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Herein, Au NRs and OPC-Au NPs were prepared via the hydroquinone seedless growth method and proanthocyanidin (OPC) one-pot method, and then pH-GSH-near-infrared \u0399\u0399 (NIR-\u0399\u0399)-responsive nano-prodrugs Au\/DOX-ss LNRs and OPC-Au\/DOX-ss LNPs were designed by the encapsulation of doxorubicin prodrug DOX-ss with Au-S affinity and thermal-sensitive liposomes. Interestingly, OPC endowed OPC-Au NPs with reducibility and excellent performance in terms of particle size, zeta potential, encapsulation rate, and drug loading rate. In particular, the photothermal efficiencies of OPC-Au\/DOX-ss LNPs increased to 59.22% under the 1064 nm NIR-\u0399\u0399 irradiation. Compared with free DOX-ss and Lipid DOX-ss, the IC50 of OPC-Au\/DOX-ss LNPs was decreased by 91.68% and 97.60%, respectively. Furthermore, the expression of P-gp in MCF-7\/ADR was significantly inhibited (decreased by 65%). The potential of proanthocyanidin remodels the pH-GSH-NIR-\u0399\u0399 responsiveness and drug resistance of OPC-Au\/DOX-ss LNPs for breast cancer treatment in NIR-\u0399\u0399 photodynamic\/photothermal therapy.<\/jats:p>","DOI":"10.3390\/molecules30112334","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T09:29:36Z","timestamp":1748338176000},"page":"2334","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Proanthocyanidin-Conjugated NIR-\u0399\u0399 Nano-Prodrugs for Reversing Drug Resistance in Photothermal Therapy"],"prefix":"10.3390","volume":"30","author":[{"given":"Lan","family":"Cui","sequence":"first","affiliation":[{"name":"College of Biological Engineering, Henan University of Technology, Zhengzhou 450001, China"},{"name":"Institute for Complexity Science, Henan University of Technology, Zhengzhou 450001, China"},{"name":"College of Chemistry, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weishuang","family":"Lou","sequence":"additional","affiliation":[{"name":"College of Biological Engineering, Henan University of Technology, Zhengzhou 450001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Wei","sequence":"additional","affiliation":[{"name":"College of Biological Engineering, Henan University of Technology, Zhengzhou 450001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengdi","family":"Li","sequence":"additional","affiliation":[{"name":"College of Biological Engineering, Henan University of Technology, Zhengzhou 450001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengyao","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Biological Engineering, Henan University of Technology, Zhengzhou 450001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyue","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Biological Engineering, Henan University of Technology, Zhengzhou 450001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4857-3679","authenticated-orcid":false,"given":"Shuoye","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Biological Engineering, Henan University of Technology, Zhengzhou 450001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Biological Engineering, Henan University of Technology, Zhengzhou 450001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3672-875X","authenticated-orcid":false,"given":"Guangzhou","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Biological Engineering, Henan University of Technology, Zhengzhou 450001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8437-7408","authenticated-orcid":false,"given":"Peng","family":"Li","sequence":"additional","affiliation":[{"name":"Institute for Complexity Science, Henan University of Technology, Zhengzhou 450001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingbo","family":"Qu","sequence":"additional","affiliation":[{"name":"College of Chemistry, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e202317304","DOI":"10.1002\/anie.202317304","article-title":"Biodegradable Monometallic Aluminum as a Biotuner for Tumor Pyroptosis","volume":"63","author":"Liang","year":"2024","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"155989","DOI":"10.1016\/j.phymed.2024.155989","article-title":"Galangin Alleviated Doxorubicin-Induced Cardiotoxicity by Inhibiting through GSTP1\/JNK Pathway","volume":"134","author":"Shu","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.cclet.2021.08.020","article-title":"Liposome-Based Delivery of Biological Drugs","volume":"33","author":"Magar","year":"2022","journal-title":"Chin. Chem. Lett."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"113851","DOI":"10.1016\/j.addr.2021.113851","article-title":"Liposome Composition in Drug Delivery Design, Synthesis, Characterization, and Clinical Application","volume":"176","author":"Large","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e2301954","DOI":"10.1002\/adhm.202301954","article-title":"NIR-II Regulation of Mitochondrial Potassium Channel with Dual-Targeted Conjugated Oligomer Nanoparticles for Efficient Cancer Theranostics In Vivo","volume":"12","author":"Li","year":"2023","journal-title":"Adv. Heal. Mater."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1038\/s41467-023-38014-6","article-title":"Temperature Sensitive Liposome Based Cancer Nanomedicine Enables Tumour Lymph Node Immune Microenvironment Remodelling","volume":"14","author":"Fu","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"114503","DOI":"10.1016\/j.addr.2022.114503","article-title":"Temperature-Sensitive Polymers to Promote Heat-Triggered Drug Release from Liposomes: Towards Bypassing EPR","volume":"189","author":"Amin","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"26784","DOI":"10.1021\/acsnano.4c07403","article-title":"Engineering AIEgens-Tethered Gold Nanoparticles with Enzymatic Dual Self-Assembly for Amplified Cancer-Specific Phototheranostics","volume":"18","author":"Bian","year":"2024","journal-title":"ACS Nano"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Liu, X., Zhou, W., Wang, T., Miao, S., Lan, S., Wei, Z., Meng, Z., Dai, Q., and Fan, H. (2023). Highly Localized, Efficient, and Rapid Photothermal Therapy Using Gold Nanobipyramids for liver Cancer Cells Triggered by Femtosecond Laser. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-30526-x"},{"key":"ref_10","first-page":"1893","article-title":"Surface Coverage-Regulated Cellular Interaction of Ultrasmall Luminescent Gold Nanoparticles","volume":"13","author":"Gong","year":"2019","journal-title":"ACS Nano"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Rauf, A., Imran, M., Abu-Izneid, T., Patel, S., Pan, X., Naz, S., Silva, A.S., Saeed, F., and Suleria, H.A.R. (2019). Proanthocyanidins: A Comprehensive Review. Biomed. Pharmacother., 116.","DOI":"10.1016\/j.biopha.2019.108999"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"112858","DOI":"10.1016\/j.indcrop.2020.112858","article-title":"Seasonal Variation in Phenylpropanoid Biosynthesis and in Vitro Antioxidant Activity of Sorbus Domestica Leaves: Harvesting Time Optimisation for Medicinal Application","volume":"156","author":"Rutkowska","year":"2020","journal-title":"Ind. Crop. Prod."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"110663","DOI":"10.1016\/j.foodhyd.2024.110663","article-title":"Noncovalent Interaction between Proanthocyanidins and Soy Protein Isolate Fibers: Structure, Functionality and Interaction Mechanism","volume":"160","author":"Yin","year":"2025","journal-title":"Food Hydrocoll."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1002\/ptr.7850","article-title":"Research Progress of Proanthocyanidins and Anthocyanidins","volume":"37","author":"Zhao","year":"2023","journal-title":"Phytotherapy Res."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Nie, F., Liu, L., Cui, J., Zhao, Y., Zhang, D., Zhou, D., Wu, J., Li, B., Wang, T., and Li, M. (2023). Oligomeric Proanthocyanidins: An Updated Review of Their Natural Sources, Synthesis, and Potentials. Antioxidants, 12.","DOI":"10.3390\/antiox12051004"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Zheng, W., Feng, Y., Bai, Y., Feng, Z., Yang, X., Dang, B., Xiao, M., Zhang, J., and Han, S.-Q. (2022). Proanthocyanidins Extracted from Grape Seeds Inhibit the Growth of Hepatocellular Carcinoma Cells and Induce Apoptosis through the MAPK\/AKT Pathway. Food Biosci., 45.","DOI":"10.1016\/j.fbio.2021.101337"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Wang, T.K., Xu, S., Li, S., and Zhang, Y. (2020). Proanthocyanidins Should Be a Candidate in the Treatment of Cancer, Cardiovascular Diseases and Lipid Metabolic Disorder. Molecules, 25.","DOI":"10.3390\/molecules25245971"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1039\/D2BM01212J","article-title":"Highly Efficient Photothermal Branched Au\u2013Ag Nanoparticles Containing Procyanidins for Synergistic Antibacterial and Anti-Inflammatory Immunotherapy","volume":"11","author":"Wang","year":"2023","journal-title":"Biomater. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"214648","DOI":"10.1016\/j.ccr.2022.214648","article-title":"Functionalized DNA Nanostructures for Bioimaging","volume":"469","author":"Shaikh","year":"2022","journal-title":"Co-ord. Chem. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41392-025-02140-y","article-title":"Phototherapy in Cancer Treatment: Strategies and Challenges","volume":"10","author":"Cai","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41565-019-0392-3","article-title":"Miniature Gold Nanorods for Photoacoustic Molecular Imaging in the Second Near-Infrared Optical Window","volume":"14","author":"Chen","year":"2019","journal-title":"Nat. Nanotechnol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"107045","DOI":"10.1016\/j.microc.2021.107045","article-title":"Green Synthesis, Characterization of Procyanidin-Mediated Gold Nanoparticles and Its Application in Fluorescence Detection of Prazosin","volume":"173","author":"Liu","year":"2022","journal-title":"Microchem. J."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Cui, L., Xu, Q., Lou, W., Wang, Y., Xi, X., Chen, Y., Sun, M., Wang, Z., Zhang, P., and Yang, S. (2024). Chitosan Oligosaccharide-Functionalized Nano-Prodrug for Cascade Chemotherapy through Oxidative Stress Amplification. Int. J. Biol. Macromol., 268.","DOI":"10.1016\/j.ijbiomac.2024.131641"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"43482","DOI":"10.1021\/acsami.8b17399","article-title":"Long-Circulating Amphiphilic Doxorubicin for Tumor Mitochondria-Specific Targeting","volume":"10","author":"Xi","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Yang, S., Zhang, B., Zhao, X., Zhang, M., Zhang, M., Cui, L., and Zhang, L. (2024). Enhanced Efficacy against Drug-Resistant Tumors Enabled by Redox-Responsive Mesoporous-Silica-Nanoparticle-Supported Lipid Bilayers as Targeted Delivery Vehicles. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25105553"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1021\/acs.chemrev.2c00468","article-title":"Colloidal Synthesis of Metal Nanocrystals: From Asymmetrical Growth to Symmetry Breaking","volume":"123","author":"Nguyen","year":"2023","journal-title":"Chem. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3790","DOI":"10.1021\/acsanm.1c00230","article-title":"Insight into the Role of Ag in the Seed-Mediated Growth of Gold Nanorods: Implications for Biomedical Applications","volume":"4","author":"Zhu","year":"2021","journal-title":"ACS Appl. Nano Mater."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"34516","DOI":"10.1039\/D1RA07415F","article-title":"Symmetric and Asymmetric Overgrowth of a Ag Shell onto Gold Nanorods Assisted by Pt Pre-Deposition","volume":"11","author":"Zhang","year":"2021","journal-title":"RSC Adv."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1021\/acs.jpcc.1c10447","article-title":"Controlling the Optical Properties of Gold Nanorods in One-Pot Syntheses","volume":"126","author":"Roach","year":"2022","journal-title":"J. Phys. Chem. C"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1166\/jnn.2016.10637","article-title":"HCl-Retarded Gold Nanorod Growth for Aspect Ratio and Shape Tuning","volume":"16","author":"Wang","year":"2016","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Mannino, G., Chinig\u00f2, G., Serio, G., Genova, T., Gentile, C., Munaron, L., and Bertea, C.M. (2021). Proanthocyanidins and Where to Find Them: A Meta-Analytic Approach to Investigate Their Chemistry, Biosynthesis, Distribution, and Effect on Human Health. Antioxidants, 10.","DOI":"10.3390\/antiox10081229"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.jconrel.2022.12.028","article-title":"Applications and Challenges of Ultra-Small Particle Size Nanoparticles in Tumor Therapy","volume":"353","author":"Xu","year":"2023","journal-title":"J. Control. Release"},{"key":"ref_33","first-page":"444","article-title":"Size, Shape, Charge and \u201cStealthy\u201d Surface: Carrier Properties Affect the Drug Circulation Time in Vivo","volume":"16","author":"Di","year":"2021","journal-title":"Asian J. Pharm. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"102261","DOI":"10.1016\/j.cis.2020.102261","article-title":"Absorption, Distribution, Metabolism, and Excretion of Nanocarriers in Vivo and their Influences","volume":"284","author":"Zhang","year":"2020","journal-title":"Adv. Colloid Interface Sci."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1038\/s41401-020-00606-z","article-title":"Surface Loading of Nanoparticles on Engineered or Natural Erythrocytes for Prolonged Circulation Time: Strategies and Applications","volume":"42","author":"Zhang","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Andersen-Civil, A.I.S., Lepp\u00e4, M.M., Thamsborg, S.M., Salminen, J.-P., and Williams, A.R. (2021). Structure-Function Analysis of Purified Proanthocyanidins Reveals a Role for Polymer Size in Suppressing Inflammatory Responses. Commun. Biol., 4.","DOI":"10.1038\/s42003-021-02408-3"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.colsurfb.2018.05.050","article-title":"Synthesis and Characterization of Proanthocyanidins-Functionalized Ag Nanoparticles","volume":"169","author":"Biao","year":"2018","journal-title":"Colloids Surfaces B Biointerfaces"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"103961","DOI":"10.1016\/j.jddst.2022.103961","article-title":"Hyaluronic Acid-Targeted Mixed Micelles Encapsulating Hypericin for Breast Cancer Photodynamic Therapy","volume":"78","author":"Meng","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1208\/s12249-020-01764-3","article-title":"Lipid\/Hyaluronic Acid\u2014Coated Doxorubicin-Fe3O4 as a Dual-Targeting Nanoparticle for Enhanced Cancer Therapy","volume":"21","author":"Liang","year":"2020","journal-title":"Aaps Pharmscitech"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"4348","DOI":"10.1038\/ncomms5348","article-title":"Quantifying Thiol\u2013Gold Interactions towards the Efficient Strength Control","volume":"5","author":"Xue","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"121195","DOI":"10.1016\/j.ijpharm.2021.121195","article-title":"Thermosensitive Liposomes Encapsulating Hypericin: Characterization and Photodynamic Efficiency","volume":"609","author":"Alawak","year":"2021","journal-title":"Int. J. Pharm."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/acs.biomac.1c01210","article-title":"Poly(Disulfide)s: From Synthesis to Drug Delivery","volume":"23","author":"Zhang","year":"2022","journal-title":"Biomacromolecules"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.biopha.2017.01.144","article-title":"Synthesis, Characterization and Radiolabeling of Polymeric Nano-Micelles as a Platform for Tumor Delivering","volume":"89","author":"Oda","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.snb.2015.10.003","article-title":"Alizarin Dye Based Ultrasensitive Plasmonic SERS Probe for Trace Level Cadmium Detection in Drinking Water","volume":"224","author":"Dasary","year":"2016","journal-title":"Sensors Actuators B Chem."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Tian, F., Li, S., Yang, X., Fan, K., Zhou, M., Gao, D., Hu, D., and Ju, S. (2025). Molecular Etching-Derived High-Brightness NIR-II Gold Nanoclusters for High-Resolution Bioimaging and Photothermal Therapy. Adv. Funct. Mater., 2418867.","DOI":"10.1002\/adfm.202418867"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/11\/2334\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:41:25Z","timestamp":1760031685000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/11\/2334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,27]]},"references-count":45,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["molecules30112334"],"URL":"https:\/\/doi.org\/10.3390\/molecules30112334","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,27]]}}}