{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:58:28Z","timestamp":1787029108816,"version":"build-2736575974"},"reference-count":29,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:00:00Z","timestamp":1745971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>An efficient stereoselective strategy for the synthesis of chiral bisspiro barbituric acid\u2013oxindole derivatives was developed. The asymmetric Michael addition\/cyclization tandem reaction between benzylidene barbituric acids and oxindolylmalonitriles was catalyzed by squaramide catalyst, and the corresponding spirocyclic products were obtained in good-to-high yields (up to 97%) with excellent stereoselectivities (up to &gt;99% ee, &gt;20:1 dr). At the same time, the practicality of the reaction was verified by the gram-scale preparation reaction.<\/jats:p>","DOI":"10.3390\/molecules30092000","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T07:00:21Z","timestamp":1745996421000},"page":"2000","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Squaramide-Catalyzed Asymmetric Michael Addition\/Cyclization Reaction for the Synthesis of Chiral Bisspiro Barbituric Acid\u2013Oxindole Derivatives"],"prefix":"10.3390","volume":"30","author":[{"given":"De-Jun","family":"Qiao","sequence":"first","affiliation":[{"name":"Key Laboratory of Medicinal Molecule Science and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9924-5117","authenticated-orcid":false,"given":"Da-Ming","family":"Du","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medicinal Molecule Science and Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1021\/ed028p524","article-title":"The story of Barbituric acid","volume":"28","author":"Carter","year":"1951","journal-title":"J. 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