{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:28:34Z","timestamp":1789039714972,"version":"build-2803163510"},"reference-count":50,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015800","name":"Jilin Province Development and Reform Commission Technology Research and Development Project","doi-asserted-by":"publisher","award":["2024C016-8"],"award-info":[{"award-number":["2024C016-8"]}],"id":[{"id":"10.13039\/100015800","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015800","name":"Jilin Province Development and Reform Commission Technology Research and Development Project","doi-asserted-by":"publisher","award":["2023MK009"],"award-info":[{"award-number":["2023MK009"]}],"id":[{"id":"10.13039\/100015800","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015800","name":"Jilin Province Development and Reform Commission Technology Research and Development Project","doi-asserted-by":"publisher","award":["2023MK010"],"award-info":[{"award-number":["2023MK010"]}],"id":[{"id":"10.13039\/100015800","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015800","name":"Jilin Province Development and Reform Commission Technology Research and Development Project","doi-asserted-by":"publisher","award":["2024MK013"],"award-info":[{"award-number":["2024MK013"]}],"id":[{"id":"10.13039\/100015800","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jilin Province Science and Technology Program Project","award":["2024C016-8"],"award-info":[{"award-number":["2024C016-8"]}]},{"name":"Jilin Province Science and Technology Program Project","award":["2023MK009"],"award-info":[{"award-number":["2023MK009"]}]},{"name":"Jilin Province Science and Technology Program Project","award":["2023MK010"],"award-info":[{"award-number":["2023MK010"]}]},{"name":"Jilin Province Science and Technology Program Project","award":["2024MK013"],"award-info":[{"award-number":["2024MK013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>In this study, a novel polysaccharide (PSH) with potent anti-gout activity was extracted and separated from Sanghuangporus vaninii (S. vaninii). The structural characteristics of PSH were elucidated using analytical techniques. HPLC analysis revealed that PSH was a heteropolysaccharide with a molecular weight of 5.25 \u00d7 104 Da. FT-IR, NMR, and GC-MS collectively demonstrated that PSH was a pyranose with both \u03b1 and \u03b2 configurations, primarily composed of Glcp-(1\u2192, \u21924)-Glcp-(2\u2192, \u21923)-Galp-(1\u2192, and Araf-(1\u2192 linkages. The cell viability confirmed the non-toxicity of PSH. CAT and SOD showed that compared with the model group, PSH significantly offset the oxidative damage induced by MSU (p &lt; 0.01). The results from ROS and MDA mutually corroborated the antioxidant capacity of PSH. Furthermore, PSH effectively suppressed MSU-triggered inflammatory responses. The antioxidant and anti-inflammatory experiments provided evidence for the anti-gout efficacy of PSH. Collectively, these findings support the potential development of PSH as an anti-gout active substance.<\/jats:p>","DOI":"10.3390\/molecules30173536","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T16:18:15Z","timestamp":1756484295000},"page":"3536","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Structural Characterization and Anti-Gout Activity of a Novel Acidic Sanghuangporus vaninii Polysaccharide"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4798-0520","authenticated-orcid":false,"given":"Xu","family":"Zhang","sequence":"first","affiliation":[{"name":"Jilin Province Product Quality Supervision and Inspection Institute, Changchun 130103, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"An","sequence":"additional","affiliation":[{"name":"Jilin Province Product Quality Supervision and Inspection Institute, Changchun 130103, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Jilin Province Product Quality Supervision and Inspection Institute, Changchun 130103, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"Jilin Province Product Quality Supervision and Inspection Institute, Changchun 130103, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Yang","sequence":"additional","affiliation":[{"name":"Jilin Province Product Quality Supervision and Inspection Institute, Changchun 130103, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e507","DOI":"10.1016\/S2665-9913(24)00117-6","article-title":"Global, regional, and national burden of gout, 1990\u20132020, and projections to 2050: A systematic analysis of the Global Burden of Disease Study 2021","volume":"6","author":"Cross","year":"2024","journal-title":"Lancet Rheumatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e34396","DOI":"10.1097\/MD.0000000000034396","article-title":"Exploring the inhibition mechanism of interleukin-1-beta in gouty arthritis by polygonum cuspidatum using network pharmacology and molecular docking: A review","volume":"102","author":"Ge","year":"2023","journal-title":"Medicine"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Zhao, P., Hu, H.Z., Chen, X.T., Jiang, Q.Y., Yu, X.Z., Cen, X.L., Lin, S.Q., Mai, S.Q., Pang, W.L., and Chen, J.X. (2024). Mild hyperthermia enhanced synergistic uric acid degradation and multiple ROS elimination for an effective acute gout therapy. J. Nanobiotechnol., 22.","DOI":"10.1186\/s12951-024-02539-9"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Kimura, Y., Tsukui, D., and Kono, H. (2021). Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222212394"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1615\/IntJMedMushrooms.2025058619","article-title":"Comparison of Morphology, Components, and Activity of Four Species of Sanghuangporus Mushrooms (Agaricomycetes)","volume":"27","author":"Zhang","year":"2025","journal-title":"Int. J. Med. Mushrooms"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"118798","DOI":"10.1016\/j.carbpol.2021.118798","article-title":"Structural characterisation and antitumor activity against non-small cell lung cancer of polysaccharides from Sanghuangporus vaninii","volume":"276","author":"Wan","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Feng, X.L., Xie, T.C., Wang, Z.X., Lin, C., Li, Z.C., Huo, J., Li, Y., Liu, C., Gao, J.M., and Qi, J. (2024). Distinguishing Sanghuangporus from sanghuang-related fungi: A comparative and phylogenetic analysis based on mitogenomes. Appl. Microbiol. Biotechnol., 108.","DOI":"10.1007\/s00253-024-13207-1"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Song, J.L., Wang, Z.W., Chi, Y., Zhang, Y., Fang, C.Y., Shu, Y.T., Cui, J., Bai, H.L., and Wang, J. (2023). Anti-gout activity and the interaction mechanisms between Sanghuangporus vaninii active components and xanthine oxidase. Bioorg. Chem., 133.","DOI":"10.1016\/j.bioorg.2023.106394"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Jiang, F.C., Chen, R.B., Tang, C.H., Li, L.Q., Yan, J.K., and Zhang, H.A. (2023). Polysaccharide extracted from cultivated Sanghuangporous vaninii spores using three-phase partitioning with enzyme\/ultrasound pretreatment: Physicochemical characteristics and its biological activity in vitro. Int. J. Biol. Macromol., 253.","DOI":"10.1016\/j.ijbiomac.2023.126622"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1016\/j.ijbiomac.2021.05.139","article-title":"Classification, structure and mechanism of antiviral polysaccharides derived from edible and medicinal fungus","volume":"183","author":"Guo","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1002\/bab.2305","article-title":"Enhancement of triterpene production via in situ extractive fermentation of Sanghuangporus vaninii YC-1","volume":"69","author":"Xia","year":"2022","journal-title":"Biotechnol. Appl. Biochem."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Liu, J.Z., Song, J.Y., Gao, F.S., Chen, W.J., Zong, Y., Li, J.M., He, Z.M., and Du, R. (2023). Extraction, Purification, and Structural Characterization of Polysaccharides from Sanghuangporus vaninii with Anti-Inflammatory Activity. Molecules, 28.","DOI":"10.3390\/molecules28166081"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Qu, Y.D., Yang, H.X., Li, S.Y., Li, L.Z., Li, Y., and Wang, D. (2023). The involvement of Th1 cell differentiation in the anti-tumor effect of purified polysaccharide from Sanghuangporus vaninii in colorectal cancer via multi-omics analysis. Int. J. Biol. Macromol., 237.","DOI":"10.1016\/j.ijbiomac.2023.123927"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Sun, Z., Li, Z., Tan, Y.Y., Wang, X.X., Wang, C.X., Dong, M.Y., Liu, H.H., Chen, H., Li, Y., and Li, L.Z. (2022). Anti-Gouty Arthritis and Anti-Hyperuricemia Properties of Sanghuangporus vaninii and Inonotus hispidus in Rodent Models. Nutrients, 14.","DOI":"10.3390\/nu14204421"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.ijbiomac.2022.11.012","article-title":"Gastrointestinal digestion, probiotic fermentation behaviors and immunomodulatory effects of polysaccharides from Sanghuangporus vaninii","volume":"223","author":"Yin","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Zhou, X.B., Shi, Q.Y., Li, J.H., Quan, S.L., Zhang, X.Y., Gu, L.L., Li, H.X., Ju, Y., Hu, M., and Li, Q. (2022). Medicinal fungus Phellinus igniarius alleviates gout in vitro by modulating TLR4\/NF-kB\/NLRP3 signaling. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.1011406"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Wang, L., Tao, Y.F., Wang, X.S., Gan, Y.H., Zeng, Y.T., Li, S.S., and Zhu, Q. (2024). Aqueous extract of Phellinus igniarius ameliorates hyperuricemia and renal injury in adenine\/potassium oxonate-treated mice. Biomed. Pharmacother., 177.","DOI":"10.1016\/j.biopha.2024.116859"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"117879","DOI":"10.1016\/j.carbpol.2021.117879","article-title":"Structural characterization and antioxidant activities of one neutral polysaccharide and three acid polysaccharides from Ziziphus jujuba cv. Hamidazao: A comparison","volume":"261","author":"Yang","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.ijbiomac.2018.04.132","article-title":"Structural characterization and antiviral activity of lentinan from Lentinus edodes mycelia against infectious hematopoietic necrosis virus","volume":"115","author":"Ren","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.carbpol.2017.12.075","article-title":"Methylation analysis of polysaccharides: Technical advice","volume":"188","author":"Sims","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.ijbiomac.2020.04.190","article-title":"Isolation and purification of acidic polysaccharides from Agaricus blazei Murill and evaluation of their lipid-lowering mechanism","volume":"157","author":"Li","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.ijbiomac.2020.12.159","article-title":"Antioxidation, anti-inflammation and anti-fibrosis effect of phosphorylated polysaccharides from Pleurotus djamor mycelia on adenine-induced chronic renal failure mice","volume":"170","author":"Li","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Toto, A., Wild, P., Graille, M., Turcu, V., Cr\u00e9z\u00e9, C., Hemmendinger, M., Sauvain, J.J., Bergamaschi, E., Canu, I.G., and Hopf, N.B. (2022). Urinary Malondialdehyde (MDA) Concentrations in the General Population-A Systematic Literature Review and Meta-Analysis. Toxics, 10.","DOI":"10.3390\/toxics10040160"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"104321","DOI":"10.1016\/j.jff.2020.104321","article-title":"Sulfated Mesona chinensis benth polysaccharide enhance the anti-inflammatory activities of cyclophosphamide-treated mice","volume":"76","author":"Shen","year":"2021","journal-title":"J. Funct. Foods"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.ijbiomac.2020.02.315","article-title":"An insight into anti-inflammatory effects of natural polysaccharides","volume":"153","author":"Hou","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Chang, J.G., Tu, S.J., Huang, C.M., Chen, Y.C., Chiang, H.S., Lee, Y.T., Yen, J.C., Lin, C.L., Chung, C.C., and Liu, T.C. (2022). Single-cell RNA sequencing of immune cells in patients with acute gout. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-25871-2"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Zhang, Z.F., Song, T.T., Chen, J.F., and Lv, G.Y. (2023). Recovery of a hypolipidemic polysaccharide from artificially cultivated Sanghuangporus vaninii with an effective method. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.1095556"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Wang, H., Ma, J.X., Zhou, M., Si, J., and Cui, B.K. (2022). Current advances and potential trends of the polysaccharides derived from medicinal mushrooms sanghuang. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.965934"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"124018","DOI":"10.1016\/j.carbpol.2025.124018","article-title":"Structural characterization and osteogenic potential of polysaccharide purified from Sanghuangporus vaninii","volume":"367","author":"Song","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1007\/s11694-022-01288-3","article-title":"Structural characterization and antioxidant activity of a novel high-molecular-weight polysaccharide from Ziziphus Jujuba cv. Muzao","volume":"16","author":"Ji","year":"2022","journal-title":"J. Food Meas. Charact."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Lee, Q.C., Xue, Z.X., Luo, Y.J., Lin, Y.P., Lai, M.Y., Xu, H.Y., Liu, B., Zheng, M.F., Lv, F., and Zeng, F. (2024). Low molecular weight polysaccharide of Tremella fuciformis exhibits stronger antioxidant and immunomodulatory activities than high molecular weight polysaccharide. Int. J. Biol. Macromol., 281.","DOI":"10.1016\/j.ijbiomac.2024.136097"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Chen, X., Ni, L., Fu, X., Wang, L., Duan, D., Huang, L., Xu, J., and Gao, X. (2021). Molecular mechanism of anti-inflammatory activities of a novel sulfated galactofucan from Saccharina japonica. Mar. Drugs, 19.","DOI":"10.3390\/md19080430"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"103420","DOI":"10.1016\/j.arabjc.2021.103420","article-title":"Structural properties and antioxidant activities of polysaccharides isolated from sunflower meal after oil extraction","volume":"14","author":"Liu","year":"2021","journal-title":"Arab. J. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Guo, Q., Zhao, L.Y., Zhu, Y.H., Wu, J., Hao, C.T., Song, S., and Shi, W. (2021). Optimization of culture medium for Sanghuangporus vaninii and a study on its therapeutic effects on gout. Biomed. Pharmacother., 135.","DOI":"10.1016\/j.biopha.2020.111194"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"117284","DOI":"10.1016\/j.jep.2023.117284","article-title":"Assessment of cytotoxicity, acute, subacute toxicities and antioxidant activities (in vitro) of Sanghuangporus vaninii crude polysaccharide","volume":"319","author":"Liu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Zeng, D.Y., Yin, C.Y., Wei, H.N., Li, Y.Y., Yang, Y.Q., Nie, H.M., Pan, Y.S., Xu, R.Y., Tai, Y., and Du, J.Y. (2024). Activation of Nrf2 antioxidant signaling alleviates gout arthritis pain and inflammation. Biomed. Pharmacother., 170.","DOI":"10.1016\/j.biopha.2023.115957"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3103\/S009639251804003X","article-title":"Role of Reactive Oxygen Species in Inflammation: A Minireview","volume":"73","author":"Chelombitko","year":"2018","journal-title":"Moscow Univ. Biol. Sci. Bull."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e202310238","DOI":"10.1002\/anie.202310238","article-title":"NADH Photosynthesis System with Affordable Electron Supply and Inhibited NADH Oxidation","volume":"62","author":"Chen","year":"2023","journal-title":"Angew. Chem. Int. Edit."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"105115","DOI":"10.1016\/j.arabjc.2023.105115","article-title":"Protective effect of polysaccharide from the artificially cultivated Sanghuangporus vaninii against H2O2-induced toxicity in vitro and in zebrafish models","volume":"16","author":"Zhang","year":"2023","journal-title":"Arab. J. Chem."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Xie, Y.J., Tao, M.X., Yan, X.D., Fan, X.X., Bayoude, A., Lu, Y., Zhao, S.L., Yu, B.Y., and Li, R.S. (2025). Acidic polysaccharide CP-2 from Dioscoreae Rhizoma ameliorated acute alcoholic liver injury through the gut-liver axis and AMPK\/PPAR pathway. Int. J. Biol. Macromol., 310.","DOI":"10.1016\/j.ijbiomac.2025.143145"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e3642","DOI":"10.7717\/peerj.3642","article-title":"Laminarin protects against hydrogen peroxide-induced oxidative damage in MRC-5 cells possibly via regulating NRF2","volume":"5","author":"Liu","year":"2017","journal-title":"PeerJ"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Sun, X., Yang, L., Sun, H., Sun, Y., Wei, S.Y., Han, Y., Wang, W.K., Kong, L., and Wang, X.J. (2023). Traditional Chinese Medicine (TCM) and related active compounds in the treatment of gout: Regulation of signaling pathways and urate transporters. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1275974"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.ijbiomac.2018.11.077","article-title":"Anti-hyperuricemic and anti-gouty arthritis activities of polysaccharide purified from Lonicera japonica in model rats","volume":"123","author":"Yang","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Wang, Y., Lin, Z.J., Zhang, B., Jiang, Z.X., Guo, F.F., and Yang, T. (2019). Cichorium intybus L. Extract Suppresses Experimental Gout by Inhibiting the NF-\u03baB and NLRP3 Signalling Pathways. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20194921"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Yue, F.F., Zhang, J.R., Xu, J.X., Niu, T.F., L\u00fc, X., and Liu, M.S. (2022). Effects of monosaccharide composition on quantitative analysis of total sugar content by phenol-sulfuric acid method. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.963318"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1021\/acs.jchemed.1c00756","article-title":"Quick and Cheap Colorimetric Quantification of Proteins Using 96-Well-Plate Images","volume":"99","author":"Filgueiras","year":"2022","journal-title":"J. Chem. Educ."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.ijbiomac.2020.11.004","article-title":"Increased antioxidant activity and improved structural characterization of sulfuric acid-treated stepwise degraded polysaccharides from Pholiota nameko PN-01","volume":"166","author":"Zheng","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Zhang, X., Liu, J.X., Wang, X., Hu, H.W., Zhang, Y.R., Liu, T.T., and Zhao, H. (2022). Structure characterization and antioxidant activity of carboxymethylated polysaccharide from Pholiota nameko. J. Food Biochem., 46.","DOI":"10.1111\/jfbc.14121"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.ijbiomac.2019.09.244","article-title":"Structural characterization of a galacturonic acid-rich polysaccharide from Ziziphus jujuba cv. Muzao","volume":"147","author":"Ji","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Zhang, X., Liu, T.T., Wang, X., Zhou, L.Y., Qi, J., and An, S.Y. (2022). Structural characterization, antioxidant activity and anti-inflammatory of the phosphorylated polysaccharide from Pholiota nameko. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.976552"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/17\/3536\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:35:37Z","timestamp":1760034937000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/17\/3536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,29]]},"references-count":50,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["molecules30173536"],"URL":"https:\/\/doi.org\/10.3390\/molecules30173536","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,29]]}}}