{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:51:29Z","timestamp":1791564689517,"version":"4.3.4"},"reference-count":49,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Agricultural Research Service, U.S. Department of Agriculture","award":["NACA 58-2040-0-011"],"award-info":[{"award-number":["NACA 58-2040-0-011"]}]},{"name":"Agricultural Research Service, U.S. Department of Agriculture","award":["P20GM103466"],"award-info":[{"award-number":["P20GM103466"]}]},{"name":"Agricultural Research Service, U.S. Department of Agriculture","award":["P30CA071789"],"award-info":[{"award-number":["P30CA071789"]}]},{"name":"National Institutes of Health (NIH)","award":["NACA 58-2040-0-011"],"award-info":[{"award-number":["NACA 58-2040-0-011"]}]},{"name":"National Institutes of Health (NIH)","award":["P20GM103466"],"award-info":[{"award-number":["P20GM103466"]}]},{"name":"National Institutes of Health (NIH)","award":["P30CA071789"],"award-info":[{"award-number":["P30CA071789"]}]},{"name":"National Institute of General Medical Sciences (NIGMS)","award":["NACA 58-2040-0-011"],"award-info":[{"award-number":["NACA 58-2040-0-011"]}]},{"name":"National Institute of General Medical Sciences (NIGMS)","award":["P20GM103466"],"award-info":[{"award-number":["P20GM103466"]}]},{"name":"National Institute of General Medical Sciences (NIGMS)","award":["P30CA071789"],"award-info":[{"award-number":["P30CA071789"]}]},{"name":"IDeA Networks of Biomedical Research Excellence (INBRE)","award":["NACA 58-2040-0-011"],"award-info":[{"award-number":["NACA 58-2040-0-011"]}]},{"name":"IDeA Networks of Biomedical Research Excellence (INBRE)","award":["P20GM103466"],"award-info":[{"award-number":["P20GM103466"]}]},{"name":"IDeA Networks of Biomedical Research Excellence (INBRE)","award":["P30CA071789"],"award-info":[{"award-number":["P30CA071789"]}]},{"name":"DKICP","award":["NACA 58-2040-0-011"],"award-info":[{"award-number":["NACA 58-2040-0-011"]}]},{"name":"DKICP","award":["P20GM103466"],"award-info":[{"award-number":["P20GM103466"]}]},{"name":"DKICP","award":["P30CA071789"],"award-info":[{"award-number":["P30CA071789"]}]},{"name":"University of Hawaii Cancer Center","award":["NACA 58-2040-0-011"],"award-info":[{"award-number":["NACA 58-2040-0-011"]}]},{"name":"University of Hawaii Cancer Center","award":["P20GM103466"],"award-info":[{"award-number":["P20GM103466"]}]},{"name":"University of Hawaii Cancer Center","award":["P30CA071789"],"award-info":[{"award-number":["P30CA071789"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Dodonaea viscosa (Sapindaceae), a Hawaiian local medicinal plant, has been traditionally used to treat rashes and skin diseases. The study aimed to discover and characterize bioactive compounds from D. viscosa flowers extract with antimicrobial and antitumor properties. Thirteen compounds were isolated from the methanol extract of D. viscosa flowers, and their structures were characterized using spectroscopy data, comparing their NMR spectroscopic profiles with previously reported data. Subsequent antibacterial assays revealed that one particular compound, 12, exhibited significant antimicrobial activity against Gram-positive bacteria. Notably, it demonstrated a minimum inhibitory concentration (MIC) of 2 \u03bcg\/mL, indicating its potent antibacterial potential. In addition to antimicrobial properties, the isolated compounds demonstrated dose-dependent antiproliferative effects in breast cancer cell lines. Notably, inflammatory breast cancer (IBC) cell lines, a highly aggressive subtype, were more sensitive to compound 6, with IC50 values of 4.22 \u03bcM (BCX-010), 6.74 \u03bcM (SUM190), and 7.73 (SUM149), compared to non-IBC cell line. These findings highlight the dual antibacterial and anticancer potential of compounds from D. viscosa, emphasizing their promise as candidates for therapeutic development.<\/jats:p>","DOI":"10.3390\/molecules30112274","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T10:24:45Z","timestamp":1747909485000},"page":"2274","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bioactive Compounds from Dodonaea viscosa Flowers: Potent Antibacterial and Antiproliferative Effects in Breast Cancer Cells"],"prefix":"10.3390","volume":"30","author":[{"given":"Achara","family":"Raksat","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai\u2018i at Hilo, Hilo, HI 96720, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Yee","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai\u2018i at Hilo, Hilo, HI 96720, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Jin","family":"Gi","sequence":"additional","affiliation":[{"name":"Preclinical Core, Cancer Biology Program, University of Hawai\u2018i Cancer Center, Honolulu, HI 96813, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4447-0886","authenticated-orcid":false,"given":"Supakit","family":"Wongwiwatthananukit","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, The Daniel K. 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Inouye U.S. Pacific Basin Agricultural Research Center, Hilo, HI 96720, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6862-5686","authenticated-orcid":false,"given":"Jangsoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Preclinical Core, Cancer Biology Program, University of Hawai\u2018i Cancer Center, Honolulu, HI 96813, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leng Chee","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai\u2018i at Hilo, Hilo, HI 96720, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"ref_1","unstructured":"(2024, October 26). Nanea Valeros, Public Affairs Specialist, U.S. Fish and Wildlife Service. 17 September 2021. 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