{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:19:22Z","timestamp":1784697562272,"version":"3.55.0"},"reference-count":46,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006162","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco","doi-asserted-by":"publisher","award":["IBPG-1001-1.06\/20"],"award-info":[{"award-number":["IBPG-1001-1.06\/20"]}],"id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006162","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco","doi-asserted-by":"publisher","award":["445217\/2023-5"],"award-info":[{"award-number":["445217\/2023-5"]}],"id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["IBPG-1001-1.06\/20"],"award-info":[{"award-number":["IBPG-1001-1.06\/20"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["445217\/2023-5"],"award-info":[{"award-number":["445217\/2023-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The mosquito Aedes aegypti is the vector responsible for the transmission of important arboviruses such as dengue fever, Chikungunya, Zika virus, and yellow fever. These diseases affect millions of people and exert impacts on healthcare systems throughout the world. Given the increasing resistance to synthetic insecticides, essential oils from plants constitute an ecologically viable alternative for the control of this vector. The aim of the present study was to investigate the larvicidal activity of the essential oil (EO), aqueous extract, rutin, and hydrolate from the leaves of Myrciaria floribunda against Aedes aegypti larvae in the initial L4 stage. The yield of EO was 0.47%. Thirty-seven chemical constituents were identified and quantified using chromatographic methods. The major constituents were (E)-caryophyllene (27.35%), 1,8-cineole (11.25%), \u03b2-selinene (4.92%), and \u03b1-muurolene (4.92%). In the larvicidal tests, the lethal concentration (LC50) was 201.73 ppm for the essential oil, 15.85% for the aqueous extract, and 22.46 ppm for rutin. The hydrolate had no larvicidal activity. The compounds that exhibited larvicidal activity against Aedes aegypti constitute a promising option for the development of natural formulations to diminish the propagation of this vector.<\/jats:p>","DOI":"10.3390\/molecules30153116","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T11:38:41Z","timestamp":1753443521000},"page":"3116","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Larvicidal Activity of Essential Oil, Hydrolate, and Aqueous Extract from Leaves of Myrciaria floribunda Against Aedes Aegypti"],"prefix":"10.3390","volume":"30","author":[{"given":"Eduarda Florencio","family":"Santos","sequence":"first","affiliation":[{"name":"Department of Chemistry, Center for Exact and Natural Sciences, Federal University of Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wevertton Marllon","family":"Anselmo","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Center for Exact and Natural Sciences, Federal University of Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0299-5676","authenticated-orcid":false,"given":"Eurico Eduardo Pinto","family":"de Lemos","sequence":"additional","affiliation":[{"name":"Engineering and Agricultural Sciences Campus, Federal University of Alagoas, Macei\u00f3 57072-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5621-4831","authenticated-orcid":false,"given":"J\u00falio C\u00e9sar Ribeiro","family":"de Aguiar","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Center for Exact and Natural Sciences, Federal University of Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carla","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Center for Exact and Natural Sciences, Federal University of Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6908-4738","authenticated-orcid":false,"given":"F\u00e1bio Henrique Galdino dos","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Center for Exact and Natural Sciences, Federal University of Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4029-6806","authenticated-orcid":false,"given":"Camila Caroline Lopes","family":"Arruda","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Center for Exact and Natural Sciences, Federal University of Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Vitor Castro","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Center for Exact and Natural Sciences, Federal University of Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3675-1301","authenticated-orcid":false,"given":"Jos\u00e9 Jorge Almeida","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Center for Exact and Natural Sciences, Federal University of Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyana Karolyne Lino","family":"da Rocha","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Center for Exact and Natural Sciences, Federal University of Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liderl\u00e2nio de Almeida","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Center for Exact and Natural Sciences, Federal University of Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Gomes","family":"Pereira J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Center for Exact and Natural Sciences, Federal University of Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3905-9310","authenticated-orcid":false,"given":"Caroline Francisca de Oliveira","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Center for Exact and Natural Sciences, Federal University of Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6929-6343","authenticated-orcid":false,"given":"Edymila\u00eds da Silva","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Center for Exact and Natural Sciences, Federal University of Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2736-726X","authenticated-orcid":false,"given":"Gerlan Lino","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Center for Exact and Natural Sciences, Federal University of Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamires Zuleide","family":"da Concei\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Center for Exact and Natural Sciences, Federal University of Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2084-0896","authenticated-orcid":false,"given":"Leonardo Arcanjo","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Center for Exact and Natural Sciences, Federal University of Pernambuco, Recife 50670-901, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Alberto Lira","family":"Soares","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Center of Health Sciences, Federal University of Pernambuco, Recife 50740521, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda Rhayanny Assun\u00e7\u00e3o","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Center of Health Sciences, Federal University of Pernambuco, Recife 50740521, 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(2023). Global distribution of Aedes aegypti and Aedes albopictus in a climate change scenario of regional rivalry. Insects, 14.","DOI":"10.3390\/insects14010049"},{"key":"ref_2","first-page":"285","article-title":"Mudan\u00e7as clim\u00e1ticas e ambientais e as doen\u00e7as infecciosas: Cen\u00e1rios e incertezas para o Brasil","volume":"18","author":"Barcellos","year":"2009","journal-title":"Epidemiol. Servi\u00e7os Sa\u00fade"},{"key":"ref_3","unstructured":"WHO (2025, May 26). World Health Organization.WHO: Dengue and severe dengue. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/dengue-and-severe-dengue."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1146\/annurev-ento-011019-024918","article-title":"The global expansion of dengue: How Aedes aegypti mosquitoes enabled the first pandemic arbovirus","volume":"65","author":"Brady","year":"2020","journal-title":"Annu. Rev. Entomol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1093\/jme\/tjaa031","article-title":"Insecticide Resistance Status of Aedes aegypti (Diptera: Culicidae) in California by Biochemical Assays","volume":"57","author":"Yang","year":"2020","journal-title":"J. Med. \u00c8ntomol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jksus.2023.102991","article-title":"Evaluation of different high doses aqueous plant extracts for the sustainable control of Aedes aegypti mosquitoes under laboratory conditions","volume":"35","author":"Ahmad","year":"2023","journal-title":"J. King Saud Univ. Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pestbp.2016.03.005","article-title":"Pyrethroid resistance in Aedes aegypti and Aedes albopictus: Important mosquito vectors of human diseases","volume":"133","author":"Smith","year":"2016","journal-title":"Pest. Biochem. Physiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e20180381","DOI":"10.1590\/0001-3765201920180381","article-title":"Exploring the insecticide and acaricide potential of development regulators obtained from restinga vegetation from Brazil","volume":"91","author":"Feder","year":"2019","journal-title":"An. Acad. Bras. Ci\u00eanc."},{"key":"ref_9","first-page":"123","article-title":"Atividade repelente e inseticida do \u00f3leo essencial de Baccharis dracunculifolia DC sobre Sitophilus zeamais Mots, 1855","volume":"43","author":"Rodrigues","year":"2019","journal-title":"Perspectiva"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10412905.2019.1631894","article-title":"Green insecticide against Chagas disease: Effects of essential oil from Myrciaria floribunda (Myrtaceae) on the development of Rhodnius prolixus nymphs","volume":"32","author":"Tietbohl","year":"2019","journal-title":"J. Essent. Oil Res."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Tietbohl, L.A.C., Oliveira, A.P., Esteves, R.S., Albuquerque, R., Folly, D., Machado, F.P., Correa, A.L., Santos, M.G., Ruiz, A.L.G., and Rocha, L. (2017). Antiproliferative activity in tumor cell lines, antioxidant capacity and total phenolic, flavonoid and tannin contents of Myrciaria floribunda. An. Acad. Bras. Cienc., 1111\u20131120.","DOI":"10.1590\/0001-3765201720160461"},{"key":"ref_12","unstructured":"Morton, J.F. (1987). Rumberry. Fruits of Warm Climates, Florida Flair Books."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Garc\u00eda, Y.M., Ramos, A.L.C.C., Paula, A.C.C.F.F., Nascimento, M.H., Augusti, R., Ara\u00fajo, R.L.B., and Melo, J.O.F. (2021). Chemical physical characterization and profile of fruit volatile compounds from different accesses of Myrciaria floribunda (H. West Ex Wild.) O. Berg through polyacrylate fiber. Molecules, 26.","DOI":"10.3390\/molecules26175281"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.bjp.2014.07.009","article-title":"Laboratory evaluation of the effects of essential oil of Myrciaria floribunda leaves on the development of Dysdercus peruvianus and Oncopeltus fasciatus","volume":"24","author":"Tietbohl","year":"2014","journal-title":"Rev. Bras. Farmacogn."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Moraes, \u00c2.A.B., Ferreira, O.O., Costa, L.S., Almeida, L.Q., Varela, E.L.P., Cascaes, M.M., and Andrade, E.H.D.A. (2022). Phytochemical profile, preliminary toxicity, and antioxidant capacity of the essential oils of Myrciaria floribunda (H. West ex Willd.) O. Berg. And Myrcia sylvatica (G. Mey) DC.(Myrtaceae). Antioxidants, 11.","DOI":"10.3390\/antiox11102076"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s13205-014-0220-2","article-title":"Plant terpenes: Defense responses, phylogenetic analysis, regulation and clinical applications","volume":"5","author":"Singh","year":"2015","journal-title":"3 Biotech"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1007\/s10787-023-01300-2","article-title":"Essential oil from leaves of Myrciaria floribunda (H. West ex Willd.) O. Berg has antinociceptive and anti-inflammatory potential","volume":"31","author":"Silva","year":"2023","journal-title":"Inflammopharmacology"},{"key":"ref_18","first-page":"117","article-title":"Larvicidal activity, enzyme inhibitory effect, and molecular docking by essential oil, hydrolate, aqueous extract, and major compounds from the leaves of Eugenia uniflora against Aedes aegypti","volume":"204","author":"Marques","year":"2023","journal-title":"Ind. Crops Prod."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1080\/10412905.2024.2397688","article-title":"Phytochemical analysis and insecticidal effect of essential oils from Myroxylon peruiferum (Leguminosae) and Eugenia gracillima (Myrtaceae) for the control of Aedes aegypti (Diptera: Culicidae)","volume":"36","year":"2024","journal-title":"J. Essent. Oil Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.parint.2023.102820","article-title":"Insecticidal activity of essential oil from leaves of Eugenia stipitata McVaugh against Aedes aegypti","volume":"98","author":"Costa","year":"2024","journal-title":"Parasitol. Int."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1590\/S0100-40422004000100009","article-title":"Produtos naturais para o controle da transmiss\u00e3o da dengue: Atividade larvicida de myroxylon balsamum (\u00f3leo vermelho) e de terpen\u00f3ides e fenilpropan\u00f3ides","volume":"27","author":"Simas","year":"2004","journal-title":"Qu\u00edm. Nova"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Mabry, T., Markham, K.R., and Thomas, M.B. (1970). The Systematic Identification of Flavonoids, Springer.","DOI":"10.1007\/978-3-642-88458-0"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"112372","DOI":"10.1016\/j.indcrop.2020.112372","article-title":"Chemical composition and acetylcholinesterase inhibitory potential, in silico, of Myrciaria floribunda (H. West ex Willd.) O. Berg fruit peel essential oil","volume":"151","author":"Barbosa","year":"2020","journal-title":"Ind. Crops Prod."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Machado, F.P., Folly, D., Esteves, R., Ruppelt, B.M., da Silva, V.M., Matos, A.P.d.S., Santos, J.A.A.d., Rangel, L.d.S., Santos, M.G., and von Ranke, N.L. (2023). Molluscicidal and Cercaricidal Effects of Myrciaria floribunda Essential Oil Nanoemulsion. Molecules, 28.","DOI":"10.3390\/molecules28165944"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Dhifi, W., Bellili, S., Jazi, S., Bahloul, N., and Mnif, W. (2016). Essential oils\u2019 chemical characterization and investigation of some biological activities: A critical review. Medicines, 3.","DOI":"10.3390\/medicines3040025"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Correia, V.T.V., Da Silva, P.R., Ribeiro, C.M.S., Ramos, A.L.C.C., Mazzinghy, A.C.D.C., Silva, V.D.M., J\u00fanior, A.H.O., Nunes, B.V., Vieira, A.L.S., and Ribeiro, L.V. (2022). An integrative review on the main Flavonoids found in some species of the Myrtaceae family: Phytochemical characterization, health benefits and development of products. Plants, 11.","DOI":"10.3390\/plants11202796"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/10408347.2015.1095064","article-title":"Gallic acid: Review of the methods of determination and quantification","volume":"46","author":"Fernandes","year":"2016","journal-title":"Crit. Rev. Anal. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1007\/s12161-017-0840-3","article-title":"Antioxidant activity and determination of phenolic compounds from Eugenia involucrata DC. Fruits by UHPLC-MS\/MS","volume":"10","author":"Nicacio","year":"2017","journal-title":"Food Anal. Methods"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1080\/14786419.2020.1855640","article-title":"Phenolic compounds of eugenia involucrata (myrtaceae) extracts and associated antioxidant and inhibitory effects on acetylcholinesterase and \u03b1-glucosidase","volume":"36","author":"Cipriani","year":"2020","journal-title":"Nat. Prod. Res."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Silv\u00e9rio, M.R.S., Espindola, L.S., Lopes, N.P., and Vieira, P.C. (2020). Plant natural products for the control of Aedes aegypti: The main vector of important arboviruses. Molecules, 25.","DOI":"10.3390\/molecules25153484"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0960-8524(03)00008-7","article-title":"Bioactivity of selected plant essential oils against the yellow fever mosquito Aedes aegypti larvae","volume":"89","author":"Cheng","year":"2003","journal-title":"Bioresour. Technol."},{"key":"ref_32","first-page":"1","article-title":"Chemical composition and larvicidal activity of essential oils extracted from Brazilian legal Amazon plants against Aedes aegypti L.(Diptera: Culicidae)","volume":"2015","author":"Dias","year":"2015","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1590\/S1413-95962002000500006","article-title":"Acaricide effect of Eucalyptus spp. essential oils and concentrated emulsion on Boophilus microplus","volume":"39","author":"Chagas","year":"2002","journal-title":"Braz. J. Vet. Res. Anim. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Silva, R.C.S., Milet-pinheiro, P., Bezerra da Silva, P.C., Silva, A.G., Silva, M.V., Navarro, D.M.A.F., and Silva, N.H. (2015). (E)-Caryophyllene and \u03b1-Humulene: Aedes aegypti oviposition deterrents elucidated by gas chromatography-electrophysiological assay of commiphora leptophloeos leaf oil. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0144586"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-d\u00edaz, J., Souto, R.N.P., Escalona-arranz, J.C., Ferreira, R.M.d.A., Costa, T.S., Gonz\u00e1lez-fern\u00e1ndez, R., Heredia-d\u00edaz, Y., Chil-n\u00f0\u00f1ez, I., Lavega, J., and Monzote, L. (2023). Larvicidal and Adulticidal Activity of Essential Oils from Four Cuban Plants against Three Mosquito Vector Species. Plants, 12.","DOI":"10.3390\/plants12234009"},{"key":"ref_36","first-page":"243","article-title":"Atividade larvicida de produtos naturais e avalia\u00e7\u00e3o da susceptibilidade ao inseticida temef\u00f3s no controle do Aedes aegypti (Diptera: Culicidae)","volume":"41","author":"Guarda","year":"2016","journal-title":"Interciencia"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"165","DOI":"10.4025\/actasciagron.v38i2.27956","article-title":"Effect of the flavonoid rutin on the biology of Spodoptera frugiperda (Lepidoptera: Noctuidae)","volume":"2","author":"Silva","year":"2016","journal-title":"Acta Scientiarum. Agron."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e12702","DOI":"10.1111\/1748-5967.12702","article-title":"Impact of rutin on growth, development and oviposition of Bt-susceptible and Bt-resistant pink bollworm","volume":"54","author":"Wang","year":"2024","journal-title":"Entomol. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"132531","DOI":"10.1016\/j.foodchem.2022.132531","article-title":"Plant flavonoids: Classification, distribution, biosynthesis, and antioxidant activity","volume":"383","author":"Shen","year":"2022","journal-title":"Food Chem."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"33454","DOI":"10.1007\/s11356-024-33416-5","article-title":"Essential oil from Piper tuberculatum Jacq.(Piperaceae) and its majority compound \u03b2-caryophyllene: Mechanism of larvicidal action against Aedes aegypti (Diptera: Culicidae) and selective toxicity","volume":"31","author":"Lima","year":"2024","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"de Aguiar, J.C.R.D.O.F., da Silva, A.C., Santos, E.F., Vieira, G.J.D.S.G., Ara\u00fajo, L.D.A., de Andrade, J.J.A., Anselmo, W.M., da Rocha, S.K.L., Dos Santos, F.H.G., and Arruda, C.C.L. (2024). Larvicidal and Oviposition Activity of Commercial Essential Oils of Abies sibirica Ledeb., Pogostemon cablin (Blanco) Benth., Juniperus communis L. and Their Combinations Against Aedes aegypti. Molecules, 29.","DOI":"10.3390\/molecules29245921"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Bezerra-Silva, P.C., Dutra, K.A., Santos, G.K.N., Silva, R.C.S., Iulek, J., Milet-Pinheiro, P., and Navarro, D.M.A.F. (2016). Evaluation of the activity of the essential oil from an ornamental flower against Aedes aegypti: Electrophysiology, molecular dynamics and behavioral assays. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0150008"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0021-9673(01)80947-X","article-title":"A generalization of the retention index system including linear temperature programmed gas\u2014Liquid partition chromatography","volume":"11","author":"Dool","year":"1963","journal-title":"J. Chromatogr. A"},{"key":"ref_44","unstructured":"Adams, R.P. (2007). Identification of Essential Oil Components by Gas Chromatography\/Mass Spectrometry, Allured Publishing Corporation. [4th ed.]."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0022-2011(83)90076-9","article-title":"Relative toxicity of organic solvents to Aedes aegypti larvae","volume":"42","author":"Kramer","year":"1983","journal-title":"J. Invertebr. Pathol."},{"key":"ref_46","first-page":"1531","article-title":"Pyrimidine Derivatives: Qsar studies of larvicidal activity against Aedes aegypti","volume":"31","author":"Monte","year":"2020","journal-title":"J. Braz. Chem. Soc."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/15\/3116\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:15:56Z","timestamp":1760033756000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/15\/3116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,25]]},"references-count":46,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["molecules30153116"],"URL":"https:\/\/doi.org\/10.3390\/molecules30153116","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,25]]}}}