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Compared to traditional cyanation methods that involve harsh conditions and toxic reagents, nickel catalysis enables mild, efficient, and versatile transformations. This review systematically summarizes recent advances in this field, categorized by different cyanide sources, including metal cyanides (NaCN, KCN, Zn(CN)2, K4[Fe(CN)6]) and non-metal or organic cyanide sources (e.g., MeCN, nitriles, BrCN, CO2\/NH3). Key developments in catalyst systems, ligand design, mechanistic insights, and green chemistry aspects are highlighted. Remaining challenges and future directions are also discussed.<\/jats:p>","DOI":"10.3390\/molecules30163440","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T15:53:37Z","timestamp":1755705217000},"page":"3440","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Nickel-Catalyzed Cyanation of Aryl Halides"],"prefix":"10.3390","volume":"30","author":[{"given":"Zhenqiang","family":"Ma","sequence":"first","affiliation":[{"name":"Henan Province Key Laboratory of Environmentally Friendly Functional Materials, Institute of Chemistry, Henan Academy of Sciences, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuimeng","family":"Huo","sequence":"additional","affiliation":[{"name":"Henan Province Key Laboratory of Environmentally Friendly Functional Materials, Institute of Chemistry, Henan Academy of Sciences, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duo","family":"Zhou","sequence":"additional","affiliation":[{"name":"Henan Province Key Laboratory of Environmentally Friendly Functional Materials, Institute of Chemistry, Henan Academy of Sciences, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Henan Province Key Laboratory of Environmentally Friendly Functional Materials, Institute of Chemistry, Henan Academy of Sciences, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjun","family":"Kong","sequence":"additional","affiliation":[{"name":"Henan Province Key Laboratory of Environmentally Friendly Functional Materials, Institute of Chemistry, Henan Academy of Sciences, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenke","family":"Ren","sequence":"additional","affiliation":[{"name":"Henan Province Key Laboratory of Environmentally Friendly Functional Materials, Institute of Chemistry, Henan Academy of Sciences, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengbo","family":"Qu","sequence":"additional","affiliation":[{"name":"Henan Province Key Laboratory of Environmentally Friendly Functional Materials, Institute of Chemistry, Henan Academy of Sciences, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0156-3054","authenticated-orcid":false,"given":"Tingting","family":"Liu","sequence":"additional","affiliation":[{"name":"Henan Province Key Laboratory of Environmentally Friendly Functional Materials, Institute of Chemistry, Henan Academy of Sciences, Zhengzhou 450002, China"},{"name":"College of Chemistry, Zhengzhou University, Zhengzhou 450001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[{"name":"Henan Province Key Laboratory of Environmentally Friendly Functional Materials, Institute of Chemistry, Henan Academy of Sciences, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xilong","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan Province Key Laboratory of Environmentally Friendly Functional Materials, Institute of Chemistry, Henan Academy of Sciences, Zhengzhou 450002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,20]]},"reference":[{"key":"ref_1","unstructured":"Kleemann, A., and Engel, J. 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