{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:30:05Z","timestamp":1789050605968,"version":"build-2803163510"},"reference-count":57,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Opening Project of Guangxi Key Laboratory of Green Processing of Sugar Resources","award":["GXTZYKF202308"],"award-info":[{"award-number":["GXTZYKF202308"]}]},{"name":"Hefei University Horizontal Project: Extraction, Application, and Industrialization Process Research of Functional Natural Plant Active Ingredients","award":["GXTZYKF202308"],"award-info":[{"award-number":["GXTZYKF202308"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Chlorpheniramine maleate (CPM) is a first-generation antihistamine that is frequently used to treat allergic reactions. However, excessive consumption presents potential health risks. Therefore, it is crucial to develop a quick and precise technique for identifying CPM levels. In this study, nickel cobalt phosphide (NiCoP), a binary metal phosphide, was successfully incorporated into carbon nanofibers. This involved creating a pore structure by adding polyvinylpyrrolidone (PVP) as a pore-forming template to a polyacrylonitrile (PAN) substrate via electrostatic spinning. An innovative electrochemiluminescent sensor for CPM detection was constructed using NiCoP\/PVP\/PAN carbon nanofibers (NiCoP\/PVP\/PAN\/CNFs). Under optimal conditions, the electrochemical behavior of CPM was studied using NiCoP\/PVP\/PAN\/CNF-modified working electrodes. These findings demonstrate that the three-dimensional porous network architecture of NiCoP\/PVP\/PAN\/CNFs enhances the conductive properties of the material. Consequently, an electrochemical optical sensor fabricated using this structure exhibited remarkable performance. The linear detection range of the sensor was 1 \u00d7 10\u22128\u20137 \u00d7 10\u22125 mol\/L, and the detection limit was 7.8 \u00d7 10\u221210 mol\/L. When human urine and serum samples were examined, the sensor was found to have a high recovery rate (94.35\u2013103.36%), which is promising for practical applications.<\/jats:p>","DOI":"10.3390\/molecules30122603","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T05:28:33Z","timestamp":1750051713000},"page":"2603","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Rapid Detection of Chlorpheniramine Maleate in Human Blood and Urine Samples Based on NiCoP\/PVP\/PAN\/CNFs Electrochemiluminescence Sensor"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9229-3813","authenticated-orcid":false,"given":"Yi","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Biology, Food and Environment, Hefei University, Hefei 230601, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Green Processing of Sugar Resources, Guangxi Liuzhou Luosifen Research Center of Engineering Technology, College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou 545006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxing","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Biology, Food and Environment, Hefei University, Hefei 230601, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingfan","family":"Tang","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Green Processing of Sugar Resources, Guangxi Liuzhou Luosifen Research Center of Engineering Technology, College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou 545006, China"},{"name":"Province and Ministry Co-Sponsored Collaborative Innovation Center of Sugarcane and Sugar Industry, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3539-0139","authenticated-orcid":false,"given":"Hao","family":"Cheng","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Green Processing of Sugar Resources, Guangxi Liuzhou Luosifen Research Center of Engineering Technology, College of Biological and Chemical Engineering, Guangxi University of Science and Technology, Liuzhou 545006, China"},{"name":"Province and Ministry Co-Sponsored Collaborative Innovation Center of Sugarcane and Sugar Industry, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Lin, J., Liu, Z., Guan, T., Lei, Y., Pan, L., Yu, X., Zhang, S., Huang, X.-A., Lei, H., and Chen, J. 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