{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:06:36Z","timestamp":1787313996131,"version":"build-2736575974"},"reference-count":21,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2019s Horizon 2020 research and innovation program","award":["847581"],"award-info":[{"award-number":["847581"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation program","award":["IR0000005"],"award-info":[{"award-number":["IR0000005"]}]},{"name":"European Commission Next Generation EU","award":["847581"],"award-info":[{"award-number":["847581"]}]},{"name":"European Commission Next Generation EU","award":["IR0000005"],"award-info":[{"award-number":["IR0000005"]}]},{"name":"Cancerop\u00f4le Provence-Alpes-C\u00f4te d\u2019Azur","award":["847581"],"award-info":[{"award-number":["847581"]}]},{"name":"Cancerop\u00f4le Provence-Alpes-C\u00f4te d\u2019Azur","award":["IR0000005"],"award-info":[{"award-number":["IR0000005"]}]},{"name":"Provence-Alpes-C\u00f4te d\u2019Azur Region","award":["847581"],"award-info":[{"award-number":["847581"]}]},{"name":"Provence-Alpes-C\u00f4te d\u2019Azur Region","award":["IR0000005"],"award-info":[{"award-number":["IR0000005"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A new bicyclic polyketide, amesilide (1), along with the previously reported metabolites, chamisides A (2), B (3), and E (4), chaetoconvosins B (5) and C (6), and chaetochromins A (7) and B (8), were isolated from the marine fungus Amesia nigricolor MUT6601. The structures of the compounds were determined by extensive spectrometric (HRMS) and spectroscopic (1D and 2D NMR) analyses, as well as specific rotation. Absolute configurations of the stereogenic centers of amesilide (1) were determined by a comparison of its experimental circular dichroism (CD) spectrum with its time-dependent density functional theory (TD-DFT) electronic circular dichroism (ECD) spectra. Among them, chaetochromins A (7) and B (8) showed strong antibacterial activity against Staphylococcus aureus S25 (MBC values of 12.50 \u00b5M and MIC values of 6.25 \u00b5M) and a moderate cytotoxicity against monocytes (THP-1) and peripheral blood cells (PBMC) (IC50 values of 33.65\u201340.01 \u00b5M).<\/jats:p>","DOI":"10.3390\/molecules30153169","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T12:39:29Z","timestamp":1753792769000},"page":"3169","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Amesilide, a New Bicyclic Polyketide from the Marine Fungus Amesia nigricolor MUT6601"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5704-1813","authenticated-orcid":false,"given":"Giang Nam","family":"Pham","sequence":"first","affiliation":[{"name":"Marine Natural Products Team, Institut de Chimie de Nice, Universit\u00e9 C\u00f4te d\u2019Azur, CNRS UMR 7272, 06108 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6483-3886","authenticated-orcid":false,"given":"Matteo","family":"Florio Furno","sequence":"additional","affiliation":[{"name":"Department of Life Sciences and Systems Biology, University of Torino, Mycotheca Universitatis Taurinensis (MUT), Viale Mattioli 25, 10125 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2804-5003","authenticated-orcid":false,"given":"Juan A.","family":"Garcia-Sanchez","sequence":"additional","affiliation":[{"name":"INSERM U1065, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), B\u00e2timent Universitaire ARCHIMED, 151 Route de Saint Antoine de Ginesti\u00e8re BP, 23194 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4283-4671","authenticated-orcid":false,"given":"Patrick","family":"Munro","sequence":"additional","affiliation":[{"name":"INSERM U1065, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), B\u00e2timent Universitaire ARCHIMED, 151 Route de Saint Antoine de Ginesti\u00e8re BP, 23194 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7213-4700","authenticated-orcid":false,"given":"Fatouma Mohamed","family":"Abdoul-Latif","sequence":"additional","affiliation":[{"name":"Medicinal Research Institute, Center for Studies and Research of Djibouti, IRM-CERD, Route de l\u2019A\u00e9roport, Haramous, Djibouti City P.O. Box 486, Djibouti"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1375-1706","authenticated-orcid":false,"given":"Laurent","family":"Boyer","sequence":"additional","affiliation":[{"name":"INSERM U1065, Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M), B\u00e2timent Universitaire ARCHIMED, 151 Route de Saint Antoine de Ginesti\u00e8re BP, 23194 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1455-6208","authenticated-orcid":false,"given":"Giovanna Cristina","family":"Varese","sequence":"additional","affiliation":[{"name":"Department of Life Sciences and Systems Biology, University of Torino, Mycotheca Universitatis Taurinensis (MUT), Viale Mattioli 25, 10125 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Mehiri","sequence":"additional","affiliation":[{"name":"Marine Natural Products Team, Institut de Chimie de Nice, Universit\u00e9 C\u00f4te d\u2019Azur, CNRS UMR 7272, 06108 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3390\/md18050230","article-title":"Natural Products from Marine Fungi","volume":"18","author":"Shin","year":"2020","journal-title":"Mar. 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