{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T18:17:57Z","timestamp":1785608277679,"version":"3.56.0"},"reference-count":78,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scientific Research Projects Coordination Unit of Istanbul University","award":["TDK-2020-36825"],"award-info":[{"award-number":["TDK-2020-36825"]}]},{"name":"Scientific Research Projects Coordination Unit of Istanbul University","award":["2214-A"],"award-info":[{"award-number":["2214-A"]}]},{"name":"Scientific Research Projects Coordination Unit of Istanbul University","award":["ZIABC011470"],"award-info":[{"award-number":["ZIABC011470"]}]},{"name":"Scientific Research Projects Coordination Unit of Istanbul University","award":["ZIABC011657"],"award-info":[{"award-number":["ZIABC011657"]}]},{"name":"Scientific Research Projects Coordination Unit of Istanbul University","award":["75N91019D00024"],"award-info":[{"award-number":["75N91019D00024"]}]},{"name":"Scientific and Technological Research Council of Turkey (T\u00dcB\u0130TAK)","award":["TDK-2020-36825"],"award-info":[{"award-number":["TDK-2020-36825"]}]},{"name":"Scientific and Technological Research Council of Turkey (T\u00dcB\u0130TAK)","award":["2214-A"],"award-info":[{"award-number":["2214-A"]}]},{"name":"Scientific and Technological Research Council of Turkey (T\u00dcB\u0130TAK)","award":["ZIABC011470"],"award-info":[{"award-number":["ZIABC011470"]}]},{"name":"Scientific and Technological Research Council of Turkey (T\u00dcB\u0130TAK)","award":["ZIABC011657"],"award-info":[{"award-number":["ZIABC011657"]}]},{"name":"Scientific and Technological Research Council of Turkey (T\u00dcB\u0130TAK)","award":["75N91019D00024"],"award-info":[{"award-number":["75N91019D00024"]}]},{"name":"Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research","award":["TDK-2020-36825"],"award-info":[{"award-number":["TDK-2020-36825"]}]},{"name":"Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research","award":["2214-A"],"award-info":[{"award-number":["2214-A"]}]},{"name":"Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research","award":["ZIABC011470"],"award-info":[{"award-number":["ZIABC011470"]}]},{"name":"Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research","award":["ZIABC011657"],"award-info":[{"award-number":["ZIABC011657"]}]},{"name":"Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research","award":["75N91019D00024"],"award-info":[{"award-number":["75N91019D00024"]}]},{"name":"National Cancer Institute, National Institutes of Health","award":["TDK-2020-36825"],"award-info":[{"award-number":["TDK-2020-36825"]}]},{"name":"National Cancer Institute, National Institutes of Health","award":["2214-A"],"award-info":[{"award-number":["2214-A"]}]},{"name":"National Cancer Institute, National Institutes of Health","award":["ZIABC011470"],"award-info":[{"award-number":["ZIABC011470"]}]},{"name":"National Cancer Institute, National Institutes of Health","award":["ZIABC011657"],"award-info":[{"award-number":["ZIABC011657"]}]},{"name":"National Cancer Institute, National Institutes of Health","award":["75N91019D00024"],"award-info":[{"award-number":["75N91019D00024"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Four new sesquiterpene coumarin ethers (1\u20134) and a new phenylpropanoid compound (5) were isolated from a hexane extract of the roots of Ferula drudeana, the putative Anatolian ecotype of the silphion plant, in addition to nineteen previously described sesquiterpene coumarins (6\u201324) and four known phenylpropanoid derivatives (25\u201328). The structures of these compounds were elucidated by extensive spectroscopic analysis and computational studies. The cytotoxic activities of all isolated compounds were evaluated on renal, malignant pleural mesothelioma (MPM) and colon cancer cell lines. While 11 sesquiterpene coumarin derivatives showed strong-to-moderate cytotoxic activity against the UO31 renal cancer cell line, 13 compounds showed strong cytotoxic activity against the MPM cell line, and four sesquiterpene coumarin derivatives displayed moderate cytotoxic activity against the colon cancer cell line.<\/jats:p>","DOI":"10.3390\/molecules30091916","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T08:02:57Z","timestamp":1745568177000},"page":"1916","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Sesquiterpene Coumarin Ethers and Phenylpropanoids from the Roots of Ferula drudeana, the Putative Anatolian Ecotype of the Silphion Plant"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2793-0577","authenticated-orcid":false,"given":"Fad\u0131l Kaan","family":"Kuran","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Istanbul University, Istanbul 34116, T\u00fcrkiye"},{"name":"Department of Pharmacognosy, Institute of Graduate Studies in Health Sciences, Istanbul University, Istanbul 34116, T\u00fcrkiye"},{"name":"Molecular Targets Program, National Cancer Institute, Frederick, MD 21702, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9323-3812","authenticated-orcid":false,"given":"Sarath P. D.","family":"Senadeera","sequence":"additional","affiliation":[{"name":"Molecular Targets Program, National Cancer Institute, Frederick, MD 21702, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7824-2507","authenticated-orcid":false,"given":"Dongdong","family":"Wang","sequence":"additional","affiliation":[{"name":"Molecular Targets Program, National Cancer Institute, Frederick, MD 21702, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0157-5724","authenticated-orcid":false,"given":"Ji-Yeon","family":"Hwang","sequence":"additional","affiliation":[{"name":"Molecular Targets Program, National Cancer Institute, Frederick, MD 21702, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Goncharova","sequence":"additional","affiliation":[{"name":"Molecular Targets Program, National Cancer Institute, Frederick, MD 21702, USA"},{"name":"Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2381-1338","authenticated-orcid":false,"given":"Jennifer","family":"Wilson","sequence":"additional","affiliation":[{"name":"Molecular Targets Program, National Cancer Institute, Frederick, MD 21702, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony","family":"Wamiru","sequence":"additional","affiliation":[{"name":"Molecular Targets Program, National Cancer Institute, Frederick, MD 21702, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8988-1964","authenticated-orcid":false,"given":"Brice A. 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