{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:58:43Z","timestamp":1787029123522,"version":"build-2736575974"},"reference-count":201,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>This study presents a general overview of the important problem of pharmaceutical pollutants, aiming to draw attention to the global danger they represent and the need for concrete solutions for their remediation. Here, we summarize the available advanced knowledge on the occurrence and fate of pharmaceutical residues in the environment, particularly in water effluents, since they need a special approach when one takes into account the increasing consumption of medicines by both humans and animals, that might be discharged in aqueous systems and bio-accumulated in aquatic flora and fauna. This review details the presence of pharmaceutical wastes in water sources; their trajectories from production to consumption and release in household taps; their concentrations in natural water; methods for monitoring them; their risks; and their worldwide impacts. Adequate methods and advanced removal techniques for selected contaminants or classes of pharmaceutical compounds are discussed, together with their remediation potential and strategies. Local and global limiting proposals for these types of contaminants and concrete solutions for their remediation are recommended.<\/jats:p>","DOI":"10.3390\/molecules30173483","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T06:26:14Z","timestamp":1756189574000},"page":"3483","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["An Integrative Approach to Hazardous Effects Caused by Pharmaceutical Contaminants on Aquatic Effluents"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8471-1122","authenticated-orcid":false,"given":"Irina","family":"Meghea","sequence":"first","affiliation":[{"name":"Department of Mathematical Methods and Models, Faculty of Applied Sciences, National University of Science and Technology POLITEHNICA Bucharest, 313 Splaiul Independentei, 060042 Bucharest, Romania"},{"name":"Research Centre for Environmental Protection and Eco-Friendly Technologies, National University of Science and Technology POLITEHNICA Bucharest, 1 Polizu Street, 011061 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9787-194X","authenticated-orcid":false,"given":"Daniela Simina","family":"Stefan","sequence":"additional","affiliation":[{"name":"Department of Inorganic Technology, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, 1 Polizu Street, 011061 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florina","family":"Ioni\u0163\u0103","sequence":"additional","affiliation":[{"name":"Department of Inorganic Technology, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, 1 Polizu Street, 011061 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai","family":"Lesnic","sequence":"additional","affiliation":[{"name":"Research Centre for Environmental Protection and Eco-Friendly Technologies, National University of Science and Technology POLITEHNICA Bucharest, 1 Polizu Street, 011061 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1570-564X","authenticated-orcid":false,"given":"Ana-Maria","family":"Manea-Saghin","sequence":"additional","affiliation":[{"name":"Research Centre for Environmental Protection and Eco-Friendly Technologies, National University of Science and Technology POLITEHNICA Bucharest, 1 Polizu Street, 011061 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"ref_1","unstructured":"WHO (2012). 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