{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:24:54Z","timestamp":1787934294993,"version":"build-2784847793"},"reference-count":41,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T00:00:00Z","timestamp":1752451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical University of Lublin, Poland","award":["DS 30"],"award-info":[{"award-number":["DS 30"]}]},{"name":"Medical University of Lublin, Poland","award":["IRN AP23487559"],"award-info":[{"award-number":["IRN AP23487559"]}]},{"name":"\u201cDevelopment of production of complete cycle of plant substances based on medicinal plants of the South region of Kazakhstan\u201d","award":["DS 30"],"award-info":[{"award-number":["DS 30"]}]},{"name":"\u201cDevelopment of production of complete cycle of plant substances based on medicinal plants of the South region of Kazakhstan\u201d","award":["IRN AP23487559"],"award-info":[{"award-number":["IRN AP23487559"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Artemisia serotina Bunge represents one of the endemic Artemisia L. species in flora of Central Asia. There is scant information on the phytochemistry and biological activity of this species. The aim of the present study was to analyze the chemical composition of essential oil from A. serotina (ASEO) growing in south Kazakhstan, together with the determination of its biological activity. ASEO isolation was carried out by hydrodistillation according to the State Pharmacopoeia of the Republic of Kazakhstan. Analysis of GC\/MS data revealed that the most characteristic components of ASEO were irregular monoterpenes from three families: santolinane, artemisane, and lavandulane. The major compound was santolina alcohol (34.6%). Antimicrobial activity was studied against the reference bacterial and fungal strains using the recommended methods, allowing for an estimation of MIC (minimum inhibitory concentration). ASEO was most effective against Candida albicans (MIC = 2 mg\/mL), exerting fungicidal activity. Thw MIC for bacterial species was higher, i.e., 4\u201316 mg\/mL. Antiviral activity was tested against Coxsackievirus B3 (CVB3) and Human Herpesvirus type 1 (HHV-1) propagated in VERO cells. No antiviral effect against either virus was found at an ASEO concentration of 0.25 mg\/mL, but a noticeable decrease in the intensity of HHV-1-related cytopathic effects was observed. Anticancer activity studies included several cancer cell lines. Cytotoxicity, cell cycle, thiol levels, and cell vitality were analyzed. Among the cancer cell lines tested, the breast cancer T47-D cell line exhibited the highest sensitivity to ASEO (IC50 = 40.81 \u00b1 4.21 \u00b5g\/mL at 24 h; IC50 = 33.17 \u00b1 2.11 \u00b5g\/mL at 48 h). The anticancer effect was suggested to be mainly due to the induction of cytostatic effects, accompanied by a disturbance of the intracellular redox balance. The obtained data provide novel information on the unique chemical composition of ASEO from south Kazakhstan, representing a new chemotype. Its bioactivity, including promising antifungal and anticancer properties, was demonstrated for the first time.<\/jats:p>","DOI":"10.3390\/molecules30142956","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T09:56:54Z","timestamp":1752487014000},"page":"2956","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Essential Oil from the Aerial Parts of Artemisia serotina Bunge (Winter Wormwood) Growing in Kazakhstan\u2014Phytochemical Profile and Bioactivity"],"prefix":"10.3390","volume":"30","author":[{"given":"Arshyn","family":"Kadyrbay","sequence":"first","affiliation":[{"name":"School of Pharmacy, Asfendiarov Kazakh National Medical University, Tole-bi Str. 94, Almaty 000050, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliya N.","family":"Ibragimova","sequence":"additional","affiliation":[{"name":"Pharmacy and Pharmacology Center, Asfendiarov Kazakh National Medical University, Tole-bi Str. 94, Almaty 000050, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7834-0828","authenticated-orcid":false,"given":"Magdalena","family":"Iwan","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Medical University of Lublin, Chodzki 6 Str., 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1108-613X","authenticated-orcid":false,"given":"Agnieszka","family":"Ludwiczuk","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy with the Medicinal Plant Garden, Medical University of Lublin, Chodzki 1 Str., 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2844-9876","authenticated-orcid":false,"given":"Anna","family":"Biernasiuk","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Microbiology, Medical University of Lublin, Chodzki 1 Str., 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1400-1971","authenticated-orcid":false,"given":"Zuriyadda B.","family":"Sakipova","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Asfendiarov Kazakh National Medical University, Tole-bi Str. 94, Almaty 000050, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1626-680X","authenticated-orcid":false,"given":"\u0141ukasz","family":"\u015awi\u0105tek","sequence":"additional","affiliation":[{"name":"Department of Virology with Viral Diagnostics Laboratory, Medical University of Lublin, Chodzki 1 Str., 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2155-625X","authenticated-orcid":false,"given":"Kinga","family":"Salwa","sequence":"additional","affiliation":[{"name":"Department of Virology with Viral Diagnostics Laboratory, Medical University of Lublin, Chodzki 1 Str., 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2027-9681","authenticated-orcid":false,"given":"Agnieszka","family":"Korga-Plewko","sequence":"additional","affiliation":[{"name":"Independent Medical Biology Unit, Medical University of Lublin, Jaczewskiego 8b Str., 20-090 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karlygash A.","family":"Zhaparkulova","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and General Chemical Engineering, Asfendiarov Kazakh National Medical University, Tole-bi Str. 94, Almaty 000050, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tolkyn S.","family":"Bekezhanova","sequence":"additional","affiliation":[{"name":"Department of Engineering Disciplines and Good Practices, Asfendiarov Kazakh National Medical University, Tole-bi Str. 94, Almaty 000050, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6033-4692","authenticated-orcid":false,"given":"Aleksandra","family":"J\u00f3zefczyk","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy with the Medicinal Plant Garden, Medical University of Lublin, Chodzki 1 Str., 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9917-2907","authenticated-orcid":false,"given":"Jolanta","family":"Szyma\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Paediatric and Adult Dentistry, Medical University of Lublin, Chodzki 6 Str., 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1503-7634","authenticated-orcid":false,"given":"Anna","family":"Malm","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Microbiology, Medical University of Lublin, Chodzki 1 Str., 20-093 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3109\/13880209.2010.497815","article-title":"The Genus Artemisia: A Comprehensive Review","volume":"49","author":"Bora","year":"2011","journal-title":"Pharm. 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