{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:08:38Z","timestamp":1791313718297,"version":"4.3.1"},"reference-count":55,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:00:00Z","timestamp":1761696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["24-23-00056"],"award-info":[{"award-number":["24-23-00056"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>The emergence of drug-resistant influenza virus strains necessitates the development of novel antiviral agents with unique mechanisms of action. This study presents the synthesis and in vitro evaluation of a new class of antiviral compounds: sodium salts of amino acid ester conjugates based on the closo-dodecaborate anion [B12H12]2\u2212, linked via a tetrahydropyran-derived spacer (Na2[B12H11O(CH2)6C(O)X], where X = L-Trp-OMe (Na22); L-His-OMe (Na23); L-Met-OMe (Na24); Pld-OMe (Na25)). The antiviral activity was assessed against contemporary, multidrug-resistant influenza A virus strains, including A\/Cheboksary\/125\/2020 (H1N1)pdm09 and A\/IIV-Orenburg\/83\/2012 (H1N1)pdm09. Cross-platform comparison revealed that the dodecaborate-tryptophan conjugate Na22 exhibited comparable efficacy to its lead decaborate analog against the Orenburg strain while demonstrating potent activity (IC50 = 5.0 \u00b5g\/mL) against the Cheboksary strain with reduced susceptibility to neuraminidase inhibitors (oseltamivir; zanamivir) and complete resistance to M2 channel blockers. The histidine-based conjugate Na23 also showed significant efficacy against the Cheboksary strain, while methionine and lactam derivatives (Na24; Na25) remained inactive. This work confirms boron clusters as versatile platforms for antiviral development and establishes structure\u2013activity relationships crucial for optimizing both B10 and B12-based therapeutics against resistant influenza strains.<\/jats:p>","DOI":"10.3390\/molecules30214225","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:50:19Z","timestamp":1761785419000},"page":"4225","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Exploring the Anti-Influenza Activity of closo-Borate Platforms: Structure\u2013Activity Relationship of Amino Acid-Functionalized closo-Dodecaborate Derivatives Against Influenza Virus A\/Cheboksary\/125\/2020 (H1N1)pdm09"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3651-5730","authenticated-orcid":false,"given":"Timur M.","family":"Garaev","sequence":"first","affiliation":[{"name":"Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of Russian Federation, Moscow 123098, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3461-9763","authenticated-orcid":false,"given":"Ilya I.","family":"Yudin","sequence":"additional","affiliation":[{"name":"Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of Russian Federation, Moscow 123098, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6946-5119","authenticated-orcid":false,"given":"Natalya V.","family":"Breslav","sequence":"additional","affiliation":[{"name":"Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of Russian Federation, Moscow 123098, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6141-9361","authenticated-orcid":false,"given":"Tatyana V.","family":"Grebennikova","sequence":"additional","affiliation":[{"name":"Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of Russian Federation, Moscow 123098, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0478-0705","authenticated-orcid":false,"given":"Evgenii Yu.","family":"Matveev","sequence":"additional","affiliation":[{"name":"Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow 119991, Russia"},{"name":"Institute of Fine Chemical Technologies named after M. V. Lomonosov, MIREA\u2014Russian Technological University, Moscow 119571, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3729-4466","authenticated-orcid":false,"given":"Elizaveta A.","family":"Eshtukova-Shcheglova","sequence":"additional","affiliation":[{"name":"Institute of Fine Chemical Technologies named after M. V. Lomonosov, MIREA\u2014Russian Technological University, Moscow 119571, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2819-6001","authenticated-orcid":false,"given":"Ilya E.","family":"Sokolov","sequence":"additional","affiliation":[{"name":"Federal Research Centre of Nutrition and Biotechnology, Moscow 109240, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0655-1052","authenticated-orcid":false,"given":"Varvara V.","family":"Avdeeva","sequence":"additional","affiliation":[{"name":"Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow 119991, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4475-124X","authenticated-orcid":false,"given":"Konstantin Yu.","family":"Zhizhin","sequence":"additional","affiliation":[{"name":"Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow 119991, Russia"},{"name":"Institute of Fine Chemical Technologies named after M. V. Lomonosov, MIREA\u2014Russian Technological University, Moscow 119571, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolai T.","family":"Kuznetsov","sequence":"additional","affiliation":[{"name":"Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow 119991, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Di Gennaro, F., Pizzol, D., Marotta, C., Antunes, M., Racalbuto, V., Veronese, N., and Smith, L. (2020). Coronavirus Diseases (COVID-19) Current Status and Future Perspectives: A Narrative Review. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17082690"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Adamson, C.S. (2020). Antiviral Agents: Discovery to Resistance. 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