{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:06:28Z","timestamp":1788174388970,"version":"build-2803163510"},"reference-count":60,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Obesity, along with dyslipidemia and hyperglycemia, is a metabolic disorder growing in prevalence that is linked to chronic diseases such as atherosclerosis, hypertension, and type 2 diabetes. This study evaluated the anti-obesity, lipid-lowering, and anti-hyperglycemic effects of CB-02 capsules containing dry extracts of Phyllanthus emblica L., Dendrobium catenatum Lindl., and Gynostemma pentaphyllum in HFD-induced obese Swiss albino mice. After 12 weeks of HFD induction, mice were treated orally with CB-02 (576 or 1152 mg\/kg\/day) for 8 weeks. CB-02 significantly reduced BW gain, AC, the Lee obesity index, and the relative weights of visceral fat and major organs. It also improved lipid profiles by decreasing TC, TG, LDL-C, and non-HDL-C, while increasing HDL-C. These effects were comparable to orlistat (60 mg\/kg\/day). Furthermore, CB-02 lowered fasting glucose and improved insulin sensitivity, as indicated by an increased QUICKI and HOMA-\u03b2 and reduced HOMA-IR. Histopathological evaluation showed that CB-02 reduced hepatic steatosis and inflammatory cell infiltration and also attenuated \u03b2-cell morphological alterations and pancreatic histopathological damage. These results suggest that CB-02 may be a promising therapeutic candidate for managing obesity and its comorbidities, including dyslipidemia, hyperglycemia, and hepatic steatosis, contributing to the prevention of type 2 diabetes and cardiovascular diseases in obese individuals.<\/jats:p>","DOI":"10.3390\/molecules30183678","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T10:27:12Z","timestamp":1757500032000},"page":"3678","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anti-Obesity, Lipid-Lowering, and Anti-Hyperglycemic Effects of CB-02 in High-Fat-Diet-Induced Obese Mice"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7027-8365","authenticated-orcid":false,"given":"Hoang Lan","family":"Hiep","sequence":"first","affiliation":[{"name":"Military Institute of Traditional Medicine, 442 Kim Giang, Dinh Cong, Hanoi 11717, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2240-6711","authenticated-orcid":false,"given":"Phung Van","family":"Bang","sequence":"additional","affiliation":[{"name":"Military Institute of Traditional Medicine, 442 Kim Giang, Dinh Cong, Hanoi 11717, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Dinh","family":"Nhan","sequence":"additional","affiliation":[{"name":"Military Institute of Traditional Medicine, 442 Kim Giang, Dinh Cong, Hanoi 11717, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1721-4211","authenticated-orcid":false,"given":"Nguyen Hoang","family":"Ngan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Institute of Pharmacy Education, Vietnam Military Medical University, 160 Phung Hung, Ha Dong, Hanoi 12108, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dao Cuong","family":"To","sequence":"additional","affiliation":[{"name":"Phenikaa University Nano Institute (PHENA), Phenikaa School of Engineering (PSE), Phenikaa University, Nguyen Van Trac, Duong Noi, Hanoi 12116, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4174-5500","authenticated-orcid":false,"given":"Nguyen Van","family":"Dung","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Thai Nguyen University of Medicine and Pharmacy, 284 Luong Ngoc Quyen, Phan Dinh Phung, Thai Nguyen 24124, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le Hong","family":"Phu","sequence":"additional","affiliation":[{"name":"Military Institute of Traditional Medicine, 442 Kim Giang, Dinh Cong, Hanoi 11717, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Yamada, T., Kimura-Koyanagi, M., Sakaguchi, K., Ogawa, W., and Tamori, Y. 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