{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T16:10:32Z","timestamp":1764864632208,"version":"3.46.0"},"reference-count":93,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Medicinal plants have long been used for therapeutic purposes in many cultures. They represent sources of important bioactive compounds, often of pharmacological significance. Ageratina Spach is the largest genus in Mexico and is characterised by its traditional use in the treatment of cancer and infections of the skin, blood, and intestines. Different species of Ageratina have been biologically evaluated at the extract and compound levels, and their chemical contents have been purified and characterised. Following a PRISMA meta-analysis, 29 scientific reports were selected and analysed. Tables of different Ageratina species were integrated to compare their cytotoxic and antimicrobial activity at the extract and compound levels. Twelve pure and isolated natural compounds were tested for cytotoxic activity against several cell lines from lung, colon, and breast cancer, cervical carcinoma, hepatocarcinoma, promyelocytic leukaemia, and histiocytic lymphoma. Forty-one pure and isolated natural compounds were evaluated for antimicrobial activity against a wide spectrum of microorganisms, including Gram-positive and Gram-negative bacteria, yeast, fungi, parasites and viruses. Ageratina Spach contains cytotoxic and antimicrobial substances with broad chemical profiles. In addition to being a plant with active compounds, it could be useful for future rational drug design.<\/jats:p>","DOI":"10.3390\/molecules30234656","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T16:07:38Z","timestamp":1764864458000},"page":"4656","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cytotoxic and Antimicrobial Activity of the Ageratina Genus"],"prefix":"10.3390","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8664-0147","authenticated-orcid":false,"given":"Sarai","family":"Rojas-Jim\u00e9nez","sequence":"first","affiliation":[{"name":"Laboratorio de Glicobiolog\u00eda Humana y Diagn\u00f3stico Molecular, Centro de Investigaci\u00f3n en Din\u00e1mica Celular, Instituto de Investigaci\u00f3n en Ciencias B\u00e1sicas y Aplicadas, Universidad Aut\u00f3noma del Estado de Morelos, Cuernavaca 62209, Morelos, Mexico"},{"name":"Facultad de Ciencias Qu\u00edmicas e Ingenier\u00eda, Universidad Aut\u00f3noma del Estado de Morelos (UAEM), Av. Universidad 1001, Col. Chamilpa, Cuernavaca 62209, Morelos, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0183-4560","authenticated-orcid":false,"given":"David Osvaldo","family":"Salinas-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Biodiversidad y Conservaci\u00f3n, Universidad Aut\u00f3noma del Estado de Morelos (UAEM), Av. Universidad 1001, Col. Chamilpa, Cuernavaca 62209, Morelos, Mexico"},{"name":"Escuela de Estudios Superiores Jicarero (EESJ), Universidad Aut\u00f3noma del Estado de Morelos (UAEM), Carretera Galeana-Tequesquitengo s\/n, Comunidad El Jicarero, Jojutla 62915, Morelos, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7805-2693","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"Rodr\u00edguez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Facultad de Farmacia, Universidad Aut\u00f3noma del Estado de Morelos (UAEM), Av. Universidad 1001, Col. Chamilpa, Cuernavaca 62209, Morelos, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0815-447X","authenticated-orcid":false,"given":"Roberta","family":"Salinas-Mar\u00edn","sequence":"additional","affiliation":[{"name":"Laboratorio de Glicobiolog\u00eda Humana y Diagn\u00f3stico Molecular, Centro de Investigaci\u00f3n en Din\u00e1mica Celular, Instituto de Investigaci\u00f3n en Ciencias B\u00e1sicas y Aplicadas, Universidad Aut\u00f3noma del Estado de Morelos, Cuernavaca 62209, Morelos, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0352-2395","authenticated-orcid":false,"given":"Dante","family":"Avil\u00e9s-Montes","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Biol\u00f3gicas, Universidad Aut\u00f3noma del Estado de Morelos (UAEM), Av. Universidad 1001, Col. Chamilpa, Cuernavaca 62209, Morelos, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4710-4590","authenticated-orcid":false,"given":"C\u00e9sar","family":"Sotelo-Leyva","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Qu\u00edmico-Biol\u00f3gicas (FCQB), Universidad Aut\u00f3noma de Guerrero, Chilpancingo de los Bravo 39090, Guerrero, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2435-1425","authenticated-orcid":false,"given":"Rodolfo","family":"Figueroa-Brito","sequence":"additional","affiliation":[{"name":"Centro de Desarrollo de Productos Bi\u00f3ticos (CEPROBI-IPN), Yautepec 62730, Morelos, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3228-6387","authenticated-orcid":false,"given":"Genoveva","family":"Bustos Rivera-Bahena","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Qu\u00edmicas e Ingenier\u00eda, Universidad Aut\u00f3noma del Estado de Morelos (UAEM), Av. Universidad 1001, Col. Chamilpa, Cuernavaca 62209, Morelos, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9468-3484","authenticated-orcid":false,"given":"Rodolfo","family":"Abarca-Vargas","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Universidad Aut\u00f3noma del Estado de Morelos (UAEM), Le\u00f1eros, Esquina Iztazz\u00edhuatl s\/n, Col. Volcanes, Cuernavaca 62350, Morelos, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4248-1140","authenticated-orcid":false,"given":"Dulce Mar\u00eda","family":"Arias-Ataide","sequence":"additional","affiliation":[{"name":"Escuela de Estudios Superiores Jicarero (EESJ), Universidad Aut\u00f3noma del Estado de Morelos (UAEM), Carretera Galeana-Tequesquitengo s\/n, Comunidad El Jicarero, Jojutla 62915, Morelos, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7676-2325","authenticated-orcid":false,"given":"Mar\u00eda Guadalupe","family":"Valladares-Cisneros","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Qu\u00edmicas e Ingenier\u00eda, Universidad Aut\u00f3noma del Estado de Morelos (UAEM), Av. Universidad 1001, Col. Chamilpa, Cuernavaca 62209, Morelos, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Bukowski, K., Kciuk, M., and Kontek, R. (2020). Mechanisms of multidrug resistance in cancer chemotherapy. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21093233"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Garg, P., Malhotra, J., Kulkarni, P., Horne, D., Salgia, R., and Singhal, S.S. (2024). Emerging therapeutic strategies to overcome drug resistance in cancer cells. Cancers, 16.","DOI":"10.3390\/cancers16132478"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e2443198","DOI":"10.1001\/jamanetworkopen.2024.43198","article-title":"Global disparities of cancer and its projected burden in 2050","volume":"7","author":"Bizuayehu","year":"2024","journal-title":"JAMA Netw. 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