{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T20:41:44Z","timestamp":1788295304628,"version":"build-2803163510"},"reference-count":62,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico: UNAM-PAPIIT","award":["IN201820"],"award-info":[{"award-number":["IN201820"]}]},{"name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico: UNAM-PAPIIT","award":["IN201723"],"award-info":[{"award-number":["IN201723"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The objective of this study was to determine the pharmacological interaction of some common NSAIDs in the presence of quercetin (QUER). Indomethacin (IND), ketorolac (KET), or celecoxib (CEL) were assessed alone and in combination with QUER using experimental gout-arthritic pain and the carrageenan-induced edema test in rats to evaluate their antinociceptive and anti-inflammatory effects, respectively. The antinociceptive effect of each NSAID was also analyzed after the repeated administration of QUER for 10 days. Molecular docking analysis on COX-1\/COX-2 with each drug was explored to analyze the pharmacological interaction. QUER produced minimal antinociceptive or anti-inflammatory effects on experimental gout-arthritic pain or on the carrageenan-induced edema in rats. Additionally, QUER reduced the antinociceptive effect of NSAIDs, mainly those COX-1 inhibitors (IND and KET), when they were combined. However, QUER did not modify the anti-inflammatory effect of these COX-1 inhibitors and slightly improved the anti-inflammatory effect of the COX-2 inhibitor (CEL). According to the docking analysis, COX-1 and COX-2 are likely implicated in these pharmacological interactions. In conclusion, QUER, a known bioactive natural product, may alter the antinociceptive efficacy of NSAIDs commonly used to relieve gout-like pain and suggests not using them together to prevent a negative therapeutic interaction in this effect.<\/jats:p>","DOI":"10.3390\/molecules30153196","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:00:41Z","timestamp":1753884041000},"page":"3196","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Quercetin Reduces Antinociceptive but Not the Anti-Inflammatory Effects of Indomethacin, Ketorolac, and Celecoxib in Rats with Gout-like Pain"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8162-9915","authenticated-orcid":false,"given":"Jos\u00e9","family":"Aviles-Herrera","sequence":"first","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe Esther","family":"\u00c1ngeles-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1467-9486","authenticated-orcid":false,"given":"Myrna","family":"D\u00e9ciga-Campos","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional (IPN), Ciudad de M\u00e9xico 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Eva","family":"Gonz\u00e1lez-Trujano","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofarmacolog\u00eda de Productos Naturales, Direcci\u00f3n de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatr\u00eda \u201cRam\u00f3n de la Fuente Mu\u00f1iz\u201d, Ciudad de M\u00e9xico 14370, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1968-8813","authenticated-orcid":false,"given":"Gabriel Fernando","family":"Moreno-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofarmacolog\u00eda de Productos Naturales, Direcci\u00f3n de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatr\u00eda \u201cRam\u00f3n de la Fuente Mu\u00f1iz\u201d, Ciudad de M\u00e9xico 14370, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Reyes-Chilpa","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2317-5466","authenticated-orcid":false,"given":"Irma","family":"Romero","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia","family":"Alejo-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Laboratorio 7 de Dolor y Analgesia, Departamento de Farmacobiolog\u00eda, Centro de Investigaci\u00f3n y de Estudios Avanzados (CINVESTAV), Sede Sur, Ciudad de M\u00e9xico 14330, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Ventura-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM), Ciudad de M\u00e9xico 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.2147\/DDDT.S80686","article-title":"Impact of potential inappropriate NSAIDs use in chronic pain","volume":"9","author":"Ussai","year":"2015","journal-title":"Drug. 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