{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:19:26Z","timestamp":1760059166405,"version":"build-2065373602"},"reference-count":51,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Higher Education","award":["N N204 445240"],"award-info":[{"award-number":["N N204 445240"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A stereoselective and scalable strategy for the synthesis of phosphorus-containing bicyclic and tricyclic compounds from 1-phenylphosphin-2-en-4-one 1-oxide is presented. This activated dienophile, available in both racemic and enantiopure forms, undergoes smooth [4+2] cycloadditions with acyclic and cyclic dienes, affording products with excellent yields and controlled stereochemistry. Notably, the cis\/trans-fusion of the cycloadducts (phosphadecalones and phosphahexahydrochrysene) can be selectively controlled by fine-tuning the conditions of microwave-assisted cycloaddition reaction. The influence of temperature, time, and steric effects on cis\/trans and endo\/exo selectivity was examined in detail. The molecular structure, including the absolute configuration, of eight products has been determined by X-ray crystallography. These analyses further established the endo-selective nature of the cycloaddition, favoring the P=O face of the dienophile. Post-cycloaddition transformations of selected P-stereogenic phosphadecalone, such as isomerization, reduction and deoxygenation, demonstrate the synthetic versatility of the resulting products.<\/jats:p>","DOI":"10.3390\/molecules30112338","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T09:29:36Z","timestamp":1748338176000},"page":"2338","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Straightforward Approach Towards Phosphadecalones by Microwave-Assisted Diels\u2013Alder Reaction"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6546-1519","authenticated-orcid":false,"given":"El\u017cbieta","family":"\u0141astawiecka","sequence":"first","affiliation":[{"name":"Faculty of Chemistry, Maria Curie-Sk\u0142odowska University, 20-031 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5339-7505","authenticated-orcid":false,"given":"Anna E.","family":"Kozio\u0142","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Maria Curie-Sk\u0142odowska University, 20-031 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0969-4689","authenticated-orcid":false,"given":"K. Micha\u0142","family":"Pietrusiewicz","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Maria Curie-Sk\u0142odowska University, 20-031 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/ejp.1002","article-title":"The Analgesic and Anti-Inflammatory Effects of Salvinorin A Analogue \u03b2-Tetrahydropyran Salvinorin B in Mice","volume":"21","author":"Paton","year":"2017","journal-title":"Eur. J. 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