{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T13:13:28Z","timestamp":1781183608742,"version":"3.54.1"},"reference-count":135,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:00:00Z","timestamp":1759536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Molecules"],"abstract":"<jats:p>Non-diabetic chronic kidney disease (ND-CKD) refers to the progressive and irreversible decline in kidney function occurring in the absence of diabetes mellitus\u2014a distinction that sets it apart from the more prevalent diabetic CKD. While diabetic nephropathy remains the leading cause of CKD globally, ND-CKD encompasses a heterogeneous group of etiologies, including hypertensive nephrosclerosis, glomerulonephritis, and interstitial nephritis. Its incidence and prevalence are steadily increasing, particularly in aging populations, and are often underrecognized. Importantly, ND-CKD is not a benign entity; it independently contributes to systemic inflammation, oxidative stress, and metabolic dysregulation, which in turn amplify cardiovascular risk. Among the most severe complications is heart failure (HF), a complex syndrome arising from structural and functional impairments in cardiac performance. Despite ongoing advancements in HF management, mortality remains unacceptably high, ranging from 2\u20133% at 30 days to up to 50\u201375% over five years. Standard pharmacologic therapies frequently fall short in halting disease progression and may provoke undesirable side effects. This therapeutic gap has spurred growing interest in natural compounds with multi-targeted effects. Bioactive molecules such as arjunolic acid, kaempferol, luteolin, and resveratrol have shown anti-inflammatory and antioxidant properties that may offer dual benefits for both renal and cardiac function. By modulating shared molecular pathways\u2014including those involved in inflammation, oxidative damage, and cellular dysfunction\u2014these agents hold promise as adjunctive treatments in ND-CKD complicated by heart failure.<\/jats:p>","DOI":"10.3390\/molecules30193982","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T13:33:41Z","timestamp":1759757621000},"page":"3982","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["From Plants to Protection: Cardiorenal Benefits in Non-Diabetic Chronic Kidney Disease and Heart Failure"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4883-3856","authenticated-orcid":false,"given":"Dan Claudiu","family":"M\u0103gureanu","sequence":"first","affiliation":[{"name":"Pharmacology, Toxicology and Clinical Pharmacology, Department of Morphofunctional Sciences, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, Victor Babes, No 8, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1899-5977","authenticated-orcid":false,"given":"Raluca Maria","family":"Pop","sequence":"additional","affiliation":[{"name":"Pharmacology, Toxicology and Clinical Pharmacology, Department of Morphofunctional Sciences, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, Victor Babes, No 8, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3279-5384","authenticated-orcid":false,"given":"Ioana Corina","family":"Bocsan","sequence":"additional","affiliation":[{"name":"Pharmacology, Toxicology and Clinical Pharmacology, Department of Morphofunctional Sciences, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, Victor Babes, No 8, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3904-2852","authenticated-orcid":false,"given":"Maria Adriana","family":"Neag","sequence":"additional","affiliation":[{"name":"Pharmacology, Toxicology and Clinical Pharmacology, Department of Morphofunctional Sciences, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, Victor Babes, No 8, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3989-2291","authenticated-orcid":false,"given":"Angela","family":"Cozma","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia Mihaela","family":"Levai","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, Department of Mother and Child, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, Victor Babe\u0219, No 8, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7075-8867","authenticated-orcid":false,"given":"Veronica Sanda","family":"Chedea","sequence":"additional","affiliation":[{"name":"Research Station for Viticulture and Enology Blaj (SCDVV Blaj), 515400 Blaj, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3511-2788","authenticated-orcid":false,"given":"Anca Dana","family":"Buzoianu","sequence":"additional","affiliation":[{"name":"Pharmacology, Toxicology and Clinical Pharmacology, Department of Morphofunctional Sciences, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, Victor Babes, No 8, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","article-title":"Global, Regional, and National Burden of Chronic Kidney Disease, 1990\u20132017: A Systematic Analysis for the Global Burden of Disease Study 2017","volume":"395","author":"Bikbov","year":"2020","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0140-6736(13)60687-X","article-title":"Chronic Kidney Disease: Global Dimension and Perspectives","volume":"382","author":"Jha","year":"2013","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1056\/NEJMra0902710","article-title":"Hemodialysis","volume":"363","author":"Himmelfarb","year":"2010","journal-title":"N. 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