{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:04:29Z","timestamp":1790805869704,"version":"4.1.0"},"reference-count":108,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T00:00:00Z","timestamp":1761436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Dihydroquercetin (taxifolin) is a natural bioflavonoid with diverse biological activities, including antioxidant, anti-inflammatory, antibacterial, antiviral, and geroprotective effects. The review summarizes current advances in the research of dihydroquercetin with a focus on its structural features, physicochemical properties, and biological functions. Particular attention is drawn to its low solubility and limited bioavailability, which have stimulated the development of nanotechnology-based delivery systems. In the paper, the systematization of the systems, namely nanoparticles, liposomes, hydrogels, nanofibers, nanoenzymes, and crystalline complexes, is presented. Moreover, some specific features of the antibacterial and antiviral action of the compound are described. Recent findings on the molecular mechanisms of action, including regulation of oxidative stress and cellular signaling pathways, highlight the therapeutic promise of dihydroquercetin. Taken together, the data support its potential as a valuable compound for pharmaceutical and biomedical applications, though further comprehensive investigations are required.<\/jats:p>","DOI":"10.3390\/molecules30214187","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T02:23:28Z","timestamp":1761704608000},"page":"4187","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Modern Developing Directions in the Dihydroquercetin Study"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9615-5805","authenticated-orcid":false,"given":"Svetlana Yu.","family":"Filippovich","sequence":"first","affiliation":[{"name":"A.N. Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Leninsky Ave. 33\/2, 119071 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena P.","family":"Isakova","sequence":"additional","affiliation":[{"name":"A.N. Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Leninsky Ave. 33\/2, 119071 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galina P.","family":"Bachurina","sequence":"additional","affiliation":[{"name":"A.N. Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Leninsky Ave. 33\/2, 119071 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulia I.","family":"Deryabina","sequence":"additional","affiliation":[{"name":"A.N. 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Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"100240","DOI":"10.1016\/j.prmcm.2023.100240","article-title":"Comprehensive review on pharmacological effects and mechanism of actions of taxifolin: A bioactive flavonoid","volume":"7","author":"Jain","year":"2023","journal-title":"Pharmacol. Res.\u2013Mod. Chin. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"107551","DOI":"10.1016\/j.phrs.2024.107551","article-title":"The multifaceted anti-atherosclerotic properties of herbal flavonoids: A comprehensive review","volume":"211","author":"Huang","year":"2025","journal-title":"Pharmacol. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"155934","DOI":"10.1016\/j.phymed.2024.155934","article-title":"Unveiling the Therapeutic Potential of Taxifolin in Cancer: From Molecular Mechanisms to Immune Modulation and Synergistic Combinations","volume":"133","author":"Sarg","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"134093","DOI":"10.1016\/j.molstruc.2022.134093","article-title":"Dihydroquercetin (DHQ) has the potential to promote apoptosis in ovarian cancer cells: An in silico and in vitro study","volume":"1271","author":"Qazi","year":"2023","journal-title":"J. Mol. Struct."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e29807","DOI":"10.1016\/j.heliyon.2024.e29807","article-title":"Dihydroquercetin regulates HIF-1\u03b1\/AKT\/NR2B signalling to improve impaired brain function in rats with metabolic syndrome","volume":"10","author":"Fu","year":"2024","journal-title":"Heliyon"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11094-022-02548-8","article-title":"Molecular-biological problems of drug design and mechanism of drug action bioavailability and safety of dihydroquercetin (review)","volume":"55","author":"Orlova","year":"2022","journal-title":"Pharm. Chem. J."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Das, A., Baidya, R., Chakraborty, T., Samanta, A.K., and Roy, S. (2021). Pharmacological basis and new insights of taxifolin: A comprehensive review. Biomed. Pharmacother., 142.","DOI":"10.1016\/j.biopha.2021.112004"},{"key":"ref_10","first-page":"140","article-title":"The Effectiveness of Using Dihydroquercetin (Taxifolin) in Animal Husbandry, Poultry and Apiculture for Prevention of Metabolic Disorders, Higher Antioxidative Capacity, Better Resistence and Realisation of a Productive Potential of Organism","volume":"4","author":"Fomichev","year":"2016","journal-title":"J. Int. Sci. Public Agric. Food"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.rvsc.2021.10.001","article-title":"Antioxidant status and growth performance of broiler chickens fed diets containing graded levels of supplementary dihydroquercetin","volume":"141","author":"Pirgozliev","year":"2021","journal-title":"Res. Vet. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Yang, R., Li, D.D., Li, X.X., Yang, X.X., Gao, H.M., and Zhang, F. (2024). Dihydroquercetin alleviates dopamine neuron loss via regulating TREM2 activation. Int. J. Biol. Macromol., 269.","DOI":"10.1016\/j.ijbiomac.2024.132179"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1021\/acssuschemeng.2c06406","article-title":"Production and Characterization of Hydrothermal Extracts of the Needles from Four Conifer Tree Species: Scots Pine, Norway Spruce, Common Juniper, and European Larch","volume":"11","author":"Mofikoya","year":"2023","journal-title":"ACS Sustain. Chem. Eng."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e05505","DOI":"10.1016\/j.heliyon.2020.e05505","article-title":"In vitro anti-inflammatory and anti-lipid accumulation properties of taxifolin-rich extract from the Japanese larch, Larix kaempferi","volume":"6","author":"Muramatsu","year":"2020","journal-title":"Heliyon"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"112066","DOI":"10.1016\/j.phytochem.2019.112066","article-title":"An insight into the health-promoting effects of taxifolin (dihydroquercetin)","volume":"166","author":"Sunil","year":"2019","journal-title":"Phytochemistry"},{"key":"ref_16","first-page":"51","article-title":"Polyphenol Composition in the Samples from Russian Conifers","volume":"2","author":"Gavrilov","year":"2019","journal-title":"Khimiya Rastitel\u2019nogo Syr\u2019ya"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.fsi.2014.12.009","article-title":"Effects of dihydroquercetin obtained from deodar (Cedrus deodara) on immune status of gilthead seabream (Sparus aurata L.)","volume":"43","author":"Awad","year":"2015","journal-title":"Fish Shellfish. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Yang, C.-J., Wang, Z.-B., Mi, Y.-Y., Gao, M.-J., Lv, J.-N., Meng, Y.-H., Yang, B.-Y., and Kuang, H.-X. (2016). UHPLC-MS\/MS Determination, Pharmacokinetic, and Bioavailability Study of Taxifolin in Rat Plasma after Oral Administration of its Nanodispersion. Molecules, 21.","DOI":"10.3390\/molecules21040494"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"124814","DOI":"10.1016\/j.ijpharm.2024.124814","article-title":"Dihydroquercetin nanoparticles nasal gel is a promising formulation for amelioration of Alzheimer\u2019s disease","volume":"666","author":"Masoud","year":"2024","journal-title":"Int. J. Pharm."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"7003","DOI":"10.1021\/acsomega.3c08870","article-title":"Rheumatoid arthritis treatment potential of stearic acid nanoparticles of quercetin in rats","volume":"9","author":"Alotaibi","year":"2024","journal-title":"ACS Omega"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"110137","DOI":"10.1016\/j.microc.2024.110137","article-title":"Investigation of ziziphus jujube seeds as a new source of taxifolin and silibinin with three different extraction methods","volume":"198","year":"2024","journal-title":"Microchem. J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"15596","DOI":"10.1038\/s41598-021-95071-x","article-title":"Exploring the genes involved in biosynthesis of dihydroquercetin and dihydromyricetin in Ampelopsis grossedentata","volume":"11","author":"Yu","year":"2021","journal-title":"Sci Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"19436","DOI":"10.1021\/acs.jafc.4c05546","article-title":"De Novo Biosynthesis of Dihydroquercetin in Saccharomyces cerevisiae","volume":"72","author":"Li","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4880","DOI":"10.1021\/acs.jafc.3c09376","article-title":"Optimizing the Biosynthesis of Dihydroquercetin from Naringenin in Saccharomyces cerevisiae","volume":"72","author":"Pan","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1021\/acssynbio.9b00193","article-title":"Optimizing Oleaginous Yeast Cell Factories for Flavonoids and Hydroxylated Flavonoids Biosynthesis","volume":"8","author":"Lv","year":"2019","journal-title":"ACS Synth. Biol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Muhammad, A., Feng, X., Rasool, A., Sun, W., and Li, C. (2020). Production of plant natural products through engineered Yarrowia lipolytica. Biotechnol. Adv., 43.","DOI":"10.1016\/j.biotechadv.2020.107555"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"He, Q., Yue, M., Liu, M., Ren, X., Wang, H., Chen, J., Xiang, J., He, W., Ye, S., and Gao, S. (2025). De novo biosynthesis of dihydroquercetin in an engineered Yarrowia lipolytica with enhanced (2S)-eriodictyol. Food Biosci., 64.","DOI":"10.1016\/j.fbio.2025.105912"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1021\/acssynbio.4c00853","article-title":"De Novo Synthesis of Reticuline and Taxifolin Using Re-engineered Homologous Recombination in Yarrowia lipolytica","volume":"14","author":"Zhang","year":"2025","journal-title":"ACS Synth. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1007\/s12010-024-05099-8","article-title":"Heterologous Biosynthesis of Taxifolin in Yarrowia lipolytica: Metabolic Engineering and Genome-Scale Metabolic Modeling","volume":"197","author":"Sui","year":"2025","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1134\/S1607672920010044","article-title":"Influence of Natural Polyphenols on Isolated Yeast Dipodascus magnusii Mitochondria","volume":"490","author":"Dergacheva","year":"2020","journal-title":"Dokl. Biochem. Biophys."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1179\/135100001101536391","article-title":"Antioxidant capacity of phenolic and related compounds: Correlation among electrochemical, visible spectroscopy methods and structure-antioxidant activity","volume":"6","author":"Galato","year":"2001","journal-title":"Redox Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jpha.2020.06.008","article-title":"Taxifolin stability: In silico prediction and in vitro degradation with HPLC-UV\/UPLCeESI-MS monitoring","volume":"11","author":"Moura","year":"2021","journal-title":"J. Pharm. Anal."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Shamsudin, N.F., Ahmed, Q.U., Mahmood, S., Ali Shah, S.A., Khatib, A., Mukhtar, S., Alsharif, M.A., Parveen, H., and Zakaria, Z.A. (2022). Antibacterial Effects of Flavonoids and Their Structure-Activity Relationship Study: A Comparative Interpretation. Molecules, 57.","DOI":"10.3390\/molecules27041149"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1134\/S1068162009050069","article-title":"Kinetic regulation of dihydroquercetin oxidation with horseradish peroxide","volume":"35","author":"Rogozhin","year":"2009","journal-title":"Russ. J. Bioorg. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ejphar.2012.03.035","article-title":"Dihydroquercetin: More than just an impurity?","volume":"684","author":"Weidmann","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1007\/s13197-017-2573-0","article-title":"Antioxidant and iron-chelating properties of taxifolin and its condensation product with glyoxylic acid","volume":"54","author":"Shubina","year":"2017","journal-title":"J. Food Sci. Technol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"114394","DOI":"10.1016\/j.comptc.2023.114394","article-title":"Non-covalent interactions between dihydroquercetin and arabinogalactan molecules: Theoretical study","volume":"1230","author":"Petrushenko","year":"2023","journal-title":"Comput. Theor. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.biochi.2015.02.003","article-title":"Isolation and structural characterization of 2R, 3R taxifolin 3-Orhamnoside from ethyl acetate extract of Hydnocarpus alpine and its hypoglycemic effect by attenuating hepatic key enzymes of glucose metabolism in streptozotocin-induced diabetic rats","volume":"111","author":"Balamurugan","year":"2015","journal-title":"Biochimie"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1021\/np50062a039","article-title":"Isolation and characterization of taxifolin 6-C-glucoside from Garcinia epunctata","volume":"52","author":"Mbafor","year":"1989","journal-title":"J. Nat. Prod."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Teles, Y.C.F., Souza, M.S.R., and Souza, M.F.V. (2018). Sulphated Flavonoids: Biosynthesis, Structures, and Biological Activities. Molecules, 23.","DOI":"10.3390\/molecules23020480"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1002\/bab.2156","article-title":"Advances in biochemistry and the biotechnological production of taxifolin and its derivatives","volume":"69","author":"Thuan","year":"2022","journal-title":"Biotechnol. Appl. Biochem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1900105","DOI":"10.1002\/ejlt.201900105","article-title":"Formulation and Characterization of Taxifolin-Loaded Lipid Nanovesicles (Liposomes, Niosomes, and Transfersomes) for Beverage Fortification","volume":"122","author":"Hasibi","year":"2019","journal-title":"Eur. J. Lipid Sci. Technol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s11094-009-0308-x","article-title":"Development and in vitro biopharmaceutical evaluation of a dihydroquercetin microemulsion","volume":"43","author":"Karlina","year":"2009","journal-title":"Pharm. Chem. J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1134\/S1990747811010053","article-title":"Cytotoxic Effect of Dihydroquercetin and Its Derivatives in Liposomal Form and in the Form of Fat Nanoscale Emulsions","volume":"5","author":"Fadeev","year":"2011","journal-title":"Biochem. Suppl. Ser. A"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1039\/C6MD00496B","article-title":"Synthesis, Characterization, Solubilization, Cytotoxicity and Antioxidant Activity of Aminomethylated Dihydroquercetin","volume":"8","author":"Li","year":"2017","journal-title":"Med. Chem. Commun."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1134\/S0006350911030298","article-title":"Biological activity of water-soluble nanostructures of dihydroquercetin with cyclodextrins","volume":"56","author":"Zinchenko","year":"2011","journal-title":"Biophys."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ijpharm.2014.10.027","article-title":"The high water solubility of inclusion complex of taxifolin-\u03b3-CD prepared and characterized by the emulsion solvent evaporation and the freeze drying combination method","volume":"477","author":"Zu","year":"2014","journal-title":"Int. J. Pharm."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1007\/s11094-021-02493-y","article-title":"Antioxidant and anti-inflammatory activities of dihydroquercetin, its aminomethylated derivative, and their inclusion complexes with cyclodextrin","volume":"55","author":"Rogovskii","year":"2021","journal-title":"Pharm. Chem. J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s11094-020-02126-w","article-title":"Engineering of Dihydroquercetin Crystals","volume":"53","author":"Selivanova","year":"2020","journal-title":"Pharm. Chem. J."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Terekhov, R.P., Ilyasov, I.R., Beloborodov, V.L., Zhevlakova, A.K., Pankov, D.I., Dzuban, A.V., Bogdanov, A.G., Davidovich, G.N., Shilov, G.V., and Utenyshev, A.N. (2022). Solubility Enhancement of Dihydroquercetin via \u201cGreen\u201d Phase Modification. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232415965"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Taldaev, R.P., Terekhov, I.A., Selivanova, D.I., Pankov, M.N., Anurova, I.Y., Markovina, Z., Cong, S., Ma, Z., Dong, F., and Yang, Y. (2022). Modification of taxifolin properties by spray drying. Sci. Pharm., 90.","DOI":"10.3390\/scipharm90040067"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ijbiomac.2020.11.119","article-title":"Antioxidant and antibacterial polyelectrolyte wound dressing based on chitosan\/hyaluronan\/phosphatidylcholine dihydroquercetin","volume":"166","author":"Hassan","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1177\/1091581815576975","article-title":"Toxicological and genotoxicity assessment of a dihydroquercetin-rich Dahurian larch tree (Larix gmelinii Rupr) extract (Lavitol)","volume":"34","author":"Schauss","year":"2015","journal-title":"Int. J. Toxicol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.ijbiomac.2022.02.110","article-title":"Fabrication of chitosan\/PVP\/dihydroquercetin nanocomposite film for in vitro and in vivo evaluation of wound healing","volume":"206","author":"Zhang","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Kundrapu, D.B., Rao, P.A., and Malla, R.R. (2025). Enhanced efficacy of quercetin and taxifolin encapsulated with pH-responsive injectable BSA hydrogel for targeting triple-negative breast cancer cells. Int. J. Biol. Macromol., 287.","DOI":"10.1016\/j.ijbiomac.2024.138477"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Lakeev, A.P., Yanovskaya, E.A., Yanovsky, V.A., Frelikh, G.A., and Andropov, M.O. (2023). Novel aspects of taxifolin pharmacokinetics: Dose proportionality, cumulative effect, metabolism, microemulsion dosage forms. J. Pharm. Biomed. Anal., 236.","DOI":"10.1016\/j.jpba.2023.115744"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.ijpharm.2014.05.049","article-title":"Enhancement of solubility, antioxidant ability and bioavailability of taxifolin nanoparticles by liquid antisolvent precipitation technique","volume":"471","author":"Zu","year":"2014","journal-title":"Int. J. Pharm."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1016\/j.fshw.2023.03.034","article-title":"Fabrication of taxifolin loaded zein-caseinate nanoparticles and its bioavailability in rat","volume":"12","author":"Li","year":"2023","journal-title":"Food Sci. Hum. Wellness"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s10876-019-01642-4","article-title":"Meticulous taxifolin releasing performance by the zinc oxide nanoparticles: As a short road to drug delivery system for cancer therapeutics","volume":"31","author":"Sundraraman","year":"2020","journal-title":"J. Clust. Sci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"100513","DOI":"10.1016\/j.mtnano.2024.100513","article-title":"Taxifolin-iron nanozymes with excellent RONS scavenging ability for alleviating ethanol-induced gastric ulcer","volume":"28","author":"Luo","year":"2024","journal-title":"Mater. Today Nano"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Luo, F., Wang, X., Tian, W., Zhu, B., and Hu, J. (2025). Multifunctional CuTax nanozyme-based chitosan edible coatings for fruit preservation. Int. J. Biol. Macromol., 310.","DOI":"10.1016\/j.ijbiomac.2025.143204"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ijpharm.2009.04.044","article-title":"Nanodispersions of taxifolin: Impact of solid-state propertieson dissolution behavior","volume":"377","author":"Shikov","year":"2009","journal-title":"Int. J. Pharm."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Zhang, J., Zheng, Y., Hong, B., Ma, L., Zhao, Y., Zhang, S., Sun, S., Ding, Q., Wang, Y., and Liu, W. (2022). Dihydroquercetin composite nanofibrous membrane prevents UVA radiation-mediated inflammation, apoptosis and oxidative stress by modulating MAPKs\/Nrf2 signaling in human epidermal keratinocytes. Biomed. Pharmacother., 155.","DOI":"10.1016\/j.biopha.2022.113727"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e33770","DOI":"10.1016\/j.heliyon.2024.e33770","article-title":"The polycaprolactone and silk fibroin nanofibers with Janus-structured sheaths for antibacterial and antioxidant by loading Taxifolin","volume":"10","author":"Jiao","year":"2024","journal-title":"Heliyon"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Wang, Y., Ding, C., Zhao, Y., Zhang, J., Ding, Q., Zhang, S., Wang, N., Yang, J., Xi, S., and Zhao, T. (2023). Sodium alginate\/poly(vinyl alcohol)\/taxifolin nanofiber mat promoting diabetic wound healing by modulating the inflammatory response, angiogenesis, and skin flora. Int. J. Biol. Macromol., 252.","DOI":"10.1016\/j.ijbiomac.2023.126530"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Naumov, A.A., and Potselueva, M.M. (2010). Liposomal form of dihydroquercetin contributes to skin regeneration after thermal burns. Cell Tissue Biol., 4.","DOI":"10.1134\/S1990519X10030041"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Ding, Q., Ding, C., Liu, X., Zheng, Y., Zhao, Y., Zhang, S., Sun, S., Peng, Z., and Liu, W. (2023). Preparation of nanocomposite membranes loaded with taxifolin liposome and its mechanism of wound healing in diabetic mice. Int. J. Biol. Macromol., 241.","DOI":"10.1016\/j.ijbiomac.2023.124537"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Zhao, Y., Ding, Q., He, Q., Zu, T., Rong, Z., Wu, Y., Shmanai, V.V., Jiao, J., and Zheng, R. (2025). Reno protective potential of taxifolin liposomes modified by chitosan in diabetic mice. Int. J. Biol. Macromol., 30.","DOI":"10.1016\/j.ijbiomac.2025.141464"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Ding, Q., Chen, K., Liu, X., Ding, C., Zhao, Y., Sun, S., Zhang, Y., Zhang, J., Liu, S., and Liu, W. (2022). Modification of taxifolin particles with an enteric coating material promotes repair of acute liver injury in mice through modulation of inflammation and autophagy signaling pathway. Biomed. Pharmacother., 152.","DOI":"10.1016\/j.biopha.2022.113242"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Ding, Q., Liu, X., Liu, X., Chai, G., Wang, N., Ma, S., Zhang, L., Zhang, S., Yang, J., and Wang, Y. (2024). Polyvinyl alcohol\/carboxymethyl chitosan-based hydrogels loaded with taxifolin liposomes promote diabetic wound healing by inhibiting inflammation and regulating autophagy. Int. J. Biol. Macromol., 263.","DOI":"10.1016\/j.ijbiomac.2024.130226"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"122115","DOI":"10.1016\/j.carbpol.2024.122115","article-title":"Hydrogel loaded with thiolated chitosan modified taxifolin liposome promotes osteoblast proliferation and regulates Wnt signaling pathway to repair rat skull defects","volume":"336","author":"Ding","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"163133","DOI":"10.1016\/j.cej.2025.163133","article-title":"Triple-effect strategy with taxifolin-whitlockite nanoparticles embedded hydrogel for osteoporotic bone defect repair and bone homeostasis modulation","volume":"515","author":"Jiang","year":"2025","journal-title":"Chem. Eng. J."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"116199","DOI":"10.1016\/j.foodres.2025.116199","article-title":"Effect of starch structuring and processing on the bioaccessibility of polyphenols in starchy foodstuffs: A review","volume":"208","author":"Tovar","year":"2025","journal-title":"Food Res. Int."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"109221","DOI":"10.1016\/j.foodhyd.2023.109221","article-title":"Recent advances in the conjugation approaches for enhancing the bioavailability of polyphenols","volume":"146","author":"Sahraeian","year":"2024","journal-title":"Food Hydrocoll."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Artem\u2019eva, O.A., Pereselkova, D.A., and Fomichev, Y.P. (2015). Dihydroquercetin, the bioactive substance, to be used against pathogenic microorganisms as an alternative to antibiotics. Agric. Biol., 50.","DOI":"10.15389\/agrobiology.2015.4.513eng"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Yang, D., Zhu, R., Xu, H.-X., and Zhang, Q.-F. (2023). Antibacterial Mechanism of Taxifolin and its Application in Milk Preservation. Food Biosci., 53.","DOI":"10.1016\/j.fbio.2023.102811"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"46","DOI":"10.24075\/brsmu.2018.043","article-title":"A study of antimicrobial activity of polyphenols derived from wood","volume":"4","author":"Shevelev","year":"2018","journal-title":"Bull. RSMU"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s40203-018-0045-5","article-title":"Taxifolin as dual inhibitor of Mtb DNA gyrase and isoleucyl-tRNA synthetase: In silico molecular docking, dynamics simulation and in vitro assays","volume":"6","author":"Nasla","year":"2018","journal-title":"Silico Pharmacol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1021\/np800698d","article-title":"Screening of flavonoids as candidate antibiotics against Enterococcus faecalis","volume":"72","author":"Jeong","year":"2009","journal-title":"J. Nat. Prod."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Oh, E., and Jeon, B. (2015). Synergistic anti-Campylobacter jejuni activity of fluoroquinolone and macrolide antibiotics with phenolic compounds. Front. Microbiol., 6.","DOI":"10.3389\/fmicb.2015.01129"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Wang, L., Wang, G., Qu, H., Wang, K., Jing, S., Guan, S., Su, L., Li, Q., and Wang, D. (2021). Taxifolin, an inhibitor of sortase a, interferes with the adhesion of methicillin-resistant Staphylococcal aureus. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.686864"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1016\/j.bmcl.2018.04.005","article-title":"Quinone skeleton as a new class of irreversible inhibitors against Staphylococcus aureus sortase A","volume":"28","author":"Hou","year":"2018","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Abid, N.A., Hamad, E.M., Ibragim, M.A., and Abid, H. (2022). Antibacterial and antibiofilm activities of taxifolin against vancomycin-resistant S. aureus (VRSA). Baghdad J. Biochem. Appl. Biol. Sci., 3.","DOI":"10.47419\/bjbabs.v3i04.126"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s10086-009-1026-4","article-title":"Antimicrobial activity against Streptococcus sobrinus and glucosyltransferase inhibitory activity of taxifolin and some flavanonol rhamnosides from kempas (Koompassia malaccensis) extracts","volume":"55","author":"Kuspradini","year":"2009","journal-title":"J. Wood Sci."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Wang, Y., Zhu, S., Chi, Y., Fu, D., Yao, L., Ji, M., Jiang, L., Han, Q., and Zou, L. (2025). Preventive effects of taxifolin on dental caries in vitro and in vivo. Arch. Oral Biol., 172.","DOI":"10.1016\/j.archoralbio.2025.106174"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Hou, J., Hu, M., Zhang, L., Gao, Y., Ma, L., and Xu, Q. (2021). Dietary taxifolin protects against dextran sulfate sodium-induced colitis via NF-\u03baB signaling, enhancing intestinal barrier and modulating gut microbiota. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.631809"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Li, W., Zhang, L., Xu, Q., Yang, W., Zhao, J., Ren, Y., Yu, Z., and Ma, L. (2022). Taxifolin alleviates DSS-induced ulcerative colitis by acting on gut microbiome to produce butyric acid. Nutrients, 14.","DOI":"10.3390\/nu14051069"},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Yang, D., Li, M.M., Xu, H.X., Wang, W.J., Yin, Z.P., and Zhang, Q.F. (2025). Retrograded starch as colonic delivery carrier of taxifolin for treatment of DSS-induced ulcerative colitis in mice. Int. J. Biol. Macromol., 288.","DOI":"10.1016\/j.ijbiomac.2024.138602"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.aninu.2024.10.002","article-title":"Dihydroquercetin attenuated Prevotella copri-caused intestinal injury by modulating gut microbiota and bile acids in weaned piglets","volume":"20","author":"Wang","year":"2025","journal-title":"Anim. Nutr."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Stenger Moura, F.C., Cechinel-Filho, V., Greco, F.A., Venzon, L., Meurer, M.C., Fran\u00e7a, T.C.D.S., Longo, B., Somensi, L.B., Mariano, L.N.B., and Cruz, A. (2021). Taxifolin and gastro-adhesive microparticles containing taxifolin promotes gastric healing in vivo, inhibits Helicobacter pylori in vitro and proton pump reversibly in silico. Chem. Biol. Interact., 339.","DOI":"10.1016\/j.cbi.2021.109445"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Liu, Y., Shi, X., Tian, Y., Zhai, S., Liu, Y., Xiong, Z., and Chu, S. (2023). An insight into novel therapeutic potentials of taxifolin. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1173855"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.virol.2022.04.005","article-title":"Flavonols and dihydroflavonols inhibit the main protease activity of SARS-CoV-2 and the replication of human coronavirus 229E","volume":"571","author":"Zhu","year":"2022","journal-title":"Virology"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Castro e Silva, J.H., Souza, J.T., Schitine, C., J\u00fanior, A.d.F.S., Bastos, E.M.S., and Costa, S.L. (2022). Pharmacological Potential of Flavonoids against Neurotropic Viruses. Pharmaceuticals, 15.","DOI":"10.3390\/ph15091149"},{"key":"ref_94","first-page":"200192","article-title":"The antiviral properties of flavonoids","volume":"6","author":"Chen","year":"2025","journal-title":"CTMP"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/s00705-016-2749-3","article-title":"Virus-inhibiting activity of dihydroquercetin, a flavonoid from Larix sibirica, against coxsackievirus B4 in a model of viral pancreatitis","volume":"161","author":"Galochkina","year":"2016","journal-title":"Arch. Virol."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Fischer, A., Sellner, M., Neranjan, S., Smie\u0161ko, M., and Lill, M.A. (2020). Potential inhibitors for novel coronavirus protease identified by virtual screening of 606 million compounds. Int. J. Mol. Sci., 21.","DOI":"10.26434\/chemrxiv.11923239.v2"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1007\/s11030-020-10150-x","article-title":"Computational guided identification of a citrus flavonoid as potential inhibitor of SARSCoV-2 main protease","volume":"25","author":"Gogoi","year":"2021","journal-title":"Mol. Divers."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Al-Karmalawy, A.A., Farid, M.M., Mostafa, A., Ragheb, A.Y., Mahmoud, H.S., Shehata, M., Abo Shama, N.M., GabAllah, M., Mostafa-Hedeab, G., and Marzouk, M.M. (2021). Naturally available flavonoid aglycones as potential antiviral drug candidates against SARS-CoV-2. Molecules, 26.","DOI":"10.3390\/molecules26216559"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Yang, X., He, Z., Zheng, Y., Wang, N., Mulinge, M., Schmit, J.-C., Steinmetz, A., and Seguin-Devaux, C. (2021). Chemical Constituents of Cassia abbreviata and Their Anti-HIV-1 Activity. Molecules, 26.","DOI":"10.3390\/molecules26092455"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Zheng, Y., Yang, X.-W., Schols, D., Mori, M., Botta, B., Chevign\u00e9, A., Mulinge, M., Steinmetz, A., Schmit, J.-C., and Seguin-Devaux, C. (2021). Active Components from Cassia abbreviata Prevent HIV-1 Entry by Distinct Mechanisms of Action. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22095052"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1007\/s00204-023-03562-9","article-title":"Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging","volume":"97","author":"Jomova","year":"2023","journal-title":"Arch. Toxicol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1016\/j.cmet.2023.10.011","article-title":"Mitohormesis","volume":"35","author":"Cheng","year":"2023","journal-title":"Cell Metab."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Pusev, M.S., Klein, O.I., Gessler, N.N., Bachurina, G.P., Filippovich, S.Y., Isakova, E.P., and Deryabina, Y.I. (2024). Effect of Dihydroquercetin During Long-Last Growth of Yarrowia lipolytica Yeast: Anti-Aging Potential and Hormetic Properties. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252312574"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Dergacheva, D.I., Mashkova, A.A., Isakova, E.P., Gessler, N.N., and Deryabina, Y.I. (2019). Influence of Resveratrol and Dihydroquercetin on Physiological and Biochemical Parameters of Poly-Extremophile Yarrowia lipolytica Yeast at Temperature Stress. Appl. Biochem. Microbiol., 55.","DOI":"10.1134\/S0003683819020042"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"12142","DOI":"10.1039\/D1FO01349A","article-title":"Taxifolin retards the D-galactose-induced aging process through inhibiting Nrf2-mediated oxidative stress and regulating the gut microbiota in mice","volume":"12","author":"Liu","year":"2021","journal-title":"Food Funct."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"102619","DOI":"10.1016\/j.arr.2024.102619","article-title":"The senotherapeutic potential of phytochemicals for age-related intestinal disease","volume":"104","author":"Costa","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1080\/10286020.2024.2421925","article-title":"Taxifolin ameliorates the D-galactose-induced aging of mouse hippocampal neurons HT-22 cells through modulating SIRT1\/p53 and PI3K\/AKT signaling pathways","volume":"27","author":"Liu","year":"2024","journal-title":"J. Asian Nat. Prod. Res."},{"key":"ref_108","first-page":"520","article-title":"Taxifolin protects RPE cells against oxidative stress-induced apoptosis","volume":"23","author":"Xie","year":"2017","journal-title":"Mol. Vis."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/21\/4187\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T05:24:03Z","timestamp":1761715443000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/30\/21\/4187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,26]]},"references-count":108,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["molecules30214187"],"URL":"https:\/\/doi.org\/10.3390\/molecules30214187","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,26]]}}}