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Investigaci\u00f3n, SENACYT, Panam\u00e1","award":["Programa I 2025"],"award-info":[{"award-number":["Programa I 2025"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The phytochemical investigation and evaluation of the antioxidant activity of the leaves, bark, and roots of Cochlospermum angolense Welw ex Oliv\u2014a valued plant that is widely used in traditional Angolan medicine\u2014hold significant importance. Compounds were extracted from the aforementioned plant using acetone and ethanol and identified by HPLC-ESI-MSn. Both extracts demonstrated notable abilities to scavenge 2,2-diphenyl-1-picrylhydrazyl, nitric oxide, and superoxide radicals, as well as to inhibit lipid peroxidation. A HPLC analysis revealed a diverse array of bioactive compounds, including flavonoids, phenols, alkaloids, quinones, and terpenes, which help neutralize free radicals and protect cells against oxidative stress, thereby contributing to the prevention of various diseases. Moreover, the acetone and ethanol extracts proved to be excellent sources of antioxidants. For the first time, the present study identified new compounds never reported in this species, such as (+)-abscisic acid, angustine B, pinobanksin, dihydrogenistein, (\u2212)-8-prenylnaringenin, isoquercetin, samandarine, dihydromyricetin, and eupatoriocromene, in the leaves, bark, and roots, marking a significant advance in the chemical characterization of C. angolense. These findings enhance our understanding of the bioactive phytochemicals and antioxidant properties of C. angolense and open new avenues for future therapeutic and pharmacological research, further supporting its traditional use in Angolan medicine.<\/jats:p>","DOI":"10.3390\/molecules30132768","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T11:37:51Z","timestamp":1751283471000},"page":"2768","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cochlospermum angolense Welw ex Oliv: Phytochemical Profile, Antioxidant Activity, and Therapeutic Prospects"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3973-6272","authenticated-orcid":false,"given":"Nsevolo","family":"Samba","sequence":"first","affiliation":[{"name":"Chemistry Department, University of Beira Interior, 6201-001 Covilh\u00e3, Portugal"},{"name":"Department of Clinical Analysis and Public Health, University Kimpa Vita, Uige 77, Angola"},{"name":"Fiber Materials and Environmental Technologies (FibEnTech-UBI), University of Beira Interior, 6201-001 Covilh\u00e3, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdy Morales","family":"Barrios","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00edas, Facultad de Medicina, Universidad de Panam\u00e1, Panama City 7096, Panama"},{"name":"Centro de Investigaciones Psicofarmacol\u00f3gicas, Universidad de Panam\u00e1, Panama City 7096, Panama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estela Guerrero","family":"De Le\u00f3n","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00edas, Facultad de Medicina, Universidad de Panam\u00e1, Panama City 7096, Panama"},{"name":"Centro de Investigaciones Psicofarmacol\u00f3gicas, Universidad de Panam\u00e1, Panama City 7096, Panama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7906-3316","authenticated-orcid":false,"given":"Cesar","family":"Raposo","sequence":"additional","affiliation":[{"name":"Mass Spectrometry Service, NUCLEUS, University of Salamanca, 37005 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6911-6947","authenticated-orcid":false,"given":"Radhia Aitfella","family":"Lahlou","sequence":"additional","affiliation":[{"name":"Chemistry Department, University of Beira Interior, 6201-001 Covilh\u00e3, Portugal"},{"name":"Fiber Materials and Environmental Technologies (FibEnTech-UBI), University of Beira Interior, 6201-001 Covilh\u00e3, Portugal"},{"name":"RISE-Health, Faculdade de Ci\u00eancias da Sa\u00fade, Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilh\u00e3, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5379-7688","authenticated-orcid":false,"given":"Joana","family":"Curto","sequence":"additional","affiliation":[{"name":"Chemistry Department, University of Beira Interior, 6201-001 Covilh\u00e3, Portugal"},{"name":"Fiber Materials and Environmental Technologies (FibEnTech-UBI), University of Beira Interior, 6201-001 Covilh\u00e3, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6114-3572","authenticated-orcid":false,"given":"Jesus M.","family":"Rodilla","sequence":"additional","affiliation":[{"name":"Chemistry Department, University of Beira Interior, 6201-001 Covilh\u00e3, Portugal"},{"name":"Fiber Materials and Environmental Technologies (FibEnTech-UBI), University of Beira Interior, 6201-001 Covilh\u00e3, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9458-0717","authenticated-orcid":false,"given":"Alejandro M.","family":"Roncero","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica, Facultad de Ciencias Qu\u00edmicas, Universidad de Salamanca, Avda de los Ca\u00eddos s\/n, 37008 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7261-8454","authenticated-orcid":false,"given":"David","family":"Diez","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica, Facultad de Ciencias Qu\u00edmicas, Universidad de Salamanca, Avda de los Ca\u00eddos s\/n, 37008 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7386-0330","authenticated-orcid":false,"given":"L\u00facia","family":"Silva","sequence":"additional","affiliation":[{"name":"Chemistry Department, University of Beira Interior, 6201-001 Covilh\u00e3, Portugal"},{"name":"Fiber Materials and Environmental Technologies (FibEnTech-UBI), University of Beira Interior, 6201-001 Covilh\u00e3, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Huntley, B.J., Russo, V., Lages, F., and Ferrand, N. 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