{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T21:50:21Z","timestamp":1785275421452,"version":"3.55.0"},"reference-count":70,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Higher Education in Poland"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Skin diseases are prevalent and encompass a wide range of disorders with varying clinical manifestations and diverse etiopathogenesis. The response to the necessity of multidirectional treatment is provided by species belonging to the genus Alchemilla, which is used in traditional medicine as well as in cosmetic formulations. Responsible for the healing properties of these plants for skin diseases are mainly compounds such as tannins, phenolic acids, flavonoids, and anthocyanins. The aim of the study was to analyze and synthesize the published literature on the Alchemilla species in skincare with a timeframe of December 2024. The literature indicates that due to antioxidant, anti-inflammatory, astringent, antimicrobial, elastase activity and tyrosinase inhibitory properties of various Alchemilla species, extracts obtained from these plants can be successfully applied in skin rashes, acne, stretch marks, eczema, psoriasis, wrinkles and other dermatological issues. To the best of our knowledge, this is the first review of the cosmetic activities of Alchemilla species.<\/jats:p>","DOI":"10.3390\/molecules30081861","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T20:38:26Z","timestamp":1745267906000},"page":"1861","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Harnessing the Power of Alchemilla: A Natural Solution for Skin Health and Dermatological Disorders"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9308-8635","authenticated-orcid":false,"given":"Sebastian","family":"Kanak","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Botany, Medical University of Lublin, Chod\u017aki 1, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3797-4346","authenticated-orcid":false,"given":"Barbara","family":"Krzemi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany, Medical University of Lublin, Chod\u017aki 1, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3995-0612","authenticated-orcid":false,"given":"Anna","family":"Berecka-Rycerz","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5412-0399","authenticated-orcid":false,"given":"Monika","family":"Kope\u0107","sequence":"additional","affiliation":[{"name":"Chair and Department of Obstetrics and Perinatology, Medical University of Lublin, Jaczewskiego 8, 20-090 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4884-9110","authenticated-orcid":false,"given":"Katarzyna","family":"Dos Santos Szewczyk","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany, Medical University of Lublin, Chod\u017aki 1, 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zhang, X., You, L.Y., Zhang, Z.Y., Jiang, D.X., Qiu, Y., Ruan, Y.P., and Mao, Z.J. (2022). Integrating pharmacological evaluation and computational identification for deciphering the action mechanism of Yunpi-Huoxue-Sanjie formula alleviates diabetic cardiomyopathy. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.957829"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1046\/j.1467-2494.1998.176608.x","article-title":"Study of the refirming effect of a plant complex","volume":"20","author":"Benaiges","year":"1998","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_3","unstructured":"(2024, September 15). Available online: https:\/\/powo.science.kew.org\/taxon\/urn:lsid:ipni.org:names:30008181-2."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jep.2014.05.014","article-title":"Ethnobotanical study on medicinal plants in Ge\u00e7itli and its surrounding (Hakkari-Turkey)","volume":"155","author":"Kaval","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Mladenova, S.G., Vasileva, L.V., Savova, M.S., Marchev, A.S., Tews, D., Wabitsch, M., Ferrante, C., Orlando, G., and Georgiev, M.I. (2021). Anti-adipogenic effect of Alchemilla monticola is mediated via PI3K\/AKT signaling inhibition in human adipocytes. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.707507"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Kanak, S., Krzemi\u0144ska, B., Celi\u0144ski, R., Bakalczuk, M., and Dos Santos Szewczyk, K. (2022). Phenolic composition and antioxidant activity of Alchemilla species. Plants, 11.","DOI":"10.3390\/plants11202709"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jclinepi.2021.02.003","article-title":"Updating guidance for reporting systematic reviews: Development of the PRISMA 2020 statement","volume":"134","author":"Page","year":"2021","journal-title":"J. Clin. Epidemiol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Dos Santos Szewczyk, K., Pietrzak, W., Klimek, K., and Gogacz, M. (2022). LC-ESI-MS\/MS identification of biologically active phenolics in different extracts of Alchemilla acutiloba Opiz. Molecules, 27.","DOI":"10.3390\/molecules27030621"},{"key":"ref_9","first-page":"2260","article-title":"Determination of antimicrobial and antioxidant activity of Alchemilla alpina L.","volume":"9","author":"Eren","year":"2021","journal-title":"Turk. J. Agric. Food Sci. Technol."},{"key":"ref_10","first-page":"457","article-title":"Evaluation of phytochemical and pharmacological activities of Taraxacum syriacum and Alchemilla arvensis","volume":"14","author":"Ali","year":"2021","journal-title":"Jordan. J. Pharm. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"76","DOI":"10.25135\/rnp.07.17.07.117","article-title":"Bioassay guided isolation of active compounds from Alchemilla barbatiflora Juz","volume":"12","author":"Renda","year":"2018","journal-title":"Rec. Nat. Prod."},{"key":"ref_12","first-page":"113","article-title":"Determination of antioxidant and antimicrobial properties of lady\u2019s mantle (Alchemilla ellenbergiana) extracts","volume":"8","author":"Acet","year":"2018","journal-title":"G\u00fcm\u00fc\u015fhane \u00dcniversitesi Fen. Bilim. Enstit\u00fcs\u00fc Derg."},{"key":"ref_13","first-page":"1410","article-title":"Sivas Ili Do gal Floras\u0131ndan Toplanan Sar\u0131 Kantaron (Hypericum scabrum L.) ve Aslan Pen\u00e7esi (Alchemilla mollis (Buser) Rothm) Bitkilerinin Baz\u0131 Kalite Kriterlerinin Belirlenmesi","volume":"10","author":"Eruygur","year":"2020","journal-title":"J. Inst. Sci. Tech."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"359","DOI":"10.18388\/abp.2014_1907","article-title":"Antioxidant, antimicrobial and neutrophil-modulating activities of herb extracts","volume":"61","author":"Denev","year":"2014","journal-title":"Acta Biochim. Pol."},{"key":"ref_15","unstructured":"Unkovic, N., \u0106o\u0107i\u0107, D., D\u017eami\u0107, A., Savkovi\u0107, Z., \u017divkovi\u0107, L., and Ljaljevi\u0107 Grbi\u0107, M. (2022). Fungal contamination of make-up products and assessment of Alchemilla hybrida L. extracts as potential cosmetic ingredients. FEMS Conference on Microbiology, Electronic Abstract Book, University of Belgrade."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1055\/s-0031-1282722","article-title":"Phenolic acids and free radical scavenging activity of Bulgarian endemic\u2014Alchemilla jumrukczalica Pawl","volume":"77","author":"Nikolova","year":"2011","journal-title":"Planta Med."},{"key":"ref_17","first-page":"25","article-title":"Assessment of antioxidant, acetylcholinesterase, paraoxonase inhibition activities and phenolic content of Alchemilla lithophila","volume":"37","year":"2024","journal-title":"Pak. J. Pharm. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.phymed.2017.12.025","article-title":"Protective effect of dietary Alchemilla mollis on UVB-irradiated premature skin aging through regulation of transcription factor NFATc1 and Nrf2\/ARE pathways","volume":"39","author":"Hwang","year":"2018","journal-title":"Phytomedicine"},{"key":"ref_19","first-page":"33","article-title":"Antiradical, antimicrobial and cytotoxic activity evaluations of Alchemilla mollis (Buser) Rothm","volume":"6","author":"Karatoprak","year":"2018","journal-title":"Int. J. Herb. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3329\/bjp.v11i3.26024","article-title":"Effects of Alchemilla mollis and Alchemilla persica on the wound healing process","volume":"11","author":"Oz","year":"2016","journal-title":"Bangladesh J. Pharmacol."},{"key":"ref_21","first-page":"1491","article-title":"Influence of the ethanol concentration on the antioxidant capacity and polyphenol content of Alchemilla mollis extracts","volume":"68","author":"Nedyalkov","year":"2015","journal-title":"Comptes Rendus L\u2019Academie Bulg. Sci."},{"key":"ref_22","first-page":"1851","article-title":"Flavonoid constituents and free radical scavenging activity of Alchemilla mollis","volume":"6","author":"Trendafilova","year":"2011","journal-title":"Nat. Prod. Commun."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1501\/Eczfak_0000000560","article-title":"Antioxidant activity and phytochemical analysis of Alchemilla persica Rothm","volume":"39","author":"Ergene","year":"2010","journal-title":"Ank. Univ. Eczac. Fak. Derg."},{"key":"ref_24","first-page":"9","article-title":"Chemical constituents, antioxidant and antibacterial activities of the hexane extract of Alchemilla sericata Reichenb","volume":"43","author":"Shafaghat","year":"2019","journal-title":"J. Food Biochem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jtice.2015.01.026","article-title":"Assessment of acetylcholinesterase and tyrosinase inhibitory and antioxidant activity of Alchemilla vulgaris and Filipendula ulmaria extracts","volume":"52","author":"Neagu","year":"2015","journal-title":"J. Taiwan. Inst. Chem. Eng."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.sajb.2018.03.007","article-title":"The biological activities of roots and aerial parts of Alchemilla vulgaris L.","volume":"116","author":"Boroja","year":"2018","journal-title":"S. Afr. J. Bot."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"37474","DOI":"10.1039\/C9RA08231J","article-title":"Alchemilla vulgaris agg. (Lady\u2019s mantle) from central Balkan: Antioxidant, anticancer and enzyme inhibition properties","volume":"9","author":"Zengin","year":"2019","journal-title":"RSC Adv."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1111\/j.1365-2672.2008.04083.x","article-title":"Assessment of anti-oxidant activity of plant extracts using microbial test systems","volume":"106","author":"Oktyabrsky","year":"2009","journal-title":"J. Appl. Microbiol."},{"key":"ref_29","first-page":"46","article-title":"Effect of Lion\u2019s Foot (Alchemilla vulgaris) on liver and renal functions in rats induced by CCl4","volume":"9","author":"Refat","year":"2018","journal-title":"Food Nutr. Sci."},{"key":"ref_30","first-page":"986","article-title":"Alchemilla vulgaris and Filipendula ulmaria extracts as potential natural preservatives in beef patties","volume":"21","author":"Hamid","year":"2017","journal-title":"Malays. J. Anal. Sci."},{"key":"ref_31","first-page":"313","article-title":"Isolation of antioxidants from Alchemilla xanthochlora","volume":"9","year":"2009","journal-title":"Nov. Biotechnol. Chim."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e18373","DOI":"10.1590\/s2175-97902022e18373","article-title":"Bioactivities of Alchemilla mollis, Alchemilla persica and their active constituents","volume":"58","author":"Kurtul","year":"2022","journal-title":"Braz. J. Pharm. Sci."},{"key":"ref_33","first-page":"13","article-title":"Formulation of topical antimicrobials containing the extracts of Alchemilla pedata and Maesa lanceolata","volume":"21","author":"Taddese","year":"2009","journal-title":"Ethiop. Pharm. J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4028\/www.scientific.net\/KEM.762.8","article-title":"Anti-bacterial activity and online HPLC-DPPH based antiradical kinetics of medicinal plant extracts of high relevance for cosmetics production","volume":"762","author":"Dzabijeva","year":"2018","journal-title":"Key Eng. Mater."},{"key":"ref_35","first-page":"16","article-title":"Towards a modern approach to traditional use: In vitro and in vivo evaluation of Alchemilla vulgaris L. gel wound healing potential","volume":"238","author":"Najman","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"567","DOI":"10.2165\/00044011-200626100-00003","article-title":"Treatment of aphthous stomatitis with topical Alchemilla vulgaris in glycerine","volume":"26","author":"Shrivastava","year":"2006","journal-title":"Clin. Drug Investig."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.biopha.2018.06.141","article-title":"Effect of herbal mixture composed of Alchemilla vulgaris and Mimosa on wound healing process","volume":"106","author":"Choi","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_38","unstructured":"Mandrone, M. (2016). Medicinal Plants from Ancient Tradition as a Source for Matrix Proteases Inhibitors. Study of Correlation Between Biological Activity and Phytochemical Profile. [Ph.D. Thesis, University of Bologna]."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1055\/a-0630-2079","article-title":"Identification of a collagenase-inhibiting flavonoid from Alchemilla vulgaris using NMR-based metabolomics","volume":"84","author":"Mandrone","year":"2018","journal-title":"Planta Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.indcrop.2018.06.029","article-title":"Screening of a hundred plant extracts as tyrosinase and elastase inhibitors, two enzymatic targets of cosmetic interest","volume":"122","author":"Chiocchio","year":"2018","journal-title":"Ind. Crops Prod."},{"key":"ref_41","first-page":"352","article-title":"Multiple effects of Alchemilla vulgaris L. extract on melanoma cells and tumor microenvironment","volume":"51","year":"2021","journal-title":"Eur. J. Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Merecz-Sadowska, A., Sitarek, P., Kucharska, E., Kowalczyk, T., Zajdel, K., Cegli\u0144ski, T., and Zajdel, R. (2021). Antioxidant properties of plant-derived phenolic compounds and their effect on skin fibroblast cells. Antioxidants, 10.","DOI":"10.3390\/antiox10050726"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Chaiprasongsuk, A., and Panich, U. (2022). Role of phytochemicals in skin photoprotection via regulation of Nrf2. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.823881"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Villegas, A., Fern\u00e1ndez-Ochoa, \u00c1., Ala\u00f1\u00f3n, M.E., Rojas-Garc\u00eda, A., Arr\u00e1ez-Rom\u00e1n, D., C\u00e1diz-Gurrea, M.D.L.L., and Segura-Carretero, A. (2024). Bioactive compounds and potential health benefits through cosmetic applications of Cherry stem extract. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25073723"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Moreau, M., Naiken, T., Bru, G., Marteau, C., Canaple, L., Gourguillon, L., Leblanc, E., Oger, E., Le Mestr, A., and Mantelin, J. (2023). The impact of PSRTM (plant small RNA technology), tea extract, and its principal components on mitochondrial function and antioxidant properties in skin cells. Cosmetics, 10.","DOI":"10.3390\/cosmetics10060172"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.molmed.2020.04.004","article-title":"Metabolic pathways that control skin homeostasis and inflammation","volume":"26","author":"Cibrian","year":"2020","journal-title":"Trends Mol. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1515\/znc-2012-11-1201","article-title":"Phenolic constituents from Alchemilla vulgaris L. and Alchemilla mollis (Buser) rothm. at different dates of harvest","volume":"67C","author":"Duckstein","year":"2012","journal-title":"Z. Naturforsch. Sect. C J. Biosci."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Hoffmann, J., Casetti, F., Bullerkotte, U., Haarhaus, B., Vagedes, J., Schempp, C.M., and W\u00f6lfle, U. (2016). Anti-inflammatory effects of agrimoniin-enriched fractions of Potentilla erecta. Molecules, 21.","DOI":"10.3390\/molecules21060792"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Melnyk, N., Vlasova, I., Skowro\u0144ska, W., Bazylko, A., Piwowarski, J.P., and Granica, S. (2022). Current knowledge on interactions of plant materials traditionally used in skin diseases in Poland and Ukraine with human skin microbiota. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23179644"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/jdv.19540","article-title":"Acne microbiome: From phyla to phylotypes","volume":"38","author":"Dreno","year":"2024","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/s41580-024-00715-1","article-title":"Cellular and molecular mechanisms of skin wound healing","volume":"25","author":"Martin","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Costa, E.F., Magalh\u00e3es, W.V., and Di Stasi, L.C. (2022). Recent advances in herbal-derived products with skin anti-aging properties and cosmetic applications. Molecules, 27.","DOI":"10.3390\/molecules27217518"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jdermsci.2016.02.004","article-title":"Action of ellagic acid on the melanin biosynthesis pathway","volume":"82","author":"Berna","year":"2016","journal-title":"J. Dermatol. Sci."},{"key":"ref_54","unstructured":"Gupta, S.K. (2004). Boosting Tyrosinase Inhibiting Activity of Skin Whitening and Sunscreen Compositions. (U.S. Patent 2004\/0092606A1,)."},{"key":"ref_55","first-page":"29","article-title":"Chemical characterization and in vitro evaluation of birch sap and a complex of plant extracts for potential use in cosmetic anti-ageing products","volume":"15","author":"Nakurte","year":"2017","journal-title":"Environ. Exp. Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3436665","DOI":"10.1155\/2022\/3436665","article-title":"Profile of medicinal plants traditionally used for the treatment of skin burns","volume":"2022","author":"Mrabti","year":"2022","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Za\u0142\u0119cki, P., Rogowska, K., W\u0105s, P., \u0141uczak, K., Wysocka, M., and Nowicka, D. (2024). Impact of lifestyle on differences in skin hydration of selected body areas in young women. Cosmetics, 11.","DOI":"10.3390\/cosmetics11010013"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"117439","DOI":"10.1016\/j.jep.2023.117439","article-title":"A review of the traditional uses, phytochemistry, pharmacology, and clinical evidence for the use of the genus Alchemilla (Rosaceae)","volume":"320","author":"Jakimiuk","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Kim, M., Yin, J., Hwang, I.H., Park, D.H., Lee, E.K., Kim, M.J., and Lee, M.W. (2020). Anti-acne vulgaris effects of pedunculagin from the leaves of Quercus mongolica by anti-inflammatory activity and 5\u03b1-reductase inhibition. Molecules, 25.","DOI":"10.3390\/molecules25092154"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.sajb.2019.09.010","article-title":"Protective effects of Alchemilla vulgaris L. extracts against cisplatin-induced toxicological alterations in rats","volume":"128","year":"2020","journal-title":"South. Afr. J. Bot."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"249","DOI":"10.5152\/eurasianjmed.2020.19243","article-title":"Isolation of major compounds and gastroprotective activity of Alchemilla caucasica on indomethacin induced gastric ulcers in rats","volume":"52","author":"Karaoglan","year":"2020","journal-title":"Eurasian J. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"113390","DOI":"10.1016\/j.phytochem.2022.113390","article-title":"Apigenin and its dermatological applications: A comprehensive review","volume":"203","author":"Mojaveri","year":"2022","journal-title":"Phytochemistry"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jtemb.2014.09.008","article-title":"Elemental characterisation of the medical plant Alchemilla velebitica","volume":"31","author":"Zeiner","year":"2015","journal-title":"J. Trace Elem. Med. Biol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s10787-024-01602-z","article-title":"Naturally derived bioactive compounds as precision modulators of immune and inflammatory mechanisms in psoriatic conditions","volume":"33","author":"Radu","year":"2025","journal-title":"Inflammopharmacology"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Achagar, R., Ait-Touchente, Z., El Ati, R., Boujdi, K., Thoume, A., Abdou, A., and Touzani, R. (2024). A Comprehensive review of essential oil\u2013nanotechnology synergy for advanced dermocosmetic delivery. Cosmetics, 11.","DOI":"10.3390\/cosmetics11020048"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1080\/00914037.2017.1354202","article-title":"Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract","volume":"67","year":"2018","journal-title":"Int. J. Polym. Mater. Polym. Biomater."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Mansour, A.T., Mahboub, H.H., Elshopakey, G.E., Aziz, E.K., Alhajji, A.H.M., Rayan, G., Ghazzawy, H.S., and El-Houseiny, W. (2022). Physiological performance, antioxidant and immune status, columnaris resistance, and growth of Nile tilapia that received Alchemilla vulgaris\u2014supplemented diets. Antioxidants, 11.","DOI":"10.3390\/antiox11081494"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/wrr.12737","article-title":"A systematic review of Calendula officinalis extract for wound healing","volume":"27","author":"Givol","year":"2019","journal-title":"Wound Repair. Regen."},{"key":"ref_69","first-page":"123","article-title":"Topical effects of Chamomilla recutita in skin damage: A literature review","volume":"3","author":"Ferreira","year":"2015","journal-title":"Pharmacologyonline"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Bungau, S., Vesa, C.M., Abid, A., Behl, T., Tit, D.M., Purza, A.L., Pasca, B., Todan, L.M., and Endres, L. (2021). Withaferin A\u2014A promising phytochemical compound with multiple results in dermatological diseases. 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