{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T16:38:47Z","timestamp":1773074327157,"version":"3.50.1"},"reference-count":51,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Heilongjiang Province Postdoctoral Research Fund","award":["BS0050"],"award-info":[{"award-number":["BS0050"]}]},{"name":"Heilongjiang Province Postdoctoral Research Fund","award":["LH2022H001"],"award-info":[{"award-number":["LH2022H001"]}]},{"name":"Heilongjiang Province Postdoctoral Research Fund","award":["ZYW2023-073"],"award-info":[{"award-number":["ZYW2023-073"]}]},{"name":"Heilongjiang Natural Science Foundation Joint Guidance Project","award":["BS0050"],"award-info":[{"award-number":["BS0050"]}]},{"name":"Heilongjiang Natural Science Foundation Joint Guidance Project","award":["LH2022H001"],"award-info":[{"award-number":["LH2022H001"]}]},{"name":"Heilongjiang Natural Science Foundation Joint Guidance Project","award":["ZYW2023-073"],"award-info":[{"award-number":["ZYW2023-073"]}]},{"name":"Heilongjiang Province Traditional Chinese Medicine Research Project","award":["BS0050"],"award-info":[{"award-number":["BS0050"]}]},{"name":"Heilongjiang Province Traditional Chinese Medicine Research Project","award":["LH2022H001"],"award-info":[{"award-number":["LH2022H001"]}]},{"name":"Heilongjiang Province Traditional Chinese Medicine Research Project","award":["ZYW2023-073"],"award-info":[{"award-number":["ZYW2023-073"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>This article investigates the antifungal activity of clove essential oil (CEO) against Candida albicans, as well as its inhibitory effects on C. albicans biofilm formation and the associated developmental processes. Furthermore, it evaluates the therapeutic efficacy of CEO in a mouse model of intestinal C. albicans infection and explores its impact on intestinal microbiota. Additionally, 16S rRNA high-throughput sequencing was conducted to analyze the alterations in the intestinal microbiota. The findings indicate that the administration of CEO in mice infected with C. albicans resulted in a normalization of body weight and an improvement in their symptoms. Histological analysis utilizing HE and PAS staining demonstrated that CEO exerted beneficial effects on the intestinal mucosal status of these infected mice. Furthermore, ELISA results revealed a dose-dependent reduction in the levels of IL-6, IL-8, and IL-17A within the small intestinal tissues of C. albicans-infected mice. Additionally, 16S rRNA gene analysis indicated that CEO effectively enhanced the richness and diversity within the intestinal microbiota of CEO treatment groups of mice that were investigated. Overall, CEO exhibits therapeutic potential against inflammation induced by intestinal C. albicans infection in mice. This effect can be attributed to its anti-inflammatory properties as well as its capacity to regulate the composition of intestinal flora.<\/jats:p>","DOI":"10.3390\/molecules30112372","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T09:47:34Z","timestamp":1748512054000},"page":"2372","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Clove Essential Oil on the Intestinal Flora in Mice Infected with Candida albicans"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8942-5173","authenticated-orcid":false,"given":"Yuan","family":"Gao","sequence":"first","affiliation":[{"name":"School of Pharmacy, Engineering Research Center of Natural Antineoplastic Drugs, Ministry of Education, Harbin University of Commerce, Harbin 150076, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9792-9992","authenticated-orcid":false,"given":"Yuyang","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Engineering Research Center of Natural Antineoplastic Drugs, Ministry of Education, Harbin University of Commerce, Harbin 150076, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5018-9155","authenticated-orcid":false,"given":"Shurong","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Engineering Research Center of Natural Antineoplastic Drugs, Ministry of Education, Harbin University of Commerce, Harbin 150076, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianmei","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Engineering Research Center of Natural Antineoplastic Drugs, Ministry of Education, Harbin University of Commerce, Harbin 150076, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhe","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Engineering Research Center of Natural Antineoplastic Drugs, Ministry of Education, Harbin University of Commerce, Harbin 150076, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuling","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Engineering Research Center of Natural Antineoplastic Drugs, Ministry of Education, Harbin University of Commerce, Harbin 150076, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianghan","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Engineering Research Center of Natural Antineoplastic Drugs, Ministry of Education, Harbin University of Commerce, Harbin 150076, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Engineering Research Center of Natural Antineoplastic Drugs, Ministry of Education, Harbin University of Commerce, Harbin 150076, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"155306","DOI":"10.1016\/j.phymed.2023.155306","article-title":"Antibiofilm activity of lawsone against polymicrobial enterohemorrhagic Escherichia coli O157:H7 and Candida albicans by suppression of curli production and hyphal growth","volume":"124","author":"Lee","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nrmicro.2017.107","article-title":"Development and regulation of single- and multi-species Candida albicans biofilms","volume":"16","author":"Lohse","year":"2017","journal-title":"Nat. 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