{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T01:34:19Z","timestamp":1776821659371,"version":"3.51.2"},"reference-count":24,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T00:00:00Z","timestamp":1748649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["22108196"],"award-info":[{"award-number":["22108196"]}]},{"name":"National Natural Science Foundation of China","award":["22208237"],"award-info":[{"award-number":["22208237"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Thermodynamic parameters play a crucial role in analyzing and optimizing crystallization processes. In this investigation, the solubility profiles of erythromycin thiocyanate dihydrate were determined gravimetrically under atmospheric pressure (0.1 MPa) across six monosolvent systems (methanol, n-propanol, methyl acetate, ethyl acetate, propyl acetate, and water) and two binary solvent mixtures (water\u2013methanol and water\u2013n-propanol), spanning a temperature range of 278.15\u2013318.15 K. The results showed that the solubility of erythromycin thiocyanate dihydrate is apparently affected by temperature and solvent type. For pure solvents, erythromycin thiocyanate dihydrate has higher solubility in alcohol solvents, and lower solubility in ester solvents and water. In mixed solvent systems, erythromycin thiocyanate dihydrate exhibits reduced solubility with higher water content. The experimental solubility values in monosolvent systems were correlated using the Apelblat, Yaws, and Van\u2019t Hoff models, with the Apelblat model showing the best fitting effect. The Apelblat model, Apelblat Jouyban Acre model, and CNIBS\/R-K model were employed for data correlation in binary solvent systems, with the Apelblat model and CNIBS\/R-K model showing better fitting results.<\/jats:p>","DOI":"10.3390\/molecules30112424","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T08:34:13Z","timestamp":1748853253000},"page":"2424","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Thermodynamic Behavior of Erythromycin Thiocyanate Dihydrate in Six Pure Solvents and Two Binary Solvents"],"prefix":"10.3390","volume":"30","author":[{"given":"Jin","family":"Feng","sequence":"first","affiliation":[{"name":"National Engineering Research Center for Industrial Crystallization Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xunhui","family":"Li","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Industrial Crystallization Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianjie","family":"Zhai","sequence":"additional","affiliation":[{"name":"Xi\u2019an Modern Chemistry Research Institute, Xi\u2019an 710065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peizhou","family":"Li","sequence":"additional","affiliation":[{"name":"College of Chemistry and Chemical Engineering, Hainan University, Haikou 570228, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Qin","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Industrial Crystallization Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Wang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Industrial Crystallization Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Yili Chuanning Biotechnology Co., Ltd., Yili 835000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Yili Chuanning Biotechnology Co., Ltd., Yili 835000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Industrial Crystallization Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3358-5044","authenticated-orcid":false,"given":"Xin","family":"Huang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Industrial Crystallization Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6445-7737","authenticated-orcid":false,"given":"Hongxun","family":"Hao","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Industrial Crystallization Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4114","DOI":"10.1021\/acs.jced.4c00333","article-title":"Solubility Measurement and Model Correlation of 4-Acetoxyazetidin-2-one in 12 Pure Solvents and One Binary Solvent at 293.15 to 333.15 K","volume":"69","author":"Fu","year":"2024","journal-title":"J. Chem. Eng. Data"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1021\/acs.jced.4c00300","article-title":"Determination and Correlation of the Solubility of D-Psicose in 15 Pure Solvents at Temperatures of 283.15 to 323.15 K","volume":"69","author":"Mou","year":"2024","journal-title":"J. Chem. Eng. Data"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4186","DOI":"10.1021\/acs.jced.4c00445","article-title":"Equilibrium Solubility Determination, Correlation, and Hansen Solubility Parameters of 2-4-(Dibutylamino)-2-hydroxybenzoyl] Benzoic Acid in 12 Pure Solvents","volume":"69","author":"Li","year":"2024","journal-title":"J. Chem. Eng. Data"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1021\/acs.jced.4c00210","article-title":"Determination of l-Tryptophan Methyl Ester Hydrochloride Solubility in 12 Pure Solvent Systems from 283.15 to 323.15 K","volume":"69","author":"Xing","year":"2024","journal-title":"J. Chem. Eng. Data"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"127622","DOI":"10.1016\/j.molliq.2025.127622","article-title":"Solid\u2013liquid solubility behavior of thiourea in twelve organic solvents; solubility experiments, data correlation, solvent analysis, and molecular simulations","volume":"429","author":"Traiwongsa","year":"2025","journal-title":"J. Mol. Liq."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"123682","DOI":"10.1016\/j.molliq.2023.123682","article-title":"Solubility, correlation, Hansen solubility parameter and thermodynamic analysis of 2,4-dinitroanisole in three binary mixed solvents","volume":"393","author":"Cong","year":"2024","journal-title":"J. Mol. Liq."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.cjche.2021.04.005","article-title":"Characterization and structure analysis of the heterosolvate of erythromycin thiocyanate","volume":"44","author":"Li","year":"2022","journal-title":"Chin. J. Chem. Eng."},{"key":"ref_8","unstructured":"Liu, L. (2013). Hydrates of Erythromycin Salts, Preparation and Use Thereof. (8,470,787), U.S. Patent."},{"key":"ref_9","unstructured":"Liu, G., Zhang, X., Zou, T., Teng, Z., Liang, L., Cheng, Z., Liu, S., Wang, L., and Shen, X. (2013). Refining Method and Preparation Method of Erythromycin Thiocyanate. (103275150A), CN."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.molliq.2017.03.075","article-title":"Solid-liquid equilibrium of erythromycin thiocyanate dihydrate in four mono-solvents and three binary solvent mixtures","volume":"234","author":"Huang","year":"2017","journal-title":"J. Mol. Liq."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"126969","DOI":"10.1016\/j.molliq.2025.126969","article-title":"Investigation on solvent effect, transfer properties and preferential solvation of pentaerythritol in (methanol, ethanol and 2-propanol) + water mixtures","volume":"422","author":"Noubigh","year":"2025","journal-title":"J. Mol. Liq."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1021\/acs.jced.4c00274","article-title":"Solubility Behavior and Data Correlation of Edaravone in 12 Individual Solvents at Multiple Temperatures","volume":"69","author":"Xiao","year":"2024","journal-title":"J. Chem. Eng. Data."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1006\/jcht.1997.0267","article-title":"Solubilities of L-aspartic, DL-aspartic, DL-glutamic, p-hydroxybenzoic, o-anisic, p-anisic, and itaconic acids in water from T = 278 K to T = 345 K","volume":"29","author":"Apelblat","year":"1997","journal-title":"J. Chem. Thermodyn."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"127043","DOI":"10.1016\/j.molliq.2025.127043","article-title":"Thermodynamic data of dicloxacillin sodium in six pure solvents and three binary solvents","volume":"424","author":"Li","year":"2025","journal-title":"J. Mol. Liq."},{"key":"ref_15","unstructured":"Yaws, C.L. (1999). Chemical Properties Handbook, McGraw-Hill."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.cjche.2021.06.029","article-title":"Measurement and correlation of the solubility of sodium acetate in eight pure and binary solvents","volume":"44","author":"Wu","year":"2022","journal-title":"Chin. J. Chem. Eng."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"179791","DOI":"10.1016\/j.tca.2024.179791","article-title":"The dissolution behavior of 3,4-O-isopropylidene clindamycin in twelve mono-solvents: Solubility, intermolecular interactions, and apparent thermodynamics","volume":"738","author":"Li","year":"2024","journal-title":"Thermochim. Acta"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Van \u2018t Hoff, J.H. (1884). \u00c9tudes de Dynamique Chimique, F. M\u00fcller & Co.","DOI":"10.1002\/recl.18840031003"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"125928","DOI":"10.1016\/j.molliq.2024.125928","article-title":"Solubilities measurement and molecular simulation of (R,S)- and (S)-sulpiride in seven pure solvents and four mixtures (chiral ionic liquids + methanol) from 283.15 K to 323.15 K","volume":"413","author":"Wang","year":"2024","journal-title":"J. Mol. Liq."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0040-6031(91)80307-5","article-title":"Thermodynamic Properties of Nonelectrolyte Solutions: Part 4. Solubility and Solvent Composition","volume":"178","author":"Acree","year":"1991","journal-title":"Thermochim. Acta"},{"key":"ref_21","first-page":"177","article-title":"Mathematical Representation of Solubility of Pharmaceuticals in Mixed Solvents Using Jouyban-Acree Model","volume":"167","author":"Jouyban","year":"1998","journal-title":"Int. J. Pharm"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4206","DOI":"10.1021\/acs.jced.4c00499","article-title":"Solubility of Perindopril l-Arginine in 10 Pure Solvents and 3 Binary Solvents from 278.15 to 323.15 K","volume":"69","author":"Cao","year":"2024","journal-title":"J. Chem. Eng. Data"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3148","DOI":"10.1021\/acs.jced.4c00217","article-title":"Measurement, Solvent Effect, and Thermodynamic Modeling of the Solubility of Benzohydrazide and 2-Hydroxybenzohydrazide in Six Pure Solvents","volume":"69","author":"Noubigh","year":"2024","journal-title":"J. Chem. Eng. Data"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.1021\/acs.jced.4c00192","article-title":"Solubility Behavior, Hansen Solubility Parameters, and Thermodynamic Modeling of 9-Phenylcarbazole in 12 Monosolvents from 283.15 to 323.15 K","volume":"69","author":"Li","year":"2024","journal-title":"J. Chem. Eng. Data"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/11\/2424\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:44:51Z","timestamp":1760031891000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/11\/2424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,31]]},"references-count":24,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["molecules30112424"],"URL":"https:\/\/doi.org\/10.3390\/molecules30112424","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,31]]}}}