun","family":"Feng","sequence":"additional","affiliation":[{"name":"Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China"},{"name":"Faculty of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Gu","sequence":"additional","affiliation":[{"name":"Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China"},{"name":"Faculty of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Li","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yang","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiamin","family":"Hu","sequence":"additional","affiliation":[{"name":"Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China"},{"name":"Faculty of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8579-4150","authenticated-orcid":false,"given":"Pierre-Antoine","family":"Bonnet","sequence":"additional","affiliation":[{"name":"IBMM, Faculty of Pharmacy, Montpellier University, CNRS, ENSCM, 34093 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangguo","family":"Meng","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0140-6736(21)00312-3","article-title":"Lung cancer","volume":"398","author":"Thai","year":"2021","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"534","DOI":"10.20517\/cdr.2022.61","article-title":"Emerging insights to lung cancer drug resistance","volume":"5","author":"Su","year":"2022","journal-title":"Cancer Drug Resist."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e12901","DOI":"10.1111\/eci.12901","article-title":"Role of artificial intelligence in the care of patients with nonsmall cell lung cancer","volume":"48","author":"Rabbani","year":"2018","journal-title":"Eur. 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