{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T21:59:18Z","timestamp":1777413558157,"version":"3.51.4"},"reference-count":135,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Polish Ministry of Education and Science for The Faculty of Science and Technology of Jan Dlugosz University in Czestochowa","award":["SBR\/WNSPT\/KBBE\/18\/2023"],"award-info":[{"award-number":["SBR\/WNSPT\/KBBE\/18\/2023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Neurodegenerative diseases such as Alzheimer\u2019s disease, Parkinson\u2019s disease, Huntington\u2019s disease, and amyotrophic lateral sclerosis remain incurable. Current therapeutic strategies primarily focus on slowing disease progression, alleviating symptoms, and improving patients\u2019 quality of life, including the management of comorbid conditions. Over the past few decades, the incidence of diagnosed neurodegenerative disorders has risen significantly. As the number of affected individuals continues to grow, so does the urgent need for effective treatments that can halt or mitigate the progression of these diseases. Among the most promising therapeutic resources are bioactive compounds derived from fungi. The high quality of proteins, polysaccharides, unsaturated fatty acids, triterpenoids, sterols, and secondary metabolites found in fungi have attracted growing interest from researchers across multiple disciplines. One intensively studied direction involves the use of naturally occurring fungi-derived nutraceuticals in the treatment of various diseases, including neurodegenerative conditions. This article provides an overview of recent findings on fungal compounds\u2014such as phenolic compounds, carbohydrates, peptides and proteins, and lipids\u2014that may have potential applications in the treatment of neurodegenerative diseases and the alleviation of their symptoms.<\/jats:p>","DOI":"10.3390\/molecules30153158","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T14:50:03Z","timestamp":1753714203000},"page":"3158","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Natural Neuroinflammatory Modulators: Therapeutic Potential of Fungi-Derived Compounds in Selected Neurodegenerative Diseases"],"prefix":"10.3390","volume":"30","author":[{"given":"Agnieszka","family":"Godela","sequence":"first","affiliation":[{"name":"The Faculty of Science and Technology, Jan D\u0142ugosz University in Czestochowa, 13\/15 Armii Krajowej Av., 42-200 Czestochowa, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Rogacz","sequence":"additional","affiliation":[{"name":"The Faculty of Science and Technology, Jan D\u0142ugosz University in Czestochowa, 13\/15 Armii Krajowej Av., 42-200 Czestochowa, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5314-920X","authenticated-orcid":false,"given":"Barbara","family":"Paw\u0142owska","sequence":"additional","affiliation":[{"name":"The Faculty of Science and Technology, Jan D\u0142ugosz University in Czestochowa, 13\/15 Armii Krajowej Av., 42-200 Czestochowa, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2458-0217","authenticated-orcid":false,"given":"Robert","family":"Biczak","sequence":"additional","affiliation":[{"name":"The Faculty of Science and Technology, Jan D\u0142ugosz University in Czestochowa, 13\/15 Armii Krajowej Av., 42-200 Czestochowa, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Teleanu, D.M., Niculescu, A.-G., Lungu, I.I., Radu, C.I., Vlad\u00e2cenco, O., Roza, E., Cost\u0103chescu, B., Grumezescu, A.M., and Teleanu, R.I. 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