{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T15:54:40Z","timestamp":1781625280792,"version":"3.54.5"},"reference-count":41,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008989","name":"Universidad Aut\u00f3noma de Quer\u00e9taro","doi-asserted-by":"publisher","award":["UAQ-FONFIVE 2024"],"award-info":[{"award-number":["UAQ-FONFIVE 2024"]}],"id":[{"id":"10.13039\/100008989","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008989","name":"Universidad Aut\u00f3noma de Quer\u00e9taro","doi-asserted-by":"publisher","award":["FQU202418"],"award-info":[{"award-number":["FQU202418"]}],"id":[{"id":"10.13039\/100008989","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Arterial hypertension is a major contributor to cardiovascular disease, the leading cause of death globally. Previously, our research group has demonstrated that both organic extracts from Heliopsis longipes roots and affinin\u2014its principal bioactive compound\u2014induce vasodilation and exert antihypertensive effects in L-NAME-induced hypertensive rats. However, the poor water solubility of these extracts limits their oral administration and dosing. To address this limitation, a self-microemulsifying drug delivery system (HL-SMDS) was developed from an ethanolic extract of H. longipes root to enhance its aqueous solubility and oral bioavailability. This study evaluated the antihypertensive efficacy of HL-SMDS in spontaneously hypertensive and L-NAME-induced hypertensive rat models, as well as its effects on endothelial reactivity. HL-SMDS significantly reduced systolic blood pressure in both models, demonstrating greater efficacy than the crude extract, likely due to improved solubility and systemic bioavailability of the active constituents. Moreover, HL-SMDS enhanced endothelial function in aortas from L-NAME-treated rats. These findings support the potential of HL-SMDS as a lipid-based phytopharmaceutical formulation that improves the oral bioavailability and antihypertensive effect of the ethanolic extract of H. longipes root. HL-SMDS offers a promising strategy for the development of phytopharmaceutical drugs to treat hypertension.<\/jats:p>","DOI":"10.3390\/molecules30183711","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T12:08:16Z","timestamp":1757678896000},"page":"3711","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Antihypertensive Effect of a Self-Microemulsifying System Obtained from an Ethanolic Extract of Heliopsis longipes Root in Spontaneously and L-NAME-Induced Hypertensive Rats"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8448-4174","authenticated-orcid":false,"given":"Dailenys","family":"Marrero-Morfa","sequence":"first","affiliation":[{"name":"Posgrado en Ciencias Qu\u00edmico Biol\u00f3gicas, Facultad de Qu\u00edmica, Universidad Aut\u00f3noma de Quer\u00e9taro, Quer\u00e9taro 76010, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5217-4016","authenticated-orcid":false,"given":"Beatriz A.","family":"Luz-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Posgrado en Ciencias Qu\u00edmico Biol\u00f3gicas, Facultad de Qu\u00edmica, Universidad Aut\u00f3noma de Quer\u00e9taro, Quer\u00e9taro 76010, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8093-7068","authenticated-orcid":false,"given":"Francisco J.","family":"Luna-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n Qu\u00edmica y Farmacol\u00f3gica de Productos Naturales, Facultad de Qu\u00edmica, Universidad Aut\u00f3noma de Quer\u00e9taro, Quer\u00e9taro 76010, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5356-6572","authenticated-orcid":false,"given":"Carlos T.","family":"Quirino-Barreda","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Ciencias Biol\u00f3gicas y de La Salud, Departamento de Sistemas Biol\u00f3gicos, Universidad Aut\u00f3noma Metropolitana, Ciudad de M\u00e9xico 04960, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isela","family":"Rojas-Molina","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n Qu\u00edmica y Farmacol\u00f3gica de Productos Naturales, Facultad de Qu\u00edmica, Universidad Aut\u00f3noma de Quer\u00e9taro, Quer\u00e9taro 76010, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1849-7374","authenticated-orcid":false,"given":"Mart\u00edn","family":"Garc\u00eda-Serv\u00edn","sequence":"additional","affiliation":[{"name":"Laboratorio Universitario Bioterio, Instituto de Neurobiolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Quer\u00e9taro 76230, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro A.","family":"V\u00e1zquez-Landaverde","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Ciencia Aplicada y Tecnolog\u00eda Avanzada del Instituto Polit\u00e9cnico Nacional, Unidad Quer\u00e9taro, Quer\u00e9taro 76090, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4967-2927","authenticated-orcid":false,"given":"Victoria","family":"Ruiz-Castillo","sequence":"additional","affiliation":[{"name":"Posgrado en Ciencias Qu\u00edmico Biol\u00f3gicas, Facultad de Qu\u00edmica, Universidad Aut\u00f3noma de Quer\u00e9taro, Quer\u00e9taro 76010, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3711-6491","authenticated-orcid":false,"given":"C\u00e9sar","family":"Ibarra-Alvarado","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n Qu\u00edmica y Farmacol\u00f3gica de Productos Naturales, Facultad de Qu\u00edmica, Universidad Aut\u00f3noma de Quer\u00e9taro, Quer\u00e9taro 76010, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6131-9013","authenticated-orcid":false,"given":"Alejandra","family":"Rojas-Molina","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n Qu\u00edmica y Farmacol\u00f3gica de Productos Naturales, Facultad de Qu\u00edmica, Universidad Aut\u00f3noma de Quer\u00e9taro, Quer\u00e9taro 76010, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1016\/j.numecd.2022.06.010","article-title":"Transition from metabolically healthy to unhealthy overweight\/obesity and risk of cardiovascular disease incidence: A systematic review and meta-analysis","volume":"32","author":"Abiri","year":"2022","journal-title":"Nutr. 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