{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:48:31Z","timestamp":1790772511303,"version":"4.1.0"},"reference-count":261,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Journal Molecules, MDPI"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Obesity and depression frequently coexist, sharing overlapping molecular pathways such as inflammation, oxidative stress, gut microbiota dysbiosis, and neuroendocrine dysfunction. Recent research highlights the therapeutic potential of plant-derived bioactive compounds in targeting these shared mechanisms. This scoping review followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and included 261 peer-reviewed studies identified through PubMed, Scopus, and the Web of Science up to December 2024. Studies were screened based on predefined inclusion and exclusion criteria. This review synthesizes data from peer-reviewed studies, including both preclinical and clinical investigations, focusing on polyphenols, flavonoids, alkaloids, and other phytochemicals with anti-inflammatory, antioxidant, neuroprotective, and metabolic effects. Compounds such as quercetin, epigallocatechin gallate (EGCG), resveratrol, curcumin, anthocyanins, and luteolin demonstrate promise in modulating adenosine monophosphate-activated protein kinase (AMPK), brain-derived neurotrophic factor (BDNF), nuclear factor kappa B (NF-\u03baB), and gut\u2013brain axis pathways. Our scoping review, conducted in accordance with PRISMA guidelines, identifies promising combinations and mechanisms for integrative phytotherapy. These findings underscore the potential of botanical strategies in developing future interventions for metabolic and mood comorbidities.<\/jats:p>","DOI":"10.3390\/molecules30132827","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T04:04:22Z","timestamp":1751342662000},"page":"2827","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Phytotherapy and the Role of Bioactive Compounds in Modulating Mechanisms of Overweight and Obesity Comorbid with Depressive Symptoms\u2014A Scoping Review of Mechanisms of Action"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7572-270X","authenticated-orcid":false,"given":"Klaudia","family":"Sochacka","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Science, University of Kalisz, pl. W. Bogus\u0142awskiego 2, 62-800 Kalisz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Lachowicz-Wi\u015bniewska","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Science, University of Kalisz, pl. W. Bogus\u0142awskiego 2, 62-800 Kalisz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/1468-0009.12238","article-title":"Obesity and Diabetes: The Slow-Motion Disaster","volume":"95","author":"Chan","year":"2017","journal-title":"Milbank Q."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.prrv.2006.08.002","article-title":"Obesity and inflammation in children","volume":"7","author":"Schwarzenberg","year":"2006","journal-title":"Paediatr. Respir. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.orcp.2016.07.003","article-title":"The interface of depression and obesity","volume":"11","author":"Jantaratnotai","year":"2017","journal-title":"Obes. Res. Clin. Pract."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1001\/archgenpsychiatry.2010.2","article-title":"Overweight, obesity, and depression: A systematic review and meta-analysis of longitudinal studies","volume":"67","author":"Luppino","year":"2010","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1080\/10408398.2013.767221","article-title":"Fruit Polyphenols: A Review of Anti-inflammatory Effects in Humans","volume":"56","author":"Joseph","year":"2016","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.31887\/DCNS.2011.13.1\/rshelton","article-title":"Inflammation in depression: Is adiposity a cause?","volume":"13","author":"Shelton","year":"2011","journal-title":"Dialogues Clin. Neurosci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"929","DOI":"10.2174\/1570159X20666220103140834","article-title":"The Role of Natural Products in Treatment of Depressive Disorder","volume":"20","author":"Noori","year":"2022","journal-title":"Curr. Neuropharmacol."},{"key":"ref_8","first-page":"2095","article-title":"Global and regional burden of diseases and injuries in 2010: A systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Lim","year":"2012","journal-title":"Lancet"},{"key":"ref_9","first-page":"78","article-title":"Depression\u2014Cause or result of obesity? Endokrynol","volume":"4","year":"2008","journal-title":"Oty\u0142o\u015b\u0107 Zab. Przem. Mat."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"112072","DOI":"10.1016\/j.exger.2022.112072","article-title":"The relationship between nutrition and depression in the life process: A mini-review","volume":"172","author":"Ekinci","year":"2023","journal-title":"Exp. Gerontol."},{"key":"ref_11","first-page":"14","article-title":"Oty\u0142o\u015b\u0107 to choroba, a nie defekt estetyczny","volume":"2","author":"Kazimierska","year":"2021","journal-title":"Kurier Medyczny"},{"key":"ref_12","first-page":"65","article-title":"Obesity\u2014Causes, Types, Treatment, Effects","volume":"4","author":"Kopacz","year":"2018","journal-title":"Eng. Sci. Technol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S0006-3223(03)00608-5","article-title":"Depression and obesity","volume":"54","author":"Stunkard","year":"2003","journal-title":"Biol. Psychiatry"},{"key":"ref_14","first-page":"225","article-title":"El Adipocito Como \u00d3rgano Endocrino: Implicaciones Fisiopatol\u00f3gicas y Terap\u00e9uticas","volume":"152","author":"Mayorga","year":"2007","journal-title":"Rev. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.coph.2017.08.006","article-title":"Adipose tissue inflammation in obesity: A metabolic or immune response?","volume":"37","author":"Stolarczyk","year":"2017","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_16","first-page":"6697","article-title":"Flavonoids and phenolic acids: Role and biochemical activity in plants and humans","volume":"5","author":"Ghasemzadeh","year":"2011","journal-title":"J. Med. Plants Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.1002\/jssc.200700261","article-title":"Extraction, separation, and detection methods for phenolic acids and flavonoids","volume":"30","author":"Stalikas","year":"2007","journal-title":"J. Sep. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Tanase, C., Cosarc\u0103, S., and Muntean, D.L. (2019). A critical review of phenolic compounds extracted from the shoulder of woody vascular plants and their potential biological activity. Molecules, 24.","DOI":"10.3390\/molecules24061182"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Aranaz, P., Navarro-Herrera, D., Zabala, M., Migu\u00e9liz, I., Romo-Hualde, A., L\u00f3pez-Yoldi, M., Alfredo Mart\u00ednez, J., Vizmanos, J.L., Milagro, F.I., and Gonz\u00e1lez-Navarro, C.J. (2019). Phenolic compounds inhibit 3T3-L1 adipogenesis depending on the stage of differentiation and their binding affinity to PPAR\u03b3. Molecules, 24.","DOI":"10.3390\/molecules24061045"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"8404","DOI":"10.1021\/jf071695r","article-title":"Effects of flavonoids and phenolic acids on the inhibition of adipogenesis in 3T3-L1 adipocytes","volume":"55","author":"Hsu","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12986-016-0080-3","article-title":"Hydroxycinnamic acid derivatives: A potential class of natural compounds for the management of lipid metabolism and obesity","volume":"13","author":"Alam","year":"2016","journal-title":"Nutr. Metab."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1080\/13813455.2017.1415938","article-title":"Dietary phenolic acids reverse insulin resistance, hyperglycaemia, dyslipidaemia, inflammation and oxidative stress in high-fructose diet-induced metabolic syndrome rats","volume":"124","author":"Ibitoye","year":"2018","journal-title":"Arch. Physiol. Biochem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1089\/jmf.2014.3342","article-title":"Gallic acid decreases inflammatory cytokine secretion through histone acetyltransferase\/histone deacetylase regulation in high glucose-induced human monocytes","volume":"18","author":"Lee","year":"2015","journal-title":"J. Med. Food"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4303","DOI":"10.1021\/jf9803841","article-title":"Antioxidant dietary fiber product: A new concept and potential food ingredient","volume":"46","year":"1998","journal-title":"J. Agric. Food Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"487","DOI":"10.17221\/42\/2015-CJFS","article-title":"Antioxidant dietary fibres: Potential functional food ingredients from plant processing by-products","volume":"33","author":"Eskicioglu","year":"2016","journal-title":"Czech J. Food Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"233","DOI":"10.17306\/J.AFS.2016.3.23","article-title":"Effect of food processing on the physicochemical properties of dietary fibre","volume":"15","author":"Ozyurt","year":"2016","journal-title":"Acta Sci. Pol. Technol. Aliment."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.fbio.2016.08.001","article-title":"Functional and physico-chemical properties of six desert-sources of dietary fiber","volume":"16","author":"Requena","year":"2016","journal-title":"Food Biosci."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Zhou, Q., Wu, J., Tang, J., Wang, J.-J., Lu, C.-H., and Wang, P.-X. (2015). Beneficial effect of higher dietary fiber intake on plasma HDL-C and TC\/HDL-C ratio among Chinese rural-to-urban migrant workers. Int. J. Environ. Res. Public Health, 12.","DOI":"10.3390\/ijerph120504726"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Adam, C.L., Thomson, L.M., Williams, P.A., and Ross, A.W. (2015). Soluble Fermentable Dietary Fibre (Pectin) Decreases Caloric Intake, Adiposity and Lipidaemia in High-Fat Diet-Induced Obese Rats. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0140392"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nut.2017.05.002","article-title":"Effects of high \u03b2-glucan barley on visceral fat obesity in Japanese individuals: A randomized, double-blind study","volume":"42","author":"Aoe","year":"2017","journal-title":"Nutrition"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"449","DOI":"10.17221\/200\/2015-CJFS","article-title":"Production and characterisation of alcohol-insoluble dietary fibre as a potential source for functional carbohydrates produced by enzymatic depolymerisation of buckwheat hulls","volume":"33","author":"Im","year":"2016","journal-title":"Czech J. Food Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/19390211.2016.1207005","article-title":"Yeast \u03b2-glucan modulates inflammation and waist circumference in overweight and obese subjects","volume":"14","author":"Mosikanon","year":"2017","journal-title":"J. Diet. Suppl."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1016\/j.biopha.2016.10.105","article-title":"Beneficial effects of Plantago albicans on high-fat diet-induced obesity in rats","volume":"84","author":"Samout","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.chom.2017.11.003","article-title":"Fiber-mediated nutrition of the gut microbiota protects against diet-induced obesity by restoring IL-22-dependent colonic health","volume":"23","author":"Zou","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.phrs.2011.02.005","article-title":"Diets enriched in soluble fiber improve indices of inflammation and oxidative stress in rats with Zucker fat syndrome","volume":"64","author":"Moulay","year":"2011","journal-title":"Pharmacol. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1093\/ajcn\/83.4.760","article-title":"Relationship between dietary fiber and serum C-reactive protein levels","volume":"83","author":"Ma","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jff.2015.11.011","article-title":"Potential use of dietary fibre from Hibiscus sabdariffa and Agave tequilana in obesity management","volume":"21","author":"Moyano","year":"2016","journal-title":"J. Funct. Foods"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Dahiya, D.K., Puniya, M., Shandilya, U.K., Dhewa, T., Kumar, N., Kumar, S., Puniya, A.K., and Shukla, P. (2017). Modulation of gut microbiota and its association with obesity using prebiotic fiber and probiotics: A review. Front. Microbiol., 8.","DOI":"10.3389\/fmicb.2017.00563"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/CS20070456","article-title":"Effects of N-3 polyunsaturated fatty acids on adipose tissue biology and metabolism at the cellular and molecular levels","volume":"116","author":"Flachs","year":"2009","journal-title":"Clin. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jnutbio.2018.02.012","article-title":"Omega-3 fatty acids in obesity and metabolic syndrome: A mechanistic update","volume":"58","author":"Kalupahana","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Ram\u00edrez-Moreno, E., Arias-Rico, J., Jim\u00e9nez-S\u00e1nchez, R.C., Estrada-Luna, D., Jim\u00e9nez-Osorio, A.S., Zafra-Rojas, Q.Y., Ariza-Ortega, J.A., Flores-Ch\u00e1vez, O.R., Morales-Castillejos, L., and Sandoval-Gallegos, E.M. (2022). Role of Bioactive Compounds in Obesity: Metabolic Mechanism Focused on Inflammation. Foods, 11.","DOI":"10.3390\/foods11091232"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Grosso, G., Laudisio, D., Frias-Toral, E., Barrea, L., Muscogiuri, G., Savastano, S., and Colao, A. (2022). Anti-Inflammatory Nutrients and Obesity-Associated Metabolic-Inflammation: State of the Art and Future Direction. Nutrients, 14.","DOI":"10.3390\/nu14061137"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Pelczy\u0144ska, M., Moszak, M., Weso\u0142ek, A., and Bogda\u0144ski, P. (2023). The Preventive Mechanisms of Bioactive Food Compounds against Obesity-Induced Inflammation. Antioxidants, 12.","DOI":"10.3390\/antiox12061232"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/BF02836413","article-title":"Effects on animal models of depression of bioactive compounds from entomogenous fungi, a novel antioxidant","volume":"10","author":"Liang","year":"2004","journal-title":"Chin. J. Integr. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.euroneuro.2011.04.002","article-title":"Herbal medicine for depression, anxiety and insomnia: A review of psychopharmacology and clinical evidence","volume":"21","author":"Sarris","year":"2011","journal-title":"Eur. Neuropsychopharmacol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13020-018-0214-9","article-title":"A preliminary review of studies on adaptogens: Comparison of their bioactivity in TCM with that of ginseng-like herbs used worldwide","volume":"13","author":"Liao","year":"2018","journal-title":"Chin. Med."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Lee, G., and Bae, H. (2017). Therapeutic Effects of Phytochemicals and Medicinal Herbs on Depression. BioMed Res. Int., 2017.","DOI":"10.1155\/2017\/6596241"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Nurzy\u0144ska-Wierdak, R. (2024). Plants with Potential Importance in Supporting the Treatment of Depression: Current Trends, and Research. Pharmaceuticals, 17.","DOI":"10.3390\/ph17111489"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/da.20262","article-title":"Role of GABA in anxiety and depression","volume":"24","author":"Kalueff","year":"2007","journal-title":"Depress. Anxiety"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.nut.2009.04.023","article-title":"Bioactive compounds: Definition and assessment of activity","volume":"25","author":"Biesalski","year":"2009","journal-title":"Nutrition"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Kussmann, M., Abe Cunha, D.H., and Berciano, S. (2023). Bioactive compounds for human and planetary health. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1193848"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"4171","DOI":"10.1002\/ptr.7079","article-title":"Phytonutrient supplements and metabolic biomarkers of cardiovascular disease: An umbrella review of meta-analyses of clinical trials","volume":"35","author":"Hoang","year":"2021","journal-title":"Phytother. Res."},{"key":"ref_53","first-page":"466","article-title":"Adipose tissue\u2014Morphological and biochemical characteristic of different depots","volume":"71","year":"2017","journal-title":"Postepy Hig. Med. Dosw."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Kolb, H. (2022). Obese visceral fat tissue inflammation: From protective to detrimental?. BMC Med., 20.","DOI":"10.1186\/s12916-022-02672-y"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"802078","DOI":"10.1155\/2010\/802078","article-title":"The role of adipose tissue and adipokines in obesity-related inflammatory diseases","volume":"2010","author":"Balistreri","year":"2010","journal-title":"Mediat. Inflamm."},{"key":"ref_56","first-page":"21","article-title":"The role of adipose tissue in the endocrine system","volume":"1","author":"Fichna","year":"2005","journal-title":"Endokrynol. Oty\u0142. Zab. Przem. Mat."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"P\u00e9rez-Torres, I., Castrej\u00f3n-T\u00e9llez, V., Soto, M.E., Rubio-Ruiz, M.E., Manzano-Pech, L., and Guarner-Lans, V. (2021). Oxidative Stress, Plant Natural Antioxidants, and Obesity. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22041786"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Kuntz, S., Kunz, C., Domann, E., W\u00fcrdemann, N., Unger, F., R\u00f6mpp, A., and Rudloff, S. (2016). Inhibition of Low-Grade Inflammation by Anthocyanins after Microbial Fermentation In vitro. Nutrients, 8.","DOI":"10.3390\/nu8070411"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/nbu.12278","article-title":"The Role of Polyphenols in Modern Nutrition","volume":"42","author":"Williamson","year":"2017","journal-title":"Nutr. Bull."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.ejmech.2019.07.033","article-title":"Protective Effect of Piceatannol and Bioactive Stilbene Derivatives against Hypoxia-Induced Toxicity in H9c2 Cardiomyocytes and Structural Elucidation as 5-LOX Inhibitors","volume":"180","author":"Boccellino","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1753-4887.1998.tb01670.x","article-title":"Polyphenols: Chemistry, Dietary Sources, Metabolism, and Nutritional Significance","volume":"56","author":"Bravo","year":"1998","journal-title":"Nutr. Rev."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Xu, D.-P., Li, Y., Meng, X., Zhou, T., Zhou, Y., Zheng, J., Zhang, J.-J., and Li, H.-B. (2017). Natural Antioxidants in Foods and Medicinal Plants: Extraction, Assessment and Resources. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18010096"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jnutbio.2013.09.001","article-title":"Novel insights of dietary polyphenols and obesity","volume":"25","author":"Wang","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.foodchem.2013.10.032","article-title":"Cranberries (Oxycoccus quadripetalus) inhibit adipogenesis and lipogenesis in 3T3-L1 cells","volume":"148","author":"Kowalska","year":"2014","journal-title":"Food Chem."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1002\/mnfr.201200686","article-title":"Prevention of diet-induced obesity by apple polyphenols in Wistar rats through regulation of adipocyte gene expression and DNA methylation patterns","volume":"57","author":"Milagro","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1021\/acs.jafc.9b06817","article-title":"Beneficial Effects of Dietary Polyphenols on High-Fat Diet-Induced Obesity Linking with Modulation of Gut Microbiota","volume":"68","author":"Liu","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"100002","DOI":"10.1016\/j.fufo.2020.100002","article-title":"Managing obesity through natural polyphenols: A review","volume":"1\u20132","author":"Singh","year":"2020","journal-title":"Future Foods"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1459497","DOI":"10.1155\/2017\/1459497","article-title":"The Beneficial Effects of Quercetin, Curcumin, and Resveratrol in Obesity","volume":"2017","author":"Zhao","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"E201","DOI":"10.1152\/ajpendo.00285.2017","article-title":"Curcumin and other dietary polyphenols: Potential mechanisms of metabolic actions and therapy for diabetes and obesity","volume":"314","author":"Jin","year":"2018","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.foodchem.2015.02.006","article-title":"Role of quercetin as an alternative for obesity treatment: You are what you eat!","volume":"179","author":"Nabavi","year":"2015","journal-title":"Food Chem."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.bbrc.2008.06.077","article-title":"The anti-obesity effect of quercetin is mediated by the AMPK and APK signaling pathways","volume":"373","author":"Ahn","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1002\/ptr.3604","article-title":"Suppressive effects of quercetin-3-O-(6\u201d-Feruloyl)-\u03b2-D-galactopyranoside on adipogenesis in 3T3\u2013L1 preadipocytes through down-regulation of PPAR\u03b3 and C\/EBP\u03b1 expression","volume":"26","author":"Yang","year":"2012","journal-title":"Phytother. Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1038\/ijo.2010.272","article-title":"Quercetin attenuates inflammation in human macrophages and adipocytes exposed to macrophage-conditioned media","volume":"35","author":"Overman","year":"2011","journal-title":"Int. J. Obes."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.bcp.2006.07.016","article-title":"Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: Analysis of the structure-activity relationship","volume":"72","author":"Comalada","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"12458","DOI":"10.1021\/jf3028107","article-title":"Differential effects of grape powder and its extract on glucose tolerance and chronic inflammation in high-fat-fed obese mice","volume":"60","author":"Chuang","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.3945\/ajcn.2010.29807","article-title":"Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor-\u03b1-mediated inflammation and insulin resistance in primary human adipocytes","volume":"92","author":"Chuang","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.numecd.2011.08.010","article-title":"Effect of quercetin on traits of the metabolic syndrome, endothelial function and inflammation in men with different APOE isoforms","volume":"23","author":"Pfeuffer","year":"2013","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_78","first-page":"39","article-title":"Quercetin inhibits adipogenesis of muscle progenitor cells in vitro","volume":"13","author":"Funakoshi","year":"2018","journal-title":"Biochem. Biophys. Rep."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.jnutbio.2009.01.008","article-title":"Suppressive effect of quercetin on acute stress-induced hypothalamic-pituitary-adrenal axis response in Wistar rats","volume":"21","author":"Kawabata","year":"2010","journal-title":"J. Nutr. Biochem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s00210-014-1008-y","article-title":"Quercetin mitigates Adriamycin-induced anxiety- and depression-like behaviors, immune dysfunction, and brain oxidative stress in rats","volume":"387","author":"Merzoug","year":"2014","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"4892415","DOI":"10.1155\/2020\/4892415","article-title":"Protective Effects of Quercetin on Anxiety-Like Symptoms and Neuroinflammation Induced by Lipopolysaccharide in Rats","volume":"2020","author":"Lee","year":"2020","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1271\/bbb.100238","article-title":"Genistein Regulated Serotonergic Activity in the Hippocampus of Ovariectomized Rats under Forced Swimming Stress","volume":"74","author":"Kageyama","year":"2010","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.2147\/DMSO.S216312","article-title":"Genistein diet improves body weight, serum glucose and triglyceride levels in both male and female ob\/ob mice","volume":"12","author":"Rockwood","year":"2019","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1093\/jn\/136.2.409","article-title":"Genistein Decreases Food Intake, Body Weight, and Fat Pad Weight and Causes Adipose Tissue Apoptosis in Ovariectomized Female Mice","volume":"136","author":"Kim","year":"2006","journal-title":"J. Nutr."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.bbrc.2021.04.067","article-title":"Genistein improves systemic metabolism and enhances cold resistance by promoting adipose tissue beiging","volume":"558","author":"Chen","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Bany\u015b, K., Stawarska, A., Wyr\u0119biak, R., Bielecki, W., and Bobrowska-Korczak, B. (2022). The Effect of Genistein Supplementation on Cholesterol Oxidation Products and Fatty Acid Profiles in Serums of Rats with Breast Cancer. Foods, 11.","DOI":"10.3390\/foods11040605"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s00198-013-2512-5","article-title":"Genistein effects on quality of life and depression symptoms in osteopenic postmenopausal women: A 2-year randomized, double-blind, controlled study","volume":"25","author":"Atteritano","year":"2014","journal-title":"Osteoporos. Int."},{"key":"ref_88","first-page":"164943","article-title":"Pharmacological Evaluation of Antidepressant-Like Effect of Genistein and Its Combination with Amitriptyline: An Acute and Chronic Study","volume":"2015","author":"Gupta","year":"2015","journal-title":"Adv. Pharmacol. Sci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1423052","DOI":"10.1155\/2016\/1423052","article-title":"Evaluation of the Isoflavone Genistein as Reversible Human Monoamine Oxidase-A and -B Inhibitor","volume":"2016","author":"Zarmouh","year":"2016","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"R77","DOI":"10.1152\/ajpregu.00832.2005","article-title":"Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea","volume":"292","author":"Diepvens","year":"2007","journal-title":"Am. J. Physiol.-Regul. Integr. Comp. Physiol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1111\/bph.13492","article-title":"Antioxidant effects of resveratrol in the cardiovascular system","volume":"174","author":"Xia","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/mnfr.201100673","article-title":"Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: A triple-blind, 6-month follow-up, placebo-controlled, randomized trial","volume":"56","author":"Larrosa","year":"2012","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.lfs.2008.03.003","article-title":"Enhanced inhibition of adipogenesis and induction of apoptosis in 3T3-L1 adipocytes with combinations of resveratrol and quercetin","volume":"82","author":"Yang","year":"2008","journal-title":"Life Sci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.jnutbio.2011.06.003","article-title":"Resveratrol induces Sirt1-dependent apoptosis in 3T3-L1 preadipocytes by activating AMPK and suppressing AKT activity and survivin expression","volume":"23","author":"Chen","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s11033-012-2041-x","article-title":"Lentivirus-mediated Sirt1 shRNA and resveratrol independently induce porcine preadipocyte apoptosis by canonical apoptotic pathway","volume":"40","author":"Pang","year":"2013","journal-title":"Mol. Biol. Rep."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1743-7075-8-29","article-title":"Changes in white adipose tissue metabolism induced by resveratrol in rats","volume":"8","author":"Alberdi","year":"2011","journal-title":"Nutr. Metab."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1476-511X-12-8","article-title":"Effect of dietary resveratrol on the metabolic profile of nutrients in obese OLETF rats","volume":"12","author":"Nagao","year":"2013","journal-title":"Lipids Health Dis."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/biof.118","article-title":"Neuroprotective properties of resveratrol in different neurodegenerative disorders","volume":"36","author":"Albani","year":"2010","journal-title":"Biofactors"},{"key":"ref_99","first-page":"3015","article-title":"Therapeutic effect of resveratrol on mice with depression","volume":"18","author":"Gu","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.steroids.2015.05.010","article-title":"Resveratrol ameliorates depressive-like behavior in repeated corticosterone-induced depression in mice","volume":"101","author":"Ali","year":"2015","journal-title":"Steroids"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"56045","DOI":"10.18632\/oncotarget.11178","article-title":"Resveratrol counteracts lipopolysaccharide-induced depressive-like behaviors via enhanced hippocampal neurogenesis","volume":"7","author":"Liu","year":"2016","journal-title":"Oncotarget"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/mnfr.201500428","article-title":"Mechanisms of body weight reduction and metabolic syndrome alleviation by tea","volume":"60","author":"Yang","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Gu, Q., Xia, L., Du, Q., Shao, Y., He, J., Wu, P., Liang, L., and Shen, X. (2023). The therapeutic role and potential mechanism of EGCG in obesity-related precocious puberty as determined by integrated metabolomics and network pharmacology. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1159657"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/cmi.2010.1","article-title":"Epigallocatechin-3-gallate (EGCG) attenuates inflammation in MRL\/lpr mouse mesangial cells","volume":"7","author":"Peairs","year":"2010","journal-title":"Cell. Moth. Immunol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1089\/jmf.2017.4161","article-title":"Effects of Epigallocatechin Gallate on Behavioral and Cognitive Impairments, Hypothalamic\u2013Pituitary\u2013Adrenal Axis Dysfunction, and Alterations in Hippocampal BDNF Expression Under Single Prolonged Stress","volume":"21","author":"Lee","year":"2018","journal-title":"J. Med. Food"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1080\/09553002.2018.1492755","article-title":"Neuroprotective effect of epigallocatechin-3-gallate (EGCG) on radiation-induced damage and apoptosis in the rat hippocampus","volume":"94","author":"Othman","year":"2018","journal-title":"Int. J. Radiat. Biol."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Li, F., Gao, C., Yan, P., Zhang, M., Wang, Y., Hu, Y., Wu, X., Wang, X., and Sheng, J. (2018). EGCG Reduces Obesity and White Adipose Tissue Gain Partly Through AMPK Activation in Mice. Front. Pharmacol., 9.","DOI":"10.3389\/fphar.2018.01366"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.nutres.2011.09.026","article-title":"Purple sweet potato anthocyanins attenuate hepatic lipid accumulation through activating adenosine monophosphate\u2013activated protein kinase in human HepG2 cells and obese mice","volume":"31","author":"Hwang","year":"2011","journal-title":"Nutr. Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"539","DOI":"10.3109\/09637486.2015.1028907","article-title":"Black soybean extract reduces fatty acid contents in subcutaneous, but not in visceral adipose triglyceride in high-fat fed rats","volume":"66","author":"Sato","year":"2015","journal-title":"Int. J. Food Sci. Nutr."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"e00114","DOI":"10.1002\/pld3.114","article-title":"Identification and functional analysis of three new anthocyanin R2R3-MYB genes in Petunia","volume":"3","author":"Zhang","year":"2019","journal-title":"Plant Direct"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"391","DOI":"10.2174\/1389201015666140617104643","article-title":"The antidiabetic therapeutic potential of dietary polyphenols","volume":"15","author":"Habtemariam","year":"2014","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jff.2018.03.042","article-title":"The effects of anthocyanins on body weight and expression of adipocyte\u2019s hormones: Leptin and adiponectin","volume":"45","author":"Tucakovic","year":"2018","journal-title":"J. Funct. Foods"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/fst.39119","article-title":"Obesity-associated Pathways of Anthocyanins","volume":"41","author":"Yildiz","year":"2021","journal-title":"Food Sci. Technol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1039\/C7FO00983F","article-title":"Hypoglycemic and hypolipidemic effects of anthocyanins extract from black soybean seed coat in high fat diet and streptozotocin-induced diabetic mice","volume":"9","author":"Chen","year":"2018","journal-title":"Food Funct."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.molcel.2017.05.032","article-title":"AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance","volume":"66","author":"Garcia","year":"2017","journal-title":"Mol. Cell"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.1021\/jf3002153","article-title":"Metabolism of anthocyanins by human gut microflora and their influence on gut bacterial growth","volume":"60","author":"Hidalgo","year":"2012","journal-title":"J. Agric. Food Chem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1002\/biof.1365","article-title":"Contribution of anthocyanin-rich foods in obesity control through gut microbiota interactions","volume":"43","author":"Jamar","year":"2017","journal-title":"Biofactors"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"6086","DOI":"10.1021\/jf020145k","article-title":"Fruit flesh betacyanin pigments in Hylocereus cacti","volume":"50","author":"Wybraniec","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/S0031-9422(01)00336-3","article-title":"Betacyanins from vine cactus Hylocereus polyrhizus","volume":"58","author":"Wybraniec","year":"2001","journal-title":"Phytochemistry"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jjcc.2013.11.006","article-title":"Adipokines: A link between obesity and cardiovascular disease","volume":"63","author":"Nakamura","year":"2014","journal-title":"J. Cardiol."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Ahmadi, H., Nayeri, Z., Minuchehr, Z., Sabouni, F., and Mohammadi, M. (2020). Betanin purification from red beetroots and evaluation of its antioxidant and anti-inflammatory activity on LPS-activated microglial cells. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0233088"},{"key":"ref_122","first-page":"431","article-title":"Hypocholesterolemic effect of red pitaya (Hylocereus sp.) on hypercholesterolemia induced rats","volume":"16","author":"Khalili","year":"2009","journal-title":"Int. Food Res. J."},{"key":"ref_123","first-page":"1934578X20932013","article-title":"Inhibitory effect of betanin from Hylocereus ocamponis against steatohepatitis in mice fed a high-fat diet","volume":"15","year":"2020","journal-title":"Nat. Prod. Commun."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3109\/10715762.2011.641157","article-title":"Beetroot betalain inhibits peroxynitrite-mediated tyrosine nitration and DNA strand cleavage","volume":"46","author":"Sakihama","year":"2012","journal-title":"Free Radic. Res."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s11130-021-00914-7","article-title":"In vitro antioxidant capacity of Opuntia spp. fruits measured by the LOX-FL method and its high sensitivity towards betalains","volume":"76","author":"Soccio","year":"2021","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1002\/ptr.6345","article-title":"Opuntia ficus-indica (L.) Mill. fruit as source of betalains with antioxidant, cytoprotective, and anti-angiogenic properties","volume":"33","author":"Smeriglio","year":"2019","journal-title":"Phytother. Res."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Khoo, H.E., He, X., Tang, Y., Li, Z., Li, C., Zeng, Y., Tang, J., and Sun, J. (2022). Betacyanins and anthocyanins in pulp and peel of red pitaya (Hylocereus polyrhizus cv. Jindu), inhibition of oxidative stress, lipid reducing, and cytotoxic effects. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.894438"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.foodchem.2017.04.187","article-title":"Characterization of betalains, saponins and antioxidant power in differently colored quinoa (Chenopodium quinoa) varieties","volume":"234","author":"Escribano","year":"2017","journal-title":"Food Chem."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.tifs.2022.02.020","article-title":"Health-promoting potential of betalains in vivo and their relevance as functional ingredients: A review","volume":"122","year":"2022","journal-title":"Trends Food Sci. Technol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"59","DOI":"10.12740\/PP\/21865","article-title":"Herbal remedies in depression\u2014State of the art","volume":"48","year":"2014","journal-title":"Psychiatr. Pol."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Pohl, F., and Kong Thoo Lin, P. (2018). The potential use of plant natural products and plant extracts with antioxidant properties for the prevention\/treatment of neurodegenerative diseases: In vitro, in vivo and clinical trials. Molecules, 23.","DOI":"10.3390\/molecules23123283"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"738","DOI":"10.2174\/1381612825666190402105803","article-title":"Depression and treatment with effective herbs","volume":"25","author":"Fathinezhad","year":"2019","journal-title":"Curr. Pharm. Des."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Bruni, O., Ferini-Strambi, L., Giacomoni, E., and Pellegrino, P. (2021). Herbal remedies and their possible effect on the GABAergic system and sleep. Nutrients, 13.","DOI":"10.3390\/nu13020530"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0091-3057(03)00156-4","article-title":"Adaptogenic effect of Bacopa monniera (Brahmi)","volume":"75","author":"Rai","year":"2003","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1742-7843.2011.00736.x","article-title":"Effects of fluoxetine on the oxidative status of peripheral blood leucocytes of restraint-stressed mice","volume":"109","author":"Amigo","year":"2011","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3329\/bjp.v12i1.29184","article-title":"A review on antidepressant effect of medicinal plants","volume":"12","author":"Rabiei","year":"2017","journal-title":"Bangladesh J. Pharmacol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"444","DOI":"10.4274\/balkanmedj.2016.1386","article-title":"Effects of apigenin on experimental ischemia\/reperfusion injury in the rat ovary","volume":"34","author":"Soyman","year":"2017","journal-title":"Balkan Med. J."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Salehi, B., Venditti, A., Sharifi-Rad, M., Kr\u0119giel, D., Sharifi-Rad, J., Durazzo, A., Lucarini, M., Santini, A., Souto, E.B., and Novellino, E. (2019). The therapeutic potential of apigenin. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20061305"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ejphar.2016.01.015","article-title":"Apigenin reverses depression-like behavior induced by chronic corticosterone treatment in mice","volume":"774","author":"Weng","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neulet.2015.03.040","article-title":"The effects of apigenin on lipopolysaccharide-induced depressive-like behavior in mice","volume":"594","author":"Li","year":"2015","journal-title":"Neurosci. Lett."},{"key":"ref_141","first-page":"2867","article-title":"The antidepressant effects of apigenin are associated with the promotion of autophagy via the mTOR\/AMPK\/ULK1 pathway","volume":"20","author":"Zhang","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.pnpbp.2012.06.009","article-title":"Antidepressant-like behavioral, neurochemical and neuroendocrine effects of naringenin in the mouse repeated tail suspension test","volume":"39","author":"Yi","year":"2012","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.pnpbp.2013.10.002","article-title":"BDNF signaling is necessary for the antidepressant-like effect of naringenin","volume":"48","author":"Yi","year":"2014","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.taap.2018.07.010","article-title":"Naringenin protects against oxido-inflammatory aberrations and altered tryptophan metabolism in olfactory bulbectomized mice model of depression","volume":"355","author":"Bansal","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1002\/jcp.27229","article-title":"Potential therapeutic effects of curcumin in gastric cancer","volume":"234","author":"Barati","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1192\/bjp.bp.114.148361","article-title":"Effect of long-term supplementation with folic acid and B vitamins on risk of depression in older women","volume":"206","author":"Okereke","year":"2015","journal-title":"Br. J. Psychiatry"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00213-008-1300-y","article-title":"Antidepressant activity of curcumin: Involvement of serotonin and dopamine system","volume":"201","author":"Kulkarni","year":"2008","journal-title":"Psychopharmacology"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.jamda.2016.12.071","article-title":"Clinical use of curcumin in depression: A meta-analysis","volume":"18","author":"Ng","year":"2017","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.pbb.2008.10.007","article-title":"Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes","volume":"92","author":"Bhutani","year":"2009","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"3","DOI":"10.33945\/SAMI\/AJCB.2019.1.2","article-title":"Antidepressant activity of curcumin by monoamine oxidase\u2013A inhibition","volume":"1","author":"Nazemi","year":"2019","journal-title":"Adv. J. Chem.-Sect. B"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"e1110","DOI":"10.4088\/JCP.14f09489","article-title":"A Critical Examination of Studies on Curcumin for Depression","volume":"75","author":"Andrade","year":"2014","journal-title":"J. Clin. Psychiatry"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1080\/10408398.2019.1653260","article-title":"Curcumin for depression: A meta-analysis","volume":"60","author":"Vozza","year":"2020","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.pnpbp.2011.03.017","article-title":"Involvement of serotonergic system in the antidepressant-like effect of piperine","volume":"35","author":"Mao","year":"2011","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1248\/cpb.53.832","article-title":"Piperine from the Fruits of Piper longum with Inhibitory Effect on Monoamine Oxidase and Antidepressant-Like Activity","volume":"53","author":"Lee","year":"2005","journal-title":"Chem. Pharm. Bull."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1080\/10286020500384302","article-title":"Antidepressant-like effects of piperine and its derivative, antiepilepsirine","volume":"9","author":"Li","year":"2007","journal-title":"J. Asian Nat. Prod. Res."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.neulet.2011.09.038","article-title":"Role of 5-HT1A and 5-HT1B receptors in the antidepressant-like effect of piperine in the forced swim test","volume":"504","author":"Mao","year":"2011","journal-title":"Neurosci. Lett."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.neuint.2014.04.017","article-title":"Piperine reverses the effects of corticosterone on behavior and hippocampal BDNF expression in mice","volume":"74","author":"Mao","year":"2014","journal-title":"Neurochem. Int."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.lfs.2006.12.027","article-title":"Antidepressant-like effects of piperine in chronic mild stress treated mice and its possible mechanisms","volume":"80","author":"Li","year":"2007","journal-title":"Life Sci."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1248\/bpb.34.1481","article-title":"Luteolin shows an antidepressant-like effect via suppressing endoplasmic reticulum stress","volume":"34","author":"Ishisaka","year":"2011","journal-title":"Biol. Pharm. Bull."},{"key":"ref_160","first-page":"Doc211","article-title":"Recent updates on neuropharmacological effects of luteolin","volume":"17","author":"Gupta","year":"2018","journal-title":"EXCLI J."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/j.bcp.2009.01.009","article-title":"Suppression of the TRIF-dependent signaling pathway of Toll-like receptors by luteolin","volume":"77","author":"Lee","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.1021\/jf904061x","article-title":"Neurotrophic and cytoprotective action of luteolin in PC12 cells through ERK-dependent induction of Nrf2-driven HO-1 expression","volume":"58","author":"Lin","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1080\/19768354.2022.2104925","article-title":"Luteolin reduces fear, anxiety, and depression in rats with post-traumatic stress disorder","volume":"26","author":"Sur","year":"2022","journal-title":"Anim. Cells Syst."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.jff.2019.01.048","article-title":"Luteolin shows antidepressant-like effect by inhibiting and downregulating plasma membrane monoamine transporter (PMAT, Slc29a4)","volume":"54","author":"Zhu","year":"2019","journal-title":"J. Funct. Foods"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1401790","DOI":"10.1155\/2017\/1401790","article-title":"Baicalin attenuates subarachnoid hemorrhagic brain injury by modulating blood\u2013brain barrier disruption, inflammation, and oxidative damage in mice","volume":"2017","author":"Shi","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s12640-016-9611-y","article-title":"Baicalin attenuates ketamine-induced neurotoxicity in the developing rats: Involvement of PI3K\/Akt and CREB\/BDNF\/Bcl-2 pathways","volume":"30","author":"Zuo","year":"2016","journal-title":"Neurotox. Res."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nri.2015.5","article-title":"The role of inflammation in depression: From evolutionary imperative to modern treatment target","volume":"16","author":"Miller","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Lu, Y., Sun, G., Yang, F., Guan, Z., Zhang, Z., Zhao, J., Liu, Y., Chu, L., and Pei, L. (2019). Baicalin regulates depression behavior in mice exposed to chronic mild stress via the Rac\/LIMK\/cofilin pathway. Biomed. Pharmacother., 116.","DOI":"10.1016\/j.biopha.2019.109054"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.bbrc.2014.07.041","article-title":"Baicalin reverses AMPA receptor expression and neuron apoptosis in chronic unpredictable mild stress rats","volume":"451","author":"Yu","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Wang, D., Ren, Y.-M., Guo, Y.-X., Zhang, Z.-Q., Sui, H., and Zhang, H.-Y. (2024). The effects of baicalin in depression: Preclinical evidence construction based on meta-analysis. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1425094"},{"key":"ref_171","first-page":"793","article-title":"Resveratrol inhibits cell differentiation in 3T3-L1 adipocytes via activation of AMPK","volume":"89","author":"Chen","year":"2011","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_172","unstructured":"Zhao, L., Chen, J., Liu, Y., Ding, W., Yang, L., and Li, Y. (2020). Curcumin inhibits lipid accumulation and inflammation in 3T3-L1 cells through modulation of NF-\u03baB signaling pathway. Biochim. Biophys. Acta Mol. Cell Biol. Lipids, 1865."},{"key":"ref_173","first-page":"126","article-title":"Curcumin attenuates inflammation in macrophages via NF-\u03baB pathway inhibition","volume":"59","author":"Jang","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"ref_174","first-page":"2090","article-title":"Epigallocatechin gallate suppresses adipocyte differentiation and lipid accumulation in 3T3-L1 cells via downregulation of PPAR\u03b3 and C\/EBP\u03b1","volume":"9","author":"Wang","year":"2018","journal-title":"Food Funct."},{"key":"ref_175","unstructured":"Kim, Y., Lee, S., Park, J., and Choi, S. (2021). Effects of Curcuma longa extract supplementation on obesity and depression in high-fat diet-fed female rats. J. Nutr. Biochem., 89."},{"key":"ref_176","first-page":"108234","article-title":"Anthocyanin-rich acai berry extract improves metabolic and behavioral parameters in a mouse model of depression induced by chronic stress and high carbohydrate diet","volume":"178","author":"Zhang","year":"2020","journal-title":"Neuropharmacology"},{"key":"ref_177","first-page":"66","article-title":"Epigallocatechin gallate ameliorates obesity and depression-like behaviors in high-fat diet-fed mice","volume":"155","author":"Khan","year":"2019","journal-title":"Neuropharmacology"},{"key":"ref_178","first-page":"102076","article-title":"Omega-3 fatty acids improve metabolic and neurochemical parameters in diet-induced obese rats","volume":"157","author":"Zhang","year":"2020","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"ref_179","first-page":"1522","article-title":"Nigella sativa oil ameliorates obesity and depression-like behavior in rats: Role of anti-inflammatory and neuroprotective mechanisms","volume":"36","author":"Singh","year":"2022","journal-title":"Phytother. Res."},{"key":"ref_180","first-page":"312","article-title":"Curcumin supplementation ameliorates depression and metabolic disturbances in stressed rats","volume":"42","author":"Nguyen","year":"2021","journal-title":"Neuroendocrinol. Lett."},{"key":"ref_181","first-page":"1254","article-title":"Dietary bioactive compounds for managing obesity and depression: A clinical perspective","volume":"13","author":"Lee","year":"2021","journal-title":"Nutrients"},{"key":"ref_182","first-page":"62","article-title":"Curcumin supplementation improves metabolic profiles and behavior in obese mice","volume":"64","author":"Kim","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"ref_183","first-page":"1","article-title":"Resveratrol improves insulin sensitivity and reduces adiposity in high-fat diet-fed mice","volume":"16","author":"Inoue","year":"2019","journal-title":"Nutr. Metab."},{"key":"ref_184","first-page":"135278","article-title":"Green tea extract modulates gut microbiota and alleviates obesity and depression in rats","volume":"736","author":"Zhang","year":"2020","journal-title":"Neurosci. Lett."},{"key":"ref_185","unstructured":"Li, Y., Zhang, J., Wang, X., Liu, J., Lin, J., Chen, J., Wei, H., and Wang, T. (2021). Synergistic effects of curcumin and probiotics on obesity and mood in diet-induced obese mice. Front. Microbiol., 12."},{"key":"ref_186","first-page":"2112","article-title":"Combined effect of ginger extract and probiotics on metabolic and psychological parameters in obese patients: A randomized controlled trial","volume":"11","author":"Wang","year":"2022","journal-title":"J. Clin. Med."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.foodchem.2019.03.134","article-title":"Phenolic compounds from berries modulate gut microbiota and SCFA production","volume":"278","author":"Li","year":"2019","journal-title":"Food Chem."},{"key":"ref_188","first-page":"1024","article-title":"Fermentation of berry extracts enhances SCFA production and gut barrier function","volume":"69","author":"Zhao","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_189","first-page":"3543","article-title":"Effects of dietary polyphenols on gut microbiota and metabolic health in obese rats","volume":"11","author":"Chen","year":"2020","journal-title":"Food Funct."},{"key":"ref_190","first-page":"40","article-title":"The role of short-chain fatty acids in gut-brain communication","volume":"87","author":"Silva","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"ref_191","first-page":"137","article-title":"Curcumin ameliorates depression-like behavior and metabolic disturbances via gut microbiota modulation","volume":"154","author":"Kaur","year":"2019","journal-title":"Neuropharmacology"},{"key":"ref_192","first-page":"135564","article-title":"Curcumin supplementation alleviates depressive behaviors and modulates gut microbiota in obese rats","volume":"744","author":"Zhou","year":"2021","journal-title":"Neurosci. Lett."},{"key":"ref_193","first-page":"107","article-title":"Synergistic effects of probiotics and herbal extracts on gut health and metabolic parameters in mice","volume":"45","author":"Gao","year":"2018","journal-title":"J. Funct. Foods"},{"key":"ref_194","unstructured":"Wang, H., Zhang, J., Wang, X., Liu, J., Lin, J., Chen, J., Wei, H., and Wang, T. (2020). Synbiotic intervention improves metabolic health and gut microbiota in obese mice. Sci. Rep., 10."},{"key":"ref_195","first-page":"2151","article-title":"The microbiota\u2013gut\u2013brain axis","volume":"100","author":"Cryan","year":"2020","journal-title":"Physiol. Rev."},{"key":"ref_196","unstructured":"Li, X., Chen, X., Sun, H., Ma, B., Wang, Q., Zhang, H., Li, J., Zhao, Z., and Wang, X. (2022). Prebiotics and probiotics in the management of obesity and depression: A translational perspective. Front. Nutr., 9."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1124\/dmd.104.000885","article-title":"High absorption but very low bioavailability of oral resveratrol in humans","volume":"32","author":"Walle","year":"2004","journal-title":"Drug Metab. Dispos."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ejpb.2015.04.002","article-title":"Stability and solubility of trans-resveratrol are strongly influenced by pH and temperature","volume":"93","author":"Zupancic","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/bmc.747","article-title":"Stereospecific determination of cis- and trans-resveratrol in rat plasma by HPLC: Application to pharmacokinetic studies","volume":"21","author":"Chen","year":"2007","journal-title":"Biomed. Chromatogr."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1749-6632.2010.05871.x","article-title":"Transport, stability, and biological activity of resveratrol","volume":"1215","author":"Delmas","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/mnfr.200700290","article-title":"Quantification of free and protein-bound trans-resveratrol metabolites and identification of trans-resveratrol-C\/O-conjugated diglucuronides\u2014Two novel resveratrol metabolites in human plasma","volume":"52","author":"Burkon","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nrd2060","article-title":"Therapeutic potential of resveratrol: The in vivo evidence","volume":"5","author":"Baur","year":"2006","journal-title":"Nat. Rev. Drug Discov"},{"key":"ref_203","doi-asserted-by":"crossref","unstructured":"Giuliani, C., Bucci, I., Di Santo, S., Rossi, C., Grassadonia, A., Mariotti, M., Piantelli, M., Monaco, F., and Napolitano, G. (2014). Resveratrol inhibits sodium\/iodide symporter gene expression and function in rat thyroid cells. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0107936"},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.fct.2017.06.044","article-title":"Resveratrol has anti-thyroid effects both in vitro and in vivo","volume":"107","author":"Giuliani","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1021\/acs.chemrestox.6b00256","article-title":"Formation and Biological Targets of Quinones: Cytotoxic versus Cytoprotective Effects","volume":"30","author":"Bolton","year":"2017","journal-title":"Chem. Res. Toxicol."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1021\/acs.chemrestox.6b00115","article-title":"Prodrugs Bioactivated to Quinones Target NF-kappaB and Multiple Protein Networks: Identification of the Quinonome","volume":"29","author":"Pierce","year":"2016","journal-title":"Chem. Res. Toxicol."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.bcp.2004.05.008","article-title":"Involvement of cytochrome P450 1A2 in the biotransformation of trans-resveratrol in human liver microsomes","volume":"68","author":"Piver","year":"2004","journal-title":"Biochem. Pharm."},{"key":"ref_208","doi-asserted-by":"crossref","unstructured":"Atmaca, N., Y\u0131ld\u0131r\u0131m, E., G\u00fcner, B., Kabak\u00e7i, R., and Bilmen, F. (2014). Effect of Resveratrol on Hematological and Biochemical Alterations in Rats Exposed to Fluoride. BioMed Res. Int., 2014.","DOI":"10.1155\/2014\/698628"},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Wang, Y., Cui, H., Niu, F., Liu, S.-L., Li, Y., Zhang, L.-M., Du, H.-B., Zhao, Z.-G., and Niu, C.-Y. (2018). Effect of Resveratrol on Blood Rheological Properties in LPS-Challenged Rats. Front. Physiol., 9.","DOI":"10.3389\/fphys.2018.01202"},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Mu\u00f1oz, O., and Bustamante, S. (2015). Pharmacological Properties of Resveratrol. A Pre-Clinical and Clinical Review. Biochem. Pharmacol. Open Access, 4.","DOI":"10.4172\/2167-0501.1000184"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1016\/j.fct.2011.08.023","article-title":"Subchronic oral toxicity and cardiovascular safety pharmacology studies of resveratrol, a naturally occurring polyphenol with cancer preventive activity","volume":"49","author":"Johnson","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.phymed.2018.12.024","article-title":"Resveratrol exerts dose-dependent anti-fibrotic or pro-fibrotic effects in kidneys: A potential risk to individuals with impaired kidney function","volume":"57","author":"Liu","year":"2019","journal-title":"Phytomedicine"},{"key":"ref_213","first-page":"892","article-title":"Resveratrol suppresses angiogenesis by down-regulating Vegf\/Vegfr2 in Zebrafish (Danio rerio) embryos","volume":"6","author":"Nathan","year":"2014","journal-title":"J. Chem. Pharm. Res."},{"key":"ref_214","first-page":"133","article-title":"Evaluation of resveratrol toxicity in the embryolarval stage of Danio rerio fish","volume":"12","author":"Cavalcante","year":"2017","journal-title":"Ecotoxicol. Environ."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/mnfr.200900437","article-title":"Resveratrol bioavailability and toxicity in humans","volume":"54","author":"Cottart","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_216","doi-asserted-by":"crossref","unstructured":"Salehi, B., Mishra, A.P., Nigam, M., Sener, B., Kilic, M., Sharifi-Rad, M., Fokou, P.V.T., Martins, N., and Sharifi-Rad, J. (2018). Resveratrol: A Double-Edged Sword in Health Benefits. Biomedicines, 6.","DOI":"10.3390\/biomedicines6030091"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.clnu.2013.03.008","article-title":"Green tea polyphenol epigallocatechin-3-gallate (EGCG) as adjuvant in cancer therapy","volume":"32","author":"Lecumberri","year":"2013","journal-title":"Clin. Nutr."},{"key":"ref_218","unstructured":"Fujiki, H., Imai, K., Nakachi, K., Sueoka, E., Watanabe, T., and Suganuma, M. (2015). Innovative strategy of cancer treatment with the combination of green tea catechins and anticancer compounds. Cancer Cell Microenviron., 2."},{"key":"ref_219","doi-asserted-by":"crossref","unstructured":"Sharifi-Rad, M., Pezzani, R., Redaelli, M., Zorzan, M., Imran, M., Ahmed Khalil, A., Salehi, B., Sharopov, F., Cho, W.C., and Sharifi-Rad, J. (2020). Preclinical pharmacological activities of epigallocatechin-3-gallate in signaling pathways: An update on cancer. Molecules, 25.","DOI":"10.3390\/molecules25030467"},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1111\/bph.12009","article-title":"Anti-infective properties of epigallocatechin-3-gallate (EGCG), a component of green tea","volume":"168","author":"Steinmann","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"66","DOI":"10.2183\/pjab.87.66","article-title":"Green tea polyphenol sensing","volume":"87","author":"Tachibana","year":"2011","journal-title":"Proc. Jpn. Acad. Ser. B Phys. Biol. Sci."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/2045-824X-5-9","article-title":"EGCG, a major green tea catechin suppresses breast tumor angiogenesis and growth via inhibiting the activation of HIF-1\u03b1 and NF\u03baB, and VEGF expression","volume":"5","author":"Gu","year":"2013","journal-title":"Vasc. Cell"},{"key":"ref_223","doi-asserted-by":"crossref","unstructured":"Zhou, J., Farah, B.L., Sinha, R.A., Wu, Y., Singh, B.K., Bay, B.H., Yang, C.S., and Yen, P.M. (2014). Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, stimulates hepatic autophagy and lipid clearance. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0087161"},{"key":"ref_224","doi-asserted-by":"crossref","unstructured":"Zhao, T., Li, C., Wang, S., and Song, X. (2022). Green Tea (Camellia sinensis): A Review of Its Phytochemistry, Pharmacology, and Toxicology. Molecules, 27.","DOI":"10.3390\/molecules27123909"},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1001\/jama.2012.96863","article-title":"Policy responses to demand for health care access: From the individual to the population","volume":"309","author":"Vickery","year":"2013","journal-title":"JAMA"},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"5592","DOI":"10.3390\/ijms12095592","article-title":"Epigallocatechin-3-gallate (EGCG) for clinical trials: More pitfalls than promises?","volume":"12","author":"Mereles","year":"2011","journal-title":"Int. J. Mol. Sci."},{"key":"ref_227","doi-asserted-by":"crossref","unstructured":"Siriphap, A., Kiddee, A., Duangjai, A., Yosboonruang, A., Pook-In, G., Saokaew, S., Sutheinkul, O., and Rawangkan, A. (2022). Antimicrobial activity of the green tea polyphenol (-)-epigallocatechin-3-gallate (egcg) against clinical isolates of multidrug-resistant vibrio cholerae. Antibiotics, 11.","DOI":"10.3390\/antibiotics11040518"},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.nutres.2009.06.008","article-title":"Green tea and bone metabolism","volume":"29","author":"Shen","year":"2009","journal-title":"Nutr. Res."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/S0006-291X(03)00067-6","article-title":"Inhibition of Epstein-Barr virus lytic cycle by (-)-epigallocatechin gallate","volume":"301","author":"Chang","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.antiviral.2005.06.010","article-title":"Antiviral effect of catechins in green tea on influenza virus","volume":"68","author":"Song","year":"2005","journal-title":"Antivir. Res."},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0166-3542(02)00212-7","article-title":"Inhibition of adenovirus infection and adenain by green tea catechins","volume":"58","author":"Weber","year":"2003","journal-title":"Antivir. Res."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"5443","DOI":"10.3390\/nu7075230","article-title":"Epigallocatechin gallate: A review of its beneficial properties to prevent metabolic syndrome","volume":"7","author":"Legeay","year":"2015","journal-title":"Nutrients"},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"6141","DOI":"10.2174\/1381612811319340008","article-title":"Tea and health: Studies in humans","volume":"19","author":"Khan","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.foodres.2013.01.038","article-title":"Tea: A new perspective on health benefits","volume":"53","year":"2013","journal-title":"Food Res. Int."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1631\/jzus.B1300307","article-title":"Green tea polyphenol, epigallocatechin-3-gallate, possesses the antiviral activity necessary to fight against the hepatitis B virus replication in vitro","volume":"15","author":"Pang","year":"2014","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0015-6264(76)80356-2","article-title":"Effects of food seasonings on the cell cycle and chromosome morphology of mammalian cells in vitro with special reference to turmeric","volume":"14","author":"Goodpasture","year":"1976","journal-title":"Food Cosmet. Toxicol."},{"key":"ref_237","first-page":"111","article-title":"Sister chromatid exchange and chromosome aberrations induced by curcumin and tartrazine on mammalian cells in vivo","volume":"62","author":"Giri","year":"1990","journal-title":"Cytobios"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0003-9861(02)00302-8","article-title":"Metal-mediated DNA damage induced by curcumin in the presence of human cytochrome P450 isozymes","volume":"405","author":"Sakano","year":"2002","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1093\/carcin\/bgi073","article-title":"Apoptosis and age-dependant induction of nuclear and mitochondrial etheno-DNA adducts in Long-Evans Cinnamon (LEC) rats: Enhanced DNA damage by dietary curcumin upon copper accumulation","volume":"26","author":"Nair","year":"2005","journal-title":"Carcinogenesis"},{"key":"ref_240","first-page":"271","article-title":"Curcumin damages DNA in human gastric mucosa cells and lymphocytes","volume":"18","author":"Blasiak","year":"1999","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1080\/01635580701458186","article-title":"Putative cancer chemopreventive agents of dietary origin\u2014How safe are they?","volume":"59","author":"Verschoyle","year":"2007","journal-title":"Nutr. Cancer"},{"key":"ref_242","unstructured":"National Toxicology Program (1993). NTP Toxicology and Carcinogenesis Studies of Turmeric Oleoresin (CAS No. 8024-37-1) (Major Component 79%-85% Curcumin, CAS No. 458-37-7) in F344\/N Rats and B6C3F1 Mice (Feed Studies). Natl. Toxicol. Program Tech. Rep. Ser., 427, 1\u2013275."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1093\/carcin\/bgp082","article-title":"Lung tumor promotion by curcumin","volume":"30","author":"Kock","year":"2009","journal-title":"Carcinogenesis"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"25284","DOI":"10.1074\/jbc.M414645200","article-title":"Thioredoxin reductase is irreversibly modified by curcumin: A novel molecular mechanism for its anticancer activity","volume":"280","author":"Fang","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_245","first-page":"165","article-title":"Curcumin induces heme oxygenase 1 through generation of reactive oxygen species, p38 activation and phosphatase inhibition","volume":"19","author":"McNally","year":"2007","journal-title":"Int. J. Mol. Med."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/j.1601-0825.2005.01067.x","article-title":"Relationship between intracellular ROS production and membrane mobility in curcumin- and tetrahydrocurcumin-treated human gingival fibroblasts and human submandibular gland carcinoma cells","volume":"11","author":"Atsumi","year":"2005","journal-title":"Oral Dis."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.freeradbiomed.2007.05.009","article-title":"Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane)","volume":"43","author":"Sandur","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1093\/carcin\/bgh163","article-title":"Curcumin impairs tumor suppressor p53 function in colon cancer cells","volume":"25","author":"Moos","year":"2004","journal-title":"Carcinogenesis"},{"key":"ref_249","first-page":"S103","article-title":"Anticancer and carcinogenic properties of curcumin: Considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent","volume":"52","year":"2008","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1158\/1055-9965.EPI-07-2693","article-title":"Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects","volume":"17","author":"Vareed","year":"2008","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"ref_251","first-page":"1058","article-title":"Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production","volume":"61","author":"Ireson","year":"2001","journal-title":"Cancer Res."},{"key":"ref_252","first-page":"105","article-title":"Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine","volume":"11","author":"Ireson","year":"2002","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.tips.2009.04.004","article-title":"Curcumin in clinical practice: Myth or reality?","volume":"30","author":"Mancuso","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0006-2952(95)02113-2","article-title":"Effects of curcumin on cytochrome P450 and glutathione S-transferase activities in rat liver","volume":"51","author":"Oetari","year":"1996","journal-title":"Biochem. Pharmacol."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.tox.2007.03.007","article-title":"Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products","volume":"235","author":"Commandeur","year":"2007","journal-title":"Toxicology"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0278-6915(00)00165-4","article-title":"Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo","volume":"39","author":"Thapliyal","year":"2001","journal-title":"Food Chem. Toxicol."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1182\/blood-2008-05-155952","article-title":"Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator","volume":"113","author":"Jiao","year":"2009","journal-title":"Blood"},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1182\/blood-2008-10-184630","article-title":"Ironing out complementary medicine","volume":"113","author":"Means","year":"2009","journal-title":"Blood"},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1080\/10408398.2015.1077195","article-title":"Curcumin, an active component of turmeric (Curcuma longa), and its effects on health","volume":"57","author":"Kocaadam","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"6847","DOI":"10.1158\/1078-0432.CCR-04-0744","article-title":"Phase I clinical trial of oral curcumin: Biomarkers of systemic activity and compliance","volume":"10","author":"Sharma","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"3917","DOI":"10.1158\/1078-0432.CCR-21-1804","article-title":"Cancer Immunoediting in the Era of Immuno-oncology","volume":"28","author":"Gubin","year":"2020","journal-title":"Clin. Cancer Res."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/13\/2827\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:01:59Z","timestamp":1760032919000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/13\/2827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,30]]},"references-count":261,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["molecules30132827"],"URL":"https:\/\/doi.org\/10.3390\/molecules30132827","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,30]]}}}