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The overall yield was improved from 25% to 52%. However, despite significant efforts, the key olefination step could not be improved.<\/jats:p>","DOI":"10.3390\/molecules30173594","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T12:07:32Z","timestamp":1756901252000},"page":"3594","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Improved Synthesis of a Sub-Nanomolar Vinyl Phosphonate Inhibitor of Dehydroquinate Synthase"],"prefix":"10.3390","volume":"30","author":[{"given":"Ella","family":"Fitterer","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry, TCU Box 298860, Texas Christian University, Fort Worth, TX 76129, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7327-1800","authenticated-orcid":false,"given":"Jean-Luc","family":"Montchamp","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, TCU Box 298860, Texas Christian University, Fort Worth, TX 76129, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7645","DOI":"10.1021\/ja961771z","article-title":"Cyclohexenyl and Cyclohexylidene Inhibitors of 3-Dehydroquinate Synthase: Active Site Interactions Relevant to Enzyme Mechanism and Inhibitor Design","volume":"119","author":"Montchamp","year":"1997","journal-title":"J. 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