{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:55:07Z","timestamp":1787846107022,"version":"build-2784847793"},"reference-count":95,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The genus Bauhinia has over 350 species distributed on different continents of the world. The vast majority of the species in this genus possess interesting biological activities. Also, they are good sources of flavonoids, which are known to elicit excellent pharmacological properties and are well-positioned as potential drug candidates. A literature search was performed with proper consideration of articles published and indexed in PubMed, Scopus, Springer Link, Google Scholar, ScienceDirect, SciFinder, and Medline databases between 1980 and 2023. A total of 164 flavonoids isolated from the genus Bauhinia were reviewed, and biological activities including antidiabetic, anti-cancer, antibacterial, cytotoxicity, antidiarrheal, antioxidant, anti-inflammatory, and anti-cataract were all reported. This study gave a comprehensive review of these flavonoids through detailed classification, structural diversity, and pharmacological activities.<\/jats:p>","DOI":"10.3390\/molecules30163335","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T09:04:53Z","timestamp":1754903093000},"page":"3335","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Flavonoid in All Their Therapeutic Values: An Odyssey into the Phytochemistry and Pharmacology of Naturally Occurring Flavonoid from Genus Bauhinia"],"prefix":"10.3390","volume":"30","author":[{"given":"Esther Oluwatosin","family":"Shalom","sequence":"first","affiliation":[{"name":"Drug Research and Production Unit, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife 220101, Nigeria"},{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife 220101, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4992-2092","authenticated-orcid":false,"given":"Kolade Olatubosun","family":"Faloye","sequence":"additional","affiliation":[{"name":"Department of Industrial Chemistry, Faculty of Sciences, University of Ilesa, Ilesa 5089, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3150-3690","authenticated-orcid":false,"given":"Stephen Adeleke","family":"Adesida","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife 220101, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4983-245X","authenticated-orcid":false,"given":"Adetola Henry","family":"Adewole","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0012-753X","authenticated-orcid":false,"given":"Oluwaseun Emmanuel","family":"Olatunji","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife 220101, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blessing Ibukun","family":"Okunribido","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Obafemi Awolowo University, Ile-Ife 220101, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwatosin Funke","family":"Olawuni","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife 220101, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther Aina","family":"Olanudun","sequence":"additional","affiliation":[{"name":"Department of Industrial Chemistry, Faculty of Sciences, University of Ilesa, Ilesa 5089, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seun Bayonle","family":"Ogundele","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Natural Products, College of Pharmacy, Afe Babalola University, Ado-Ekiti 360001, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samson Oluwaseyi","family":"Famuyiwa","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, Obafemi Awolowo University, Ile-Ife 220101, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Therapeutic applications of natural products in herbal medicines, biodiscovery programs, and biomedicine","volume":"8","author":"Wangchuk","year":"2018","journal-title":"J. Biol. Act. Prod. Nat."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1139\/B09-065","article-title":"The genus Bauhinia sl (Leguminosae): A phylogeny based on the plastid trnL\u2013trnF region","volume":"87","author":"Sinou","year":"2009","journal-title":"Botany"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"164","DOI":"10.31024\/ajpp.2020.6.3.2","article-title":"Bauhinia acuminate Linn: A brief review of its phytochemistry and pharmacology","volume":"6","author":"Sebastian","year":"2020","journal-title":"Asian J. Pharm. Pharmacol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Fortunato, R.H., and Nores, M.J. (2020). \u201cCow\u2019s Hoof\u201d (Bauhinia L., Leguminosae): A Review on Pharmacological Properties of Austral South American Species. Plants, 12.","DOI":"10.3390\/plants12010031"},{"key":"ref_5","first-page":"39","article-title":"Nutritional value of tropical plant seeds","volume":"51","author":"Ezeagu","year":"2009","journal-title":"Modif. Seed Compos. Promot. Health Nutr."},{"key":"ref_6","first-page":"1347","article-title":"Chemical composition and biological potential of plants from the genus Bauhinia","volume":"23","author":"Filho","year":"2009","journal-title":"Phytother. Res. Int. J. Devoted Pharmacol. Toxicol. Eval. Nat. Prod. Deriv."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s43094-021-00251-1","article-title":"Traditional uses, phytochemistry and pharmacology of Bauhinia racemosa Lam.: A comprehensive review","volume":"7","author":"Prabhu","year":"2021","journal-title":"Future J. Pharm. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"64","DOI":"10.4103\/0976-500X.92518","article-title":"Antidiabetic activity of stem bark of Bauhinia variegata in alloxan-induced hyperglycemic rats","volume":"3","author":"Kumar","year":"2012","journal-title":"J. Pharmacol. Pharmacother."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4103\/0253-7613.51345","article-title":"Screening of Bauhinia purpurea Linn. for analgesic and anti-inflammatory activities","volume":"41","author":"Shreedhara","year":"2009","journal-title":"Indian. J. Pharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s13596-012-0059-1","article-title":"Anticataract activity of rhamnocitrin isolated from Bauhinia variegata stem bark","volume":"12","author":"Bodakhe","year":"2012","journal-title":"Orient. Pharm. Exp. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.jep.2012.08.004","article-title":"The antimicrobial, antioxidative, anti-inflammatory activity and cytotoxicity of different fractions of four South African Bauhinia species used traditionally to treat diarrhoea","volume":"143","author":"Ahmed","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"ref_12","first-page":"420","article-title":"Bauhinia purpurea Linn.: A review of its ethnobotany, phytochemical and pharmacological profile","volume":"5","author":"Kumar","year":"2012","journal-title":"Res. J. Med. Plant"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.3390\/nu5093367","article-title":"Flavonoid bioavailability and attempts for bioavailability enhancement","volume":"5","author":"Thilakarathna","year":"2013","journal-title":"Nutrients"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Xiong, H.H., Lin, S.Y., Chen, L.L., Ouyang, K.H., and Wang, W.J. (2023). The interaction between flavonoids and intestinal microbes: A review. Foods, 12.","DOI":"10.3390\/foods12020320"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Sl\u00e1mov\u00e1, K., Kape\u0161ov\u00e1, J., and Valentov\u00e1, K. (2018). \u201cSweet flavonoids\u201d: Glycosidase-catalyzed modifications. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19072126"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1002\/ptr.2448","article-title":"Antiinflammatory activities of flavonoids and a triterpene caffeate isolated from Bauhinia variegata","volume":"22","author":"Rao","year":"2008","journal-title":"Phytother. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1080\/14786419.2021.1887176","article-title":"Bauhinia pulchella: Chemical constituents, antioxidant and alpha-glucosidase inhibitory activities","volume":"36","author":"Monteiro","year":"2022","journal-title":"Nat. Prod. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"5277","DOI":"10.1080\/14786419.2020.1752206","article-title":"Chemical constituents and acetylcholinesterase inhibitory activity from the stems of Bauhinia pentandra","volume":"35","author":"Pinto","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"9806160","DOI":"10.1155\/2018\/9806160","article-title":"Apoptosis effects of dihydrokaempferol isolated from Bauhinia championii on synoviocytes","volume":"2018","author":"Zhang","year":"2018","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e202217809","DOI":"10.1002\/ange.202217809","article-title":"Influence of side chain conformation on the activity of glycosidase inhibitors","volume":"135","author":"Tseng","year":"2023","journal-title":"Angew. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5","DOI":"10.24820\/ark.5550190.p011.809","article-title":"Synthesis of (5, 6 & 6, 6)-oxa-oxa annulated sugars as glycosidase inhibitors from 2-formyl galactal using iodocyclization as a key step","volume":"2022","author":"Rajasekaran","year":"2022","journal-title":"Arkivoc"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Nabavi, S.M., \u0160amec, D., Tomczyk, M., Milella, L., Russo, D., Habtemariam, S., Suntar, I., Rastrelli, L., Daglia, M., and Xiao, J. (2020). Flavonoid biosynthetic pathways in plants: Versatile targets for metabolic engineering. Biotechnol. Adv., 38.","DOI":"10.1016\/j.biotechadv.2018.11.005"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Butnariu, M. (2023). Plant Genome Engineering for Improved Flavonoids Production. Plants as Bioreactors for Industrial Molecules, John Wiley & Sons.","DOI":"10.1002\/9781119875116.ch8"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Bhatla, S.C., and Lal, M.A. (2023). Secondary metabolites. Plant Physiology, Development and Metabolism 2023, Springer Nature.","DOI":"10.1007\/978-981-99-5736-1"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1016\/S0031-9422(98)00226-X","article-title":"A novel 6-butyl-3-hydroxyflavanone from heartwood of Bauhinia purpurea","volume":"49","author":"Kuo","year":"1998","journal-title":"Phytochemistry"},{"key":"ref_26","first-page":"478","article-title":"Novel propenyl flavonoids glycoside and antioxidant activity of Egyptian Bauhinia retusa","volume":"6","author":"Hassan","year":"2015","journal-title":"Int. J. Pharm. Sci. Res."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Sharma, N., Sharma, A., Bhatia, G., Landi, M., Brestic, M., Singh, B., Singh, J., Kaur, S., and Bhardwaj, R. (2019). Isolation of phytochemicals from Bauhinia variegata L. Bark and their in vitro antioxidant and cytotoxic potential. Antioxidants, 8.","DOI":"10.3390\/antiox8100492"},{"key":"ref_28","first-page":"51","article-title":"Bioactive constituents from Bauhinia variegata Linn","volume":"5","author":"Jash","year":"2014","journal-title":"Int. J. Pharm. Biomed. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/jccs.199700056","article-title":"Chemical constituents of heartwood of Bauhinia purpurea","volume":"44","author":"Kuo","year":"1997","journal-title":"J. Chin. Chem. Soc."},{"key":"ref_30","first-page":"1073","article-title":"Antimicrobial and antioxidant activities of Bauhinia racemosa Lam. and chemical content","volume":"13","author":"Rashed","year":"2014","journal-title":"Iran. J. Pharm. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"14323","DOI":"10.3390\/molecules171214323","article-title":"Ionic liquid-based microwave-assisted extraction of flavonoids from Bauhinia championii (Benth.) Benth","volume":"17","author":"Xu","year":"2012","journal-title":"Molecules"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1080\/14786419.2011.559948","article-title":"Antioxidant, xanthine oxidase and lipoxygenase inhibitory activities and phenolics of Bauhinia rufescens Lam.(Caesalpiniaceae)","volume":"26","author":"Lamien","year":"2012","journal-title":"Nat. Prod. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1080\/14786419.2015.1050671","article-title":"Role of the flavonoid-rich fraction in the antioxidant and cytotoxic activities of Bauhinia forficata Link.(Fabaceae) leaves extract","volume":"30","author":"Miceli","year":"2016","journal-title":"Nat. Prod. Res."},{"key":"ref_34","first-page":"312","article-title":"Isolation, characterization, and biological evaluation of flavonols and 1, 2-diphenylethanes from Bauhinia vahlii","volume":"11","author":"Ketha","year":"2020","journal-title":"Nat. Prod. Radiance"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Nguyen, T.T., Ketha, A., Hieu, H.V., and Tatipamula, V.B. (2021). In vitro antimycobacterial studies of flavonols from Bauhinia vahlii Wight and Arn. 3 Biotech, 11.","DOI":"10.1007\/s13205-021-02672-4"},{"key":"ref_36","first-page":"1","article-title":"Antioxidant activities and HPLC-DAD based phenolic content determination of Bauhinia scandens","volume":"14","author":"Hossain","year":"2016","journal-title":"J. Pharm. Res. Int."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1016\/j.bmcl.2015.05.089","article-title":"Potential therapeutic agents for circulatory diseases from Bauhinia glauca Benth. subsp. pernervosa. (Da Ye Guan Men)","volume":"25","author":"Tang","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_38","first-page":"859","article-title":"Evaluation of flavonoids from Bauhinia megalandra leaves as inhibitors of glucose-6-phosphatase system","volume":"19","author":"Estrada","year":"2005","journal-title":"Phytother. Res. Int. J. Devoted Pharmacol. Toxicol. Eval. Nat. Prod. Deriv."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s11418-013-0762-3","article-title":"\u03b2-Sitosterol and flavonoids isolated from Bauhinia malabarica found during screening for Wnt signaling inhibitory activity","volume":"68","author":"Park","year":"2014","journal-title":"J. Nat. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"9","DOI":"10.31069\/japsr.v3i2.2","article-title":"Extraction, isolation and characterization of Bauhinia variegata flower","volume":"3","author":"Gupta","year":"2020","journal-title":"J. Appl. Pharm. Sci. Res."},{"key":"ref_41","first-page":"227","article-title":"Bioassay Guided Isolation of Anti-Inflammatory Compounds from Bauhinia variegata L.: A Key Ingredient in Herbo-Mineral Formulation, Gandmala Kandan Ras","volume":"85","author":"Killari","year":"2023","journal-title":"Indian. J. Pharm. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.jep.2013.09.025","article-title":"Anti-cancer activity of compounds from Bauhinia strychnifolia stem","volume":"150","author":"Yuenyongsawad","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1753-0407.2012.00222.x","article-title":"Quercetin, a minor constituent of the antihyperglycemic fraction of Bauhinia monandra leaf","volume":"4","author":"Alade","year":"2012","journal-title":"J. Diabetes"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Dej-Adisai, S., Rais, I.R., Wattanapiromsakul, C., and Pitakbut, T. (2021). Alpha-glucosidase inhibitory assay-screened isolation and molecular docking model from Bauhinia pulla active compounds. Molecules, 26.","DOI":"10.3390\/molecules26195970"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.bse.2007.08.006","article-title":"Flavonoids and alkaloids from leaves of Bauhinia ungulata L.","volume":"36","author":"Neto","year":"2008","journal-title":"Biochem. Syst. Ecol."},{"key":"ref_46","first-page":"269","article-title":"Chemical investigation of Bauhinia vahlii Wight and Arnott leaves grown in Egypt","volume":"8","author":"Elbanna","year":"2016","journal-title":"Int. J. Pharm. Pharm. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/1756-3305-7-130","article-title":"Quercetin and quercetin 3-O-glycosides from Bauhinia longifolia (Bong.) Steud. show anti-Mayaro virus activity","volume":"7","author":"Kuster","year":"2014","journal-title":"Parasites Vectors"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Xu, J., Zhao, Q., Wei, L., Yang, Y., Xu, R., Yu, N., and Zhao, Y. (2015). Phytochemical composition and antinociceptive activity of Bauhinia glauca subsp. hupehana in rats. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0117801"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.52711\/0974-360X.2023.00357","article-title":"Isolation and Characterization of a Flavonoid and Analgesic activity of leaves of Bauhinia acuminata Linn","volume":"16","author":"Chakraborty","year":"2023","journal-title":"Res. J. Pharm. Technol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1080\/14786419.2019.1669030","article-title":"Bauhinia holophylla (Bong.) Steud. leaves-derived extracts as potent anti-dengue serotype 2","volume":"35","author":"Teixeira","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1080\/14786419.2022.2128347","article-title":"A new flavonol derivative and other compounds from the leaves of Bauhinia thonningii Schum with activity against multidrug-resistant bacteria","volume":"37","author":"Nouemsi","year":"2023","journal-title":"Nat. Prod. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1055\/s-0029-1240868","article-title":"Enhancement of insulin release from the \u03b2-cell line INS-1 by an ethanolic extract of Bauhinia variegata and its major constituent roseoside","volume":"76","author":"Frankish","year":"2010","journal-title":"Planta Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"S161","DOI":"10.4103\/pm.pm_433_19","article-title":"A new stilbene derivative and isolated compounds from Bauhinia pottsii var. pottsii with their anti-alpha-glucosidase activity","volume":"16","author":"Phoopha","year":"2020","journal-title":"Pharmacogn. Mag."},{"key":"ref_54","first-page":"92","article-title":"Antibacterial activity of phytochemicals from Bauhinia thonningii significantly increased in the presence of the efflux pump inhibitor, phenylalanine-arginine-\u03b2-naphthylamide towards multidrug-resistant phenotypes","volume":"7","author":"Matieta","year":"2024","journal-title":"Investig. Med. Chem. Pharmacol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Praparatana, R., Maliyam, P., Barrows, L.R., and Puttarak, P. (2020). Flavonoids and Phenols, the Potential Anti-Diabetic Compounds from Bauhinia strychnifolia Craib. Stem. Molecules, 27.","DOI":"10.3390\/molecules27082393"},{"key":"ref_56","first-page":"5933","article-title":"Bauhinia championii flavone inhibits apoptosis and autophagy via the PI3K\/Akt pathway in myocardial ischemia\/reperfusion injury in rats","volume":"9","author":"Jian","year":"2015","journal-title":"Drug Des. Devel. Ther."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.bjp.2017.09.002","article-title":"Chemical constituents from Bauhinia acuruana and their cytotoxicity","volume":"27","author":"Sousa","year":"2017","journal-title":"Rev. Bras. Farmacogn."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"140","DOI":"10.22271\/phyto.2023.v12.i4b.14702","article-title":"Isolation, structural characterization and evaluation of the in vitro antioxidant potential of four compounds isolated from the selective leaf extracts of Bauhinia monandra Kurz (Fabaceae)","volume":"12","author":"Aicha","year":"2023","journal-title":"J. Pharmacogn. Phytochem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1002\/cbdv.201600058","article-title":"New cytotoxic bibenzyl and other constituents from Bauhinia ungulata L. (Fabaceae)","volume":"13","author":"Lemos","year":"2016","journal-title":"Chem. Biodivers."},{"key":"ref_60","first-page":"434","article-title":"Flavonoids from the Stem Bark of Bauhinia semibifida L.","volume":"6","author":"Tanjung","year":"2014","journal-title":"Der Pharm. Lett."},{"key":"ref_61","first-page":"14","article-title":"Antibacterial activity of flavonoids from Bauhinia sirindhorniae","volume":"19","author":"Athikomkulchai","year":"2005","journal-title":"Thai J. Health Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1248\/cpb.57.628","article-title":"Flavonoids from Bauhinia glauca subsp. pernervosa","volume":"57","author":"Wu","year":"2009","journal-title":"Chem. Pharm. Bull."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1007\/s10600-022-03887-4","article-title":"Chemical Composition of the Stem Barks of Bauhinia glauca subsp. hupehana","volume":"58","author":"Zhang","year":"2022","journal-title":"Chem. Nat. Compd."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S0031-9422(03)00416-3","article-title":"A flavanone and a dihydrodibenzoxepin from Bauhinia variegata","volume":"64","author":"Reddy","year":"2003","journal-title":"Phytochemistry"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1080\/14786410802553752","article-title":"Cytotoxic activity of a flavanone from the stem of Bauhinia variegata Linn","volume":"23","author":"Rajkapoor","year":"2009","journal-title":"Nat. Prod. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/jccs.200200042","article-title":"Studies on the constituents from the bark of Bauhinia purpurea","volume":"49","author":"Kuo","year":"2002","journal-title":"J. Chin. Chem. Soc."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Saldanha, L.L., Quintiliano Delgado, A., Marcourt, L., de Paula Camaforte, N.A., Ponce Vareda, P.M., Nejad Ebrahimi, S., Vilegas, W., Dokkedal, A.L., Queiroz, E.F., and Wolfender, J.L. (2021). Hypoglycemic active principles from the leaves of Bauhinia holophylla: Comprehensive phytochemical characterization and in vivo activity profile. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0258016"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.3109\/0886022X.2015.1061886","article-title":"Protective role of polyphenols from Bauhinia hookeri against carbon tetrachloride-induced hepato-and nephrotoxicity in mice","volume":"37","author":"Kilany","year":"2015","journal-title":"Ren. Fail."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1248\/cpb.32.166","article-title":"New flavones from Bauhinia championii BENTH","volume":"32","author":"Chen","year":"1984","journal-title":"Chem. Pharm. Bull."},{"key":"ref_70","first-page":"312","article-title":"Studies on the chemical constituents of Baubinia championii benth.(II)","volume":"16","author":"Haiyun","year":"2004","journal-title":"Nat. Prod. Res. Dev."},{"key":"ref_71","first-page":"754","article-title":"Chemical Constituents of Bauhinia brachycarpa","volume":"24","author":"Lei","year":"2012","journal-title":"Nat. Prod. Res. Dev."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"135","DOI":"10.7324\/JAPS.2020.103018","article-title":"Isolation, characterization, and cytotoxic studies of secondary metabolites from the leaves of Bauhinia foveolata Dalzell: An endemic tree from the Western Ghats, India","volume":"10","author":"Habbu","year":"2020","journal-title":"J. Appl. Pharm. Sci."},{"key":"ref_73","first-page":"179","article-title":"Extraction and isolation of Isoflavonoids from stem bark of Bauhinia purpurea (L): Its biological antipsychotic and analgesic activities","volume":"3","author":"Shamala","year":"2022","journal-title":"Smart Mater. Med."},{"key":"ref_74","first-page":"2604","article-title":"Two dimeric flavonoids from Bauhinia purpurea","volume":"44","author":"Yadav","year":"2009","journal-title":"Indian. J. Chem."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3923\/ijp.2015.372.376","article-title":"Anti-inflammatory and cytotoxic constituents of Bauhinia retusa","volume":"11","author":"Perveen","year":"2015","journal-title":"Int. J. Pharm."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1080\/10286020108040374","article-title":"A new flavone glycoside, 5-hydroxy 7, 3\u2032, 4\u2032, 5\u2032-tetra-methoxyflavone 5-O-\u03b2-D-xylopyranosyl-(1\u2192 2)-\u03b1-L-rhamnopyranoside from Bauhinia variegata Linn","volume":"3","author":"Yadava","year":"2001","journal-title":"J. Asian Nat. Prod. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1055\/s-2008-1074857","article-title":"Chemical examination of the stem of Bauhinia variegata","volume":"38","author":"Gupta","year":"1980","journal-title":"Planta Med."},{"key":"ref_78","first-page":"1934578X20967875","article-title":"Isolation of prunin from Bauhinia variegata and its antioxidant activity in rats Fed an atherogenic diet","volume":"15","author":"Zhang","year":"2020","journal-title":"Nat. Prod. Comm."},{"key":"ref_79","first-page":"50","article-title":"Cytotoxicity study of antioxidant flavonoids from Bauhinia tomentosa leaf extract","volume":"12","author":"Aderogba","year":"2008","journal-title":"Nigerian J. Nat. Prod. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"59","DOI":"10.4314\/ajtcam.v3i4.31177","article-title":"Isolation of two flavonoids from Bauhinia monandra (Kurz) leaves and their antioxidative effects","volume":"3","author":"Aderogba","year":"2006","journal-title":"Afr. J. Tradit. Complement. Altern. Med."},{"key":"ref_81","first-page":"3201463","article-title":"HPTLC fingerprint profile and identification of antidiabetic and antioxidant leads from Bauhinia rufescens L.","volume":"2020","author":"Osman","year":"2020","journal-title":"Adv. Pharmacol. Pharm. Sci."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.foodchem.2012.02.201","article-title":"Bauhinia forficata Link authenticity using flavonoids profile: Relation with their biological properties","volume":"134","author":"Ferreres","year":"2012","journal-title":"Food Chem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0367-326X(99)00114-8","article-title":"A novel flavone glycoside from the stem of Bauhinia purpurea","volume":"71","author":"Yadava","year":"2000","journal-title":"Fitoterapia"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1080\/14786410701369557","article-title":"Antioxidant activity and cytotoxicity study of the flavonol glycosides from Bauhinia galpinii","volume":"21","author":"Aderogba","year":"2007","journal-title":"Nat. Prod. Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.sajb.2019.06.011","article-title":"Bioactive compounds from the leaf extract of Bauhinia galpinii (Fabaceae) used as antidiarrhoeal therapy in southern Africa","volume":"126","author":"Ahmed","year":"2019","journal-title":"S. Afr. J. Botany."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1021\/np0100845","article-title":"Antioxidant principles from Bauhinia t arapotensis","volume":"64","author":"Braca","year":"2001","journal-title":"J. Nat. Prod."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1556\/ABiol.64.2013.1.3","article-title":"Chemical composition and in vitro antioxidant activity of hydro-ethanolic extracts from Bauhinia forficata subsp. pruinosa and B. variegata","volume":"64","author":"Sayago","year":"2013","journal-title":"Acta Biol. Hung."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1515\/znc-2000-5-627","article-title":"Phytochemical and pharmacognostic investigation of Bauhinia forficata Link (Leguminosae)","volume":"55","author":"Silva","year":"2000","journal-title":"Z. F\u00fcr Naturforschung C"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"208","DOI":"10.4236\/ajps.2019.101016","article-title":"Seasonal flavonoid profile and kaempferitrin content in the leaf extracts of Bauhinia forficata subspecies forficata from two locations in southeastern Brazil","volume":"10","author":"Tostes","year":"2019","journal-title":"Am. J. Plant Sci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.indcrop.2019.01.040","article-title":"Chemical secondary metabolite profiling of Bauhinia longifolia ethanolic leaves extracts","volume":"132","author":"Aquino","year":"2019","journal-title":"Ind. Crop. Prod."},{"key":"ref_91","first-page":"16","article-title":"Antioxidative flavonoids from the leaves of Bauhinia retusa Roxb","volume":"32","author":"Suman","year":"2010","journal-title":"J. Med. Aromat. Plant Sci."},{"key":"ref_92","first-page":"200","article-title":"Evaluation of the antioxidant and phototoxic potentials of Bauhinia microstachya var. massambabensis Vaz leaf extracts","volume":"31","author":"Mansur","year":"2012","journal-title":"Lat. Am. J. Pharm."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1080\/14786419.2015.1129332","article-title":"Chemical constituents from the flowering buds of Bauhinia tomentosa Linn (FBBT)","volume":"30","author":"Radha","year":"2016","journal-title":"Nat. Prod. Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.fitote.2010.08.007","article-title":"Inhibition of glucose intestinal absorption by kaempferol 3-O-\u03b1-rhamnoside purified from Bauhinia megalandra leaves","volume":"81","author":"Hasegawa","year":"2010","journal-title":"Fitoterapia"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1080\/10286020.2012.728209","article-title":"Chemical constituents of Bauhinia aurea","volume":"14","author":"Shang","year":"2012","journal-title":"J. Asian Nat. Prod. Res."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/16\/3335\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:27:52Z","timestamp":1760034472000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/16\/3335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,11]]},"references-count":95,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["molecules30163335"],"URL":"https:\/\/doi.org\/10.3390\/molecules30163335","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,11]]}}}