{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:55:37Z","timestamp":1792706137967,"version":"4.5.0"},"reference-count":146,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The emergence of bacterial strains resistant to available antibiotics due to overprescription has prompted a search for alternative treatments. Among the most promising is baicalin, a flavonoid extracted from the roots of Scutellaria baicalensis. Roots, the primary natural source of baicalin, have been extensively explored using emerging extraction technologies such as ultrasonic-assisted extraction and supercritical fluid extraction. These methods offer significant advantages over traditional reflux extraction for baicalin preparation, including shorter extraction times, lower energy consumption, and improved environmental sustainability. Baicalin exhibits remarkable antibacterial activity in vitro and has demonstrated therapeutic efficacy against gastrointestinal infections, meningitis, pulmonary diseases, and sepsis, among other infectious disorders, in animal models. Documented mechanisms of action include disrupting the Escherichia coli membrane, downregulating quorum-sensing gene expression in Pseudomonas aeruginosa, and inhibiting host inflammatory pathways such as PI3K\/Akt\/NF-\u03baB. However, its clinical translation faces several bottlenecks, including reliance on animal experiment data, low bioavailability, and regulatory compliance issues. This review compares baicalin extraction yields from different natural sources, summarizes the advantages and disadvantages of various extraction technologies, analyzes possible mechanisms of action in treating different bacterial diseases, and discusses outstanding challenges and best strategies for expanded clinical use against bacterial infection. Our aim is to provide a valuable reference for future research and clinical applications.<\/jats:p>","DOI":"10.3390\/molecules30173464","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T15:57:47Z","timestamp":1755878267000},"page":"3464","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Baicalin: Natural Sources, Extraction Techniques, and Therapeutic Applications Against Bacterial Infections"],"prefix":"10.3390","volume":"30","author":[{"given":"Xin","family":"Meng","sequence":"first","affiliation":[{"name":"College of Life Science, Jilin Normal University, Siping 136000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Ning","sequence":"additional","affiliation":[{"name":"College of Life Science, Jilin Normal University, Siping 136000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengna","family":"Kang","sequence":"additional","affiliation":[{"name":"College of Life Science, Jilin Normal University, Siping 136000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuwen","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Life Science, Jilin Normal University, Siping 136000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9982-7303","authenticated-orcid":false,"given":"Zhiyun","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Life Science, Jilin Normal University, Siping 136000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyu","family":"Hao","sequence":"additional","affiliation":[{"name":"College of Food and Biology, Changchun Polytechnic, Changchun 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyong","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Life Science, Jilin Normal University, Siping 136000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"ref_1","unstructured":"Antimicrobial Resistance Collaborators (2022). Global burden of bacterial antimicrobial resistance in 2019: A systematic analysis. Lancet, 399, 629\u2013655."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/ejoc.201601264","article-title":"Convenient Synthesis of 3-Glycosylated Isocoumarins","volume":"2017","author":"Sudarshan","year":"2017","journal-title":"Eur. J. Org. Chem."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.ejmech.2016.08.066","article-title":"Inhibition of the enzymes in the leukotriene and prostaglandin pathways in inflammation by 3-aryl isocoumarins","volume":"124","author":"Ramanan","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Costine, B., Zhang, M., Chhajed, S., Pearson, B., Chen, S., and Nadakuduti, S.S. (2022). Exploring native Scutellaria species provides insight into differential accumulation of flavones with medicinal properties. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-17586-1"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Si, L., and Lai, Y. (2024). Pharmacological mechanisms by which baicalin ameliorates cardiovascular disease. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1415971"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1007\/s43450-021-00182-1","article-title":"Antiviral Properties of Baicalin: A Concise Review","volume":"31","author":"Li","year":"2021","journal-title":"Rev. Bras. Farmacogn."},{"key":"ref_7","first-page":"3623","article-title":"Preparation, pharmacokinetics and biodistribution of baicalin-loaded liposomes","volume":"9","author":"Wei","year":"2014","journal-title":"Int. J. Nanomed."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Li, N., Feng, L., Tan, Y., Xiang, Y., Zhang, R., and Yang, M. (2018). Preparation, Characterization, Pharmacokinetics and Biodistribution of Baicalin-Loaded Liposome on Cerebral Ischemia-Reperfusion after i.v. Administration in Rats. Molecules, 23.","DOI":"10.3390\/molecules23071747"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1007\/s00210-023-02704-1","article-title":"Baicalin and lung diseases","volume":"397","author":"Sharawi","year":"2024","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Wen, Y., Wang, Y., Zhao, C., Zhao, B., and Wang, J. (2023). The Pharmacological Efficacy of Baicalin in Inflammatory Diseases. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24119317"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Medina-Torres, N., Ayora-Talavera, T., Espinosa-Andrews, H., S\u00e1nchez-Contreras, A., and Pacheco, N. (2017). Ultrasound Assisted Extraction for the Recovery of Phenolic Compounds from Vegetable Sources. Agronomy, 7.","DOI":"10.3390\/agronomy7030047"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"23140","DOI":"10.1021\/acsomega.0c02898","article-title":"Extraction of Flavonoids from Scutellariae Radix using Ultrasound-Assisted Deep Eutectic Solvents and Evaluation of Their Anti-Inflammatory Activities","volume":"5","author":"Hao","year":"2020","journal-title":"ACS Omega"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Wang, H., Ma, X., Cheng, Q., Wang, L., and Zhang, L. (2018). Deep Eutectic Solvent-Based Ultrahigh Pressure Extraction of Baicalin from Scutellaria baicalensis Georgi. Molecules, 23.","DOI":"10.3390\/molecules23123233"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s13197-023-05863-4","article-title":"Valorization of pineapple rind for bromelain extraction using microwave assisted technique: Optimization, purification, and structural characterization","volume":"61","author":"Kaushal","year":"2024","journal-title":"J. Food Sci. Technol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1080\/10826068.2020.1808791","article-title":"Application of enzyme-assisted extraction of baicalin from Scutellaria baicalensis Georgi","volume":"51","author":"Ma","year":"2021","journal-title":"Prep. Biochem. Biotechnol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e0021022","DOI":"10.1128\/msphere.00210-22","article-title":"Role of RpoS in Regulating Stationary Phase Salmonella Typhimurium Pathogenesis-Related Stress Responses under Physiological Low Fluid Shear Force Conditions","volume":"7","author":"Crenshaw","year":"2022","journal-title":"mSphere"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13567-022-01088-z","article-title":"Baicalin acts as an adjuvant to potentiate the activity of azithromycin against Staphylococcus saprophyticus biofilm: An in vitro, in vivo, and molecular study","volume":"53","author":"Wang","year":"2022","journal-title":"Vet. Res."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Luo, J., Dong, B., Wang, K., Cai, S., Liu, T., Cheng, X., Lei, D., Chen, Y., Li, Y., and Kong, J. (2017). Baicalin inhibits biofilm formation, attenuates the quorum sensing-controlled virulence and enhances Pseudomonas aeruginosa clearance in a mouse peritoneal implant infection model. PLoS ONE., 12.","DOI":"10.1371\/journal.pone.0176883"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.3748\/wjg.v28.i26.3047","article-title":"Role of baicalin as a potential therapeutic agent in hepatobiliary and gastrointestinal disorders: A review","volume":"28","author":"Ganguly","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Zong, B., Xiao, Y., Ren, M., Wang, P., Fu, S., and Qiu, Y. (2023). Baicalin Weakens the Porcine ExPEC-Induced Inflammatory Response in 3D4\/21 Cells by Inhibiting the Expression of NF-\u03baB\/MAPK Signaling Pathways and Reducing NLRP3 Inflammasome Activation. Microorganisms, 11.","DOI":"10.3390\/microorganisms11082126"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"111530","DOI":"10.1016\/j.cellsig.2024.111530","article-title":"The mechanism of baicalin in improving pulmonary inflammatory response and injury and regulating intestinal flora in Mycoplasma pneumoniae pneumonia mice","volume":"126","author":"Song","year":"2025","journal-title":"Cell Signal."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Zeng, W., Cheng, N.M., Liang, X., Hu, H., Luo, F., Jin, J., and Li, Y.W. (2022). Electrospun polycaprolactone nanofibrous membranes loaded with baicalin for antibacterial wound dressing. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-13141-0"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3769","DOI":"10.2147\/IJN.S51578","article-title":"Nanoemulsion improves the oral bioavailability of baicalin in rats: In vitro and in vivo evaluation","volume":"8","author":"Zhao","year":"2013","journal-title":"Int. J. Nanomed."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e2410951","DOI":"10.1002\/advs.202410951","article-title":"A Baicalin-Based Functional Polymer in Dynamic Reversible Networks Alleviates Osteoarthritis by Cellular Interactions","volume":"12","author":"Yang","year":"2025","journal-title":"Adv. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Chen, N., Sun, H., Wang, M.X., Chen, M., Guo, X., Ren, Q.D., Han, Q.Q., Chen, Y.Y., Liu, C., and Li, N.Y. (2025). Baicalin-loaded peony seed polypeptide nanoparticles via a pH-driven method: Characterization, release kinetics, and in vitro anti-inflammatory effects. Int. J. Biol. Macromol., 310.","DOI":"10.1016\/j.ijbiomac.2025.142958"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"9715","DOI":"10.1016\/j.biortech.2010.07.083","article-title":"Molecular cloning and characterization of phenylalanine ammonia-lyase, cinnamate 4-hydroxylase and genes involved in flavone biosynthesis in Scutellaria baicalensis","volume":"101","author":"Xu","year":"2010","journal-title":"Bioresour. Technol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e1501780","DOI":"10.1126\/sciadv.1501780","article-title":"A specialized flavone biosynthetic pathway has evolved in the medicinal plant, Scutellaria baicalensis","volume":"2","author":"Zhao","year":"2016","journal-title":"Sci. Adv."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/j.sjbs.2016.08.011","article-title":"Molecular characterization of flavonoid biosynthetic genes and accumulation of baicalin, baicalein, and wogonin in plant and hairy root of Scutellaria lateriflora","volume":"25","author":"Tuan","year":"2018","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1002\/jssc.201401298","article-title":"Rapid extraction and analysis method for the simultaneous determination of 21 bioflavonoids in Siegesbeckia pubescens Makino","volume":"38","author":"Yao","year":"2015","journal-title":"J. Sep. Sci."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.indcrop.2014.09.034","article-title":"Phenolic profile and anti-inflammatory activity of three Veronica species","volume":"63","author":"Beara","year":"2015","journal-title":"Ind. Crops Prod."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Sithisarn, P., Rojsanga, P., and Sithisarn, P. (2021). Flavone-Rich Fractions and Extracts from Oroxylum indicum and Their Antibacterial Activities against Clinically Isolated Zoonotic Bacteria and Free Radical Scavenging Effects. Molecules, 26.","DOI":"10.3390\/molecules26061773"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1007\/s11306-010-0269-9","article-title":"Comparative analysis of bioactive phytochemicals from Scutellaria baicalensis, Scutellaria lateriflora, Scutellaria racemosa, Scutellaria tomentosa and Scutellaria wrightii by LC-DADMS","volume":"7","author":"Downey","year":"2011","journal-title":"Metabolomics"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2068834","DOI":"10.1080\/15592324.2022.2068834","article-title":"The cultivable endophytic fungal community of Scutellaria baicalensis: Diversity and relevance to flavonoid production by the host","volume":"17","author":"Cui","year":"2022","journal-title":"Plant Signal Behav."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Yeo, H.J., Park, C.H., Park, S.Y., Chung, S.O., Kim, J.K., and Park, S.U. (2021). Metabolic Analysis of Root, Stem, and Leaf of Scutellaria baicalensis Plantlets Treated with Different LED Lights. Plants, 10.","DOI":"10.3390\/plants10050940"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e2300712","DOI":"10.1002\/jssc.202300712","article-title":"Comparison of different extraction methods of active ingredients of Chinese medicine and natural products","volume":"47","author":"Li","year":"2024","journal-title":"J. Sep. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1080\/00032719.2014.979360","article-title":"Optimization of Extraction Conditions for Flavonoid Composition and Antioxidant Activity of Radix Scutellariae","volume":"48","author":"Li","year":"2015","journal-title":"Anal. Lett."},{"key":"ref_37","first-page":"1089","article-title":"Defatting technique for two ground spices using simple reflux apparatus: Collaborative study","volume":"65","author":"Dent","year":"1982","journal-title":"J. Assoc. Off. Anal. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1615\/IntJMedMushrooms.2021041447","article-title":"Green Synthesis of Mycometabolites: A Review on Aqueous Extraction and Bioactivities","volume":"23","author":"Adeeyo","year":"2021","journal-title":"Int. J. Med. Mushrooms"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Li, J.C., Wang, R., Sheng, Z.L., Wu, Z.Y., Chen, C.L., and Ishfaq, M. (2019). Optimization of Baicalin, Wogonoside, and Chlorogenic Acid Water Extraction Process from the Roots of Scutellariae Radix and Lonicerae japonicae Flos Using Response Surface Methodology (RSM). Processes, 7.","DOI":"10.3390\/pr7110854"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.bjp.2018.02.001","article-title":"Optimization of baicalin water extraction process from Scutellaria baicalensis (a traditional Chinese medicine) by using orthogonal test and HPLC","volume":"28","author":"Ni","year":"2018","journal-title":"Rev. Bras. Farmacogn."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1002\/tox.24154","article-title":"An alleviative effect of Lonicerae japonicae flos water extract against liver fibrogenesis in vitro and in vivo","volume":"39","author":"Lin","year":"2024","journal-title":"Environ. Toxicol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"116150","DOI":"10.1016\/j.jenvman.2022.116150","article-title":"Valorization of distillery stillage by polyphenol recovery using microwave-assisted, ultrasound-assisted and conventional extractions","volume":"322","author":"Mikucka","year":"2022","journal-title":"J. Environ. Manage."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"106646","DOI":"10.1016\/j.ultsonch.2023.106646","article-title":"A comprehensive review of ultrasonic assisted extraction (UAE) for bioactive components: Principles, advantages, equipment, and combined technologies","volume":"101","author":"Shen","year":"2023","journal-title":"Ultrason. Sonochem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"118555","DOI":"10.1016\/j.indcrop.2024.118555","article-title":"Optimization of extraction, separation and purification of baicalin in Scutellaria baicalensis using response surface methodology","volume":"214","author":"Liu","year":"2024","journal-title":"Ind. Crops Prod."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ultsonch.2014.06.010","article-title":"Changes of gallic acid mediated by ultrasound in a model extraction solution","volume":"22","author":"Zhang","year":"2015","journal-title":"Ultrason. Sonochem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e12904","DOI":"10.1111\/jfpe.12904","article-title":"Investigation of (+)-catechin stability under ultrasonic treatment and its degradation kinetic modeling","volume":"41","author":"Zhu","year":"2018","journal-title":"J. Food Process Eng."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1007\/s11694-020-00464-7","article-title":"Recovery and analysis of phenolic extracts from Oudemansiella radicata using ultrasonic-assisted extraction","volume":"14","author":"Zhang","year":"2020","journal-title":"J. Food Meas. Charact."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Fang, X., Gu, S., Jin, Z., Hao, M., Yin, Z., and Wang, J. (2018). Optimization of Ultrasonic-Assisted Simultaneous Extraction of Three Active Compounds from the Fruits of Forsythia suspensa and Comparison with Conventional Extraction Methods. Molecules, 23.","DOI":"10.3390\/molecules23092115"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Yeom, S., Gam, D.H., Kim, J.H., and Kim, J.W. (2022). Development of Ultrasound-Assisted Extraction to Produce Skin-Whitening and Anti-Wrinkle Substances from Safflower Seed. Molecules, 27.","DOI":"10.3390\/molecules27041296"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"103593","DOI":"10.1016\/j.ifset.2024.103593","article-title":"Recent research and prospects of non-thermal physical technologies in green and high-efficient extraction of natural pigments: A review","volume":"92","author":"Zhang","year":"2024","journal-title":"Innov. Food Sci. Emerg."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"135271","DOI":"10.1016\/j.foodchem.2022.135271","article-title":"Effect of ultra-high pressure pretreatment on the phenolic profiles, antioxidative activity and cytoprotective capacity of different phenolic fractions from Que Zui tea","volume":"409","author":"Wang","year":"2023","journal-title":"Food Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"13474","DOI":"10.1039\/D2CP00084A","article-title":"Current understanding and insights towards protein stabilization and activation in deep eutectic solvents as sustainable solvent media","volume":"24","author":"Yadav","year":"2022","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jpba.2005.10.043","article-title":"Ginsenoside extraction from Panax quinquefolium L. (American ginseng) root by using ultrahigh pressure","volume":"41","author":"Zhang","year":"2006","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1080\/10408347.2019.1686966","article-title":"Recent Advances in Microwave Assisted Extraction of Bioactive Compounds from Complex Herbal Samples: A Review","volume":"51","author":"Bagade","year":"2021","journal-title":"Crit. Rev. Anal. Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"133772","DOI":"10.1016\/j.jclepro.2022.133772","article-title":"Separation of essential oil from fresh leaves of Phellodendron amurense rupr. By solvent-free microwave-assisted distillation with the addition of lithium salts","volume":"372","author":"Peng","year":"2022","journal-title":"J. Clean. Prod."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Jie, X., Wu, J.J., Qi, J., Li, J., Liu, Y.J., Miao, Z.K., Qiu, G.F., and Jia, W.K. (2021). Microwave-assisted Extraction of Flavonoids from Phyllostachys heterocycla Leaves: Optimization, Mechanism, and Antioxidant Activity in vitro. BioResources, 16.","DOI":"10.15376\/biores.16.4.8060-8081"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"4299","DOI":"10.1007\/s13197-020-04433-2","article-title":"Recent advances and comparisons of conventional and alternative extraction techniques of phenolic compounds","volume":"57","year":"2020","journal-title":"J. Food Sci. Technol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"30467","DOI":"10.1007\/s13399-023-04848-9","article-title":"Zanthoxylum alatum fruits: Process optimization for tambulin-rich valuable phyto-compounds, antifungal action coupled with molecular modeling analysis","volume":"14","author":"Kumar","year":"2024","journal-title":"Biomass Convers. Biorefin."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"022024","DOI":"10.1088\/1757-899X\/736\/2\/022024","article-title":"Determination of phenolics and saponins in fenugreek seed extracted via microwave-assisted extraction method at the optimal condition","volume":"736","author":"Akbari","year":"2020","journal-title":"IOP Conf. Ser. Mater. Sci. Eng."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S1383-5866(02)00043-6","article-title":"Microwave-assisted extraction of artemisinin from Artemisia annua L.","volume":"28","author":"Hao","year":"2002","journal-title":"Sep. Purif. Technol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1039\/D3GC04501C","article-title":"Advancements and applications of microwave-assisted deep eutectic solvent (MW-DES) lignin extraction: A comprehensive review","volume":"26","author":"Zou","year":"2024","journal-title":"Green Chem."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Saifullah, M., Akanbi, T.O., McCullum, R., and Vuong, Q.V. (2021). Optimization of Commercial Microwave Assisted-Extraction Conditions for Recovery of Phenolics from Lemon-Scented Tee Tree (Leptospermum petersonii) and Comparison with Other Extraction Techniques. Foods, 11.","DOI":"10.3390\/foods11010050"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Stanek-Wandzel, N., Krzyszowska, A., Zar\u0119bska, M., G\u0119bura, K., Wasilewski, T., Hordyjewicz-Baran, Z., and Tomaka, M. (2024). Evaluation of Cellulase, Pectinase, and Hemicellulase Effectiveness in Extraction of Phenolic Compounds from Grape Pomace. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252413538"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Zhang, X.G., Lu, Y., Wang, W.N., Liu, Z.Y., Liu, J.W., and Chen, X.Q. (2017). A novel enzyme-assisted approach for efficient extraction of Z-ligustilide from Angelica sinensis plants. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-10004-x"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.ijbiomac.2021.09.060","article-title":"Integrated strategies for enzyme assisted extraction of bioactive molecules: A review","volume":"191","author":"Das","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/S1473-3099(18)30475-4","article-title":"Morbidity and mortality due to shigella and enterotoxigenic Escherichia coli diarrhoea: The Global Burden of Disease Study 1990\u20132016","volume":"18","author":"Khalil","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1007\/s00204-021-03213-x","article-title":"Impaired intestinal stem cell activity in ETEC infection: Enterotoxins, cyclic nucleotides, and Wnt signaling","volume":"96","author":"Ren","year":"2022","journal-title":"Arch. Toxicol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Wu, Z., Liu, H., and Wang, X. (2024). Advancements in understanding bacterial enteritis pathogenesis through organoids. Mol. Biol. Rep., 51.","DOI":"10.1007\/s11033-024-09495-5"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1128\/IAI.00639-16","article-title":"Intestinal Enteroids Model Guanylate Cyclase C-Dependent Secretion Induced by Heat-Stable Enterotoxins","volume":"84","author":"Pattison","year":"2016","journal-title":"Infect. Immun."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Gao, J., Yin, J., Xu, K., Li, T., and Yin, Y. (2019). What is the impact of diet on nutritional diarrhea associated with gut microbiota in weaning piglets: A System Review. BioMed Res. Int., 2019.","DOI":"10.1155\/2019\/6916189"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Zhang, S., Luo, C., Li, K., Wang, J., Wang, H., Zhong, R., Chen, L., Ma, Q., and Zhang, H. (2024). Baicalin alleviates intestinal inflammation and microbial disturbances by regulating Th17\/Treg balance and enhancing Lactobacillus colonization in piglets. J. Anim. Sci. Biotechnol., 15.","DOI":"10.1186\/s40104-024-01126-0"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"13079","DOI":"10.1002\/slct.201902739","article-title":"Synthesis, characterization of a baicalin-strontium(II) complex and its BSA-binding activity","volume":"4","author":"Yang","year":"2019","journal-title":"ChemistrySelect"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e33038","DOI":"10.1016\/j.heliyon.2024.e33038","article-title":"Baicalin-aluminum complex on the regulation of IPEC-1 infected with enterotoxigenic Escherichia coli","volume":"10","author":"Ye","year":"2024","journal-title":"Heliyon"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"484","DOI":"10.15585\/mmwr.mm7218a2","article-title":"Salmonella outbreaks associated with not Ready-to-Eat breaded, stuffed chicken products-United States, 1998\u20132022","volume":"72","author":"Ford","year":"2023","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"100432","DOI":"10.1016\/j.hermed.2021.100432","article-title":"Baicalin, a natural antimicrobial and anti-biofilm agent","volume":"27","author":"Ozma","year":"2021","journal-title":"J. Herb. Med."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Farhadi, K., Rajabi, E., Varpaei, H.A., Iranzadasl, M., Khodaparast, S., and Salehi, M. (2024). Thymol and carvacrol against Klebsiella: Anti-bacterial, anti-biofilm, and synergistic activities\u2014A systematic review. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1487083"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"114458","DOI":"10.1016\/j.foodres.2024.114458","article-title":"Prophylactic efficacy of baicalin and carvacrol against Salmonella Typhimurium biofilm on food and food contact surfaces","volume":"187","author":"Ashrafudoulla","year":"2024","journal-title":"Food Res. Int."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"102346","DOI":"10.1016\/j.psj.2022.102346","article-title":"Synergistic antibacterial activity of baicalin and EDTA in combination with colistin against colistin-resistant Salmonella","volume":"102","author":"Cui","year":"2023","journal-title":"Poult. Sci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1968258","DOI":"10.1080\/19490976.2021.1968258","article-title":"IL-27 induces LL-37\/CRAMP expression from intestinal epithelial cells: Implications for immunotherapy of Clostridioides difficile infection","volume":"13","author":"Xu","year":"2021","journal-title":"Gut Microbes"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2052698","DOI":"10.1080\/19490976.2022.2052698","article-title":"The development of live biotherapeutics against Clostridioides difficile infection towards reconstituting gut microbiota","volume":"14","author":"Zhang","year":"2022","journal-title":"Gut Microbes"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1093\/cid\/ciae259","article-title":"Influence of antibiotic exposure intensity on the risk of clostridioides difficile Infection","volume":"79","author":"Ray","year":"2024","journal-title":"Clin. Infect. Dis."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1002\/prot.26770","article-title":"MuGger toxins: Exploring the selective binding mechanism of clostridial glucosyltransferase toxin B and Host GTPases","volume":"93","author":"Camli","year":"2025","journal-title":"Proteins"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Castro-Cordova, P., Lopez-Garcia, O.K., Orozco, J., Montes-Bravo, N., Gil, F., Pizarro-Guajardo, M., and Paredes-Sabja, D. (2025). Clostridioides difficile major toxins remodel the intestinal epithelia, affecting spore adherence\/internalization into intestinal tissue and their association with gut vitronectin. bioRxiv.","DOI":"10.1101\/2025.01.29.635439"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Law, S.K.K., and Tan, H.S. (2022). The role of quorum sensing, biofilm formation, and iron acquisition as key virulence mechanisms in Acinetobacter baumannii and the corresponding anti-virulence strategies. Microbiol. Res., 260.","DOI":"10.1016\/j.micres.2022.127032"},{"key":"ref_85","first-page":"05557","article-title":"Baicalin promotes appetite by regulating gut microbiome and immunity?","volume":"105","author":"Shunfen","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1099\/jmm.0.001179","article-title":"In vitro antivirulence activity of baicalin against Clostridioides difficile","volume":"69","author":"Pellissery","year":"2020","journal-title":"J. Med. Microbio."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Pellissery, A.J., Vinayamohan, P.G., Kuttappan, D.A., Mishra, N., Fragomeni, B.O., Maas, K., Mooyottu, S., and Venkitanarayanan, K. (2021). Protective effect of baicalin against Clostridioides difficile infection in mice. Antibiotics, 10.","DOI":"10.3390\/antibiotics10080926"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.3748\/wjg.v30.i41.4449","article-title":"Amino acid deletions at positions 893 and 894 of cytotoxin-associated gene A protein affect Helicobacter pylori gastric epithelial cell interactions","volume":"30","author":"Xue","year":"2024","journal-title":"World J. Gastroenterol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00784-025-06160-4","article-title":"Co-culture of Helicobacter pylori with oral microorganisms in human saliva","volume":"29","author":"Scholz","year":"2025","journal-title":"Clin. Oral. Investig."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e01168-17","DOI":"10.1128\/mBio.01168-17","article-title":"TIFA signaling in gastric epithelial Cells initiates the cag type 4 secretion system-dependent innate immune response to Helicobacter pylori Infection","volume":"8","author":"Gall","year":"2017","journal-title":"mBio"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1111\/j.1462-5822.2008.01156.x","article-title":"Role of type IV secretion in Helicobacter pylori pathogenesis","volume":"10","author":"Backert","year":"2008","journal-title":"Cell Microbiol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.chom.2008.11.010","article-title":"Helicobacter pylori CagA phosphorylation-independent function in epithelial proliferation and inflammation","volume":"5","author":"Suzuki","year":"2009","journal-title":"Cell Host Microbe"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1186\/s12935-024-03598-6","article-title":"Intestinal metaplasia key molecules and UPP1 activation via Helicobacter pylori\/NF-kB: Drivers of malignant progression in gastric cancer","volume":"24","author":"Chen","year":"2024","journal-title":"Cancer Cell Int."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Elbehiry, A., Abalkhail, A., Anajirih, N., Alkhamisi, F., Aldamegh, M., Alramzi, A., AlShaqi, R., Alotaibi, N., Aljuaid, A., and Alzahrani, H. (2024). Helicobacter pylori: Routes of infection, antimicrobial resistance, and alternative therapies as a means to develop infection control. Diseases, 12.","DOI":"10.3390\/diseases12120311"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Fiorani, M., Tohumcu, E., Del Vecchio, L.E., Porcari, S., Cammarota, G., Gasbarrini, A., and Ianiro, G. (2023). The Influence of helicobacter pylori on human gastric and gut microbiota. Antibiotics, 12.","DOI":"10.3390\/antibiotics12040765"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Dmitrieva, A., Kozlova, O., Atuchin, V., Milentieva, I., Vesnina, A., Ivanova, S., Asyakina, L., and Prosekov, A. (2023). Study of the effect of baicalin from Scutellaria baicalensis on the gastrointestinal tract normoflora and Helicobacter pylori. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241511906"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1111\/1750-3841.14372","article-title":"Baicalin, baicalein, and Lactobacillus Rhamnosus JB3 alleviated Helicobacter pylori Infections in vitro and in vivo","volume":"83","author":"Chen","year":"2018","journal-title":"J. Food Sci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s12098-007-0062-6","article-title":"Predictors of long term neurological outcome in bacterial meningitis","volume":"74","author":"Singhi","year":"2007","journal-title":"Indian. J. Pediatr."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00401-015-1531-z","article-title":"Host-pathogen interactions in bacterial meningitis","volume":"131","author":"Doran","year":"2016","journal-title":"Acta Neuropathol."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Yang, R., Wang, J., Wang, F., Zhang, H., Tan, C., Chen, H., and Wang, X. (2023). Blood-Brain barrier integrity damage in bacterial meningitis: The underlying link, mechanisms, and therapeutic targets. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032852"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1097\/WCO.0000000000000934","article-title":"Acute bacterial meningitis","volume":"34","author":"Wall","year":"2021","journal-title":"Curr. Opin. Neurol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.intimp.2017.05.039","article-title":"Chronic dexamethasone treatment results in hippocampal neurons injury due to activate NLRP1 inflammasome in vitro","volume":"49","author":"Zhang","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Jeong, D., Ko, W.K., Kim, S.J., Han, G.H., Lee, D., Sheen, S.H., and Sohn, S. (2021). Lobeglitazone exerts anti-inflammatory effect in lipopolysaccharide-induced bone-marrow derived macrophages. Biomedicines, 9.","DOI":"10.3390\/biomedicines9101432"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"An, H.J., Lee, J.Y., and Park, W. (2022). Baicalin modulates inflammatory response of macrophages activated by LPS via calcium-CHOP pathway. Cells, 11.","DOI":"10.3390\/cells11193076"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s10753-009-9172-9","article-title":"Multiple therapeutic effects of adjunctive baicalin therapy in experimental bacterial meningitis","volume":"33","author":"Tang","year":"2010","journal-title":"Inflammation"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1016\/S2214-109X(18)30408-X","article-title":"Global, regional, and national estimates of pneumonia morbidity and mortality in children younger than 5 years between 2000 and 2015: A systematic analysis","volume":"7","author":"McAllister","year":"2019","journal-title":"Lancet Glob. Health"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.2147\/COPD.S107409","article-title":"Elevated circulating PAI-1 levels are related to lung function decline, systemic inflammation, and small airway obstruction in chronic obstructive pulmonary disease","volume":"11","author":"Wang","year":"2016","journal-title":"Int. J. Chron. Obs. Pulmon Dis."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"102061","DOI":"10.1016\/j.pupt.2021.102061","article-title":"Baicalin ameliorates cigarette smoke-induced airway inflammation in rats by modulating HDAC2\/NF-\u03baB\/PAI-1 signalling","volume":"70","author":"Zhang","year":"2021","journal-title":"Pulm. Pharmacol. Ther."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1128\/AAC.00045-11","article-title":"Quorum sensing inhibitors increase the susceptibility of bacterial biofilms to antibiotics in vitro and in vivo","volume":"55","author":"Brackman","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.ajpath.2021.02.019","article-title":"Gut-Lung Dysbiosis Accompanied by Diabetes Mellitus Leads to Pulmonary Fibrotic Change through the NF-\u03baB Signaling Pathway","volume":"191","author":"Wang","year":"2021","journal-title":"Am. J. Pathol."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Zhang, Q., Sun, J., Wang, Y., He, W., Wang, L., Zheng, Y., Wu, J., Zhang, Y., and Jiang, X. (2017). Antimycobacterial and Anti-inflammatory Mechanisms of Baicalin via Induced Autophagy in Macrophages Infected with Mycobacterium tuberculosis. Front. Microbiol., 8.","DOI":"10.3389\/fmicb.2017.02142"},{"key":"ref_112","first-page":"1805147","article-title":"Inhibition of the PERK\/TXNIP\/NLRP3 Axis by Baicalin Reduces NLRP3 Inflammasome-Mediated Pyroptosis in Macrophages Infected with Mycobacterium tuberculosis","volume":"8","author":"Fu","year":"2021","journal-title":"Mediat. Inflamm."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.tim.2024.07.001","article-title":"Toll-like receptor 4-a multifunctional virus recognition receptor","volume":"33","author":"Blanchet","year":"2025","journal-title":"Trends Microbiol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"110267","DOI":"10.1016\/j.vetimm.2021.110267","article-title":"Lipopolysaccharide (LPS) induced inflammatory changes to differentially expressed miRNAs of the host inflammatory response","volume":"237","author":"Swain","year":"2021","journal-title":"Vet. Immunol. Immunopathol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1165\/rcmb.2023-0009OC","article-title":"Calpain Promotes LPS-induced Lung Endothelial Barrier Dysfunction via Cleavage of Talin","volume":"69","author":"Song","year":"2023","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1142\/S0192415X08005783","article-title":"Therapeutic effects of baicalin on lipopolysaccharide-induced acute lung injury in rats","volume":"36","author":"Huang","year":"2008","journal-title":"Am. J. Chin. Med."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3892\/ijmm.2016.2456","article-title":"Baicalin exerts protective effects against lipopolysaccharide-induced acute lung injury by regulating the crosstalk between the CX3CL1-CX3CR1 axis and NF-\u03baB pathway in CX3CL1-knockout mice","volume":"37","author":"Ding","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1177\/17534259211013887","article-title":"Baicalin attenuates LPS-induced alveolar type II epithelial cell A549 injury by attenuation of the FSTL1 signaling pathway via increasing miR-200b-3p expression","volume":"27","author":"Duan","year":"2021","journal-title":"Innate Immun."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1007\/s00210-019-01680-9","article-title":"Baicalin ameliorates lipopolysaccharide-induced acute lung injury in mice by suppressing oxidative stress and inflammation via the activation of the Nrf2-mediated HO-1 signaling pathway","volume":"392","author":"Meng","year":"2019","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3892\/mmr.2021.12210","article-title":"Baicalin relieves Mycoplasma pneumoniae infection-induced lung injury through regulating microRNA-221 to inhibit the TLR4\/NF-\u03baB signaling pathway","volume":"24","author":"Zhang","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"e29530","DOI":"10.1016\/j.heliyon.2024.e29530","article-title":"Clinical image of sepsis-associated encephalopathy midst E. coli urosepsis: Emergency department database study","volume":"10","author":"Wityk","year":"2024","journal-title":"Heliyon"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Kal\u0131n, G., Alp, E., Chouaikhi, A., and Roger, C. (2023). Antimicrobial Multidrug Resistance: Clinical Implications for Infection Management in Critically Ill Patients. Microorganisms, 11.","DOI":"10.3390\/microorganisms11102575"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"113966","DOI":"10.1016\/j.intimp.2024.113966","article-title":"Sesamol hinders the proliferation of intracellular bacteria by promoting fatty acid metabolism and decreasing excessive inflammation","volume":"146","author":"Jiang","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1002\/JLB.2MIR0917-377R","article-title":"A novel role for coinhibitory receptors\/checkpoint proteins in the immunopathology of sepsis","volume":"2","author":"Fallon","year":"2018","journal-title":"J. Leukoc. Biol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1002\/JLB.3AB0820-576RRR","article-title":"Baicalin protects mice from infection with methicillin-resistant Staphylococcus aureus via alleviating inflammatory response","volume":"108","author":"Shi","year":"2020","journal-title":"J. Leukoc. Biol."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Zhu, J., Wang, J., Sheng, Y., Zou, Y., Bo, L., Wang, F., Lou, J., Fan, X., Bao, R., and Wu, Y. (2012). Baicalin improves survival in a murine model of polymicrobial sepsis via suppressing inflammatory response and lymphocyte apoptosis. PLoS ONE., 7.","DOI":"10.1371\/journal.pone.0035523"},{"key":"ref_127","first-page":"258","article-title":"Combination effects of baicalin with linezolid against Staphylococcus aureus biofilm-related infections: In vivo animal model","volume":"46","author":"Du","year":"2023","journal-title":"New Microbiol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1089\/fpd.2024.0074","article-title":"The Antibacterial Activities and Effects of Baicalin on Ampicillin Resistance of MRSA and Stenotrophomonas maltophilia","volume":"22","author":"Chen","year":"2025","journal-title":"Foodborne Pathog. Dis."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Liu, S., Liu, B., Luo, Z.Q., Qiu, J., Zhou, X., Li, G., Zhang, B., Deng, X., Yang, Z., and Wang, J. (2017). The combination of osthole with baicalin protects mice from Staphylococcus aureus pneumonia. World J. Microbiol. Biotechnol., 33.","DOI":"10.1007\/s11274-016-2162-9"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Cheng, P., Sun, Y., Wang, B., Liang, S., Yang, Y., Gui, S., Zhang, K., Qu, S., and Li, L. (2024). Mechanism of synergistic action of colistin with resveratrol and baicalin against mcr-1-positive Escherichia coli. Biomed. Pharmacother., 180.","DOI":"10.1016\/j.biopha.2024.117487"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s10020-021-00309-z","article-title":"Baicalin alleviates chronic obstructive pulmonary disease through regulation of HSP72-mediated JNK pathway","volume":"27","author":"Hao","year":"2021","journal-title":"Mol. Med."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbrc.2022.10.061","article-title":"Baicalin regulates TLR4\/I\u03baB\u03b1\/NF\u03baB signaling pathway to alleviate inflammation in Doxorubicin related cardiotoxicity","volume":"637","author":"Feng","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jep.2017.07.013","article-title":"Regulatory effect of baicalin on the imbalance of Th17\/Treg responses in mice with allergic asthma","volume":"208","author":"Xu","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13020-025-01110-4","article-title":"Baicalin mitigates alcoholic-associated liver disease via SOCS1-driven reprogramming of macrophages","volume":"20","author":"Huang","year":"2025","journal-title":"Chin. Med."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s10549-020-05904-y","article-title":"Bone-protective and anti-tumor effect of baicalin in osteotropic breast cancer via induction of apoptosis","volume":"184","author":"Wang","year":"2020","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s12640-016-9611-y","article-title":"Baicalin Attenuates Ketamine-Induced Neurotoxicity in the Developing Rats: Involvement of PI3K\/Akt and CREB\/BDNF\/Bcl-2 Pathways","volume":"30","author":"Zuo","year":"2016","journal-title":"Neurotox. Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2017.08.003","article-title":"High doses of baicalin induces kidney injury and fibrosis through regulating TGF-\u03b2\/Smad signaling pathway","volume":"333","author":"Cai","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jconrel.2021.11.031","article-title":"Advanced approaches for improving bioavailability and controlled release of anthocyanins","volume":"341","author":"Shen","year":"2022","journal-title":"J. Control. Release"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/0006-291X(91)91647-U","article-title":"Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells","volume":"175","author":"Artursson","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.apsb.2014.03.002","article-title":"Combined use of phospholipid complexes and self-emulsifying microemulsions for improving the oral absorption of a BCS class IV compound, baicalin","volume":"4","author":"Wu","year":"2014","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Meher, M.K., Unnikrishnan, B.S., Tripathi, D.K., Packirisamy, G., and Poluri, K.M. (2023). Baicalin functionalized PEI-heparin carbon dots as cancer theranostic agent. Int. J. Biol. Macromol., 253.","DOI":"10.1016\/j.ijbiomac.2023.126846"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"117231","DOI":"10.1016\/j.taap.2025.117231","article-title":"Baicalin nanoemulsion mitigates cisplatin-induced hepatotoxicity by alleviating oxidative stress, inflammation, and restoring cellular integrity","volume":"495","author":"Farouk","year":"2025","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"165054","DOI":"10.1016\/j.cej.2025.165054","article-title":"Synergistic treatment of respiratory syncytial virus induced pneumonia by multifunctional Baicalin-Resveratrol self-assembled nanomedicine","volume":"519","author":"Chang","year":"2025","journal-title":"Chem. Eng. J."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"3816","DOI":"10.3382\/ps\/pey255","article-title":"Inhibition mechanisms of baicalin and its phospholipid complex against DHAV-1 replication","volume":"97","author":"Chen","year":"2018","journal-title":"Poult. Sci."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"847","DOI":"10.2174\/1389201022666210729142257","article-title":"Scutellaria baicalensis Extract-phospholipid Complex: Preparation and Initial Pharmacodynamics Research in Rats","volume":"23","author":"Chen","year":"2022","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Li, Z., Han, J., Yan, S., Lei, J., Meng, L., Tian, C., and Wu, Y. (2024). Carboxymethyl chitosan-modified folate-targeted carbon nanotubes-baicalin complexes for cancer progression and metastasis. Int. J. Biol. Macromol., 282.","DOI":"10.1016\/j.ijbiomac.2024.136896"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/17\/3464\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:34:13Z","timestamp":1760034853000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/17\/3464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,22]]},"references-count":146,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["molecules30173464"],"URL":"https:\/\/doi.org\/10.3390\/molecules30173464","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,22]]}}}