{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:30:09Z","timestamp":1791433809510,"version":"4.3.3"},"reference-count":190,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T00:00:00Z","timestamp":1756598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Micronutrients and nutraceuticals play crucial roles in wound healing and tissue regeneration, supporting various physiological processes. This review aims to synthesize and evaluate the functions of various micronutrients and nutraceuticals, emphasizing the synergistic interactions among different nutrients that facilitate wound healing processes. A thorough literature review was performed using electronic databases, including PubMed, Scopus, Web of Science, Embase, Google Scholar, and Cochrane Library, to identify molecular studies, animal models, randomized controlled trials, and observational human studies published up to January 2000. Two independent reviewers screened the articles, extracted data, and evaluated the Risk of Bias using the Risk of Bias 2 (RoB 2) tool for the 190 studies that met the inclusion criteria. Evidence suggests that bioactive compounds found in functional foods and dietary supplements can help prevent chronic conditions and promote wellness beyond basic nutrition. Vitamins A, C, and E, as well as minerals such as zinc, selenium, and iron, are essential for cell proliferation and the formation of new tissues. Additionally, nutraceuticals, including omega-3 fatty acids, glutamine, arginine, and polyphenols, exhibit anti-inflammatory and antioxidant properties, which promote healing and reduce the risk of infection. Probiotics and other bioactive compounds in nutraceuticals contribute to maintaining the balance of microbiota, reducing inflammation, and stimulating cell regeneration. Significant variability was noted in study design, sample size, intervention dosage, and outcome measures. This evidence underscores the necessity for further well-designed clinical trials to determine the optimal dosages and combinations for specific wound types across diverse patient populations. This systematic review was prospectively registered in PROSPERO (ID: 1072091).<\/jats:p>","DOI":"10.3390\/molecules30173568","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T08:23:38Z","timestamp":1756801418000},"page":"3568","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The Roles of Micronutrition and Nutraceuticals in Enhancing Wound Healing and Tissue Regeneration: A Systematic Review"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5120-9926","authenticated-orcid":false,"given":"Cristina","family":"Stanescu","sequence":"first","affiliation":[{"name":"Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University, 35 Alexandru Ioan Cuza Street, 800216 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iulia","family":"Chiscop","sequence":"additional","affiliation":[{"name":"Clinical Surgical Department, Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University, 800008 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Mihalache","sequence":"additional","affiliation":[{"name":"Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University, 35 Alexandru Ioan Cuza Street, 800216 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9265-2302","authenticated-orcid":false,"given":"Monica","family":"Boev","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University, 35 Alexandru Ioan Cuza Street, 800010 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camelia","family":"Tamas","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8211-505X","authenticated-orcid":false,"given":"Gabriela","family":"Stoleriu","sequence":"additional","affiliation":[{"name":"Clinical Medical Department, Faculty of Medicine and Pharmacy, \u201cDunarea de Jos\u201d University, 35 Alexandru Ioan Cuza Street, 800216 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.12968\/bjon.2021.30.5.S38","article-title":"The role of nutrition in wound healing: An overview","volume":"30","author":"Ghaly","year":"2021","journal-title":"Br. J. Nurs."},{"key":"ref_2","first-page":"CD011378","article-title":"Nutritional interventions for treating foot ulcers in people with diabetes","volume":"7","author":"Moore","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/iwj.13849","article-title":"Evaluating the impact of using a wound-specific oral nutritional supplement to support wound healing in a rehabilitation setting","volume":"20","author":"Clark","year":"2023","journal-title":"Int. Wound J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"61","DOI":"10.9734\/ejnfs\/2024\/v16i21388","article-title":"The Role of Functional Foods and Nutraceuticals in Disease Prevention and Health Promotion","volume":"16","author":"Sharma","year":"2024","journal-title":"Eur. J. Nutr. Food Saf."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"373","DOI":"10.2217\/rme-2020-0066","article-title":"The Biological Processes During Wound Healing","volume":"16","author":"Yang","year":"2021","journal-title":"Regen. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"118","DOI":"10.70594\/brain\/15.3\/8","article-title":"Investigating the Connection Between Skin Cancers and Mental Disorders: A Thorough Analysis","volume":"15","author":"Stanescu","year":"2024","journal-title":"BRAIN. Broad Res. Artif. Intell. Neurosci."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Cioce, A., Cavani, A., Cattani, C., and Scopelliti, F. (2014). Role of the Skin Immune System in Wound Healing. Cells, 13.","DOI":"10.3390\/cells13070624"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/ncp.10376","article-title":"The Role of Vitamin A in Wound Healing","volume":"34","author":"Polcz","year":"2019","journal-title":"Nutr. Clin. Pract."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"R121","DOI":"10.1530\/EC-17-0101","article-title":"Vitamin A, endocrine tissues and hormones: Interplay and interactions","volume":"6","author":"Brossaud","year":"2017","journal-title":"Endocr. Connect."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1002\/ncp.10420","article-title":"Vitamin A and Wound Healing","volume":"34","author":"Zinder","year":"2019","journal-title":"Nutr. Clin. Pract."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1001\/archsurg.135.11.1265","article-title":"Effects of steroids and retinoids on wound healing","volume":"135","author":"Wicke","year":"2000","journal-title":"Arch. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s41419-024-06607-8","article-title":"LncRNA SNHG26 promotes gastric cancer progression and metastasis by inducing c-Myc protein translation and an energy metabolism positive feedback loop","volume":"15","author":"Wu","year":"2024","journal-title":"Cell Death Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1146\/annurev.nutr.21.1.167","article-title":"Vitamin A, infection, and immune function","volume":"21","author":"Stephensen","year":"2001","journal-title":"Annu. Rev. Nutr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1590\/0001-3765201520140677","article-title":"The neurotoxic effects of vitamin A and retinoids","volume":"87","author":"Oliveira","year":"2015","journal-title":"An. Da Acad. Bras. De Ci\u00eancias"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/4706418","article-title":"Rinsing with L-Ascorbic Acid Exhibits Concentration-Dependent Effects on Human Gingival Fibroblast In Vitro Wound Healing Behavior","volume":"1","author":"Chaitrakoonthong","year":"2020","journal-title":"Int. J. Dent."},{"key":"ref_16","first-page":"5","article-title":"Biological Significance of Ascorbic Acid (Vitamin C) in Human Health\u2014A Review","volume":"3","author":"Iqbal","year":"2004","journal-title":"Pak. J. Nutr."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Bechara, N., Flood, V.M., and Gunton, J.E. (2022). A Systematic Review on the Role of Vitamin C in Tissue Healing. Antioxidants, 11.","DOI":"10.3390\/antiox11081605"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/lsm.22448","article-title":"Laser-assisted delivery of vitamin C, vitamin E, and ferulic acid formula serum decreases fractional laser postoperative recovery by increased beta fibroblast growth factor expression","volume":"48","author":"Waibel","year":"2015","journal-title":"Lasers Surg. Med."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Carr, A.C., and Maggini, S. (2017). Vitamin C and Immune Function. Nutrients, 9.","DOI":"10.3390\/nu9111211"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/iwj.12484","article-title":"Vitamin C promotes wound healing through novel pleiotropic mechanisms","volume":"13","author":"Mohammed","year":"2015","journal-title":"Int. Wound J."},{"key":"ref_21","first-page":"588","article-title":"Efficacy of vitamin supplementation in situations with wound healing disorders: Results from clinical intervention studies","volume":"12","author":"Ellinger","year":"2009","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"342","DOI":"10.53365\/nrfhh\/169824","article-title":"Vitamin B-Complex and its Relationship with the Health of Vegetarian People","volume":"3","author":"Ibrahim","year":"2023","journal-title":"Nat. Resour. Hum. Health"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/01.ASW.0000531351.85866.d9","article-title":"Effects of Vitamin B Complex and Vitamin C on Human Skin Cells: Is the Perceived Effect Measurable?","volume":"31","author":"Rembe","year":"2018","journal-title":"Adv. Ski. Wound Care"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1902\/jop.2005.76.7.1084","article-title":"Effects of Vitamin-B Complex Supplementation on Periodontal Wound Healing","volume":"76","author":"Neiva","year":"2005","journal-title":"J. Periodontol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1177\/00034894211069437","article-title":"A Systematic Review of Oral Nutritional Supplement and Wound Healing","volume":"131","author":"Daher","year":"2022","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"38S","DOI":"10.1097\/PRS.0b013e318201256c","article-title":"Nutrition and Wound Healing: An Update","volume":"127","author":"Kavalukas","year":"2011","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/PRS.0000000000008061","article-title":"Evidence-Based Nutritional Interventions in Wound Care","volume":"148","author":"Saeg","year":"2021","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/jctb.7526","article-title":"Electrosprayed B-complex vitamins\/zein microparticles for drug sustained release and antioxidant applications","volume":"99","author":"Coelho","year":"2023","journal-title":"J. Chem. Technol. Biotechnol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/mnfr.201000174","article-title":"A review of the critical role of vitamin D in the functioning of the immune system and the clinical implications of vitamin D deficiency","volume":"55","author":"Schwalfenberg","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s40618-022-01893-5","article-title":"Role of vitamin D and calcium signaling in epidermal wound healing","volume":"46","author":"Bikle","year":"2023","journal-title":"J. Endocrinol. Investig."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"363","DOI":"10.37349\/emed.2024.00225","article-title":"Impact of vitamin D on ultraviolet-induced photoaging and skin diseases","volume":"5","author":"Ambagaspitiya","year":"2024","journal-title":"Explor. Med."},{"key":"ref_32","first-page":"179","article-title":"Vitamin D, bone health, and other health benefits in pediatric patients","volume":"7","author":"Palermo","year":"2014","journal-title":"J. Pediatr. Rehabil. Med."},{"key":"ref_33","first-page":"123","article-title":"Vitamin D and the immunomodulation of rotator cuff injury","volume":"9","author":"Dougherty","year":"2016","journal-title":"J. Inflamm. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s00223-012-9615-4","article-title":"Vitamin D and Bone Health in Childhood and Adolescence","volume":"92","author":"Winzenberg","year":"2012","journal-title":"Calcif. Tissue Int."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Muresan, G.C., Hedesiu, M., Lucaciu, O., Boca, S., and Petrescu, N. (2022). Effect of Vitamin D on Bone Regeneration: A Review. Medicina, 58.","DOI":"10.3390\/medicina58101337"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/09674845.2013.11669951","article-title":"Vitamin D in health and disease: A literature review","volume":"70","author":"Basit","year":"2013","journal-title":"Br. J. Biomed. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3164\/jcbn.23-59","article-title":"Vitamin D insufficiency and disease risk in the elderly","volume":"74","author":"Tanaka","year":"2024","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s11154-017-9424-1","article-title":"The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention","volume":"18","author":"Holick","year":"2017","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Sun, J., and Zhang, Y.-G. (2022). Vitamin D Receptor Influences Intestinal Barriers in Health and Disease. Cells, 11.","DOI":"10.3390\/cells11071129"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Ricca, C., Aillon, A., Bergandi, L., Alotto, D., Castagnoli, C., and Silvagno, F. (2018). Vitamin D Receptor Is Necessary for Mitochondrial Function and Cell Health. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19061672"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/prd.12513","article-title":"Can vitamins improve periodontal wound healing\/regeneration?","volume":"94","author":"Cosgarea","year":"2024","journal-title":"Periodontology 2000"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/iwj.12295","article-title":"Vitamin E and wound healing: An evidence-based review","volume":"13","author":"Hobson","year":"2014","journal-title":"Int. Wound J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/ncp.10321","article-title":"Hair, Nails, and Skin: Differentiating Cutaneous Manifestations of Micronutrient Deficiency","volume":"34","author":"Dibaise","year":"2019","journal-title":"Nutr. Clin. Pract."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Makvandi, P., Caccavale, C., Della Sala, F., Zeppetelli, S., Veneziano, R., and Borzacchiello, A. (2020). Natural Formulations Provide Antioxidant Complement to Hyaluronic Acid-Based Topical Applications Used in Wound Healing. Polymers, 12.","DOI":"10.3390\/polym12081847"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s11745-005-1418-9","article-title":"Comparative effects of palm vitamin E and \u03b1-tocopherol on healing and wound tissue antioxidant enzyme levels in diabetic rats","volume":"40","author":"Musalmah","year":"2005","journal-title":"Lipids"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Hoff, J., Karl, B., Gerstmeier, J., Beekmann, U., Schm\u00f6lz, L., B\u00f6rner, F., Kralisch, D., Bauer, M., Werz, O., and Fischer, D. (2021). Controlled Release of the \u03b1-Tocopherol-Derived Metabolite \u03b1-13\u2032-Carboxychromanol from Bacterial Nanocellulose Wound Cover Improves Wound Healing. Nanomaterials, 11.","DOI":"10.3390\/nano11081939"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1089\/15230860050192189","article-title":"Mechanisms of vitamin E regulation: Research over the past decade and focus on the future","volume":"2","author":"Parks","year":"2000","journal-title":"Antioxid. Redox Signal."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"699","DOI":"10.2741\/1565","article-title":"Mechanisms mediating the antiproliferative and apoptotic effects of vitamin E in mammary cancer cells","volume":"10","author":"Sylvester","year":"2005","journal-title":"Front. Biosci. (Landmark Ed.)"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/mc.23160","article-title":"Vitamin E and cancer prevention: Studies with different forms of tocopherols and tocotrienols","volume":"59","author":"Yang","year":"2020","journal-title":"Mol. Carcinog."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Comitato, R., Ambra, R., and Virgili, F. (2017). Tocotrienols: A Family of Molecules with Specific Biological Activities. Antioxidants, 6.","DOI":"10.3390\/antiox6040093"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1007\/s11745-009-3326-2","article-title":"Tocotrienols Suppress Proinflammatory Markers and Cyclooxygenase-2 Expression in RAW264.7 Macrophages","volume":"44","author":"Yam","year":"2009","journal-title":"Lipids"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Szewczyk, K., Chojnacka, A., and G\u00f3rnicka, M. (2021). Tocopherols and Tocotrienols\u2014Bioactive Dietary Compounds; What Is Certain, What Is Doubt?. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22126222"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1002\/mnfr.200900399","article-title":"In vitro antioxidant activity of tocopherols and tocotrienols and comparison of vitamin E concentration and lipophilic antioxidant capacity in human plasma","volume":"54","author":"Theile","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1055\/s-0029-1225766","article-title":"Vitamin K\u2013Dependent Coagulation Factors Deficiency","volume":"35","author":"Brenner","year":"2009","journal-title":"Semin. Thromb. Hemost."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"88","DOI":"10.4103\/ijp.IJP_183_18","article-title":"Wound healing effects of topical Vitamin K: A randomized controlled trial","volume":"51","author":"Pazyar","year":"2019","journal-title":"Indian J. Pharmacol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"5329","DOI":"10.3402\/fnr.v56i0.5329","article-title":"Vitamin K: The effect on health beyond coagulation\u2014An overview","volume":"56","author":"Vermeer","year":"2012","journal-title":"Food Nutr. Res."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Nuszkiewicz, J., Sutkowy, P., Wr\u00f3blewski, M., Paw\u0142owska, M., Weso\u0142owski, R., Wr\u00f3blewska, J., and Wo\u017aniak, A. (2023). Links between Vitamin K, Ferroptosis and SARS-CoV-2 Infection. Antioxidants, 12.","DOI":"10.3390\/antiox12030733"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"5816","DOI":"10.1523\/JNEUROSCI.23-13-05816.2003","article-title":"Novel Role of Vitamin K in Preventing Oxidative Injury to Developing Oligodendrocytes and Neurons","volume":"23","author":"Li","year":"2003","journal-title":"J. Neurosci."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Maurya, R., and Namdeo, M. (2022). Superoxide Dismutase: A Key Enzyme for the Survival of Intracellular Pathogens in Host, IntechOpen.","DOI":"10.5772\/intechopen.100322"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1093\/jn\/134.4.811","article-title":"Dietary zinc alters early inflammatory responses during cutaneous wound healing in weanling CD-1 mice","volume":"134","author":"Lim","year":"2004","journal-title":"J. Nutr."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Kr\u0119\u017cel, A., and Maret, W. (2017). The Functions of Metamorphic Metallothioneins in Zinc and Copper Metabolism. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18061237"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Hassan, A., Elebeedy, D., Fahmy Mohamed Elsayed, A., Abd El Maksoud, A.I., and Matar, E.R. (2021). Investigation of Angiogenesis and Wound Healing Potential Mechanisms of Zinc Oxide Nanorods. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.661217"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1824-7288-38-21","article-title":"Effect of zinc supplementation on growth Hormone Insulin growth factor axis in short Egyptian children with zinc deficiency","volume":"38","author":"Hamza","year":"2012","journal-title":"Ital. J. Pediatr."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1440-1681.2005.04183.x","article-title":"Effect of zinc sulphate and zinc methionine on growth, plasma growth hormone concentration, growth hormone receptor and insulin-like growth factor-I gene expression in mice","volume":"32","author":"Yu","year":"2005","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1603497","DOI":"10.1002\/adfm.201603497","article-title":"Zinc Oxide Nanorod-Based Piezoelectric Dermal Patch for Wound Healing","volume":"27","author":"Bhang","year":"2016","journal-title":"Adv. Funct. Mater."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.2174\/1568026611208011095","article-title":"Molecular Mechanisms Regulating Matrix Metalloproteinases","volume":"12","author":"Piperi","year":"2012","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/bjs.1800610405","article-title":"The effect of zinc deficiency on wound healing","volume":"61","author":"Rahmat","year":"2005","journal-title":"Br. J. Surg."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Schoofs, H., Schmit, J., and Rink, L. (2024). Zinc Toxicity: Understanding the Limits. Molecules, 29.","DOI":"10.3390\/molecules29133130"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1080\/10715760600806248","article-title":"Selenoprotein P protects endothelial cells from oxidative damage by stimulation of glutathione peroxidase expression and activity","volume":"40","author":"Steinbrenner","year":"2006","journal-title":"Free Radic. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"7478523","DOI":"10.1155\/2017\/7478523","article-title":"Supplementation of Micronutrient Selenium in Metabolic Diseases: Its Role as an Antioxidant","volume":"2017","author":"Wang","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/mutage\/ges064","article-title":"Does a role for selenium in DNA damage repair explain apparent controversies in its use in chemoprevention?","volume":"28","author":"Bera","year":"2012","journal-title":"Mutagenesis"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Heo, J.S. (2022). Selenium-Stimulated Exosomes Enhance Wound Healing by Modulating Inflammation and Angiogenesis. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231911543"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Karas, R.A., Alexeree, S., Elsayed, H., and Attia, Y.A. (2024). Assessment of wound healing activity in diabetic mice treated with a novel therapeutic combination of selenium nanoparticles and platelets rich plasma. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-54064-2"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/pen.26549","article-title":"Microwave-assisted hydrothermal green synthesis of selenium nanoparticles incorporated with hyaluronic acid methacrylate\/gelatin methacrylate hydrogels for wound healing applications","volume":"64","author":"Nejati","year":"2023","journal-title":"Polym. Eng. Sci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10565-011-9203-9","article-title":"Selenium interactions and toxicity: A review","volume":"28","author":"Zwolak","year":"2012","journal-title":"Cell Biol. Toxicol."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Yoshino, Y., Teruya, T., Miyamoto, C., Hirose, M., Endo, S., and Ikari, A. (2024). Unraveling the Mechanisms Involved in the Beneficial Effects of Magnesium Treatment on Skin Wound Healing. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25094994"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"520","DOI":"10.7150\/ijbs.8879","article-title":"Macrophage polarization in inflammatory diseases","volume":"10","author":"Liu","year":"2014","journal-title":"Int. J. Biol. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Abbas, S.F., Haider, A.J., and Al-Musawi, S. (2023). Antimicrobial and Wound Healing Effects of Metal Oxide Nanoparticles-Enriched Wound Dressing. Nano, 18.","DOI":"10.1142\/S1793292023300050"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Jiao, Y., Li, W., Wang, L., Jiang, H., Wang, S., Jia, X., Wang, Z., Wang, H., Zhang, B., and Ding, G. (2022). Relationship between Dietary Magnesium Intake and Metabolic Syndrome. Nutrients, 14.","DOI":"10.3390\/nu14102013"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1111\/dme.12537","article-title":"Dietary magnesium intake and risk of metabolic syndrome: A meta-analysis","volume":"31","author":"Dibaba","year":"2014","journal-title":"Diabet. Med."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Bleizgys, A. (2024). Zinc, Magnesium and Vitamin K Supplementation in Vitamin D Deficiency: Pathophysiological Background and Implications for Clinical Practice. Nutrients, 16.","DOI":"10.3390\/nu16060834"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"S\u00fcntar, I., \u00c7etinkaya, S., Panieri, E., Saha, S., Buttari, B., Profumo, E., and Saso, L. (2021). Regulatory Role of Nrf2 Signaling Pathway in Wound Healing Process. Molecules, 26.","DOI":"10.3390\/molecules26092424"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2147\/JIR.S136742","article-title":"Magnesium deficiency and increased inflammation: Current perspectives","volume":"11","author":"Nielsen","year":"2018","journal-title":"J. Inflamm. Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/s41580-024-00715-1","article-title":"Cellular and molecular mechanisms of skin wound healing","volume":"25","author":"Martin","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Mathew-Steiner, S.S., Roy, S., and Sen, C.K. (2021). Collagen in Wound Healing. Bioengineering, 8.","DOI":"10.3390\/bioengineering8050063"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1365-2133.2010.09804.x","article-title":"Oxygen in acute and chronic wound healing","volume":"163","author":"Schreml","year":"2010","journal-title":"Br. J. Dermatol."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Rehak, L., Giurato, L., Meloni, M., Panunzi, A., Manti, G.M., and Uccioli, L. (2022). The Immune-Centric Revolution in the Diabetic Foot: Monocytes and Lymphocytes Role in Wound Healing and Tissue Regeneration\u2014A Narrative Review. J. Clin. Med., 11.","DOI":"10.3390\/jcm11030889"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41420-024-02181-2","article-title":"Repair and regeneration: Ferroptosis in the process of remodeling and fibrosis in impaired organs","volume":"10","author":"Yin","year":"2024","journal-title":"Cell Death Discov."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1002\/cam4.1670","article-title":"Iron overloaded polarizes macrophage to proinflammation phenotype through ROS\/acetyl-p53 pathway","volume":"7","author":"Zhou","year":"2018","journal-title":"Cancer Med."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Saboor, M., Zehra, A., Hamali, H., and Mobarki, A. (2021). Revisiting Iron Metabolism, Iron Homeostasis and Iron Deficiency Anemia. Clin. Lab., 67.","DOI":"10.7754\/Clin.Lab.2020.200742"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Avnee, M., Sood, S., Chaudhary, D.R., Jhorar, P., and Rana, R.S. (2023). Biofortification: An approach to eradicate micronutrient deficiency. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1233070"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"B\u0103d\u0103lu\u021b\u0103, V.A., Curu\u021biu, C., Di\u021bu, L.M., Holban, A.M., and Laz\u0103r, V. (2024). Probiotics in Wound Healing. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25115723"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"e70087","DOI":"10.1111\/iwj.70087","article-title":"Modulations of the skin microbiome in skin disorders: A narrative review from a wound care perspective","volume":"21","author":"Piazzesi","year":"2024","journal-title":"Int. Wound J."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/JOE-21-0081","article-title":"Micronutrients impact the gut microbiota and blood glucose","volume":"250","author":"Barra","year":"2021","journal-title":"J. Endocrinol."},{"key":"ref_95","first-page":"1421","article-title":"Lactobacillus bulgaricus and Lactobacillus plantarum improve diabetic wound healing through modulating inflammatory factors","volume":"68","author":"Mohtashami","year":"2020","journal-title":"Biotechnol. Appl. Biochem."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Boev, M., St\u0103nescu, C., Turturic\u0103, M., Cot\u00e2rle\u0163, M., Bat\u00eer-Marin, D., Maftei, N., Chi\u0163escu, C., Grigore-Gurgu, L., Barbu, V., and Enachi, E. (2024). Bioactive Potential of Carrot-Based Products Enriched with Lactobacillus plantarum. Molecules, 29.","DOI":"10.3390\/molecules29040917"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Yin, Z., Wang, Y., Feng, X., Liu, C., Guan, X., Liu, S., Long, Z., Miao, Z., He, F., and Cheng, R. (2024). Lactobacillus rhamnosus GG and Bifidobacterium animalis subsp. lactis BB-12 promote infected wound healing via regulation of the wound microenvironment. Microb. Biotechnol., 17.","DOI":"10.1111\/1751-7915.70031"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Panagiotou, D., Filidou, E., Gaitanidou, M., Tarapatzi, G., Spathakis, M., Kandilogiannakis, L., Stavrou, G., Arvanitidis, K., Tsetis, J.K., and Gionga, P. (2023). Role of Lactiplantibacillus plantarum UBLP-40, Lactobacillus rhamnosus UBLR-58 and Bifidobacterium longum UBBL-64 in the Wound Healing Process of the Excisional Skin. Nutrients, 15.","DOI":"10.3390\/nu15081822"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Zieli\u0144ska, M., Paw\u0142owska, A., Orze\u0142, A., Sulej, L., Muzyka-Placzy\u0144ska, K., Baran, A., Filipecka-Tyczka, D., Paw\u0142owska, P., Nowi\u0144ska, A., and Bogus\u0142awska, J. (2023). Wound Microbiota and Its Impact on Wound Healing. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242417318"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Togo, C., Zidorio, A.P., Gon\u00e7alves, V., Botelho, P., de Carvalho, K., and Dutra, E. (2021). Does Probiotic Consumption Enhance Wound Healing? A Systematic Review. Nutrients, 14.","DOI":"10.3390\/nu14010111"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Barthe, M., Gillot, L., Perdigon, L., Jacobs, A., Schoonbroodt, G., Mauhin, P., Bouhajja, E., and Osman-Ponchet, H. (2023). Topical Probiotic Formulation Promotes Rapid Healing in Dog Keratinocyte Cells: A Promising Approach for Wound Management. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241512360"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Johnson, T.R., G\u00f3mez, B.I., McIntyre, M.K., Dubick, M.A., Christy, R.J., Nicholson, S.E., and Burmeister, D.M. (2018). The Cutaneous Microbiome and Wounds: New Molecular Targets to Promote Wound Healing. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19092699"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Bekiaridou, A., Karlafti, E., Oikonomou, I.M., Ioannidis, A., and Papavramidis, T.S. (2021). Probiotics and Their Effect on Surgical Wound Healing: A Systematic Review and New Insights into the Role of Nanotechnology. Nutrients, 13.","DOI":"10.3390\/nu13124265"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1111\/iwj.13451","article-title":"The role of topical probiotics on wound healing: A review of animal and human studies","volume":"17","author":"Knackstedt","year":"2020","journal-title":"Int. Wound J."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"8925","DOI":"10.1002\/jcp.29737","article-title":"Probiotics with ameliorating effects on the severity of skin inflammation in psoriasis: Evidence from experimental and clinical studies","volume":"235","author":"Atabati","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Ersanli, C., Tzora, A., Voidarou, C., Skoufos, S., Zeugolis, D.I., and Skoufos, I. (2023). Biodiversity of Skin Microbiota as an Important Biomarker for Wound Healing. Biology, 12.","DOI":"10.3390\/biology12091187"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Arribas-L\u00f3pez, E., Zand, N., Ojo, O., Snowden, M.J., and Kochhar, T. (2021). The Effect of Amino Acids on Wound Healing: A Systematic Review and Meta-Analysis on Arginine and Glutamine. Nutrients, 13.","DOI":"10.3390\/nu13082498"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1900824","DOI":"10.1002\/mnfr.201900824","article-title":"Immuno-Resolving Ability of Resolvins, Protectins, and Maresins Derived from Omega-3 Fatty Acids in Metabolic Syndrome","volume":"64","author":"Kwon","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Burger, B., K\u00fchl, C.M.C., Candreva, T., Cardoso, R.S., Silva, J.R., Castelucci, B.G., Consonni, S.R., Fisk, H.L., Calder, P.C., and Vinolo, M.A.R. (2019). Oral administration of EPA-rich oil impairs collagen reorganization due to elevated production of IL-10 during skin wound healing in mice. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-45508-1"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1093\/jn\/nxz324","article-title":"Multinutrient Supplementation Increases Collagen Synthesis during Early Wound Repair in a Randomized Controlled Trial in Patients with Inguinal Hernia","volume":"150","author":"Kjaer","year":"2020","journal-title":"J. Nutr."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1590\/S0102-86502008000300009","article-title":"Effect of a combination of medium chain triglycerides, linoleic acid, soy lecithin and vitamins A and E on wound healing in rats","volume":"23","author":"Fechine","year":"2008","journal-title":"Acta Cir. Bras."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Choudhary, V., Choudhary, M., and Bollag, W.B. (2024). Exploring Skin Wound Healing Models and the Impact of Natural Lipids on the Healing Process. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25073790"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s11883-004-0087-5","article-title":"Omega-3 fatty acids and inflammation","volume":"6","author":"Mori","year":"2004","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s00281-019-00767-y","article-title":"The resolution of inflammation through omega-3 fatty acids in atherosclerosis, intimal hyperplasia, and vascular calcification","volume":"41","author":"Carracedo","year":"2019","journal-title":"Semin. Immunopathol."},{"key":"ref_115","first-page":"2503950","article-title":"Wound Healing and Omega-6 Fatty Acids: From Inflammation to Repair","volume":"5","author":"Silva","year":"2018","journal-title":"Mediat. Inflamm."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"358","DOI":"10.2741\/2069","article-title":"Glutamine signalling in bacteria","volume":"12","author":"Forchhammer","year":"2007","journal-title":"Front. Biosci. (Landmark Ed.)"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Khalaf, A.T., Wei, Y., Alneamah, S.J.A., Al-Shawi, S.G., Kadir, S.Y.A., Zainol, J., and Liu, X. (2021). What Is New in the Preventive and Therapeutic Role of Dairy Products as Nutraceuticals and Functional Foods?. BioMed Res. Int., 2021.","DOI":"10.1155\/2021\/8823222"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Basak, S., and Gokhale, J. (2021). Immunity boosting nutraceuticals: Current trends and challenges. J. Food Biochem., 46.","DOI":"10.1111\/jfbc.13902"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"636","DOI":"10.2174\/1570159X18666200114125628","article-title":"Evaluation of Anti-inflammatory Nutraceuticals in LPS-induced Mouse Neuroinflammation Model: An Update","volume":"18","author":"Catorce","year":"2020","journal-title":"Curr. Neuropharmacol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1051\/rnd:2005001","article-title":"Omega-3 fatty acids and neuropsychiatric disorders","volume":"45","author":"Young","year":"2005","journal-title":"Reprod. Nutr. Dev."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1089\/wound.2012.0415","article-title":"Immunonutrition: Role in Wound Healing and Tissue Regeneration","volume":"3","author":"Chow","year":"2014","journal-title":"Adv. Wound Care"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1089\/wound.2013.0469","article-title":"Role of Arginine and Omega-3 Fatty Acids in Wound Healing and Infection","volume":"3","author":"Alexander","year":"2014","journal-title":"Adv. Wound Care"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1046\/j.1524-475X.2003.11605.x","article-title":"Arginine physiology and its implication for wound healing","volume":"11","author":"Witte","year":"2003","journal-title":"Wound Repair Regen."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41467-017-00369-y","article-title":"Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation","volume":"8","author":"Tan","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Vidal-Casanella, O., N\u00fa\u00f1ez, O., Granados, M., Saurina, J., and Sentellas, S. (2021). Analytical Methods for Exploring Nutraceuticals Based on Phenolic Acids and Polyphenols. Appl. Sci., 11.","DOI":"10.3390\/app11188276"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"34","DOI":"10.2174\/1871528112666131119211002","article-title":"Antagonism by Bioactive Polyphenols Against Inflammation: A Systematic View","volume":"13","author":"Chu","year":"2014","journal-title":"Inflamm. Allergy-Drug Targets"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"304","DOI":"10.2174\/138920101504140825113815","article-title":"Polyphenols in disease: From diet to supplements","volume":"15","author":"Rodrigo","year":"2014","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"577","DOI":"10.2174\/157341310793348632","article-title":"Nanomaterials: New Generation Therapeutics in Wound Healing and Tissue Repair","volume":"6","author":"Singh","year":"2010","journal-title":"Curr. Nanosci."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1007\/s10439-014-1010-z","article-title":"Tissue Engineering and Regenerative Repair in Wound Healing","volume":"42","author":"Hu","year":"2014","journal-title":"Ann. Biomed. Eng."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1007\/s00210-024-03538-1","article-title":"Polyphenols in wound healing: Unlocking prospects with clinical applications","volume":"398","author":"Utpal","year":"2024","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Jia, Y., Shao, J.-H., Zhang, K.-W., Zou, M.-L., Teng, Y.-Y., Tian, F., Chen, M.-N., Chen, W.-W., Yuan, Z.-D., and Wu, J.-J. (2022). Emerging Effects of Resveratrol on Wound Healing: A Comprehensive Review. Molecules, 27.","DOI":"10.3390\/molecules27196736"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"De S\u00e1 Coutinho, D., Pacheco, M.T., Frozza, R.L., and Bernardi, A. (2018). Anti-Inflammatory Effects of Resveratrol: Mechanistic Insights. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19061812"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"5193","DOI":"10.1002\/ptr.7981","article-title":"The protective role of resveratrol in diabetic wound healing","volume":"37","author":"Bi","year":"2023","journal-title":"Phytother. Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/iwj.13601","article-title":"The impact of resveratrol on skin wound healing, scarring, and aging","volume":"19","author":"Hecker","year":"2021","journal-title":"Int. Wound J."},{"key":"ref_135","first-page":"99","article-title":"Resveratrol-loaded peptide-hydrogels inhibit scar formation in wound healing through suppressing inflammation","volume":"7","author":"Zhao","year":"2019","journal-title":"Regen. Biomater."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Pignet, A.-L., Schellnegger, M., Hecker, A., Kohlhauser, M., Kotzbeck, P., and Kamolz, L.-P. (2021). Resveratrol-Induced Signal Transduction in Wound Healing. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222312614"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Meng, X., Zhou, J., Zhao, C.-N., Gan, R.-Y., and Li, H.-B. (2020). Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review. Foods, 9.","DOI":"10.3390\/foods9030340"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1158\/1940-6207.CAPR-08-0160","article-title":"Cancer Prevention and Treatment with Resveratrol: From Rodent Studies to Clinical Trials","volume":"2","author":"Bishayee","year":"2009","journal-title":"Cancer Prev. Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.2174\/1389201017666160721123109","article-title":"Wound Healing Effects of Curcumin: A Short Review","volume":"17","author":"Tejada","year":"2016","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"e392124","DOI":"10.1590\/acb392124","article-title":"Effects of curcumin supplementation on abdominal surgical wound healing","volume":"39","author":"Santos","year":"2024","journal-title":"Acta Cir. Bras."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.molimm.2004.09.029","article-title":"L-gamma-Glutamyl-L-cysteinyl-glycine (glutathione; GSH) and GSH-related enzymes in the regulation of pro- and anti-inflammatory cytokines: A signaling transcriptional scenario for redox(y) immunologic sensor(s)?","volume":"42","author":"Haddad","year":"2005","journal-title":"Mol. Immunol."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Barchitta, M., Maugeri, A., Favara, G., Magnano San Lio, R., Evola, G., Agodi, A., and Basile, G. (2019). Nutrition and Wound Healing: An Overview Focusing on the Beneficial Effects of Curcumin. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20051119"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1097\/00005373-200111000-00017","article-title":"Protective effects of curcumin against oxidative damage on skin cells in vitro: Its implication for wound healing","volume":"51","author":"Phan","year":"2001","journal-title":"J. Trauma Inj. Infect. Crit. Care"},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Omidian, H., Wilson, R.L., and Chowdhury, S.D. (2023). Enhancing Therapeutic Efficacy of Curcumin: Advances in Delivery Systems and Clinical Applications. Gels, 9.","DOI":"10.3390\/gels9080596"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Elkhateeb, O., Badawy, M.E.I., Tohamy, H.G., Abou-Ahmed, H., El-Kammar, M., and Elkhenany, H. (2023). Curcumin-infused nanostructured lipid carriers: A promising strategy for enhancing skin regeneration and combating microbial infection. BMC Vet. Res., 19.","DOI":"10.1186\/s12917-023-03774-2"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1089\/ten.teb.2023.0085","article-title":"Technological Interventions Enhancing Curcumin Bioavailability in Wound-Healing Therapeutics","volume":"30","author":"Singh","year":"2023","journal-title":"Tissue Eng. Part B Rev."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"562","DOI":"10.3390\/nutraceuticals4040031","article-title":"Potential Applications of the Anti-Inflammatory, Antithrombotic and Antioxidant Health-Promoting Properties of Curcumin: A Critical Review","volume":"4","author":"Rapti","year":"2024","journal-title":"Nutraceuticals"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/jbm.a.36845","article-title":"Development of a chitosan hydrogel containing flavonoids extracted from Passiflora edulis leaves and the evaluation of its antioxidant and wound healing properties for the treatment of skin lesions in diabetic mice","volume":"108","author":"Soares","year":"2019","journal-title":"J. Biomed. Mater. Res."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Zulkefli, N., Che Zahari, C.N.M., Sayuti, N.H., Kamarudin, A.A., Saad, N., Hamezah, H.S., Bunawan, H., Baharum, S.N., Mediani, A., and Ahmed, Q.U. (2023). Flavonoids as Potential Wound-Healing Molecules: Emphasis on Pathways Perspective. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24054607"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Pang, Y., Zhang, Y., Huang, L., Xu, L., Wang, K., Wang, D., Guan, L., Zhang, Y., Yu, F., and Chen, Z. (2017). Effects and Mechanisms of Total Flavonoids from Blumea balsamifera (L.) DC. on Skin Wound in Rats. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18122766"},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Yang, J., Zhang, L., Ding, Q., Zhang, S., Sun, S., Liu, W., Liu, J., Han, X., and Ding, C. (2023). Flavonoid-Loaded Biomaterials in Bone Defect Repair. Molecules, 28.","DOI":"10.3390\/molecules28196888"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.2174\/1568026615666150619141702","article-title":"Anti-inflammatory glycosylated flavonoids as therapeutic agents for treatment of diabetes-impaired wounds","volume":"15","year":"2015","journal-title":"Curr. Top. Med. Chem."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.2174\/0929867043365288","article-title":"Proanthocyanidins in health care: Current and new trends","volume":"11","author":"Cos","year":"2004","journal-title":"Curr. Med. Chem."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/mnfr.200900476","article-title":"Hypolipidemic effects of proanthocyanidins and their underlying biochemical and molecular mechanisms","volume":"54","author":"Arola","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_155","first-page":"1","article-title":"Proanthocyanidins against Oxidative Stress: From Molecular Mechanisms to Clinical Applications","volume":"2","author":"Yang","year":"2018","journal-title":"BioMed Res. Int."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Liang, L., Meng, F., Zhong, W., Weng, L., Qiu, H., Wu, L., and Liu, Y. (2024). Advances in Extraction Protocols, Degradation Methods, and Bioactivities of Proanthocyanidins. Molecules, 29.","DOI":"10.3390\/molecules29102179"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.3390\/ijms11041679","article-title":"Flavanols and Anthocyanins in Cardiovascular Health: A Review of Current Evidence","volume":"11","author":"Moreno","year":"2010","journal-title":"Int. J. Mol. Sci."},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"McKay, T.B., Emmitte, K.A., German, C., and Karamichos, D. (2023). Quercetin and Related Analogs as Therapeutics to Promote Tissue Repair. Bioengineering, 10.","DOI":"10.3390\/bioengineering10101127"},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Yadav, E., Neupane, N.P., Otuechere, C.A., Yadav, J.P., Bhat, M.A., Al-Omar, M.A., Yadav, P., and Verma, A. (2024). Cutaneous Wound-Healing Activity of Quercetin-Functionalized Bimetallic Nanoparticles. Chem. Biodivers., 22.","DOI":"10.1002\/cbdv.202401551"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1089\/ped.2019.1137","article-title":"Quercetin Improves Inflammation, Oxidative Stress, and Impaired Wound Healing in Atopic Dermatitis Model of Human Keratinocytes","volume":"33","author":"Beken","year":"2020","journal-title":"Pediatr. Allergy Immunol. Pulmonol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"e14389","DOI":"10.1111\/iwj.14389","article-title":"Quercetin and its derivatives for wound healing in rats\/mice: Evidence from animal studies and insight into molecular mechanisms","volume":"21","author":"Huang","year":"2023","journal-title":"Int. Wound J."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Alharbi, H.O.A., Alshebremi, M., Babiker, A.Y., and Rahmani, A.H. (2025). The Role of Quercetin, a Flavonoid in the Management of Pathogenesis Through Regulation of Oxidative Stress, Inflammation, and Biological Activities. Biomolecules, 15.","DOI":"10.3390\/biom15010151"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/exd.13679","article-title":"Topical application of quercetin improves wound healing in pressure ulcer lesions","volume":"27","author":"Yin","year":"2018","journal-title":"Exp. Dermatol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1039\/D4TB01699H","article-title":"Quercetin nanocrystal-loaded alginate hydrogel patch for wound healing applications","volume":"13","author":"Nayak","year":"2025","journal-title":"J. Mater. Chem. B"},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Dong, W., Jia, C., Li, J., Zhou, Y., Luo, Y., Liu, J., Zhao, Z., Zhang, J., Lin, S., and Chen, Y. (2022). Fisetin Attenuates Diabetic Nephropathy-Induced Podocyte Injury by Inhibiting NLRP3 Inflammasome. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.783706"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"17964","DOI":"10.1021\/acs.jafc.4c02985","article-title":"Fisetin Promotes Functional Recovery after Spinal Cord Injury by Inhibiting Microglia\/Macrophage M1 Polarization and JAK2\/STAT3 Signaling Pathway","volume":"72","author":"Ji","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_167","first-page":"811","article-title":"Anti-cancer effects of fisetin on mammary carcinoma cells via regulation of the PI3K\/Akt\/mTOR pathway: Invitro and in vivo studies","volume":"42","author":"Sun","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Yang, H., Hong, Y., Gong, M., Cai, S., Yuan, Z., Feng, S., Chen, Q., Liu, X., and Mei, Z. (2024). Fisetin exerts neuroprotective effects in vivo and in vitro by inhibiting ferroptosis and oxidative stress after traumatic brain injury. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1480345"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/ptr.5246","article-title":"Neuroprotection by saponins","volume":"29","author":"Sun","year":"2014","journal-title":"Phytother. Res."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/jocd.13042","article-title":"Panax notoginseng saponins promotes cutaneous wound healing and suppresses scar formation in mice","volume":"19","author":"Men","year":"2019","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Shen, L., Luo, H., Fan, L., Tian, X., Tang, A., Wu, X., Dong, K., and Su, Z. (2024). Potential Immunoregulatory Mechanism of Plant Saponins: A Review. Molecules, 29.","DOI":"10.3390\/molecules29010113"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/biof.1835","article-title":"Gut microbiome-micronutrient interaction: The key to controlling the bioavailability of minerals and vitamins?","volume":"48","author":"Barone","year":"2022","journal-title":"BioFactors"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1001\/jama.2022.8970","article-title":"Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and Cancer","volume":"327","author":"Chelmow","year":"2022","journal-title":"JAMA"},{"key":"ref_174","first-page":"1","article-title":"Health Benefits of Micronutrients (Vitamins and Minerals) and their Associated Deficiency Diseases: A Systematic Review","volume":"3","author":"Godswill","year":"2020","journal-title":"Int. J. Food Sci."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/sj.ejcn.1601998","article-title":"Reduced production of immunoregulatory cytokines in vitamin A- and zinc-deficient Indonesian infants","volume":"58","author":"Wieringa","year":"2004","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_176","first-page":"1","article-title":"The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review","volume":"4","author":"Pilz","year":"2017","journal-title":"Int. J. Endocrinol."},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Razzaque, M.S., and Wimalawansa, S.J. (2025). Minerals and Human Health: From Deficiency to Toxicity. Nutrients, 17.","DOI":"10.3390\/nu17030454"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"7017","DOI":"10.1039\/D4FO01805B","article-title":"The combined use of B vitamins and probiotics promotes B vitamin absorption and increases Akkermansia abundance","volume":"15","author":"Sang","year":"2024","journal-title":"Food Funct."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1189\/jlb.4MR0316-102R","article-title":"Angiogenesis and wound repair: When enough is enough","volume":"100","author":"DiPietro","year":"2016","journal-title":"J. Leukoc. Biol."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"107796","DOI":"10.1016\/j.phrs.2025.107796","article-title":"Junctional adhesion molecule A orchestrates endothelial cell-driven angiogenesis and wound healing in diabetes","volume":"217","author":"Shu","year":"2025","journal-title":"Pharmacol. Res."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3349\/ymj.2005.46.5.585","article-title":"Molecular Targets of Dietary Polyphenols with Anti-inflammatory Properties","volume":"46","author":"Yoon","year":"2005","journal-title":"Yonsei Med. J."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"3274","DOI":"10.1039\/D3FO04579J","article-title":"Effectiveness of anthocyanin-containing foods and nutraceuticals in mitigating oxidative stress, inflammation, and cardiovascular health-related biomarkers: A systematic review of animal and human interventions","volume":"15","author":"Mohammadi","year":"2024","journal-title":"Food Funct."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"658","DOI":"10.18662\/brain\/14.4\/526","article-title":"Depression in the diabetic patient","volume":"14","author":"Anghel","year":"2023","journal-title":"BRAIN Broad Res. Artif. Intell. Neurosci."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Batir-Marin, D., \u0218tefan, C.S., Boev, M., Gur\u0103u, G., Popa, G.V., Matei, M.N., Ursu, M., Nechita, A., and Maftei, N.-M. (2025). A Multidisciplinary Approach of Type 1 Diabetes: The Intersection of Technology, Immunotherapy, and Personalized Medicine. J. Clin. Med., 14.","DOI":"10.3390\/jcm14072144"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/j.1753-4887.2011.00443.x","article-title":"Leucine as a pharmaconutrient to prevent and treat sarcopenia and type 2 diabetes","volume":"69","author":"Leenders","year":"2011","journal-title":"Nutr. Rev."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4049\/jimmunol.1700223","article-title":"Macrophage-Mediated Inflammation in Normal and Diabetic Wound Healing","volume":"199","author":"Boniakowski","year":"2017","journal-title":"J. Immunol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1177\/0884533609358997","article-title":"Understanding the Role of Nutrition and Wound Healing","volume":"25","author":"Stechmiller","year":"2010","journal-title":"Nutr. Clin. Pract."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"683","DOI":"10.12968\/jowc.2019.28.10.683","article-title":"Nutrition in wound healing: Investigation of the molecular mechanisms, a narrative review","volume":"28","author":"Palmieri","year":"2019","journal-title":"J. Wound Care"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"324","DOI":"10.70594\/brain\/16.S1\/26","article-title":"Education of Patients and Their Families to Manage Emotional Impact of Skin Scars","volume":"16","author":"Stanescu","year":"2025","journal-title":"BRAIN Broad Res. Artif. Intell. Neurosci."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jpra.2024.01.006","article-title":"Impact of nutrition on skin wound healing and aesthetic outcomes: A comprehensive narrative review","volume":"39","author":"Seth","year":"2024","journal-title":"JPRAS Open"}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/17\/3568\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:36:36Z","timestamp":1760034996000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/17\/3568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,31]]},"references-count":190,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["molecules30173568"],"URL":"https:\/\/doi.org\/10.3390\/molecules30173568","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,31]]}}}