{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:48:52Z","timestamp":1790038132131,"version":"4.0.1"},"reference-count":62,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Special Research Account of the National and Kapodistrian University of Athens (NKUA)","award":["21983"],"award-info":[{"award-number":["21983"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Searching for new and efficient transfer hydrogenation catalysts, a series of new organometallic ruthenium(II)-arene complexes of the formulae [Ru(\u03b76-p-cymene)(L)Cl][PF6] (1\u20138) and [Ru(\u03b76-p-cymene)(L)Cl][Ru(\u03b76-p-cymene)Cl3] (9\u201311) were synthesized and fully characterized. These were prepared from the reaction of pyridine\u2013quinoline and biquinoline-based ligands (L) with [Ru(\u03b76-p-cymene)(\u03bc-Cl)Cl]2, in 1:2 and 1:1, metal (M) to ligand (L) molar ratios. Characterization includes a combination of spectroscopic methods (FT-IR, UV-Vis, multi nuclear NMR), elemental analysis and single-crystal X-ray crystallography. The pyridine\u2013quinoline organic entities encountered, were prepared in high yield either via the thermal decarboxylation of the carboxylic acid congeners, namely 2,2\u2032-pyridyl-quinoline-4-carboxylic acid (pqca), 8-methyl-2,2\u2032-pyridyl-quinoline-4-carboxylic acid (8-Mepqca), 6\u2032-methyl-2,2\u2032-pyridyl-quinoline-4-carboxylic acid (6\u2032-Mepqca) and 8,6\u2032-dimethyl-2,2\u2032-pyridyl-quinoline-4-carboxylic acid (8,6\u2032-Me2pqca), affording the desired ligands pq, 8-Mepq, 6\u2032-Mepq and 8,6\u2032-Me2pq, or by the classical Friedl\u00e4nder condensation, to yield 4,6\u2032-dimethyl-2,2\u2032-pyridyl-quinoline (4,6\u2032-Me2pq) and 4-methyl-2,2\u2032-pyridyl-quinoline (4-Mepq), respectively. The solid-state structures of complexes 1\u20134, 6, 8 and 9 were determined showing a distorted octahedral coordination geometry. The unit cell of 3 contains two independent molecules (Ru-3), (Ru\u2032-3) in a 1:1 ratio, due to a slight rotation of the arene ring. All complexes catalyze the transfer hydrogenation of acetophenone, using 2-propanol as a hydrogen donor in the presence of KOiPr. Among them, complexes 1 and 5 bearing methyl groups at the 8 and 4 position of the quinoline moiety, convert acetophenone to 1-phenylethanol quantitatively, within approximately 10 min with final TOFs of 1600 h\u22121. The catalytic performance of complexes 1\u201311, towards the transfer hydrogenation of p-substituted acetophenone derivatives and benzophenone, ranges from moderate to excellent. An inner-sphere mechanism has been suggested based on the detection of ruthenium(II) hydride species.<\/jats:p>","DOI":"10.3390\/molecules30142945","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T09:56:54Z","timestamp":1752487014000},"page":"2945","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pyridine\u2013Quinoline and Biquinoline-Based Ruthenium p-Cymene Complexes as Efficient Catalysts for Transfer Hydrogenation Studies: Synthesis and Structural Characterization"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3012-8306","authenticated-orcid":false,"given":"Nikolaos","family":"Zacharopoulos","sequence":"first","affiliation":[{"name":"Laboratory of Inorganic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6489-2106","authenticated-orcid":false,"given":"Gregor","family":"Schnakenburg","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Anorganische Chemie, Rheinische Friedrich-Wilhelms-Universit\u00e4t Bonn, Gerhard-Domagk-Stra\u00dfe 1, D-53121 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9790-7252","authenticated-orcid":false,"given":"Eleni I.","family":"Panagopoulou","sequence":"additional","affiliation":[{"name":"Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4624-4735","authenticated-orcid":false,"given":"Nikolaos S.","family":"Thomaidis","sequence":"additional","affiliation":[{"name":"Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5261-5654","authenticated-orcid":false,"given":"Athanassios I.","family":"Philippopoulos","sequence":"additional","affiliation":[{"name":"Laboratory of Inorganic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/adsc.200390000","article-title":"Selective Hydrogenation for Fine Chemicals: Recent Trends and New Developments","volume":"345","author":"Blaser","year":"2003","journal-title":"Adv. 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