{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T01:06:25Z","timestamp":1769907985572,"version":"3.49.0"},"reference-count":95,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Heilongjiang Touyan Innovation Team Program","award":["[2019] No.5"],"award-info":[{"award-number":["[2019] No.5"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Viola yedoensis Makino (V. yedoensis), a perennial herb in the Violaceae family, is recognized for its violet flowers and has a longstanding role in ethnomedicine for treating various inflammatory diseases, such as boils, furuncles, carbuncles, and both acute and chronic hepatitis, among others. A comprehensive literature review was conducted utilizing resources including the Chinese Pharmacopoeia, Flora of China, Web of Science, PubMed, Baidu Scholar, Google Scholar, and China National Knowledge Infrastructure (CNKI). This paper serves as the inaugural comprehensive review of the latest findings regarding the botany, traditional applications, phytochemistry, pharmacological properties, quality control, and prospective uses of V. yedoensis. The objective is to provide a robust foundation for future research and to suggest novel avenues for exploring its potential applications. To date, 162 chemical constituents have been isolated from V. yedoensis, with flavonoids and coumarins identified as particularly abundant. These compounds exhibit promising activities, including anti-inflammatory, anti-pyretic, anti-viral, anti-tumor, anti-lung injury, anti-liver injury, anti-bacterial, anti-coagulant, anti-complement, and anti-oxidant properties. Despite considerable advancements in fundamental research on V. yedoensis, further investigations are required to elucidate the underlying mechanisms of action and to discover additional uncharacterized compounds. This review underscores the plant\u2019s significant development potential, highlighting the necessity for more in-depth exploration.<\/jats:p>","DOI":"10.3390\/molecules30091922","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T10:42:09Z","timestamp":1745577729000},"page":"1922","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Comprehensive Review of the Phytochemistry and Therapeutic Efficacy of Viola yedoensis Makino"],"prefix":"10.3390","volume":"30","author":[{"given":"Shuang","family":"Wang","sequence":"first","affiliation":[{"name":"School of Pharmacy, Heilongjiang University of Chinese Medicine, 24 Heping Road, Xiangfang District, Harbin 150040, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congcong","family":"Shen","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Heilongjiang University of Chinese Medicine, 24 Heping Road, Xiangfang District, Harbin 150040, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Heilongjiang University of Chinese Medicine, 24 Heping Road, Xiangfang District, Harbin 150040, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Di","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Heilongjiang University of Chinese Medicine, 24 Heping Road, Xiangfang District, Harbin 150040, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhong","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Heilongjiang University of Chinese Medicine, 24 Heping Road, Xiangfang District, Harbin 150040, China"},{"name":"Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Heilongjiang University of Chinese Medicine, 24 Heping Road, Xiangfang District, Harbin 150040, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7234-1135","authenticated-orcid":false,"given":"Feng","family":"Guan","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Heilongjiang University of Chinese Medicine, 24 Heping Road, Xiangfang District, Harbin 150040, China"},{"name":"Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Heilongjiang University of Chinese Medicine, 24 Heping Road, Xiangfang District, Harbin 150040, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.fitote.2009.03.005","article-title":"A new dicoumarin and anticoagulant activity from Viola yedoensis Makino","volume":"80","author":"Zhou","year":"2009","journal-title":"Fitoterapia"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1002\/cbdv.201400240","article-title":"Chemical Constituents and Biological Activities of Plants from the Genus Viola","volume":"12","author":"Zhu","year":"2015","journal-title":"Chem. Biodivers."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/ptr.1497","article-title":"Antibacterial activity of the Chinese traditional medicine, Zi Hua Di Ding","volume":"18","author":"Xie","year":"2004","journal-title":"Phytother. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1248\/cpb.51.1204","article-title":"Flavone C-glycosides from Viola yedoensis MAKINO","volume":"51","author":"Xie","year":"2003","journal-title":"Chem. Pharm. Bull."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1007\/s11418-012-0665-8","article-title":"Collagenase inhibitors from Viola yedoensis","volume":"67","author":"Oshima","year":"2013","journal-title":"J. Nat. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1080\/14786419.2017.1423305","article-title":"Lignans, flavonoids and coumarins from Viola philippica and their \u03b1-glucosidase and HCV protease inhibitory activities","volume":"33","author":"Wang","year":"2019","journal-title":"Nat. Prod. Res."},{"key":"ref_7","unstructured":"Chinese Pharmacopoeia Commission (2020). Pharmacopoeia of the People\u2019s Republic of China."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s10600-010-9752-9","article-title":"Chemical constituents from Viola yedoensis","volume":"46","author":"Xia","year":"2010","journal-title":"Chem. Nat. Compd."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.fitote.2014.12.015","article-title":"Anti-complement sesquiterpenes from Viola yedoensis","volume":"101","author":"Du","year":"2015","journal-title":"Fitoterapia"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Yu, L., Pan, H., Chen, X., Gong, S., Zhang, Q., Zhang, Y., and Zhan, Z. (2024). Comprehensive Mapping of Cyclotides from Viola philippica by Using Mass Spectrometry-Based Strategy. Molecules, 29.","DOI":"10.3390\/molecules29184344"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jpp\/rgac041","article-title":"A comprehensive review of phytochemistry, pharmacology and quality control of plants from the genus Viola","volume":"75","author":"Zhang","year":"2023","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_12","first-page":"214","article-title":"Ethnomedicinal, phytochemical and pharmacological profile of genus Viola","volume":"3","author":"Muhammad","year":"2012","journal-title":"Phytopharmacology"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Jeong, Y.H., Oh, Y.C., Cho, W.K., Shin, H., Lee, K.Y., and Ma, J.Y. (2016). Anti-inflammatory effects of Viola yedoensis and the application of cell extraction methods for investigating bioactive constituents in macrophages. BMC Complement Altern. Med., 16.","DOI":"10.1186\/s12906-016-1142-9"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"154228","DOI":"10.1016\/j.phymed.2022.154228","article-title":"Viola yedoensis Makino formula alleviates DNCB-induced atopic dermatitis by activating JAK2\/STAT3 signaling pathway and promoting M2 macrophages polarization","volume":"103","author":"Zeng","year":"2022","journal-title":"Phytomedicine"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Chu, H., Wang, J., Wang, Q., Chen, J., Li, J., Li, H., and Zhang, L. (2021). Protective Effect of n-Butanol Extract from Viola yedoensis on Immunological Liver Injury. Chem. Biodivers., 18.","DOI":"10.1002\/cbdv.202001043"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1021\/np070393g","article-title":"Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis","volume":"71","author":"Wang","year":"2008","journal-title":"J. Nat. Prod."},{"key":"ref_17","first-page":"80","article-title":"Antipyretic effects of liposoluble fractions of Viola yedoensis","volume":"7","author":"Song","year":"2015","journal-title":"Chin. Herb. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.joim.2024.06.001","article-title":"From ancient wisdom to modern science: Gut microbiota sheds light on property theory of traditional Chinese medicine","volume":"22","author":"Yang","year":"2024","journal-title":"J. Integr. Med."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Qu, S., Qiao, M., Wang, J., Gao, M., Chen, D., Li, S., Wei, E., and Guo, Y. (2022). Network Pharmacology and Data Mining Approach Reveal the Medication Rule of Traditional Chinese Medicine in the Treatment of Premenstrual Syndrome\/Premenstrual Dysphoric Disorder. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.811030"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13020-017-0150-0","article-title":"Effect of methanol extract of Salviae miltiorrhizae Radix in high-fat diet-induced hyperlipidemic mice","volume":"12","author":"Lim","year":"2017","journal-title":"Chin. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5406039","DOI":"10.1155\/2023\/5406039","article-title":"A systematic review of phytochemistry, nutritional composition, and pharmacologic application of species of the genus Viola in noncommunicable diseases (NCDs)","volume":"1","author":"Batiha","year":"2023","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"114474","DOI":"10.1016\/j.jep.2021.114474","article-title":"Anti-atopic effect of Viola yedoensis ethanol extract against 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin dysfunction","volume":"280","author":"Fan","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"290","DOI":"10.3724\/SP.J.1009.2008.00290","article-title":"Chemical constituents of Viola yedoensis","volume":"7","author":"Zhou","year":"2009","journal-title":"Chin. J. Nat. Med."},{"key":"ref_24","first-page":"117","article-title":"Analysis of Chemical Constituents in Violae Herba and Investigation of Its Antioxidant Activity in Vitro","volume":"24","author":"Cui","year":"2021","journal-title":"Chin. J. Exp. Tradit. Med. Formulae"},{"key":"ref_25","first-page":"1068","article-title":"Chemical constituents in ethyl acetate fraction from Viola yedoensis","volume":"19","author":"Liu","year":"2015","journal-title":"Anhui Med. Pharm. J."},{"key":"ref_26","first-page":"1423","article-title":"Chemical constituents from Viola yedoensis","volume":"41","author":"Xu","year":"2010","journal-title":"Chin. Trad. Herb. Drugs"},{"key":"ref_27","first-page":"282","article-title":"Chemical constituents of Viola yedoensis and their antioxidant activity","volume":"19","author":"Cao","year":"2013","journal-title":"Chin. J. Exp. Trad. Med. Form"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jep.2016.05.030","article-title":"Effects of Viola yedoensis Makino anti-itching compound on degranulation and cytokine generation in RBL-2H3 mast cells","volume":"189","author":"Zeng","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref_29","first-page":"1114","article-title":"Studies on chemical constituents from herbs of Viola yedoensis","volume":"34","author":"Huang","year":"2009","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref_30","first-page":"2666","article-title":"Study on antibacterial active components from Viola yedoensis","volume":"36","author":"Sun","year":"2011","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref_31","first-page":"4794","article-title":"Anti-complement alkaloids from whole plants of Viola yedoensis","volume":"42","author":"Du","year":"2017","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref_32","first-page":"185","article-title":"Study on chemical constituents of Viola yedoensis","volume":"25","author":"Yang","year":"2008","journal-title":"J. Xinxiang Med. Univ."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Sun, W., and Shahrajabian, M.H. (2023). Therapeutic Potential of Phenolic Compounds in Medicinal Plants-Natural Health Products for Human Health. Molecules, 28.","DOI":"10.3390\/molecules28041845"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Fan, J., Zhu, R., Han, W., Han, H., and Ding, L. (2024). A multi-wavelength cross-reactive fluorescent sensor ensemble for fingerprinting flavonoids in serum and urine. Spectrochim. Acta A Mol. Biomol. Spectrosc., 310.","DOI":"10.1016\/j.saa.2024.123893"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Al-Khayri, J.M., Sahana, G.R., Nagella, P., Joseph, B.V., Alessa, F.M., and Al-Mssallem, M.Q. (2022). Flavonoids as Potential Anti-Inflammatory Molecules: A Review. Molecules, 27.","DOI":"10.3390\/molecules27092901"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1002\/ptr.8217","article-title":"Luteolin: A promising multifunctional natural flavonoid for human diseases","volume":"38","author":"Zhu","year":"2024","journal-title":"Phytother. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1002\/ptr.7397","article-title":"Chemistry, pharmacokinetics, pharmacological activities, and toxicity of Quercitrin","volume":"36","author":"Chen","year":"2022","journal-title":"Phytother. Res."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Wang, X., and Zhou, D. (2024). Synthesis and Antiallergic Activity of Dicoumarin Derivatives. Molecules, 29.","DOI":"10.3390\/molecules29163799"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s41061-024-00462-z","article-title":"Coumarin-Synthetic Methodologies, Pharmacology, and Application as Natural Fluorophore","volume":"382","author":"Gupta","year":"2024","journal-title":"Top. Curr. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Mitsiou, V.M., Antonaki, A.N., Douka, M.D., and Litinas, K.E. (2024). An Overview on the Synthesis of Lamellarins and Related Compounds with Biological Interest. Molecules, 29.","DOI":"10.3390\/molecules29174032"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"101287","DOI":"10.1016\/j.plipres.2024.101287","article-title":"Plant terpenoid biosynthetic network and its multiple layers of regulation","volume":"95","author":"Bergman","year":"2024","journal-title":"Prog. Lipid Res."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"C\u00e2mara, J.S., Perestrelo, R., Ferreira, R., Berenguer, C.V., Pereira, J.A.M., and Castilho, P.C. (2024). Plant-Derived Terpenoids: A Plethora of Bioactive Compounds with Several Health Functions and Industrial Applications-A Comprehensive Overview. Molecules, 29.","DOI":"10.3390\/molecules29163861"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Koch, W., Zag\u00f3rska, J., Michalak-Tomczyk, M., Karav, S., and Wawruszak, A. (2024). Plant Phenolics in the Prevention and Therapy of Acne: A Comprehensive Review. Molecules, 29.","DOI":"10.3390\/molecules29174234"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/pca.3338","article-title":"An insight into recent updates on analytical techniques for bioactive alkaloids","volume":"35","author":"Saini","year":"2024","journal-title":"Phytochem. Anal."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Ain, Q.U., Khan, H., Mubarak, M.S., and Pervaiz, A. (2016). Plant Alkaloids as Antiplatelet Agent: Drugs of the Future in the Light of Recent Developments. Front. Pharmacol., 7.","DOI":"10.3389\/fphar.2016.00292"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1021\/acs.jnatprod.9b01218","article-title":"Exploring the Sequence Diversity of Cyclotides from Vietnamese Viola Species","volume":"83","author":"Dang","year":"2020","journal-title":"J. Nat. Prod."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"317","DOI":"10.2174\/1389203043379495","article-title":"Novel strategies for isolation and characterization of cyclotides: The discovery of bioactive macrocyclic plant polypeptides in the Violaceae","volume":"5","author":"Claeson","year":"2004","journal-title":"Curr. Protein Pept. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1021\/acs.jnatprod.4c00168","article-title":"Isolation and Characterization of Insecticidal Cyclotides from Viola communis","volume":"88","author":"Khatibi","year":"2024","journal-title":"J. Nat. Prod."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/j.peptides.2011.06.016","article-title":"Isolation and characterization of cytotoxic cyclotides from Viola philippica","volume":"32","author":"He","year":"2011","journal-title":"Peptides"},{"key":"ref_50","first-page":"905","article-title":"A cyclotide against influenza A H1N1 virus from Viola yedoensis","volume":"49","author":"Liu","year":"2014","journal-title":"Yao Xue Xue Bao"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"117350","DOI":"10.1016\/j.jep.2023.117350","article-title":"Viola yedoensis Makino alleviates heat stress-induced inflammation, oxidative stress, and cell apoptosis in the spleen and thymus of broilers","volume":"319","author":"Mao","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"116692","DOI":"10.1016\/j.ecoenv.2024.116692","article-title":"Viola yedoensis Makino alleviates lipopolysaccharide-induced intestinal oxidative stress and inflammatory response by regulating the gut microbiota and NF-\u03baB-NLRP3\/ Nrf2-MAPK signaling pathway in broiler","volume":"282","author":"Zhao","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_53","first-page":"3812","article-title":"Effects of light intensity on cleaning away heat property of Viola yedoensis","volume":"45","author":"Shi","year":"2020","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0166-3542(88)90019-8","article-title":"Isolation, purification and partial characterization of an active anti-HIV compound from the Chinese medicinal herb Viola yedoensis","volume":"10","author":"Ngan","year":"1988","journal-title":"Antivir. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"280","DOI":"10.7150\/ijms.22793","article-title":"Viola Yedoensis Suppresses Cell Invasion by Targeting the Protease and NF-\u03baB Activities in A549 and Lewis Lung Carcinoma Cells","volume":"15","author":"Huang","year":"2018","journal-title":"Int. J. Med. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1142\/S0192415X12500747","article-title":"Viola yedoensis liposoluble fraction ameliorates lipopolysaccharide-induced acute lung injury in mice","volume":"40","author":"Li","year":"2012","journal-title":"Am. J. Chin. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e2306152","DOI":"10.1002\/advs.202306152","article-title":"Stimulus-Responsive Hydrogels as Drug Delivery Systems for Inflammation Targeted Therapy","volume":"11","author":"Yu","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1007\/s10787-023-01369-9","article-title":"Recent advances in anti-inflammatory active components and action mechanisms of natural medicines","volume":"31","author":"Wu","year":"2023","journal-title":"Inflammopharmacology"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1053\/j.gastro.2021.07.042","article-title":"Extraintestinal Manifestations of Inflammatory Bowel Disease: Current Concepts, Treatment, and Implications for Disease Management","volume":"161","author":"Rogler","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s40257-023-00827-y","article-title":"Treat-to-Target in Atopic Dermatitis","volume":"25","author":"Vestergaard","year":"2024","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"239","DOI":"10.4274\/balkanmedj.galenos.2024.2024-5-78","article-title":"Emerging Systemic Treatment Options in Atopic Dermatitis","volume":"41","author":"Salman","year":"2024","journal-title":"Balkan Med. J."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"93","DOI":"10.4103\/2225-4110.126635","article-title":"Anti-inflammatory and Antimicrobial Effects of Heat-Clearing Chinese Herbs: A Current Review","volume":"4","author":"Muluye","year":"2014","journal-title":"J. Tradit. Complement. Med."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Chen, J., Zhao, Y., Cheng, J., Wang, H., Pan, S., and Liu, Y. (2024). The Antiviral Potential of Perilla frutescens: Advances and Perspectives. Molecules, 29.","DOI":"10.3390\/molecules29143328"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s00281-023-00997-1","article-title":"The overlooked bacterial pandemic","volume":"45","author":"Moriel","year":"2024","journal-title":"Semin. Immunopathol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e13276","DOI":"10.1111\/irv.13276","article-title":"Recent Advances, Approaches and Challenges in the Development of Universal Influenza Vaccines","volume":"18","author":"Lim","year":"2024","journal-title":"Influenza Other Respir. Viruses"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1002\/jmv.24705","article-title":"A cell-based high-throughput protocol to screen entry inhibitors of highly pathogenic viruses with Traditional Chinese Medicines","volume":"89","author":"Yang","year":"2017","journal-title":"J. Med. Virol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1142\/S0192415X10007749","article-title":"Effects of herbal medicinal formulas on suppressing viral replication and modulating immune responses","volume":"38","author":"Liao","year":"2010","journal-title":"Am. J. Chin. Med."},{"key":"ref_68","unstructured":"(1989). In vitro screening of traditional medicines for anti-HIV activity: Memorandum from a WHO meeting. Bull. World Health Organ., 67, 613\u2013618."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41392-024-01808-1","article-title":"Drug repurposing for cancer therapy","volume":"9","author":"Xia","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.bbrc.2022.03.147","article-title":"AT7519 against lung cancer via the IL6\/STAT3 signaling pathway","volume":"609","author":"Zhou","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"116565","DOI":"10.1016\/j.jep.2023.116565","article-title":"The effectiveness of blood-activating and stasis-transforming traditional Chinese medicines (BAST) in lung cancer progression-a comprehensive review","volume":"314","author":"Wu","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"153727","DOI":"10.1016\/j.phymed.2021.153727","article-title":"Therapeutic potential of Scutellaria baicalensis Georgi in lung cancer therapy","volume":"95","author":"Xiang","year":"2022","journal-title":"Phytomedicine"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"118308","DOI":"10.1016\/j.lfs.2020.118308","article-title":"Autophagy markers as mediators of lung injury-implication for therapeutic intervention","volume":"260","author":"Vishnupriya","year":"2020","journal-title":"Life Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e23612","DOI":"10.1096\/fj.202400088R","article-title":"Repair and regeneration of the alveolar epithelium in lung injury","volume":"38","author":"Wang","year":"2024","journal-title":"FASEB J."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.intimp.2018.07.032","article-title":"G-CSF mediates lung injury in mice with adenine-induced acute kidney injury","volume":"63","author":"Jing","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Liu, Q.H., Zhang, K., Feng, S.S., Zhang, L.J., Li, S.Y., Wang, H.Y., and Wang, J.H. (2024). Rosavin Alleviates LPS-Induced Acute Lung Injure by Modulating the TLR-4\/NF-\u03baB\/MAPK Singnaling Pathways. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25031875"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"100777","DOI":"10.1016\/j.cpsurg.2020.100777","article-title":"Acute lung injury","volume":"57","author":"Mowery","year":"2020","journal-title":"Curr. Probl. Surg."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Saadat, S., Beigoli, S., Khazdair, M.R., Amin, F., and Boskabady, M.H. (2022). Experimental and Clinical Studies on the Effects of Natural Products on Noxious Agents-Induced Lung Disorders, a Review. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.867914"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.cnc.2022.04.008","article-title":"Trends in Reduction of Mortality in Liver Trauma","volume":"34","author":"Villegas","year":"2022","journal-title":"Crit. Care. Nurs. Clin. N. Am."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e22119","DOI":"10.1096\/fj.202101448R","article-title":"GBP5 promotes liver injury and inflammation by inducing hepatocyte apoptosis","volume":"36","author":"Ding","year":"2022","journal-title":"FASEB J."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13020-022-00585-9","article-title":"An integrated study of Violae Herba (Viola philippica) and five adulterants by morphology, chemical compositions and chloroplast genomes: Insights into its certified plant origin","volume":"17","author":"Lu","year":"2022","journal-title":"Chin. Med."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Rizwan, K., Khan, S.A., Ahmad, I., Rasool, N., Ibrahim, M., Zubair, M., Jaafar, H.Z., and Manea, R. (2019). A Comprehensive Review on Chemical and Pharmacological Potential of Viola betonicifolia: A Plant with Multiple Benefits. Molecules, 24.","DOI":"10.3390\/molecules24173138"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Cao, D.L., Zhang, X.J., Xie, S.Q., Fan, S.J., and Qu, X.J. (2022). Application of chloroplast genome in the identification of Traditional Chinese Medicine Viola philippica. BMC Genom., 23.","DOI":"10.1186\/s12864-022-08727-x"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.foodchem.2018.01.055","article-title":"Extraction techniques and analysis of anthocyanins from food sources by mass spectrometry: An update","volume":"250","author":"Ongkowijoyo","year":"2018","journal-title":"Food Chem."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.talanta.2016.09.050","article-title":"Highly sensitive determination of esculetin on TiO2-NPs-coated poly(diallyldimethylammonium chloride)-functionalized graphene modified electrode","volume":"161","author":"Li","year":"2016","journal-title":"Talanta"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s10337-024-04348-6","article-title":"Identification and Semi-quantification of 36 Compounds from Violae Herba (Zihuadiding) via UHPLC-Q-Orbitrap-MS\/MS as well as Proposal of Anti-counterfeiting Quality-marker for Pharmacopeia","volume":"87","author":"Chen","year":"2024","journal-title":"Chromatographia"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1002\/jms.3413","article-title":"Approach to the study of flavone di-C-glycosides by high performance liquid chromatography-tandem ion trap mass spectrometry and its application to characterization of flavonoid composition in Viola yedoensis","volume":"49","author":"Cao","year":"2014","journal-title":"J. Mass Spectrom."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/pca.1320","article-title":"Rapid separation and identification of anthocyanins from flowers of Viola yedoensis and V. prionantha by high-performance liquid chromatography-photodiode array detection-electrospray ionisation mass spectrometry","volume":"23","author":"Zhang","year":"2012","journal-title":"Phytochem. Anal."},{"key":"ref_89","first-page":"5230","article-title":"Comparative analysis of major constituents in Viola yedoensis Makino and different species from the Genus Viola by high-performance liquid chromatography with chemometrics methods","volume":"5","author":"Hong","year":"2011","journal-title":"J. Med. Plants Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.foodchem.2015.01.123","article-title":"Edible flowers of Viola tricolor L. as a new functional food: Antioxidant activity, individual phenolics and effects of gamma and electron-beam irradiation","volume":"179","author":"Koike","year":"2015","journal-title":"Food Chem."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Zeng, G., Li, X., Zhao, C., Pang, Y., Luo, X., and Tang, Z. (2025). Proximate Composition and In Vitro Bioactive Properties of Leaf Extracts from Seven Viola Species. Foods, 14.","DOI":"10.3390\/foods14020302"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Thonthula, S., Sousa, S., Dubuis, A., Boudah, S., Mehta, R., Singh, A., Eilstein, J., Tabet, J.C., John, S., and Roy, D. (2024). Improved Skin Barrier Function Along with Hydration Benefits of Viola yedoensis Extract, Aesculin, and Schaftoside and LC-HRMS\/MS Dereplication of Its Bio-Active Components. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252312770"},{"key":"ref_93","first-page":"13","article-title":"A Review on Herbal Plants used in Skin and Hair Treatment","volume":"1","author":"Meena","year":"2010","journal-title":"Res. J. Top. Cosmet. Sci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.bbrc.2015.02.066","article-title":"Transcriptome sequencing and differential gene expression analysis in Viola yedoensis Makino (Fam. Violaceae) responsive to cadmium (Cd) pollution","volume":"459","author":"Gao","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"280","DOI":"10.2306\/scienceasia1513-1874.2020.035","article-title":"Novel SSR and SNP markers in Viola yedoensis makino resistant to cadmium stress","volume":"46","author":"Peng","year":"2020","journal-title":"ScienceAsia"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/9\/1922\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:21:48Z","timestamp":1760030508000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/9\/1922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,25]]},"references-count":95,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["molecules30091922"],"URL":"https:\/\/doi.org\/10.3390\/molecules30091922","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,25]]}}}