{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:39:07Z","timestamp":1788349147795,"version":"build-2803163510"},"reference-count":28,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:00:00Z","timestamp":1759536000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cThe unveiling project of \u2018Research on Biosynthesis and Transformation of sweet saponins\u2019 from Science and Technology Department of Jiangxi Province\u201d","award":["20233AAE02013"],"award-info":[{"award-number":["20233AAE02013"]}]},{"name":"\u201cHunan Provincial Natural Science Fund Project\u201d","award":["2023JJ30445"],"award-info":[{"award-number":["2023JJ30445"]}]},{"name":"\u201cHunan Provincial Department of Education Outstanding Youth Project\u201d","award":["22B0378"],"award-info":[{"award-number":["22B0378"]}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Molecules"],"abstract":"<jats:p>Siraitia grosvenorii (S. grosvenorii), a traditional medicine food homology plant, serves both dietary and medicinal purposes and is increasingly exploited for its bioactivities in pharmaceuticals and nutritional value. In this research, fifteen glycosides including three new cucurbitane-type triterpenoid glycosides named Luohanguosides A\u2013C (1\u20133) and twelve known ones (4\u201315) have been isolated from the aqueous extract of fresh S. grosvenorii fruits. A comprehensive analysis of 1D, 2D-NMR, HRESIMS techniques along with some other spectroscopic methods led to the elucidation of their chemical structures. Further investigation focused on the hepatoprotective activities of compounds 1\u201315. It turned out that compounds 1, 5, and 10 exhibited significant hepatoprotective activities compared to bicyclol under the same concentration (20 \u03bcM), providing scientific support for further research on S.grosvenorii products for their preventive potential of hepatic diseases.<\/jats:p>","DOI":"10.3390\/molecules30193983","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T13:33:41Z","timestamp":1759757621000},"page":"3983","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cucurbitane Glycosides from Siraitia Grosvenorii and Their Hepatoprotective Activities"],"prefix":"10.3390","volume":"30","author":[{"given":"Jia-Nan","family":"Mao","sequence":"first","affiliation":[{"name":"TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China"},{"name":"Modernization Industry College for Innovative Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Xue","family":"Huang","sequence":"additional","affiliation":[{"name":"TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China"},{"name":"Modernization Industry College for Innovative Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, China"},{"name":"Faculty of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, China"},{"name":"Research and Development Institute of Hunan Huacheng Biotech, Inc., Changsha 410205, China"},{"name":"Hunan Natural Sweetener Engineering Technology Research Center, Changsha 410205, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Ling","family":"Xie","sequence":"additional","affiliation":[{"name":"TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China"},{"name":"Modernization Industry College for Innovative Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China"},{"name":"Modernization Industry College for Innovative Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan-Jiang","family":"Wu","sequence":"additional","affiliation":[{"name":"TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China"},{"name":"Modernization Industry College for Innovative Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, China"},{"name":"Faculty of Chinese Medicine, Macau University of Science and Technology, Macau SAR 999078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Deng","sequence":"additional","affiliation":[{"name":"TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China"},{"name":"Modernization Industry College for Innovative Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Zhan","sequence":"additional","affiliation":[{"name":"Research and Development Institute of Hunan Huacheng Biotech, Inc., Changsha 410205, China"},{"name":"Hunan Natural Sweetener Engineering Technology Research Center, Changsha 410205, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Peng","sequence":"additional","affiliation":[{"name":"Research and Development Institute of Hunan Huacheng Biotech, Inc., Changsha 410205, China"},{"name":"Hunan Natural Sweetener Engineering Technology Research Center, Changsha 410205, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7445-5428","authenticated-orcid":false,"given":"Xu-Dong","family":"Zhou","sequence":"additional","affiliation":[{"name":"TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China"},{"name":"Modernization Industry College for Innovative Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0876-2205","authenticated-orcid":false,"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"TCM and Ethnomedicine Innovation & Development International Laboratory, Innovative Materia Medica Research Institute, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China"},{"name":"Modernization Industry College for Innovative Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,4]]},"reference":[{"key":"ref_1","first-page":"89","article-title":"Chemistry and pharmacology of Siraitia grosvenorii: A review","volume":"12","author":"Li","year":"2014","journal-title":"Chin. 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