{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T05:30:10Z","timestamp":1763703010110,"version":"3.45.0"},"reference-count":34,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"crossref","award":["ZR2022QB125"],"award-info":[{"award-number":["ZR2022QB125"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Herein, we disclose a novel and efficient cobalt-catalyzed cross-coupling strategy for picolinamide-directed direct C(sp3)-H bond formation with N-(phenylsulfanyl)succinimides. This method enables the direct construction of C(sp3)\u2013S bonds under mild conditions and exhibits excellent functional group tolerance along with a broad substrate scope. Notably, the catalytic system achieves oxidative C\u2013H functionalization without relying on costly or environmentally detrimental oxidants, offering a more sustainable and practical alternative for C\u2013S bond formation.<\/jats:p>","DOI":"10.3390\/molecules30224462","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T11:17:27Z","timestamp":1763551047000},"page":"4462","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Co(II)-Catalyzed Picolinamide-Directed C(sp3)-S Bond Formation with N-(phenylsulfanyl)succinimides"],"prefix":"10.3390","volume":"30","author":[{"given":"Jinjing","family":"Qin","sequence":"first","affiliation":[{"name":"College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, China"},{"name":"Zhejiang Anglikang Pharmaceutical Co., Ltd., Shengzhou 312400, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3048-4678","authenticated-orcid":false,"given":"Shaodong","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinwen","family":"Luo","sequence":"additional","affiliation":[{"name":"Zhejiang Anglikang Pharmaceutical Co., Ltd., Shengzhou 312400, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guodong","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Qilu Medical University, Zibo 255300, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Medical Engineering, Jining Medical University, Jining 272002, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.ejmech.2018.11.017","article-title":"Pharmaceutical and medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: A critical review","volume":"162","author":"Zhao","year":"2019","journal-title":"Eur. 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