{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:08:40Z","timestamp":1790186920613,"version":"4.1.0"},"reference-count":179,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:00:00Z","timestamp":1745971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical University of Lodz","award":["503\/3-012-01\/503-31-001"],"award-info":[{"award-number":["503\/3-012-01\/503-31-001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The genus Dracocephalum (family Lamiaceae) comprises approximately 70 species, many of which have been traditionally used in various ethnomedical systems. The plants exhibit a broad distribution across steppe, semi-deserts, deserts, and alpine zones of temperate Eurasia, with isolated endemic species occurring in North America and North Africa. The traditional medicinal uses of the Dracocephalum species encompass the treatment of respiratory diseases, colds and fever, gastrointestinal disorders, liver and gallbladder ailments, musculoskeletal conditions, cardiovascular diseases, diabetes, gynecological and urological disorders, as well as ailments of the ears, throat, mouth, and eyes, as well as various dermatological conditions. The plants are rich sources of polyphenolic compounds, including flavonoids and phenolic acids, which contribute to their diverse pharmacological activities. The flavonoid profile of the Dracocephalum species is dominated by luteolin and apigenin derivatives, supplemented by mono-, di-, tri-, tetra-, and pentamethoxylated flavones. The predominant phenolic acids are chlorogenic acid, coumaric acid, rosmarinic acid, and their derivatives. Other phenolic compounds have also been identified in the genus: anthocyanins, lignans, phenylethanoids, phenylacetamide glycosides, flavonoid alkaloids, gingerols, coumarins, furanocoumarins, and cyanogenic glucosides. Despite growing scientific interest in this genus, a comprehensive review of its polyphenolic constituents, their structures, and associated biological activities remains lacking. To bridge this gap, this review presents an analysis of the polyphenolic profile of the Dracocephalum species, their ethnomedicinal uses, and the latest findings on their biological potential.<\/jats:p>","DOI":"10.3390\/molecules30092017","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T06:49:02Z","timestamp":1746082142000},"page":"2017","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Comprehensive Review of the Phenolic Compounds in Dracocephalum Genus (Lamiaceae) Related to Traditional Uses of the Species and Their Biological Activities"],"prefix":"10.3390","volume":"30","author":[{"given":"Izabela","family":"Weremczuk-Je\u017cyna","sequence":"first","affiliation":[{"name":"Department of Biology and Pharmaceutical Botany, Medical University of Lodz, 90-151 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4793-4604","authenticated-orcid":false,"given":"Izabela","family":"Grzegorczyk-Karolak","sequence":"additional","affiliation":[{"name":"Department of Biology and Pharmaceutical Botany, Medical University of Lodz, 90-151 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3390\/ddc3010011","article-title":"Plant-derived natural products: A source for drug discovery and development","volume":"3","author":"Chaachouay","year":"2024","journal-title":"Drugs Drug Candidates"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Ortiz-Mendoza, N., Mart\u00ednez-Gordillo, M.J., Mart\u00ednez-Ambriz, E., Basurto-Pe\u00f1a, F.A., Gonz\u00e1lez-Trujano, M.E., and Aguirre-Hern\u00e1ndez, E. (2023). Ethnobotanical, phytochemical, and pharmacological properties of the subfamily Nepetoideae (Lamiaceae) in inflammatory diseases. Plants, 12.","DOI":"10.3390\/plants12213752"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Liu, H., Feng, X., Zhao, Y., Lv, G., Zhang, C., Damba, T.A., Zhang, N., Hao, D., and Li, M. (2024). Pharmacophylogenetic relationships of genus Dracocephalum and its related genera based on multifaceted analysis. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1449426"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.4236\/ajps.2019.109108","article-title":"The genus Dracocephalum L. in the phytogeographical regions of Uzbekistan","volume":"10","author":"Abdullaeva","year":"2019","journal-title":"Am. J. Plant Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1080\/13880200902905904","article-title":"In vivo and in vitro antiviral activity of five Tibetan medicinal plant extracts against herpes simplex virus type 2 infection","volume":"47","author":"Zhang","year":"2009","journal-title":"Pharm. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jep.2007.03.020","article-title":"Traditional medicinal plants of cold desert Ladakh-used in treatment of cold, cough and fever","volume":"13","author":"Ballabh","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.phytochem.2014.02.007","article-title":"Monoterpene glycosides, phenylpropanoids, and acacetin glycosides from Dracocephalum foetidum","volume":"101","author":"Selenge","year":"2014","journal-title":"Phytochemistry"},{"key":"ref_8","first-page":"9465309","article-title":"Medicinal properties and active constituents of Dracocephalum kotschyi and its significance in Iran: A systematic review","volume":"2019","author":"Heydari","year":"2019","journal-title":"J. Evid.-Based Complement. Altern. Med."},{"key":"ref_9","first-page":"1568","article-title":"Broad variation in herbage yield and essential oil content among Iranian Landraces of Dracocephalum moldavica","volume":"7","author":"Borghei","year":"2015","journal-title":"Biol. Forum"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/j.lwt.2006.11.013","article-title":"Chemical composition and antioxidative activity of Moldavian balm (Dracocephalum moldavica L.) extracts","volume":"40","author":"Dastmalchi","year":"2007","journal-title":"LWT\u2014Food Sci. Technol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.foodchem.2013.03.019","article-title":"Identification and quantification of leaf surface flavonoids in wild growing populations of Dracocephalum kotschyi by LC\u2013DAD\u2013ESI-MS","volume":"141","author":"Fattahi","year":"2013","journal-title":"Food Chem."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1002\/cbdv.200900188","article-title":"Chemical constituents of plants from the genus Dracocephalum","volume":"7","author":"Zeng","year":"2010","journal-title":"Chem. Biodivers."},{"key":"ref_13","first-page":"11","article-title":"Phytochemical analysis of volatile and non-volatile fractions, antioxidant, and anti-cancer activities of Dracocephalum polychaetum and Dracocephalum kotschyi","volume":"14","author":"Taghizadeh","year":"2022","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"ref_14","first-page":"289","article-title":"Dracocephalum kotschyi: Inhibition of critical enzyme relevant to type-2, diabetes, essential oil composition, bactericidal and anti-oxidant activity","volume":"22","author":"Kazempour","year":"2024","journal-title":"Casp. J. Environ. Sci."},{"key":"ref_15","first-page":"313","article-title":"Improved oral bioavailability of total flavonoids of Dracocephalum moldavica via composite phospholipid liposomes: Preparation, in vitro drug release and pharmacokinetics in rats","volume":"12","author":"Zeng","year":"2016","journal-title":"Pharmacogn. Mag."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"60","DOI":"10.34172\/jsums.2022.11","article-title":"Optimization of antifungal extracts from Dracocephalum kotschyi using response surface methodology and evaluations of antifungal effects on Candida albicans","volume":"24","author":"Ghoratolhamide","year":"2022","journal-title":"J. Shahrekord Univ. Med. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"435","DOI":"10.34172\/jhp.2022.50","article-title":"Bioassay standardization of drug dosage form prepared from hydroalcoholic extract of Dracocephalum kotschyi","volume":"14","author":"Sadraei","year":"2022","journal-title":"J. Herbmed. Pharmacol."},{"key":"ref_18","unstructured":"World Health Organization (2013). Medicinal Plants in Mongolia. WHO Press."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/cla.12502","article-title":"Phylogeny and biogeography of the northern temperate genus Dracocephalum sl (Lamiaceae)","volume":"38","author":"Chen","year":"2022","journal-title":"Cladistics"},{"key":"ref_20","unstructured":"Zhengyi, W., Raven, P.H., and Deyuan, R.H. (1994). Flora of China, Science Press Beijing and Missouri Botanical Garden Press."},{"key":"ref_21","unstructured":"Ali, S.I., and Qaiser, M. (2001). Flora of Pakistan, Karachi University Press and Missouri Botanical Press."},{"key":"ref_22","first-page":"9","article-title":"Dracocephalum kotschyi Boiss.: An Iranian endemic medicinal plant; a review","volume":"12","author":"Foroozandeh","year":"2021","journal-title":"J. Med. Herb."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"123","DOI":"10.14232\/abs.2018.2.123-129","article-title":"Contemporary interspecific hybridization between Dracocephalum kotschyi and Dracocephalum oligadenium (Lamiaceae): Evidence from morphological, anatomical and molecular data","volume":"62","author":"Koohdar","year":"2018","journal-title":"Acta Biol. Szeged."},{"key":"ref_24","unstructured":"Davis, P.H. (1987). Flora of Turkey and East Agean Islands, University Press."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"14105","DOI":"10.3390\/molecules181114105","article-title":"Chemical composition and antioxidant activity of T\u00e1nara \u00d3t\u00f3 (Dracocephalum palmatum Stephan), a medicinal plant used by the North-Yakutian Nomads","volume":"18","author":"Olennikov","year":"2013","journal-title":"Molecules"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Okhlopkova, Z.M., Razgonova, M.P., Pikula, K.S., Zakharenko, A.M., Piekoszewski, W., Manakov, Y.A., Ercisli, S., and Golokhvast, K.S. (2022). Dracocephalum palmatum S. and Dracocephalum ruyschiana L. originating from Yakutia: A high-resolution mass spectrometric approach for the comprehensive characterization of phenolic compounds. Appl. Sci., 12.","DOI":"10.3390\/app12031766"},{"key":"ref_27","unstructured":"Bobrov, E.G. (1954). Flora URSS, Academiae Scientarum URSS."},{"key":"ref_28","unstructured":"(2024, September 10). Plants of the World Online. Available online: https:\/\/powo.science.kew.org\/taxon\/urn:lsid:ipni.org:names:77177050-1\/images."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Wang, J., Sun, J., Wang, M., Cui, H., Zhou, W., and Li, G. (2022). Chemical constituents from Dracocephalum moldavica L. and their chemotaxonomic significance. Biochem. System. Ecol., 102.","DOI":"10.1016\/j.bse.2022.104422"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.jep.2012.03.028","article-title":"Neuropharmacological study of Dracocephalum moldavica L. (Lamiaceae) in mice: Sedative effect and chemical analysis of an aqueous extract","volume":"141","author":"Heinze","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"477","DOI":"10.4103\/0973-1296.141817","article-title":"The treatment of Uygur medicine Dracocephalum moldavica L. on chronic mountain sickness rat model","volume":"10","author":"Maimaitiyiming","year":"2014","journal-title":"Pharmacogn. Mag."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2298\/ABS230307013Y","article-title":"Dracocephalum moldavica L. extract ameliorates intestinal inflammation by regulating gut microbiota and repairing the intestinal barrier in 2K1C rats","volume":"75","author":"Yu","year":"2023","journal-title":"Arch. Biol. Sci."},{"key":"ref_33","first-page":"199","article-title":"Phenolic combination and comparison of antioxidant activity in three different alcoholic extracts of Dracocephalum moldavica L.","volume":"5","author":"Aslanipour","year":"2017","journal-title":"TURJAF"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1080\/10412905.2000.9712206","article-title":"Essential oil composition of some plants cultivated in Mongolian climate","volume":"12","author":"Shatar","year":"2000","journal-title":"J. Essent. Oil Res."},{"key":"ref_35","first-page":"175","article-title":"On the distribution of Dracocephalum ruyschiana (Lamiaceae) in the Balkan Peninsula","volume":"15","year":"2009","journal-title":"Phytol. Balcan."},{"key":"ref_36","unstructured":"Tutin, T.G., Chater, A.O., Heywood, V.H., Burges, N.A., Richardson, I.B.K., Valentine, D.H., Walters, S.M., and Webb, D.A. (1972). Dracocephalum L.. Flora Europaea, Cambridge University Press."},{"key":"ref_37","unstructured":"Bilz, M., Kell, S.P., Maxted, N., and Lansdown, R.V. (2011). European Red List of Vascular Plants, Office of the European Union."},{"key":"ref_38","unstructured":"Henriksen, S., and Hilmo, O. (2015). Norsk R\u00f8dliste for Arter 2015, Artsdatabanken."},{"key":"ref_39","unstructured":"Witkowski, Z.J., Kr\u00f3l, W., and Solarz, W. (2023). Carpathian List of Endangered Species, WWF International Danube-Carpathian Programme and Institute of Nature Conservation, Polish Academy of Sciences."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e9187","DOI":"10.1002\/ece3.9187","article-title":"Spatiotemporal monitoring of the rare northern dragonhead (Dracocephalum ruyschiana, Lamiaceae)\u2014SNP genotyping and environmental niche modelling herbarium specimens","volume":"12","author":"Nygaard","year":"2022","journal-title":"Ecol. Evol."},{"key":"ref_41","unstructured":"Bornand, C., Eggenberg, S., Gygax, A., Juillera, P., Jutzi, M., Marazzi, B., M\u00f6hl, A., Rometsch, S., Sager, L., and Santiago, H. (2019). Regionale Rote Liste der Gef\u00e4sspflanzen der Schweiz, Info Flora."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1021\/np300609u","article-title":"Flavone tetraglycosides and benzyl alcohol glycosides from the Mongolian medicinal plant Dracocephalum ruyschiana","volume":"76","author":"Selenge","year":"2013","journal-title":"J. Nat. Prod."},{"key":"ref_43","first-page":"3831","article-title":"Histochemical analysis of aerial part of Dracocephalum ruyschiana L. and Dracocephalum nutans L. growing in the territory of central Kazakhstan","volume":"15","author":"Sabiyeva","year":"2022","journal-title":"Res. J. Pharm. Technol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/ffj.1439","article-title":"Volatile constituents of the cold desert plant Dracocephalum heterophyllum Benth","volume":"20","author":"Mahmood","year":"2005","journal-title":"Flavour Frag. J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"6322","DOI":"10.12659\/MSM.908912","article-title":"The effects of Dracocephalum heterophyllum Benth flavonoid on hypertrophic cardiomyocytes induced by angiotensin II in Rats","volume":"24","author":"Jiang","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Fang, Y., Sun, D., Li, G., Lv, Y., Li, J., Wang, Q., and Dang, J. (2022). Ethyl acetate extract of Dracocephalum heterophyllum Benth ameliorates nonalcoholic steatohepatitis and fibrosis via regulating bile acid metabolism, oxidative stress and inhibiting inflammation. Separations, 9.","DOI":"10.3390\/separations9100273"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Numonov, S., Sharopov, F., Qureshi, M.N., Gofrzda, L., Gulmurdov, I., Khalilov, Q., Setzer, W.N., Habasi, M., and Aisa, H.A. (2020). The ursolic acid-rich extract of Dracocephalum heterophyllum Benth. with potent antidiabetic and cytotoxic activities. Appl. Sci., 10.","DOI":"10.3390\/app10186505"},{"key":"ref_48","first-page":"112","article-title":"Antioxidative activity and phytochemical investigation on a high altitude medicinal plant Dracocephalum heterophyllum Benth","volume":"2","author":"Raj","year":"2010","journal-title":"Phcog. Net."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1080\/14786410701642847","article-title":"Essential oil composition of three accessions of Dracocephalum heterophyllum Benth. cultivated at Palampur, India","volume":"22","author":"Singht","year":"2008","journal-title":"Nat. Prod. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1016\/j.jchromb.2009.06.040","article-title":"On-line strategies for the identification of unknown flavone glycosides in Dracocephalum tanguticum Maxim","volume":"877","author":"Liu","year":"2009","journal-title":"J. Chromatogr. B"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1142\/S0192415X11008658","article-title":"Antioxidant activities of Dracocephalum tanguticum Maxim extract and its up-regulation on the expression of neurotrophic factors in a rat model of permanent focal cerebral ischemia","volume":"39","author":"Xu","year":"2011","journal-title":"Am. J. Chin. Med."},{"key":"ref_52","unstructured":"Wu, Z.Y., and Li, X.W. (2005). Flora of China, Science Press."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Olennikov, D.N., Chirikova, N.K., and Kashchenko, N.I. (2017). Effect of low temperature cultivation on the phytochemical profile and bioactivity of arctic plants: A case of Dracocephalum palmatum. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18122579"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Yan, Y., Liu, X., Gao, J., Wu, Y., and Li, Y. (2020). Inhibition of TGF-\u03b2 signaling in gliomas by the flavonoid diosmetin isolated from Dracocephalum peregrinum L.. Molecules, 25.","DOI":"10.3390\/molecules25010192"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.jpba.2008.09.013","article-title":"Simultaneous determination of nine major active compounds in Dracocephalum rupestre by HPLC","volume":"48","author":"Ren","year":"2008","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1080\/23802359.2023.2172970","article-title":"The complete chloroplast genome sequence of the medicinal plant, Dracocephalum rupestre (Lamiaceae)","volume":"8","author":"Han","year":"2023","journal-title":"Mitochondrial DNA Part B"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Zhu, C.S., Liu, K., Wang, J.L., Li, J.F., Liu, M.F., Hao, N., Lin, Y.X., and Xiao, Z.F. (2018). Antioxidant activities and hepatoprotective potential of Dracocephalum rupestre Hance extract against CCl4-induced hepatotoxicity in Kunming mice. J. Food Biochem., 42.","DOI":"10.1111\/jfbc.12484"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"111871","DOI":"10.1016\/j.foodres.2022.111871","article-title":"Metabolomic characterization of the chemical compositions of Dracocephalum rupestre Hance","volume":"161","author":"Gao","year":"2022","journal-title":"Food Res. Int."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"155","DOI":"10.34172\/ijbsm.46640","article-title":"The effects of Dracocephalum multicaule on the cognitive impairment and hippocampal neurodegeneration induced by chronic cerebral hypoperfusion","volume":"8","author":"Khojasteh","year":"2023","journal-title":"Int. J. Basic Sci. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3109\/13880209.2015.1033561","article-title":"Antidiabetic, antioxidant, and antilipid peroxidative activities of Dracocephalum polychaetum shoot extract in streptozotocin-induced diabetic rats: In vivo and in vitro studies","volume":"54","author":"Pouraboli","year":"2016","journal-title":"Pharm. Biol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"319","DOI":"10.4103\/RPS.RPS_148_23","article-title":"The effect of Dracocephalum subcapitatum hydroalcoholic extract on dexamethasone-induced hyperlipidemic rats","volume":"19","author":"Safaeian","year":"2024","journal-title":"Res. Pharm. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1515\/znc-2005-1-204","article-title":"Bioactive constituents from Dracocephalum subcapitatum (O. Kuntze) Lipsky","volume":"60","author":"Saeidnia","year":"2005","journal-title":"Z. Naturforsch. C J. Biosci."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/14786410701619076","article-title":"Chemical composition, antimicrobial and antioxidant activities of the essential oil of Tibetan herbal medicine Dracocephalum heterophyllum Benth","volume":"22","author":"Zhang","year":"2008","journal-title":"Nat. Prod. Res."},{"key":"ref_64","first-page":"32","article-title":"Biochemical evaluation of antioxidant activity, phenol and flavonoid contents, of Dracocephalum kotschyi Boiss extracts obtained with different solvents","volume":"1","author":"Mirzania","year":"2018","journal-title":"Health Biotechnol. Biopharma"},{"key":"ref_65","first-page":"31","article-title":"Evaluating the effect of Dracocephalum kotschyi methanol extract on Mycobacterium tuberculosis","volume":"2","author":"Asghari","year":"2015","journal-title":"Res. J. Pharmacogn."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1002\/ptr.2382","article-title":"Calycopterin, an immunoinhibitory compound from the extract of Dracocephalum kotschyi","volume":"22","author":"Faham","year":"2008","journal-title":"Phytother. Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/10412905.2021.1975577","article-title":"Volatile compounds and antifungal activity of Dracocephalum moldavica L. at different phenological stages","volume":"34","author":"Abbasi","year":"2022","journal-title":"J. Essent. Oil Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.indcrop.2015.11.004","article-title":"Antigenotoxic and antioxidant activities of a polyphenolic extract from European Dracocephalum moldavica L.","volume":"79","author":"Aprotosoaie","year":"2016","journal-title":"Ind. Crops Prod."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1080\/14786419.2017.1359168","article-title":"A new caffeic acid tetramer from the Dracocephalum moldavica L.","volume":"32","author":"Zhang","year":"2018","journal-title":"Nat. Prod. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.2147\/IJN.S131893","article-title":"Development of solid lipid nanoparticles containing total flavonoid extract from Dracocephalum moldavica L. and their therapeutic effect against myocardial ischemia-reperfusion injury in rats","volume":"12","author":"Tan","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"976","DOI":"10.5530\/pj.2019.11.154","article-title":"Antidepressant-like effects of Dracocephalum moldavica L. in mouse models of immobility tests","volume":"11","author":"Mariles","year":"2019","journal-title":"Pharmacogn. J."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"112680","DOI":"10.1016\/j.phytochem.2021.112680","article-title":"Abietane diterpenoids from Dracocephalum moldavica L. and their anti-inflammatory activities in vitro","volume":"184","author":"Nie","year":"2021","journal-title":"Phytochemistry"},{"key":"ref_73","first-page":"974039","article-title":"Simultaneous determination of six active compounds in Yixin Badiranjibuya Granules, a traditional Chinese Medicine, by RP-HPLC-UV method","volume":"2015","author":"Yu","year":"2015","journal-title":"J. Anal. Met. Chem."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Moldovan, C., Nitu, S., Hermeziu, M., Vidican, R., Sandor, M., G\u00e2dea, S., David, A., Stoian, V.A., V\u00e2tca, S.D., and Stoian, V. (2022). Growth characteristics of Dracocephalum moldavica L. in relation to density for sustainable cropping technology development. Agriculture, 12.","DOI":"10.3390\/agriculture12060789"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1080\/14786419.2014.881364","article-title":"Oxidative stress protective effect of Dracocephalum multicaule essential oil against human cancer cell line","volume":"28","author":"Esmaeili","year":"2014","journal-title":"Nat. Prod. Res."},{"key":"ref_76","unstructured":"Zargari, A. (1990). Medicinal Plants, Tehran University Press."},{"key":"ref_77","first-page":"2448","article-title":"Anti-candida activity of ethanolic extracts of Iranian endemic medicinal herbs against Candida albicans","volume":"6","author":"Boroujeni","year":"2012","journal-title":"J. Med. Plants Res."},{"key":"ref_78","first-page":"26","article-title":"Materials to the flora of the Verkhoyansk region of Yakutian region","volume":"Volume 1","author":"Yurinskii","year":"1915","journal-title":"The News of Yakutian Department of the Imperial Russian Geographic Association"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3126\/ijls.v9i5.12688","article-title":"Evaluation of the antioxidant capacity of the various extracts of Dracocephalum polychaetum","volume":"9","author":"Khodami","year":"2015","journal-title":"Int. J. Life Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1016\/j.fct.2012.03.059","article-title":"Eriodictyol-7-O-glucoside, a novel Nrf2 activator, confers protection against cisplatin-induced toxicity","volume":"50","author":"Hu","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"ref_81","unstructured":"Liga, U. (2006). Medicinal Plants of Mongolia Used in Western and Eastern Medicine, JCK Printing."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s12686-018-1045-9","article-title":"SNP discovery in the northern dragonhead Dracocephalum ruyschiana","volume":"11","author":"Kleven","year":"2019","journal-title":"Conserv. Genet. Resour."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.phytol.2020.08.006","article-title":"Dratanguticumides G and H, two new glucosides from Dracocephalum tanguticum Maxim relax vessels via NO pathway","volume":"40","author":"Hu","year":"2020","journal-title":"Phytochem. Lett."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1080\/14786419.2018.1562451","article-title":"Three new phenylacetamide glycosides from Dracocephalum tanguticum Maxim and their anti-hyperglycemic activity","volume":"34","author":"Ma","year":"2020","journal-title":"Nat. Prod. Res."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Li, H., Fu, Y., Sun, H., Zhang, Y., and Lan, X. (2017). Transcriptomic analyses reveal biosynthetic genes related to rosmarinic acid in Dracocephalum tanguticum. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-00078-y"},{"key":"ref_86","first-page":"187","article-title":"Chemical composition and antinociceptive effect of the essential oil of Dracocephalum moldavica L.","volume":"18","author":"Maham","year":"2013","journal-title":"Pharm. Sci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jchromb.2018.08.005","article-title":"Preparative isolation of antioxidative compounds from Dracocephalum heterophyllum using off-line two-dimensional reversed-phase liquid chromatography\/hydrophilic interaction chromatography guided by on-line HPLC-DPPH assay","volume":"1095","author":"Dang","year":"2018","journal-title":"J. Chromatogr. B"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Lv, Y., Wang, Z., Wu, Q., Fang, Y., Wang, Q., Li, G., and Dang, J. (2022). Preparation and antioxidant activities of phenylethanoids from Dracocephalum heterophyllum. Separations, 9.","DOI":"10.3390\/separations9050111"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.bbrc.2018.09.177","article-title":"A novel derivative (GTN024) from a natural product, komaroviquinone, induced the apoptosis of high-risk myeloma cells via reactive oxygen production and ER stress","volume":"505","author":"Okayama","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. Nat. Prod."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Kumar, N., and Goel, N. (2019). Phenolic acids: Natural versatile molecules with promising therapeutic applications. Biotechnol. Rep., 24.","DOI":"10.1016\/j.btre.2019.e00370"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.phytochem.2012.06.021","article-title":"Phenolic alkaloids from the aerial parts of Dracocephalum heterophyllum","volume":"82","author":"Wang","year":"2012","journal-title":"Phytochemistry"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"4278","DOI":"10.1002\/fsn3.2396","article-title":"UPLC\u2013PDA-ESI\u2013QTOF\u2013MS\/MS and GC-MS analysis of Iranian Dracocephalum moldavica L.","volume":"9","author":"Fattahi","year":"2021","journal-title":"Food Sci. Nutr."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1007\/s12272-001-2113-2","article-title":"A new ferulic acid ester and other constituents from Dracocephalum peregrinum","volume":"31","author":"Dai","year":"2008","journal-title":"Arch. Pharmacal Res."},{"key":"ref_95","first-page":"170","article-title":"Bioactive chemical constituents from Tibetan medicine Dracocephalum tanguticum Maxim","volume":"44","author":"Shen","year":"2009","journal-title":"J. Chin. Pharm. Sci."},{"key":"ref_96","first-page":"250","article-title":"Flavonoid constituents of Dracocephalum kotschyi growing in Iran and their trypanocidal activity","volume":"57","author":"Gohari","year":"2003","journal-title":"J. Nat. Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/14786419.2012.666746","article-title":"A new flavonoid glycoside and other constituents from Dracocephalum moldavica","volume":"27","author":"Yang","year":"2013","journal-title":"Nat. Prod. Res."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Simea, S., Ielciu, I., Hanganu, D., Niculae, M., Pall, E., Burtescu, R.F., Olah, N.K., Cenariu, M., Oniga, I., and Benedec, D. (2023). Evaluation of the cytotoxic, antioxidative and antimicrobial effects of Dracocephalum moldavica L. cultivcars. Molecules, 28.","DOI":"10.3390\/molecules28041604"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"4071","DOI":"10.1002\/jssc.201600645","article-title":"Chemical constituents and quality control of two Dracocephalum species based on high-performance liquid chromatographic fingerprints coupled with tandem mass spectrometry and chemometrics","volume":"39","author":"Li","year":"2016","journal-title":"J. Sep. Sci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s10600-009-9288-z","article-title":"Minor flavonols from Dracocephalum multicaule","volume":"45","author":"Oganesyan","year":"2009","journal-title":"Chem. Nat. Comp."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Zheng, R., Kader, K., Liu, D.W., Su, W.L., Xu, L., Jin, Y.Y., and Xing, Y.G. (2024). A network pharmacology approach to decipher the mechanism of total flavonoids from Dracocephalum moldavica L. in the treatment of cardiovascular diseases. BMC Complement. Med. Ther., 24.","DOI":"10.1186\/s12906-023-04316-x"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"6411","DOI":"10.1016\/j.bmcl.2010.09.086","article-title":"Flavonoids from Dracocephalum tanguticum and their cardioprotective effects against doxorubicin-induced toxicity in H9c2 cells","volume":"20","author":"Wang","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1007\/s10600-018-2499-4","article-title":"New glycosides of eridictyol from Dracocephalum palmatum","volume":"54","author":"Olennikov","year":"2018","journal-title":"Chem. Nat. Comp."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Hu, X., Mola, Y., Su, W.l., Wang, Y., Zheng, R.F., and Xing, J.G. (2023). A network pharmacology approach to decipher the total flavonoid extract of Dracocephalum moldavica L. in the treatment of cerebral ischemia-reperfusion injury. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0289118"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bse.2013.12.009","article-title":"The phenolic compounds from Dracocephalum moldavica L.","volume":"54","author":"Yang","year":"2014","journal-title":"Biochem. System. Ecol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"8","DOI":"10.15171\/jhp.2019.02","article-title":"Inhibitory effect of hydroalcoholic and flavonoids extracts of Dracocephalum kotschyi, and its components luteolin, apigenin and apigenin-4\u2019-galactoside on intestinal transit in mice","volume":"8","author":"Sadraei","year":"2019","journal-title":"J. Herbmed. Pharmacol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1007\/s10600-015-1493-3","article-title":"Dracoplasmide, a new flavonoid from Dracocephalum palmatum","volume":"51","author":"Olennikov","year":"2015","journal-title":"Chem. Nat. Comp."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1007\/s12272-011-1202-0","article-title":"New Glycosides from Dracocephalum tanguticum Maxim","volume":"34","author":"Zeng","year":"2011","journal-title":"Arch. Pharm. Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s10600-010-9461-4","article-title":"Triterpenoids and flavonoids from chloroform fraction of Dracocephalum peregrinum","volume":"45","author":"Fu","year":"2009","journal-title":"Chem. Nat. Comp."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Zeng, C., Jiang, W., Yang, X., He, C., Wang, W., and Xing, J. (2018). Pretreatment with total flavonoid extract from Dracocephalum moldavica L. attenuates ischemia reperfusion-induced apoptosis. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-35726-4"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s10600-013-0654-5","article-title":"Chemical composition of Dracocephalum heterophyllum","volume":"49","author":"Numonov","year":"2013","journal-title":"Chem. Nat. Comp."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1248\/cpb.57.207","article-title":"New flavonoid glycosides and cyanogenic glycosides from Dracocephalum peregrinum","volume":"57","author":"Fu","year":"2009","journal-title":"Chem. Pharm. Bull."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s10600-008-9065-4","article-title":"Flavonoids from Dracocephalum moldavica","volume":"44","author":"Sultan","year":"2008","journal-title":"Chem. Nat. Com."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"254261","DOI":"10.1016\/j.sajb.2021.10.002","article-title":"Simultaneous characterization of nine isolated flavonoids in Iranian Dracocephalum species and in silico study of their inhibitory properties against MTH1 enzyme","volume":"146","author":"Ashrafian","year":"2022","journal-title":"S. Afr. J. Bot."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1002\/jssc.201800812","article-title":"An effective method based on medium-pressure liquid chromatography and recycling high-speed counter-current chromatography for enrichment and separation of three minor components with similar polarity from Dracocephalum tanguticum","volume":"42","author":"Yang","year":"2019","journal-title":"J. Sep. Sci."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"J\u00f6hrer, K., P\u00e9rez, M.P., Kircher, B., and \u00c7i\u00e7ek, S.S. (2022). Flavones, flavonols, lignans, and caffeic acid derivatives from Dracocephalum moldavica and their in vitro effects on multiple myeloma and acute myeloid leukemia. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232214219"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/jssc.202100537","article-title":"Separation of five flavone glycosides including two groups with similar polarities from Dracocephalum tanguticum by a combination of three high-speed counter-current chromatography modes","volume":"45","author":"Chen","year":"2022","journal-title":"J. Sep. Sci."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1002\/ptr.3678","article-title":"Antiproliferative activity of flavonoids: Influence of the sequential methoxylation state of the flavonoid structure","volume":"26","author":"Moghaddam","year":"2012","journal-title":"Phytother. Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"104841","DOI":"10.1016\/j.fitote.2021.104841","article-title":"Dracomolphin A-E, new lignans from Dracocephalum moldavica","volume":"150","author":"Zhang","year":"2021","journal-title":"Fitoterapia"},{"key":"ref_120","first-page":"575669","article-title":"Dracocephalum heterophyllum (DH) Exhibits potent anti-proliferative effects on autoreactive CD4+ T cells and ameliorates the development of experimental autoimmune uveitis","volume":"11","author":"Bian","year":"2020","journal-title":"Frontiers"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.cclet.2019.09.036","article-title":"Dracomolphesin A\u2013E, five 3,4-seco-phenylpropanoids with Nrf2 inducing activity from Dracocephalum moldavica","volume":"31","author":"Zhang","year":"2020","journal-title":"Chin. Chem. Lett."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.phytochem.2008.01.013","article-title":"Stereochemistry of flavonoidal alkaloids from Dracocephalum rupestre","volume":"69","author":"Ren","year":"2008","journal-title":"Phytochemistry"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.1039\/D2AY01282K","article-title":"Integrated chromatographic approach for the discovery of gingerol antioxidants from Dracocephalum heterophyllum and their potential targets","volume":"14","author":"Dang","year":"2022","journal-title":"Anal. Methods"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"4375","DOI":"10.1002\/jssc.202200309","article-title":"Preparative isolation of antioxidative furanocoumarins from Dracocephalum heterophyllum and their potential action target","volume":"45","author":"Lv","year":"2022","journal-title":"J. Sep. Sci."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.chroma.2007.06.034","article-title":"Separation and structure determination of two diastereomeric pairs of enantiomers from Dracocephalum rupestre by high-performance liquid chromatography with circular dichroism detection","volume":"1161","author":"Ren","year":"2007","journal-title":"J. Chromatogr. A"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s40529-016-0133-y","article-title":"Anti-hepatitis, antioxidant activities and bioactive compounds of Dracocephalum heterophyllum extracts","volume":"57","author":"Shi","year":"2016","journal-title":"Bot. Stud."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Moradi, H., Ghavama, M., and Tavili, A. (2020). Study of antioxidant activity and some herbal compounds of Dracocephalum kotschyi Boiss. in different ages of growth. Biotechnol. Rep., 25.","DOI":"10.1016\/j.btre.2019.e00408"},{"key":"ref_128","first-page":"25","article-title":"Cholinesterase inhibitory, anti-oxidant and anti-tyrosinase activities of three Iranian species of Dracocephalum","volume":"6","author":"Khodaei","year":"2019","journal-title":"Res. J. Pharmacogn."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.supflu.2015.09.028","article-title":"Optimization of phenolic and flavonoid content and antioxidants capacity of pressurized liquid extraction from Dracocephalum kotschyi via circumscribed central composite","volume":"107","author":"Kamali","year":"2016","journal-title":"J. Supercritic. Fluids"},{"key":"ref_130","first-page":"334","article-title":"Cytotoxic and antioxidant effects of methanol, hexane, chloroform and aqueous extracts of Dracocephalum kotschyi aerial parts on MDA-MB-231 cell line","volume":"6","author":"Faghihinia","year":"2015","journal-title":"J. Bus. Econ. Stat."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Jin, M., Yu, H., Jin, X., Yan, L., Wang, J., and Wang, Z. (2020). Dracocephalum moldavica L. extracts protect H9c2 cardiomyocytes against H2O2-induced apoptosis and oxidative stress. BioMed Res. Int., 2020.","DOI":"10.1155\/2020\/8379358"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s12012-013-9221-3","article-title":"Antioxidative and cardioprotective effects of total flavonoids extracted from Dracocephalum moldavica L. against acute ischemia\/reperfusion-induced myocardial injury in isolated rat heart","volume":"14","author":"Jiang","year":"2014","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1745-4522.2001.tb00183.x","article-title":"Antioxidant properties of Moldavian dragonhead (Dracocephalum moldavica L.)","volume":"8","author":"Cuvelier","year":"2001","journal-title":"J. Food Lipids"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"162","DOI":"10.4103\/0975-9476.140474","article-title":"Anticholinesterase, antioxidant, and neuroprotective effects of Tripleurospermum disciforme and Dracocephalum multicaule","volume":"5","author":"Mandegary","year":"2014","journal-title":"J. Ayurveda Integr. Med."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1089\/jmf.2013.0057","article-title":"Antioxidant activity, total phenolic and flavonoid contents of some medicinal and aromatic plants used as herbal teas and condiments in Iran","volume":"17","author":"Pirbalouti","year":"2014","journal-title":"J. Med. Food"},{"key":"ref_136","first-page":"5","article-title":"Comparison of antioxidant activity of Dracocephalum polychaetum Bornm and Nepeta cataria L. and their effect on probiotic bacteria in a simulated gastrointestinal environment","volume":"9","author":"Shahdadi","year":"2021","journal-title":"J. Med. Microbiol. Infect. Dis."},{"key":"ref_137","first-page":"4","article-title":"Therapeutic effects of Dracocephalum heterophyllum in collagen artrithis","volume":"8","author":"Wang","year":"2022","journal-title":"A.A.P.S. Open"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"2684321","DOI":"10.1155\/2016\/2684321","article-title":"Protective effects of Dracocephalum heterophyllum in ConA-induced acute hepatitis","volume":"2016","author":"Zheng","year":"2016","journal-title":"Mediat. Inflamm."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"209","DOI":"10.34172\/jhp.2021.23","article-title":"Effect of hydroalcoholic and aqueous extracts of Dracocephalum kotschyi on bleomycin induced pulmonary fibrosis","volume":"10","author":"Sadraei","year":"2021","journal-title":"J. Herbmed. Pharmacol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"322","DOI":"10.4103\/1735-5362.212050","article-title":"Anti-inflammatory effect of apigenin and hydroalcoholic extract of Dracocephalum kotschyi on acetic acid-induced colitis in rats","volume":"12","author":"Sadraei","year":"2017","journal-title":"Res. Pharm. Sci."},{"key":"ref_141","first-page":"159","article-title":"Inhibition of nitric oxide production and proinflammatory cytokines by several medicinal plants","volume":"8","author":"Amirghofran","year":"2011","journal-title":"Iran. J. Immunol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"228","DOI":"10.3892\/mmr.2023.13115","article-title":"Dracocephalum moldavica L. extract alleviates experimental colitis in rats by modulating gut microbiome and inflammatory pathways","volume":"28","author":"Gang","year":"2023","journal-title":"Mol. Med. Rep."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1002\/ptr.7771","article-title":"Total flavonoid extract from Dracocephalum moldavica L. improves pulmonary fibrosis by reducing inflammation and inhibiting the hedgehog signaling pathway","volume":"37","author":"He","year":"2023","journal-title":"Phytother. Res."},{"key":"ref_144","first-page":"38","article-title":"Hydro-alcoholic extract of Dracocephalum moldavica for treatment of ulcerative colitis in Wistar rats","volume":"4","author":"Mahmoudzadeh","year":"2023","journal-title":"Hum. Health Halal Metr."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Kim, K.M., Kim, S.Y., Mony, T.J., Bae, H.J., Han, S.D., Lee, E.S., Choi, S.H., Hong, S.H., Lee, S.D., and Park, S.J. (2021). Dracocephalum moldavica ethanol extract suppresses LPS-induced inflammatory responses through inhibition of the JNK\/ERK\/NF-B signaling pathway and IL-6 production in RAW 264.7 macrophages and in endotoxic-treated mice. Nutrients, 13.","DOI":"10.3390\/nu13124501"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3109\/13880209.2012.711839","article-title":"Effects of total flavonoids from Dracocephalum moldavica on the proliferation, migration, and adhesion molecule expression of rat vascular smooth muscle cells induced by TNF-\u03b1","volume":"51","author":"Xing","year":"2013","journal-title":"Pharm. Biol."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Ban, D., Sang, Z.G., Fan, Y., Fu, G., Yang, H., and Si, L. (2024). Therapeutic potential of compound extract from Dracocephalum rupestre Hance. and Berberidis radix against Salmonella-induced lamb diarrhoea. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-73034-2"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Guo, M., Gu, L., Hui, H., Li, X., and Jin, L. (2022). Extracts of Dracocephalum tanguticum Maxim. ameliorate acute alcoholic liver disease via regulating transcription factors in mice. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.830532"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"112651","DOI":"10.1016\/j.jep.2020.112651","article-title":"Dracocephalum moldavica attenuates scopolamine-induced cognitive impairment through activation of hippocampal ERK-CREB signaling in mice","volume":"253","author":"Deepa","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Zheng, R.F., Du, Y.W., Zeng, C., Wang, H.F., Xing, J.G., and Xu, M. (2020). Total flavones of Dracocephalum moldavica L. protect astrocytes against H2O2-induced apoptosis through a mitochondria dependent pathway. BMC Complement. Med. Ther., 20.","DOI":"10.1186\/s12906-020-2846-4"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.9734\/ARRB\/2014\/8970","article-title":"Neuroprotective effect of Dracocephalum moldavica L. total flavonoids in transient cerebral ischemia in rats","volume":"4","author":"Sun","year":"2014","journal-title":"Annu. Res. Rev. Biol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"100430","DOI":"10.1016\/j.phyplu.2023.100430","article-title":"The therapeutic effect of the extracts of Lavandula angustifolia and Dracocephalum ruyschiana besides sertraline on patients with mild to moderate depression: A double-blind controlled trial","volume":"3","author":"Khalili","year":"2023","journal-title":"Phytomed. Plus"},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Dawuti, A., Sun, S., Wang, R., Gong, D., Yuan, T., Zhang, L., Yang, S., Xing, J., Zheng, R., and Lu, Y. (2022). Systems pharmacology-based strategy to investigate pharmacological mechanisms of total flavonoids in Dracocephalum moldavica on chronic heart failure. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23158409"},{"key":"ref_154","first-page":"14985","article-title":"The mechanism study of Dracocephalum moldavica L. the total flavonoids on apoptosis induced by myocardial ischemia\/reperfusion injury in vivo and in vitro","volume":"20","author":"Cao","year":"2019","journal-title":"Biomed. J. Sci. Tech. Res."},{"key":"ref_155","first-page":"229","article-title":"Effects of total extract of Dracocephalum moldavica on ischemia\/reperfusion induced arrhythmias and infarct size in the isolated rat heart","volume":"11","author":"Najafi","year":"2009","journal-title":"Iran. J. Basic Med. Sci."},{"key":"ref_156","first-page":"6695346","article-title":"Improvement of total flavonoids from D. moldavica L. in rats with chronic mountain sickness through 1 H-NMR metabolomics","volume":"2021","author":"Maimaiti","year":"2021","journal-title":"Evid. Based Complemnt. Altern. Med."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/s12944-018-0893-3","article-title":"Hypolipidemic activity of Dracocephalum kotschyi involves FOXO1 mediated modulation of PPAR\u03b3 expression inadipocytes","volume":"17","author":"Aslian","year":"2018","journal-title":"Lipids Health Dis."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0031-6865(98)00016-8","article-title":"Antihyperlipidemic effect of hydroalcoholic extract, and polyphenolic fraction from Dracocephalum kotschyi Boiss","volume":"73","author":"Sajjadi","year":"1998","journal-title":"Pharm. Acta Helv."},{"key":"ref_159","first-page":"32","article-title":"Basil and Dracocephalum kotschyi alcoholic extracts affect BCL2 expression and HepG2 cell proliferation","volume":"7","author":"Moghimi","year":"2019","journal-title":"Res. Mol. Med."},{"key":"ref_160","first-page":"189","article-title":"Cytotoxic and apoptogenic prerties of Dracocephalum kotschyi aerial parts different fractions on Calu-6 and Mehr-80 lung cancer cell lines","volume":"65","author":"Sani","year":"2017","journal-title":"Farmacia"},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Talari, M., Seydi, E., Salimi, A., Mohsenifar, Z., Kamalinejad, M., and Pourahmad, J. (2014). Dracocephalum: Novel anticancer plant acting on liver cancer cell mitochondria. BioMed Res. Int., 2014.","DOI":"10.1155\/2014\/892170"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.phytochem.2005.04.035","article-title":"Xanthomicrol is the main cytotoxic component of Dracocephalum kotschyii and a potential anti-cancer agent","volume":"66","author":"Jahaniani","year":"2005","journal-title":"Phytochemistry"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Jiang, H., Zeng, L., Dong, X., Guo, S., Xing, J., Li, Z., and Liu, R. (2020). Tilianin extracted from Dracocephalum moldavica L. induces intrinsic apoptosis and drives inflammatory microenvironment response on pharyngeal squamous carcinoma cells via regulating TLR4 signaling pathways. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.00205"},{"key":"ref_164","first-page":"793","article-title":"Dracocephalum palmatum Stephan extract induces apoptosis in human prostate cancer cells via the caspase-8-mediated extrinsic pathway","volume":"18","author":"Lee","year":"2020","journal-title":"Chin. J. Nat. Med."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.3892\/or.2020.7797","article-title":"Dracocephalum palmatum Stephan extract induces caspase- and mitochondria-dependent apoptosis via Myc inhibition in diffuse large B cell lymphoma","volume":"44","author":"Kim","year":"2020","journal-title":"Oncol. Rep."},{"key":"ref_166","first-page":"158","article-title":"Antibacterial activity of various extracts from Dracocephalum kotschyi against food pathogenic microorganisms","volume":"8","author":"Kamali","year":"2015","journal-title":"Pharm. Tech."},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Yu, H., Liu, M., Liu, Y., Qin, L., Jin, M., and Wang, Z. (2019). Antimicrobial activity and mechanism of action of Dracocephalum moldavica L. extracts against clinical isolates of Staphylococcus aureus. Front. Microbiol., 10.","DOI":"10.3389\/fmicb.2019.01249"},{"key":"ref_168","first-page":"e65295","article-title":"The effects of the ethanol extract of Dracocephalum moldavica (Badrashbu) against strains of antibiotic-resistant Escherichia coli and Klebsiella pneumonia","volume":"5","author":"Keikhaie","year":"2018","journal-title":"Int. J. Infect."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Yaghoobi, M.M., Khaleghi, M., Rezanejad, H., and Parsia, P. (2018). Antibiofilm activity of Dracocephalum polychaetum extract on methicillin-resistant Staphylococcus aureus. Avicenna J. Clin. Microbiol. Infect., 5.","DOI":"10.5812\/ajcmi.61772"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"145","DOI":"10.34172\/jhp.2020.19","article-title":"Antispasmodic effect of hydroalcoholic and flavonoids extracts of Dracocephalum kotschyi on rabbit bladder","volume":"9","author":"Sadraei","year":"2020","journal-title":"J. Herbmed. Pharmacol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"281","DOI":"10.15171\/jhp.2019.41","article-title":"Bronchodilator effect of apigenin and luteolin, two components of Dracocephalum kotschyi on isolated rabbit trachea","volume":"8","author":"Sadraei","year":"2019","journal-title":"J. Herbmed. Pharmacol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"100","DOI":"10.15171\/jhp.2018.17","article-title":"Antispasmodic activity of apigenin and luteolin, two components of Dracocephalum kotschyi extract, on rat ileum contractions","volume":"7","author":"Sadraei","year":"2018","journal-title":"J. Herbmed. Pharmacol."},{"key":"ref_173","first-page":"200","article-title":"Antidiarrheal assessment of hydroalcoholic and hexane extracts of Dracocephalum kotschyi Boiss. and apigenin in mice","volume":"11","author":"Sadraei","year":"2016","journal-title":"Res. Pharm. Sci."},{"key":"ref_174","first-page":"2","article-title":"Evaluation of the collagen-boosting effects of a Moldavian dragonhead extract","volume":"6","author":"Wandrey","year":"2021","journal-title":"J. Community Med. Public Health Rep."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/fsn3.3784","article-title":"Reactive oxygen species in biological systems: Pathways, associated diseases, and potential inhibitors-a review","volume":"12","author":"Rauf","year":"2024","journal-title":"Food Sci. Nutr."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.immuni.2021.12.013","article-title":"Inflammation in obesity, diabetes, and related disorders","volume":"55","author":"Rohm","year":"2022","journal-title":"Immunity"},{"key":"ref_177","first-page":"594","article-title":"Cytotoxic and apoptogenic effects of Dracocephalum kotschyi Boiss., extracts against human glioblastoma U87 cells","volume":"10","author":"Shaabani","year":"2020","journal-title":"Avicenna J. Phytomed."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"101384","DOI":"10.1016\/j.aqrep.2022.101384","article-title":"Dietary dragonhead effects on growth, immunity and antioxidant and related genes expression in zebrafish (Danio rerio)","volume":"27","author":"Safari","year":"2022","journal-title":"Aquac. Rep."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40199-016-0161-x","article-title":"Pharmacokinetics of calycopterin and xanthmicrol, two polymethoxylated hydroxyflavones with anti-angiogenic activities from Dracocephalum kotschyi Bioss","volume":"24","author":"Zamani","year":"2016","journal-title":"DARU J. Pharm. Sci."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/9\/2017\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:25:36Z","timestamp":1760030736000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/9\/2017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,30]]},"references-count":179,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["molecules30092017"],"URL":"https:\/\/doi.org\/10.3390\/molecules30092017","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,30]]}}}