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The synthesized Ln2O3@carbon nanoparticles exhibited good colloidal stability in solution and very low toxicity in in vitro cellular cytotoxicity tests. They exhibited paramagnetic magnetization values that increased with increasing applied field strength, resulting from spin\u2013orbit magnetic moments of 4f-electrons; hence, they yielded negligible r1 (&lt;0.1 s\u22121mM\u22121) and appreciable r2 values (3.446 and 3.677 s\u22121mM\u22121 for Ln = Tb and Ho, respectively) at 3 T, highlighting their potential as T2 MRI contrast agents, particularly at high MR fields. In addition, the carbon coating shell exhibited photoluminescence at 460 nm, suitable for applications in fluorescence imaging probes.<\/jats:p>","DOI":"10.3390\/molecules30204064","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T06:06:32Z","timestamp":1760508392000},"page":"4064","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Physicochemical and Multimodal Imaging Properties of Core\u2013Shell Ln2O3@Carbon Nanoparticles (Ln = Tb and Ho)"],"prefix":"10.3390","volume":"30","author":[{"given":"Huan","family":"Yue","sequence":"first","affiliation":[{"name":"Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7730-5636","authenticated-orcid":false,"given":"Tirusew","family":"Tegafaw","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2826-6536","authenticated-orcid":false,"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0785-049X","authenticated-orcid":false,"given":"Dejun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2869-0934","authenticated-orcid":false,"given":"Endale","family":"Mulugeta","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoran","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6941-8259","authenticated-orcid":false,"given":"Ahrum","family":"Baek","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering Research, School of Medicine, Kyungpook National University, Taegu 41944, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5051-0699","authenticated-orcid":false,"given":"Kwon Seok","family":"Chae","sequence":"additional","affiliation":[{"name":"Department of Biology Education, Teachers\u2019 College, Kyungpook National University, Taegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5119-6627","authenticated-orcid":false,"given":"Jihyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Chemistry Education, Teachers\u2019 College, Kyungpook National University, Taegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0585-8714","authenticated-orcid":false,"given":"Yongmin","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, School of Medicine, Kyungpook National University, Taegu 41944, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7451-6366","authenticated-orcid":false,"given":"Gang Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Natural Sciences, Kyungpook National University, Taegu 41566, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Kazi, R.N.A., Hasani, I.W., Khafaga, D.S., Kobba, S., Farhan, M., Aatif, M., Muteeb, G., and Fahim, Y.A. 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