{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:36:15Z","timestamp":1760060175412,"version":"build-2065373602"},"reference-count":22,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan","award":["AP19674667"],"award-info":[{"award-number":["AP19674667"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>A synthetic methodology of the CuAAC \u201cclick\u201d approach was exploited for the construction of 1,2-azolyltriazole quinine derivatives by the reaction of O-propargylquinine with azidomethyl-1,2-azoles in methanol. Quinine\u2013piperidine and quinine\u2013anabasine conjugates were obtained using a chloroacetate linker by reacting quinine chloroacetate with piperidine or anabasine in a diethyl ether medium. Cinchophene ester was obtained by the acylation of quinine with cinchophen acid chloride in methylene chloride. The antibacterial, fungicidal, analgesic and cytotoxic properties of the obtained compounds were examined.<\/jats:p>","DOI":"10.3390\/molecules30153301","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T08:33:06Z","timestamp":1754555586000},"page":"3301","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis and Biological Activity of Novel Polyazaheterocyclic Derivatives of Quinine"],"prefix":"10.3390","volume":"30","author":[{"given":"Gulim K.","family":"Mukusheva","sequence":"first","affiliation":[{"name":"Chemistry Faculty, Karaganda Buketov University, Karaganda 100024, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nurizat N.","family":"Toigambekova","sequence":"additional","affiliation":[{"name":"Chemistry Faculty, Karaganda Buketov University, Karaganda 100024, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roza B.","family":"Seidakhmetova","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Evidence-Based Medicine, Karaganda Medical University, Karaganda 100024, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9937-275X","authenticated-orcid":false,"given":"Roza I.","family":"Jalmakhanbetova","sequence":"additional","affiliation":[{"name":"Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Astana 010000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mukhlissa N.","family":"Babakhanova","sequence":"additional","affiliation":[{"name":"Faculty of Natural Sciences, L.N. Gumilyov Eurasian National University, Astana 010000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1878-2787","authenticated-orcid":false,"given":"Oralgazy A.","family":"Nurkenov","sequence":"additional","affiliation":[{"name":"Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, Karaganda 100008, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0803-8623","authenticated-orcid":false,"given":"Ekaterina A.","family":"Akishina","sequence":"additional","affiliation":[{"name":"Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgenij A.","family":"Dikusar","sequence":"additional","affiliation":[{"name":"Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina A.","family":"Kolesnik","sequence":"additional","affiliation":[{"name":"Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8308-960X","authenticated-orcid":false,"given":"Hongwei","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir I.","family":"Potkin","sequence":"additional","affiliation":[{"name":"Institute of Physical Organic Chemistry, National Academy of Sciences of Belarus, 220072 Minsk, Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Mukusheva, G.K., Zhasymbekova, A.R., Seidakhmetova, R.B., Nurkenov, O.A., Akishina, E.A., Petkevich, S.K., Dikusar, E.A., and Potkin, V.I. 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