{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:34:04Z","timestamp":1790393644213,"version":"4.1.0"},"reference-count":86,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T00:00:00Z","timestamp":1763251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"RSF","award":["N 25-73-20036"],"award-info":[{"award-number":["N 25-73-20036"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Conditions have been established for the direct reaction of thiosemicarbazides with carboxylic acids in the presence of polyphosphate ester (PPE) to synthesize 1,2,4-triazole-3-thiol derivatives. The synthesis involves two consecutive steps: (i) acylation of the thiosemicarbazide with a carboxylic acid in chloroform in the presence of PPE at 90 \u00b0C using a hydrothermal reaction vessel, followed by (ii) cyclodehydration of the acylation product by treatment with an aqueous alkali solution. Using this new synthetic approach, 15 derivatives of 1,2,4-triazole-3-thiol were obtained, five of which were synthesized for the first time. The structures of the synthesized compounds were confirmed by NMR spectroscopy and mass spectrometry.<\/jats:p>","DOI":"10.3390\/molecules30224422","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T12:33:04Z","timestamp":1763469184000},"page":"4422","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synthesis of 1,2,4-Triazole-3-Thiol Derivatives from Thiosemicarbazides and Carboxylic Acids Using Polyphosphate Ester"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4819-6124","authenticated-orcid":false,"given":"Bogdan A.","family":"Tretyakov","sequence":"first","affiliation":[{"name":"Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry RAS, Chernogolovka 142432, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria I.","family":"Tikhonova","sequence":"additional","affiliation":[{"name":"Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry RAS, Chernogolovka 142432, Russia"},{"name":"Moscow Center for Advanced Studies, 20 Kulakova Str., Moscow 123592, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5481-7305","authenticated-orcid":false,"given":"Svyatoslav Y.","family":"Gadomsky","sequence":"additional","affiliation":[{"name":"Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry RAS, Chernogolovka 142432, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5344-6220","authenticated-orcid":false,"given":"Nataliya A.","family":"Sanina","sequence":"additional","affiliation":[{"name":"Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry RAS, Chernogolovka 142432, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"216675","DOI":"10.1016\/j.ccr.2025.216675","article-title":"Recent advancements in the multifaceted biomedical efficacy of triazole based metal complexes","volume":"536","author":"Aman","year":"2025","journal-title":"Coord. 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