{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:15:57Z","timestamp":1774685757139,"version":"3.50.1"},"reference-count":59,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Consejo Nacional de Humanidades Ciencias y Tecnolog\u00edas de Mexico (CONAHCYT)","award":["A1-S-10616 CB 2017\u20132018"],"award-info":[{"award-number":["A1-S-10616 CB 2017\u20132018"]}]},{"name":"Consejo Nacional de Humanidades Ciencias y Tecnolog\u00edas de Mexico (CONAHCYT)","award":["774184"],"award-info":[{"award-number":["774184"]}]},{"name":"IMSS","award":["A1-S-10616 CB 2017\u20132018"],"award-info":[{"award-number":["A1-S-10616 CB 2017\u20132018"]}]},{"name":"IMSS","award":["774184"],"award-info":[{"award-number":["774184"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Current treatments against leukemia present several limitations, prompting the search for new therapeutic agents, particularly those derived from natural products. In this context, structural modifications were performed on the triterpene 3\u03b1,24-dihydroxylup-20(29)-en-28-oic acid (T1), isolated from Phoradendron wattii. Among the five derivatives obtained, 3\u03b1,24-dihydroxy-30-oxolup-20(29)-en-28-oic acid (T1c) exhibited the highest activity, with an IC50 value of 12.90 \u00b1 0.1 \u00b5M against THP-1 cells. T1c significantly reduced cell viability in both acute lymphoblastic leukemia (CCRF-CEM, REH, JURKAT, and MOLT-4) and acute myeloid leukemia (THP-1) cell lines, inducing apoptosis after 48 h of treatment, while showing minimal cytotoxicity toward normal mononuclear cells (MNCs). In silico molecular docking studies were conducted against three key protein targets: BCL-2 (B-cell lymphoma 2), EGFR (epidermal growth factor receptor, tyrosine kinase domain), and FLT3 (FMS-like tyrosine kinase 3). The lowest binding energies (kcal\/mol) observed were as follows: T1\u2013BCL-2: \u221210.12, EGFR: \u221212.75, FLT3: \u221214.05; T1c\u2013BCL-2: \u221210.23, EGFR: \u221214.50, FLT3: \u221214.07; T2\u2013BCL-2: \u221211.59, EGFR: \u221215.00, FLT3: \u221214.03. These findings highlight T1c as a promising candidate in the search for anti-leukemic drugs which deserves further study.<\/jats:p>","DOI":"10.3390\/molecules30153193","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:00:41Z","timestamp":1753884041000},"page":"3193","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Semi-Synthesis, Anti-Leukemia Activity, and Docking Study of Derivatives from 3\u03b1,24-Dihydroxylup-20(29)-en-28-Oic Acid"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9453-6262","authenticated-orcid":false,"given":"Mario J.","family":"Noh-Burgos","sequence":"first","affiliation":[{"name":"Unidad de Biotecnolog\u00eda, Centro de Investigaci\u00f3n Cient\u00edfica de Yucat\u00e1n (CICY), M\u00e9rida 97205, Mexico"},{"name":"Unidad M\u00e9dica de Alta Especialidad, Centro M\u00e9dico Ignacio Garc\u00eda T\u00e9llez, Instituto Mexicano del Seguro Social (IMSS), M\u00e9rida 97200, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Garc\u00eda-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Oncol\u00f3gicas, UMAE Hospital de Oncolog\u00eda, Centro M\u00e9dico Nacional Siglo XXI, IMSS, Ciudad de M\u00e9xico 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando J.","family":"Tun-Rosado","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4542-1023","authenticated-orcid":false,"given":"Antonieta","family":"Ch\u00e1vez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Oncol\u00f3gicas, UMAE Hospital de Oncolog\u00eda, Centro M\u00e9dico Nacional Siglo XXI, IMSS, Ciudad de M\u00e9xico 06720, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8161-501X","authenticated-orcid":false,"given":"Sergio R.","family":"Peraza-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Unidad de Biotecnolog\u00eda, Centro de Investigaci\u00f3n Cient\u00edfica de Yucat\u00e1n (CICY), M\u00e9rida 97205, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9204-6062","authenticated-orcid":false,"given":"Rosa E.","family":"Moo-Puc","sequence":"additional","affiliation":[{"name":"Secretar\u00eda de Ciencia, Humanidades, Tecnolog\u00eda e Innovaci\u00f3n-Hospital Regional de Alta Especialidad de la Pen\u00ednsula de Yucat\u00e1n, IMSS-BIENESTAR, M\u00e9rida 97130, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"ref_1","first-page":"7","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J. 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