{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:21:52Z","timestamp":1789064512734,"version":"build-2803163510"},"reference-count":65,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T00:00:00Z","timestamp":1745712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wroc\u0142aw University of Environmental and Life Sciences"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Fermentation processes, which occur under the influence of multiplying microorganisms, lead to the creation of products with beneficial health properties. Due to the growing interest of consumers in beverages with health-promoting properties, new raw materials and their processing methods are being intensively studied to obtain products with improved functional values. The purpose of the study is to determine the effect of fermentation using SCOBY (Symbiotic Culture of Bacteria and Yeast) on the chemical composition, polyphenolic profile, and biological activity of apple and pear juices. The fermentation process caused a decrease in the content of polyphenols in apple juice from 1568.8 to 1269.0 mg\/L, while in pears, an increase was observed from 492.9 to 576.7 mg\/L. Statistically significant changes were observed in the content of individual groups of polyphenolic compounds. The fermentation process also influenced the increase in the value of anti-inflammatory, antioxidant, antidiabetic, and anticholinergic activity. This indicates that fermentation can be an effective process in increasing the biological properties of fruit juices. This fact can be used in the prevention of lifestyle diseases and in the production of functional foods with targeted health-promoting properties.<\/jats:p>","DOI":"10.3390\/molecules30091940","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T06:23:32Z","timestamp":1745821412000},"page":"1940","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Evaluation of Anti-Inflammatory, Antidiabetic, Antioxidant, and Anticholinergic Activities, as Well as Chemical Composition and Polyphenolic Compounds in Novel SCOBY-Fermented Juices"],"prefix":"10.3390","volume":"30","author":[{"given":"Joanna","family":"Grondalska","sequence":"first","affiliation":[{"name":"Department of Fruit, Vegetable and Plant Nutraceutical Technology, Wroc\u0142aw University of Environmental and Life Sciences, 37 Chelmonskiego Street, 51-630 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1933-2852","authenticated-orcid":false,"given":"Joanna","family":"Kolniak-Ostek","sequence":"additional","affiliation":[{"name":"Department of Fruit, Vegetable and Plant Nutraceutical Technology, Wroc\u0142aw University of Environmental and Life Sciences, 37 Chelmonskiego Street, 51-630 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s11130-022-00983-2","article-title":"Antioxidant and Antimicrobial Properties of Selected Fruit Juices","volume":"77","author":"Nowak","year":"2022","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_2","unstructured":"Lewko, K. (2017). Leczenie Dobr\u0105 Diet\u0105, Wydawnictwo SBM. [1st ed.]. (In Polish)."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Kolniak-Ostek, J., K\u0142opotowska, D., Rutkowski, K.P., Skorupi\u0144ska, A., and Kruczy\u0144ska, D.E. (2020). Bioactive Compounds and Health-Promoting Properties of Pear (Pyrus communis L.) Fruits. Molecules, 25.","DOI":"10.3390\/molecules25194444"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.26599\/FSHW.2022.9250202","article-title":"Health effects of fruit juices and beverages with varying degrees of processing","volume":"13","author":"Zhang","year":"2024","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Pabich, M., and Materska, M. (2019). Biological Effect of Soy Isoflavones in the Prevention of Civilization Diseases. Nutrients, 11.","DOI":"10.3390\/nu11071660"},{"key":"ref_6","first-page":"3","article-title":"Choroby cywilizacyjne i ich prewencja","volume":"1","author":"Kitajewska","year":"2014","journal-title":"J. Clin. Healthc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.55225\/hppa.590","article-title":"Man in Health and Disease. Prevention and Management of Civilizational Diseases: International Scientific Conference, May 24, 2024, Tarn\u00f3w, Poland","volume":"27","year":"2024","journal-title":"Health Promot. Phys. Act."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"112909","DOI":"10.1016\/j.foodres.2023.112909","article-title":"Revealing the influence of microbiota on the flavor of kombucha during natural fermentation process by metagenomic and GC-MS analysis","volume":"169","author":"Yao","year":"2023","journal-title":"Food Res. Int."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.fm.2013.09.003","article-title":"Sequence-based analysis of the bacterial and fungal compositions of multiple kombucha (tea fungus) samples","volume":"38","author":"Marsh","year":"2014","journal-title":"Food Microbiol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Pawlu\u015b, P., and Kolniak-Ostek, J. (2024). Innovative Analogs of Unpasteurized Kombucha Beverages: Comparative Analysis of Mint\/Nettle Kombuchas, Considering Their Health-Promoting Effect, Polyphenolic Compounds and Chemical Composition. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25147572"},{"key":"ref_11","unstructured":"Nieumywakin, I. (2018). Grzyb Herbaciany: Naturalny Uzdrowiciel, Hartigrama. (In Polish)."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Kitwetcharoen, H., Phung, L.T., Klanrit, P., Thanonkeo, S., Tippayawat, P., Yamada, M., and Thanonkeo, P. (2023). Kombucha Healthy Drink\u2014Recent Advances in Production, Chemical Composition and Health Benefits. Fermentation, 9.","DOI":"10.3390\/fermentation9010048"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"100288","DOI":"10.1016\/j.focha.2023.100288","article-title":"Kombucha benefits, risks and regulatory frameworks: A review","volume":"2","author":"Ogeda","year":"2023","journal-title":"Food Chem. Adv."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"100421","DOI":"10.1016\/j.focha.2023.100421","article-title":"Kombucha fermentation: Recent trends in process dynamics, functional bioactivities, toxicity management, and potential applications","volume":"3","author":"Sanwal","year":"2023","journal-title":"Food Chem. Adv."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/1750-3841.16029","article-title":"Kombucha: A review of substrates, regulations, composition, and biological properties","volume":"87","author":"Ruiz","year":"2022","journal-title":"J. Food Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"115482","DOI":"10.1016\/j.lwt.2023.115482","article-title":"Novel kombucha beverages with antioxidant activity based on fruits as alternative substrates","volume":"189","author":"Morales","year":"2023","journal-title":"LWT-Food Sci. Technol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Chong, A.Q., Chin, N.L., Talib, R.A., and Basha, R.K. (2024). Modelling pH Dynamics, SCOBY Biomass Formation, and Acetic Acid Production of Kombucha Fermentation Using Black, Green, and Oolong Teas. Processes, 12.","DOI":"10.3390\/pr12071301"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"100646","DOI":"10.1016\/j.focha.2024.100646","article-title":"Metabolic responses of kombucha consortium fermentation upon ultrasound-processing","volume":"4","author":"Fonteles","year":"2024","journal-title":"Food Chem. Adv."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"252","DOI":"10.55730\/1300-011X.3083","article-title":"Determination of some quality properties and antimicrobial activities of kombucha tea prepared with different berries","volume":"47","author":"Tomar","year":"2023","journal-title":"Turk. J. Agric. For."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.1007\/s12011-020-02445-9","article-title":"Evaluation of Fluoride and Selected Chemical Parameters in Kombucha Derived from White, Green, Black and Red Tea","volume":"199","author":"Jakubczyk","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"key":"ref_21","first-page":"48","article-title":"Characterization and analysis kombucha tea antioxidant activity based on long fermentation as a beverage functional","volume":"2","author":"Nurikasari","year":"2017","journal-title":"J. Glob. Res. Public Health"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"012040","DOI":"10.1088\/1755-1315\/131\/1\/012040","article-title":"Characteristic of physical, chemical, and microbiological kombucha from various varieties of apples","volume":"131","author":"Zubaidah","year":"2018","journal-title":"IOP Conf. Ser. Earth Environ. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Jakubczyk, K., Ka\u0142du\u0144ska, J., Kochman, J., and Janda, K. (2020). Chemical Profile and Antioxidant Activity of the Kombucha Beverage Derived from White, Green, Black and Red Tea. Antioxidants, 9.","DOI":"10.3390\/antiox9050447"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"de Oliveira, P.M., Santos, L.P., Coelho, L.F., Neto, P.M.A., Sass, D.C., and Contiero, J. (2021). Production of L (+) Lactic Acid by Lactobacillus casei Ke11: Fed Batch Fermentation Strategies. Fermentation, 7.","DOI":"10.3390\/fermentation7030151"},{"key":"ref_25","first-page":"1686","article-title":"Lactic Acid Production Using Lactic Acid Bacteria under Optimized Conditions","volume":"2","author":"Sheeladevi","year":"2011","journal-title":"Int. J. Pharm. Biol. Arch."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Costa, S., Summa, D., Semeraro, B., Zappaterra, F., Rugiero, I., and Tamburini, E. (2020). Fermentation as a Strategy for Bio-Transforming Waste into Resources: Lactic Acid Production from Agri-Food Residues. Fermentation, 7.","DOI":"10.3390\/fermentation7010003"},{"key":"ref_27","first-page":"e01915","article-title":"Microbial conversion of agro-wastes for lactic acid production","volume":"22","author":"Oyewole","year":"2023","journal-title":"Sci. Afr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1590\/S0103-84781997000200027","article-title":"Indu\u00e7\u00e3o da fermenta\u00e7\u00e3o malol\u00e1ctica em vinho Gew\u00fcrztraminer","volume":"27","author":"Daudt","year":"1997","journal-title":"Cienc. Rural."},{"key":"ref_29","unstructured":"Binati, R.L. (2025, March 05). Avalia\u00e7\u00e3o da fermenta\u00e7\u00e3o malol\u00e1ctica em vinhos de altitude com bact\u00e9rias \u00e1cido-l\u00e1cticas aut\u00f3ctones selecionadas. Available online: https:\/\/repositorio.ufsc.br\/bitstream\/handle\/123456789\/135391\/334491.pdf?sequence=1&isAllowed=y."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Guillam\u00f3n, J.M., and Mas, A. (2009). Acetic Acid Bacteria. Biology of Microorganisms on Grapes, in Must and Wine, Springer.","DOI":"10.1007\/978-3-540-85463-0_2"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e02846-17","DOI":"10.1128\/AEM.02846-17","article-title":"Temporal and Spatial Distribution of the Acetic Acid Bacterium Communities throughout the Wooden Casks Used for the Fermentation and Maturation of Lambic Beer Underlines Their Functional Role","volume":"84","author":"Verce","year":"2018","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Wang, S., Li, C., Ying, W., Wang, S., Zhou, Y., Wu, W., and Lei, Y. (2024). Addition of Lactic Acid Bacteria Modulates Microbial Community and Promotes the Flavor Profiles of Kombucha. Food Biosci., 60.","DOI":"10.1016\/j.fbio.2024.104340"},{"key":"ref_33","first-page":"11","article-title":"Fermentation assisted functional foods","volume":"3","author":"Naik","year":"2024","journal-title":"Futur. Trends Biotechnol."},{"key":"ref_34","first-page":"668","article-title":"Fermented Foods: Fermented Vegetables and Other Products","volume":"2","author":"Filannino","year":"2016","journal-title":"Encycl. Food Health"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s00217-013-1931-z","article-title":"Effect of l-ascorbic acid addition on quality, polyphenolic compounds and antioxidant capacity of cloudy apple juices","volume":"236","year":"2013","journal-title":"Eur. Food Res. Technol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jfca.2016.04.004","article-title":"Identification and quantification of polyphenolic compounds in ten pear cultivars by UPLC-PDA-Q\/TOF-MS","volume":"49","year":"2016","journal-title":"J. Food Compos. Anal."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"117632","DOI":"10.1016\/j.lwt.2025.117632","article-title":"Comparison of polyphenol and volatile compounds and in vitro antioxidant, anti-inflammatory, antidiabetic, anti-ageing, and anticancer activities of dry tea leaves","volume":"222","author":"Chandran","year":"2025","journal-title":"LWT-Food Sci. Technol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Yang, F., Chen, C., Ni, D., Yang, Y., Tian, J., Li, Y., Chen, S., Ye, X., and Wang, L. (2023). Effects of Fermentation on Bioactivity and the Composition of Polyphenols Contained in Polyphenol-Rich Foods: A Review. Foods, 12.","DOI":"10.3390\/foods12173315"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Kim, H., Hur, S., Lim, J., Jin, K., Yang, T.-H., Keehm, I.-S., Kim, S.W., Kim, T., and Kim, D. (2023). Enhancement of the phenolic compounds and antioxidant activities of Kombucha prepared using specific bacterial and yeast. Food Biosci., 56.","DOI":"10.1016\/j.fbio.2023.103431"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Zhou, D.-D., Saimaiti, A., Luo, M., Huang, S.-Y., Xiong, R.-G., Shang, A., Gan, R.-Y., and Li, H.-B. (2022). Fermentation with Tea Residues Enhances Antioxidant Activities and Polyphenol Contents in Kombucha Beverages. Antioxidants, 11.","DOI":"10.3390\/antiox11010155"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Liang, Z., Huang, Y., Zhang, P., and Fang, Z. (2023). Impact of fermentation on the structure and antioxidant activity of selective phenolic compounds. Food Biosci., 56.","DOI":"10.1016\/j.fbio.2023.103147"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s43014-022-00101-4","article-title":"Probiotic fermentation of polyphenols: Potential sources of novel functional foods","volume":"4","author":"Sharma","year":"2022","journal-title":"Food Prod. Process. Nutr."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"12752","DOI":"10.1021\/acs.jafc.4c01393","article-title":"Exploring the Biogenic Transformation Mechanism of Polyphenols by Lactobacillus plantarum NCU137 Fermentation and Its Enhancement of Antioxidant Properties in Wolfberry Juice","volume":"72","author":"Liu","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2023\/6711132","article-title":"Exploring the Effects of Solid-State Fermentation on Polyphenols in Acanthopanax senticosus Based on Response Surface Methodology and Nontargeted Metabolomics Techniques","volume":"2023","author":"Su","year":"2023","journal-title":"J. Food Biochem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.lwt.2011.12.033","article-title":"Antimicrobial effect of Kombucha analogues","volume":"47","author":"Battikh","year":"2012","journal-title":"LWT-Food Sci. Technol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/ejoc.201601264","article-title":"Convenient Synthesis of 3-Glycosylated Isocoumarins","volume":"2017","author":"Sudarshan","year":"2016","journal-title":"Eur. J. Org. Chem."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Angeli, L., Populin, F., Morozova, K., Ding, Y., Asma, U., Bolchini, S., Cebulj, A., Busatto, N., Costa, F., and Ferrentino, G. (2024). Comparative analysis of antioxidant activity and capacity in apple varieties: Insights from stopped flow DPPH\u2022 kinetics, mass spectrometry and electrochemistry. Food Biosci., 58.","DOI":"10.1016\/j.fbio.2024.103729"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Kartelias, I.G., Karantonis, H.C., Giaouris, E., Panagiotakopoulos, I., and Nasopoulou, C. (2023). Kombucha Fermentation of Olympus Mountain Tea (Sideritis scardica) Sweetened with Thyme Honey: Physicochemical Analysis and Evaluation of Functional Properties. Foods, 12.","DOI":"10.3390\/foods12183496"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Kartelias, I.G., Panagiotakopoulos, I., Nasopoulou, C., and Karantonis, H.C. (2024). Evaluating the Effect of Adding Selected Herbs, Spices, and Fruits to Fermented Olympus Mountain Tea (Sideritis scardica) Kombucha Sweetened with Thyme Honey: Assessment of Physicochemical and Functional Properties. Beverages, 10.","DOI":"10.3390\/beverages10010009"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Kim, Y., Keogh, J.B., and Clifton, P.M. (2016). Polyphenols and Glycemic Control. Nutrients, 8.","DOI":"10.3390\/nu8010017"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Rupasinghe, H.P.V., Balasuriya, N., and Wang, Y. (2017). Prevention of Type 2 Diabetes by Polyphenols of Fruits. Nutritional Antioxidant Therapies: Treatments and Perspectives, Springer.","DOI":"10.1007\/978-3-319-67625-8_17"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3746\/pnf.2022.27.3.257","article-title":"Effects of Fruit and Vegetable Polyphenols on the Glycemic Control and Metabolic Parameters in Type 2 Diabetes Mellitus: A Review","volume":"27","author":"Zin","year":"2022","journal-title":"Prev. Nutr. Food Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"886","DOI":"10.14196\/mjiri.31.134","article-title":"Polyphenols and their effects on diabetes management: A review","volume":"31","author":"Aryaeian","year":"2017","journal-title":"Med. J. Islam. Repub. Iran"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.tifs.2021.06.038","article-title":"Effect of citrus fruit and juice consumption on risk of developing type 2 diabetes: Evidence on polyphenols from epidemiological and intervention studies","volume":"115","author":"Visvanathan","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"4288","DOI":"10.1080\/10408398.2021.2000932","article-title":"Omnifarious fruit polyphenols: An omnipotent strategy to prevent and intervene diabetes and related complication?","volume":"63","author":"Chen","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Wang, B., Liu, K., Mi, M., and Wang, J. (2014). Effect of Fruit Juice on Glucose Control and Insulin Sensitivity in Adults: A Meta-Analysis of 12 Randomized Controlled Trials. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0095323"},{"key":"ref_57","first-page":"e59","article-title":"100% Fruit juice and measures of glycemic control and insulin sensitivity: A meta-analysis of randomized controlled trials","volume":"6","author":"Murphy","year":"2017","journal-title":"FASEB J."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Mendelson, C., Sparkes, S., Merenstein, D.J., Christensen, C., Sharma, V., Desale, S., Auchtung, J.M., Kok, C.R., Hallen-Adams, H.E., and Hutkins, R. (2023). Kombucha tea as an anti-hyperglycemic agent in humans with diabetes\u2014A randomized controlled pilot investigation. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1190248"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"de Miranda, J.F., Ruiz, L.F., Uekane, T.M., Silva, K.A., and Lima, A.R. (2022). Kombucha e Seu Potencial Efeito Antidiab\u00e9tico: Revis\u00e3o, Agron Food Academy.","DOI":"10.53934\/9786599539657-5"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"484","DOI":"10.51584\/IJRIAS.2024.906043","article-title":"Myths and Potential Benefits of Kombucha as a Functional Food: A Review","volume":"IX","author":"Amalia","year":"2024","journal-title":"Int. J. Res. Innov. Appl. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e68785","DOI":"10.34119\/bjhrv7n2-323","article-title":"Efficiency of daily kombucha consumption in reducing glycemic levels and hypercholesterolemia","volume":"7","author":"Filho","year":"2024","journal-title":"Braz. J. Health Rev."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Xu, S., Wang, Y., Wang, J., and Geng, W. (2022). Kombucha Reduces Hyperglycemia in Type 2 Diabetes of Mice by Regulating Gut Microbiota and Its Metabolites. Foods, 11.","DOI":"10.3390\/foods11050754"},{"key":"ref_63","first-page":"e4501","article-title":"Utiliza\u00e7\u00e3o da kombucha em pacientes diab\u00e9ticos: Uma revis\u00e3o de literatura","volume":"15","author":"Silva","year":"2024","journal-title":"Rev. Gestao E Secr."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.ejmech.2016.08.066","article-title":"Inhibition of the enzymes in the leukotriene and prostaglandin pathways in inflammation by 3-aryl isocoumarins","volume":"124","author":"Ramanan","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"254","DOI":"10.29303\/jpm.v19i2.6320","article-title":"Total Flavonoid Content and In Vitro Anti-Inflammatory Potentials of Kombucha with Enrichment of Butterfly Pea (Clitoria ternatea) Flower Extract","volume":"19","author":"Wahyanto","year":"2024","journal-title":"J. Pijar Mipa"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/9\/1940\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:22:40Z","timestamp":1760030560000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/9\/1940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,27]]},"references-count":65,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["molecules30091940"],"URL":"https:\/\/doi.org\/10.3390\/molecules30091940","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,27]]}}}