{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:10:56Z","timestamp":1791994256165,"version":"4.4.0"},"reference-count":220,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Cognitive decline associated with healthy ageing and pathological conditions is driven by multifactorial processes, including oxidative stress, mitochondrial dysfunction and chronic neuroinflammation. Alzheimer\u2019s Disease (AD), a progressive neurodegenerative disorder affecting cognition and behaviour, is the leading cause of dementia worldwide. Current pharmacological interventions provide modest and transient benefits, targeting limited molecular pathways with safety and cost concerns, underscoring the need for safe, accessible and multi-targeted strategies. This review explores new avenues of therapy with a focus on bioactive compounds derived from brown, red and green seaweeds and their potential to modulate key mechanisms underlying AD. Preclinical and emerging clinical studies demonstrate that phlorotannins, fucoidans, fucoxanthin, lutein, zeaxanthin, ulvan, and astaxanthin exert antioxidant, anti-inflammatory, cholinergic-modulating and neuroprotective effects. Supplementation with seaweed-derived bioactive compounds has been shown to exert molecular and cellular effects that lead to reduced amyloid burden, preservation of synaptic integrity, and enhanced cognitive performance. Collectively, seaweed-derived compounds represent promising candidates for multi-target therapeutic strategies in cognitive decline prevention in the context of AD and healthy brain ageing.<\/jats:p>","DOI":"10.3390\/molecules30224456","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T08:50:07Z","timestamp":1763542207000},"page":"4456","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Therapeutic Potentials of the Seaweed-Derived Compounds for Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"30","author":[{"given":"Keanie","family":"Ward","sequence":"first","affiliation":[{"name":"School of Behavioural and Health Sciences, Faculty of Health Sciences, Australian Catholic University, Banyo, QLD 4014, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1817-7528","authenticated-orcid":false,"given":"Michael H.","family":"Cole","sequence":"additional","affiliation":[{"name":"School of Behavioural and Health Sciences, Faculty of Health Sciences, Australian Catholic University, Banyo, QLD 4014, Australia"},{"name":"Healthy Brain and Mind Research Centre, Australian Catholic University, Fitzroy, VIC 3065, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6774-5475","authenticated-orcid":false,"given":"Lyn R.","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Centre for Genomics and Personalised Health, School of Biomedical Sciences, Queensland University of Technology, 60 Musk Ave, Kelvin Grove, QLD 4059, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8512-1498","authenticated-orcid":false,"given":"Heidi G.","family":"Sutherland","sequence":"additional","affiliation":[{"name":"Centre for Genomics and Personalised Health, School of Biomedical Sciences, Queensland University of Technology, 60 Musk Ave, Kelvin Grove, QLD 4059, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2554-4955","authenticated-orcid":false,"given":"Pia","family":"Winberg","sequence":"additional","affiliation":[{"name":"Venus Shell Systems Pty Ltd., Huskisson, NSW 2540, Australia"},{"name":"School of Medical, Indigenous and Health Science, University of Wollongong, Wollongong, NSW 2522, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7962-7890","authenticated-orcid":false,"given":"Barbara J.","family":"Meyer","sequence":"additional","affiliation":[{"name":"School of Medical, Indigenous and Health Science, University of Wollongong, Wollongong, NSW 2522, Australia"},{"name":"Molecular Horizons, University of Wollongong, Wollongong, NSW 2522, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0926-5473","authenticated-orcid":false,"given":"Francesca","family":"Fernandez","sequence":"additional","affiliation":[{"name":"School of Behavioural and Health Sciences, Faculty of Health Sciences, Australian Catholic University, Banyo, QLD 4014, Australia"},{"name":"Healthy Brain and Mind Research Centre, Australian Catholic University, Fitzroy, VIC 3065, Australia"},{"name":"Centre for Genomics and Personalised Health, School of Biomedical Sciences, Queensland University of Technology, 60 Musk Ave, Kelvin Grove, QLD 4059, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"ref_1","unstructured":"World Health Organisation (2025, June 06). 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