{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:08:24Z","timestamp":1780358904207,"version":"3.54.1"},"reference-count":68,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The demand for antimicrobial and biocompatible materials in biomedical applications continues to grow, particularly in the context of wound care and textiles. This study explores the development of multifunctional coatings by applying magnesium (Mg) nanoparticles onto medical-grade cotton textiles using magnetron sputtering\u2014a solvent-free and environmentally sustainable technique. A comprehensive material characterization confirmed the formation of Mg, MgO and Mg(OH)2\/MgH2 phases, along with generally consistent particle coverage and increased fiber surface roughness. The antibacterial testing revealed the effective inhibition of both Gram-positive and Gram-negative bacteria\u2014except Enterococcus faecalis. Additionally, the growth of the fungus Candida albicans and the microalgae Prototheca spp. was reduced by over 80%. Importantly, a cytocompatibility evaluation using human umbilical vein endothelial cells (HUVECs) demonstrated not only non-toxicity but a significant increase in cell viability after 72 h, particularly in samples treated for 20 and 60 min, indicating a potential cytoprotective and proliferative effect. These findings highlight the dual functionality of plasma-sputtered Mg nanoparticle coatings, offering a promising strategy for the development of eco-friendly, antimicrobial and cell-supportive medical textiles.<\/jats:p>","DOI":"10.3390\/molecules30173526","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T08:01:01Z","timestamp":1756454461000},"page":"3526","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Towards Safe and Effective Biomedical Nanocoatings: Plasma-Sputtered Magnesium-Based Nanoparticles with Cytoprotective, Antimicrobial and Antialgal Properties"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7915-2563","authenticated-orcid":false,"given":"Raminta","family":"Rodait\u0117","sequence":"first","affiliation":[{"name":"Center for Hydrogen Energy Technologies, Lithuanian Energy Institute, Breslaujos Str. 3, LT-44403 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3637-9315","authenticated-orcid":false,"given":"Laura","family":"Kairyt\u0117","sequence":"additional","affiliation":[{"name":"Center for Hydrogen Energy Technologies, Lithuanian Energy Institute, Breslaujos Str. 3, LT-44403 Kaunas, Lithuania"},{"name":"Faculty of Natural Sciences, Vytautas Magnus University, Universiteto Str. 10, LT-53361 Akademija, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9645-2121","authenticated-orcid":false,"given":"Agn\u0117","family":"Giedraitien\u0117","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Virology, Faculty of Veterinary Medicine, Lithuanian University of Health Sciences, Mickeviciaus Str. 9, LT-44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1040-0249","authenticated-orcid":false,"given":"Modestas","family":"Ru\u017eauskas","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Virology, Faculty of Veterinary Medicine, Lithuanian University of Health Sciences, Mickeviciaus Str. 9, LT-44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6665-0430","authenticated-orcid":false,"given":"Rita","family":"\u0160iug\u017edinien\u0117","sequence":"additional","affiliation":[{"name":"Institute of Microbiology and Virology, Faculty of Veterinary Medicine, Lithuanian University of Health Sciences, Mickeviciaus Str. 9, LT-44307 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3393-1474","authenticated-orcid":false,"given":"Ieva","family":"\u010ciapien\u0117","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, Lithuanian University of Health Sciences, Sukileliu 15, LT-50103 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2389-1550","authenticated-orcid":false,"given":"Vacis","family":"Tatar\u016bnas","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, Lithuanian University of Health Sciences, Sukileliu 15, LT-50103 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4778-0257","authenticated-orcid":false,"given":"\u0160ar\u016bnas","family":"Varnagiris","sequence":"additional","affiliation":[{"name":"Center for Hydrogen Energy Technologies, Lithuanian Energy Institute, Breslaujos Str. 3, LT-44403 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9809-1777","authenticated-orcid":false,"given":"Darius","family":"Mil\u010dius","sequence":"additional","affiliation":[{"name":"Center for Hydrogen Energy Technologies, Lithuanian Energy Institute, Breslaujos Str. 3, LT-44403 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Yousefian, F., Hesari, R., Jensen, T., Obagi, S., Rgeai, A., Damiani, G., Bunick, C.G., and Grada, A. 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