{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T04:43:32Z","timestamp":1788842612950,"version":"build-2803163510"},"reference-count":74,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universidad Diego Portales","award":["1180327001"],"award-info":[{"award-number":["1180327001"]}]},{"name":"ANID FONDEF IDEA","award":["ID24I10250"],"award-info":[{"award-number":["ID24I10250"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Quitral (Tristerix corymbosus), a Chilean and Argentine parasitic mistletoe, is traditionally used by Mapuche natives to treat stomach ulcers, nervous disorders, and cholesterol reduction, although scientific support is scarce. Methanolic and chloroform extracts from its leaves and stems were prepared. Chemical analysis included antioxidant capacity assays (ORAC-FL and DPPH) and chromatographic determinations. The antimicrobial activity was tested against nine bacteria and two yeast strains. Additionally, cytotoxicity (hemolysis) and toxicity (against Caenorhabditis elegans) assays were performed. The results revealed that the methanolic leaf extracts had the highest ORAC-FL value, with DPPH assays showing solvent-dependent differences. Thirty-one compounds were tentatively identified, of which 61% were phenolic compounds, primarily flavonoids like quercetin and its derivatives. Antimicrobial results showed activity against Gram-positive bacteria (Staphylococcus aureus, Listeria monocytogenes, Bacillus cereus, and Enterococcus faecalis), but not against yeast Candida guillermondii and Candida tropicalis. Methanolic extracts induced dose-dependent erythrocyte hemolysis, while chloroform extracts showed no relevant cytotoxicity. Toxicity against Caenorhabditis elegans was also dose-dependent for methanolic extracts; leaf extract reduced survival at 50 mg mL\u22121 after 24 h. These findings partially validate some traditional uses, highlight the importance of solvent polarity in extraction and biological effects, and establish quitral as a flavonoid source.<\/jats:p>","DOI":"10.3390\/molecules30234610","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T16:47:37Z","timestamp":1764780457000},"page":"4610","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Determination of Bioactive Compounds, Antioxidant Capacity, Safety Assessment, and Antimicrobial Effect of Tristerix corymbosus Extracts"],"prefix":"10.3390","volume":"30","author":[{"given":"Katia","family":"Fern\u00e1ndez Moreno","sequence":"first","affiliation":[{"name":"Laboratory of Bioactive Natural Products, School of Medicine, Center for Biomedical Research, University Diego Portales (UDP), Ej\u00e9rcito 141, Santiago 8370007, Chile"},{"name":"Faculty of Health and Dentistry, Universidad Diego Portales, Ej\u00e9rcito 278, Santiago 8340263, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Maturana","sequence":"additional","affiliation":[{"name":"Laboratory of Bioactive Natural Products, School of Medicine, Center for Biomedical Research, University Diego Portales (UDP), Ej\u00e9rcito 141, Santiago 8370007, Chile"},{"name":"Department of Inorganic and Analytical Chemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago 8380494, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sof\u00eda","family":"Blanco-Haros","sequence":"additional","affiliation":[{"name":"Department of Inorganic and Analytical Chemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago 8380494, Chile"},{"name":"Department of Pharmacological Chemistry and Toxicology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago 8380000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulises","family":"Norambuena-Jopia","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Chemistry and Toxicology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago 8380000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Valenzuela-Barra","sequence":"additional","affiliation":[{"name":"Department of Pharmacological Chemistry and Toxicology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago 8380000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Carolina","family":"Z\u00fa\u00f1iga-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Inorganic and Analytical Chemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago 8380494, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0388-0149","authenticated-orcid":false,"given":"Jessica","family":"Bravo Garrido","sequence":"additional","affiliation":[{"name":"Laboratory of Bioactive Natural Products, School of Medicine, Center for Biomedical Research, University Diego Portales (UDP), Ej\u00e9rcito 141, Santiago 8370007, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4067\/S0717-66432018000100001","article-title":"Cat\u00e1logo de las plantas vasculares de Chile","volume":"75","author":"Rodriguez","year":"2018","journal-title":"Gayana Bot."},{"key":"ref_2","unstructured":"Ministerio de Salud (Gobierno de Chile) (2009). 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