{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:45:27Z","timestamp":1760060727137,"version":"build-2065373602"},"reference-count":35,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"French Embassy","award":["N\u00b0159105V"],"award-info":[{"award-number":["N\u00b0159105V"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Garcinia kola is an emblematic tree used in traditional medicine in many regions in Africa. In particular, its nuts are commonly used for the management of various diseases. However, to the best of our knowledge, G. kola nuts have never been investigated as potential sources of active ingredients in dermocosmetics. In this paper, nuts from G. kola were investigated to shed light on the extraction, purification and characterization of three components with potential dermocosmetic applications. The nuts were subjected to extraction with different solvents, including cyclohexane, dichloromethane, ethyl acetate, and methanol. Each extract was purified by column chromatography on silica gel. Pure compounds were characterized by NMR and mass spectrometry and comparison with reported literature data. Unsaturated fatty acids were found in the cyclohexane and dichloromethane extract, garcinoic acid (a vitamin E derivative) in the dichloromethane extract, and the biflavanone GB1 in the methanol extract. The presence of unsaturated fatty acids, garcinoic acid, and biflavanone in the nuts of G. kola as dominant compounds suggests that this plant material holds potential to be used for the development of active compounds for skin care and well-being.<\/jats:p>","DOI":"10.3390\/molecules30183813","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T16:53:42Z","timestamp":1758300822000},"page":"3813","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Garcinia kola Nuts: A Molecular Cocktail for Skin Care"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0106-7798","authenticated-orcid":false,"given":"Durand","family":"Dah-Nouvlessounon","sequence":"first","affiliation":[{"name":"Laboratory of Biology and Molecular Typing in Microbiology, Department of Biochemistry and Cell Biology, Faculty of Sciences and Techniques, University of Abomey-Calavi, Cotonou 05BP1604, Benin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8885-4133","authenticated-orcid":false,"given":"Coline","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Univ. Grenoble Alpes, INSERM, LRB, 38000 Grenoble, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3199-8547","authenticated-orcid":false,"given":"Ronald Alonso Salas","family":"Araya","sequence":"additional","affiliation":[{"name":"Univ. Grenoble Alpes, INSERM, LRB, 38000 Grenoble, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8160-5954","authenticated-orcid":false,"given":"Lamine","family":"Baba-Moussa","sequence":"additional","affiliation":[{"name":"Laboratory of Biology and Molecular Typing in Microbiology, Department of Biochemistry and Cell Biology, Faculty of Sciences and Techniques, University of Abomey-Calavi, Cotonou 05BP1604, Benin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2126-0931","authenticated-orcid":false,"given":"Rodica Mihaela","family":"Dinica","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Physics and Environment, \u201cDunarea de Jos\u201d University of Galati, 47 Domneasca Street, 800008 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1830-6409","authenticated-orcid":false,"given":"Ahc\u00e8ne","family":"Boumendjel","sequence":"additional","affiliation":[{"name":"Univ. Grenoble Alpes, INSERM, LRB, 38000 Grenoble, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/1354750X.2021.2016974","article-title":"A Review on Garcinia kola Heckel: Traditional uses, Phytochemistry, Pharmacological Activities, and Toxicology","volume":"27","author":"Emmanuel","year":"2022","journal-title":"Biomarkers"},{"key":"ref_2","first-page":"1","article-title":"Garcinia kola: A Review of its Ethnomedicinal, Chemical and Pharmacological Properties","volume":"6","author":"Ekene","year":"2014","journal-title":"Int. J. Curr. Res. 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