{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T03:20:14Z","timestamp":1787887214685,"version":"build-2784847793"},"reference-count":66,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecules"],"abstract":"<jats:p>Gelasia tomentosa (L.) Zaika, Sukhor. &amp; N.Kilian which is known formerly as Scorzonera tomentosa L., a wild edible plant species in Turkey, is traditionally used against rheumatism and for wound healing. In this study, we explore its anti-inflammatory compounds, evaluating effectiveness through human red blood cell stabilization and in silico models, alongside physico-chemical and pharmacokinetic profiles. In vitro activity-guided fractionation allowed the isolation of sixteen compounds from the aerial parts of G. tomentosa, which were identified as hyperoside (1), isoquercetin (2), quercetin 3-O-\u03b2-apiofuranosyl-(1\u21922)-\u03b2-galactopyranoside (3), quercetin 3-O-\u03b2-apiofuranosyl-(1\u21922)-\u03b2-glucopyranoside (4), 7-methoxyapigenin-6-C-\u03b2-apiofuranosyl-(1\u21922)-\u03b2-glucopyranoside (5), apigenin-6-C-\u03b2-apiofuranosyl-(1\u21922)-\u03b2-glucopyranoside (6), dihydrodehydrodiconiferyl-alcohol-4-O-\u03b2-glucopyranoside (7), cichoriin (8), 7-O-methylisoorientin (9), isoorientin (10), swertisin (11), 3,5-O-dicaffeoylquinic acid methyl ester (12), 4,5-O-dicaffeoylquinic acid methyl ester (13), staphylinioside E (14), 3,5-O-dicaffeoylquinic acid (15), and 4,5-O-dicaffeoylquinic acid (16). Compound 16 displayed the highest potential anti-inflammatory activity (IC50 = 0.55 \u00b1 0.00 mg\/mL). However, the fraction with compounds displayed stronger biological activity than the isolated ones. In silico findings supported the anti-inflammatory potential, enhancing TP53 expression and cell membrane protection. Cichoriin (8) and staphylinioside E (14) are in accordance with Lipinski\u2019s, Pfizer\u2019s, GSK\u2019s, and Golden Triangle rules, indicating a favorable ADME profile as a drug candidate. Further studies are needed to test this potential in specific inflammation models.<\/jats:p>","DOI":"10.3390\/molecules31010019","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T08:35:27Z","timestamp":1766392527000},"page":"19","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Discovering the Anti-Inflammatory Potential of Compounds Isolated from the Aerial Parts of Gelasia tomentosa (L.) Zaika, Sukhor. &amp; N.Kilian (Syn. Scorzonera tomentosa), Through In Vitro Techniques and Advanced In Silico Modeling Approaches"],"prefix":"10.3390","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0809-784X","authenticated-orcid":false,"given":"\u00d6zlem","family":"Bahad\u0131r-Ac\u0131kara","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Ankara University, Tandogan, Ankara 06560, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beyzanur","family":"Akcan","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Ankara University, Tandogan, Ankara 06560, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8387-4146","authenticated-orcid":false,"given":"Sezen","family":"Y\u0131lmaz-Sar\u0131alt\u0131n","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Ankara University, Tandogan, Ankara 06560, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8956-9874","authenticated-orcid":false,"given":"Christian","family":"Zidorn","sequence":"additional","affiliation":[{"name":"Abteilung Pharmazeutische Biologie, Pharmazeutisches Institut, Christian-Albrechts-Universit\u00e4t zu Kiel, Gutenbergstra\u00dfe 76, 24118 Kiel, Germany"},{"name":"Division of Pharmaceutical Biotechnology, Department of Pharmaceutical Biology and Biotechnology, Wroclaw Medical University, Borowska 211, 50-556 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,20]]},"reference":[{"key":"ref_1","unstructured":"McCance, K.L., Huether, S.E., Brashers, V.L., and Rote, N.S. (2010). Innate immunity: Inflammation. Pathophysiology: The Biological Basis for Disease in Adults and Children, Mosby Elsevier. [7th ed.]."},{"key":"ref_2","unstructured":"Hall, J.E. (2011). Guyton and Hall Textbook of Medical Physiology, Elsevier. [12th ed.]."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1146\/annurev-ecolsys-040212-092530","article-title":"Inflammation: Mechanisms, costs, and natural variation","volume":"43","author":"Ashley","year":"2012","journal-title":"Annu. Rev. Ecol. Evol. Syst."},{"key":"ref_4","unstructured":"Ereminsoy, E. (2014). Maclura pomifera Plant Obtained from the Water Extract Carrageenan-Induced Inflammation in Rats Model and Investigation of the Effect on Cytokines. [Master\u2019s Thesis, Atat\u00fcrk University]."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/j.bcp.2006.06.029","article-title":"Inflammation and cancer: How hot is the link?","volume":"72","author":"Aggarwal","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/B978-0-12-394591-4.00003-9","article-title":"Regulation of inflammation-mediated chronic diseases by botanicals","volume":"62","author":"Shyur","year":"2012","journal-title":"Advances in Botanical Research"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4255\/mcpharmacol.09.05","article-title":"Anti-inflammatory agents for cancer therapy","volume":"1","author":"Rayburn","year":"2009","journal-title":"Mol. Cell Pharmacol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1055\/s-0041-1731791","article-title":"Wound healing: A comprehensive review","volume":"35","author":"Lmadani","year":"2021","journal-title":"Semin. Plast. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jtv.2019.09.002","article-title":"Pharmacological control of inflammation in wound healing","volume":"28","author":"Shukla","year":"2019","journal-title":"J. Tissue Viability"},{"key":"ref_10","first-page":"632","article-title":"Scorzonera L.","volume":"5","author":"Davis","year":"1975","journal-title":"Flora of Turkey and the East Aegean Islands"},{"key":"ref_11","first-page":"17","article-title":"An ethnobotanical analysis on wild edible plants of the Turkish Asteraceae Taxa","volume":"84","author":"Bulut","year":"2019","journal-title":"Agric. Conspec. Sci."},{"key":"ref_12","unstructured":"Baytop, T. (1999). Therapy with Medicinal Plants in Turkey: Past and Present, Nobel Publishers."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF02862090","article-title":"Traditional medicine in Turkey VIII. Folk medicine in East Anatolia; Erzurum, Erz\u00edncan, Agr\u0131, Kars, Igdir Provinces","volume":"51","author":"Sezik","year":"1997","journal-title":"Econ. Bot."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.sbspro.2011.05.195","article-title":"Ethnobotanical studies on the plant resources of East Anatolia, Turkey, Procedia","volume":"19","year":"2011","journal-title":"Soc. Behav. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"211","DOI":"10.4274\/tjps.galenos.2019.24392","article-title":"Ethnobotanical study of medicinal plants in Aziziye district (Erzurum, Turkey)","volume":"17","author":"Karakaya","year":"2020","journal-title":"Turk. J. Pharm. Sci."},{"key":"ref_16","first-page":"75","article-title":"An ethnobotanical study in Kahramanmara\u015f (Turkey); wild plants used for medicinal purpose in And\u0131r\u0131n, Kahramanmara\u015f","volume":"9","author":"Demirci","year":"2012","journal-title":"Turk. J. Pharm. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.jep.2011.07.029","article-title":"Enhancement of wound healing by topical application of Scorzonera species: Determination of the constituents by HPLC with new validated reverse phase method","volume":"137","author":"Akkol","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"ref_18","first-page":"861","article-title":"Antinociceptive activity of some Scorzonera L. species","volume":"42","author":"Saltan","year":"2012","journal-title":"Turk. J. Med. Sci."},{"key":"ref_19","first-page":"715","article-title":"Preclinical Evaluation of Scorzonera sp. root extracts and major compounds against acute hepatotoxicity \u0131nduced by carbon tetrachloride","volume":"79","author":"Keskin","year":"2017","journal-title":"Indian J. Pharm. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Bahad\u0131r Acikara, \u00d6., Ho\u0161ek, J., Babula, P., Cva\u010dka, J., Bude\u0161\u00ednsk\u00fd, M., Dra\u010dinsk\u00fd, M., Saltan \u0130\u015fcan, G., Kadlecov\u00e1, D., Ballov\u00e1, L., and \u0160mejkal, K. (2016). Turkish Scorzonera species extracts attenuate cytokine secretion via inhibition of NF-kappaB activation, showing anti-inflammatory effects in vitro. Molecules, 21.","DOI":"10.3390\/molecules21010043"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"112751","DOI":"10.1016\/j.indcrop.2020.112751","article-title":"Phenolics from Scorzonera tomentosa L.: Exploring the potential use in industrial applications via an integrated approach","volume":"154","author":"Ak","year":"2020","journal-title":"Ind. Crop Prod."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1080\/13102818.2015.1080600","article-title":"In vitro evaluation of antioxidant activity of some plant methanol extracts","volume":"29","author":"Artun","year":"2015","journal-title":"Biotechnol. Biotechnol. Equip."},{"key":"ref_23","first-page":"59","article-title":"Assessment of anti-\u0131nflammatory and free radical scavenger activities of selected Scorzonera Species and determination of active components","volume":"6","author":"Ergene","year":"2014","journal-title":"Int. J. Pharmacogn. Phytochem. Res."},{"key":"ref_24","first-page":"133","article-title":"Phenolic Constituents from Phlomis lycia","volume":"26","author":"Harput","year":"2002","journal-title":"Turk. J. Chem."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"999","DOI":"10.3923\/pjbs.2014.999.1006","article-title":"Isolation of hyperoside and isoquercitrin from Camellia sasanqua as antioxidant agents","volume":"17","author":"Sukito","year":"2014","journal-title":"Pak. J. Biol. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"112168","DOI":"10.1016\/j.jep.2019.112168","article-title":"Inhibitory activity of Scorzonera latifolia and its components on enzymes connected with the healing process","volume":"5","author":"Akkol","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.phytol.2020.11.012","article-title":"Flavonol glycosides from aerial parts of Astragalus thracicus Gr\u0131seb","volume":"41","author":"Vasilev","year":"2021","journal-title":"Phytochem. Lett."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1248\/cpb.46.982","article-title":"Saponins and C-glycosyl flavones from the seeds of Abrus precatorius","volume":"46","author":"Ma","year":"1998","journal-title":"Chem. Pharm. Bull."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.apsb.2011.04.001","article-title":"A new norlignan lignanoside from Selaginella moellendorffii Hieron","volume":"1","author":"Feng","year":"2011","journal-title":"Acta Pharm. Sinic"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1248\/cpb.44.1122","article-title":"Isolation and absolute structures of the neolignan glycosides with the enantiometric aglycones from the leaves of Viburnum awabuki K. Koch","volume":"44","author":"Matsuda","year":"1996","journal-title":"Chem. Pharm. Bull."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/S0367-326X(02)00172-7","article-title":"A new coumarin glucoside ester from Cichorium intybus","volume":"73","author":"Kisiel","year":"2002","journal-title":"Fitoterapia"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"78","DOI":"10.5564\/mjc.v12i0.177","article-title":"Bioactive phenolic acids from Scorzonera radiata Fisch","volume":"12","author":"Tsevegsuren","year":"2011","journal-title":"Mong. J. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"7823541","DOI":"10.1155\/2016\/7823541","article-title":"Isolation of 4,5-O-dicaffeoylquinic acid as a pigmentation inhibitor occurring in Artemisia capillaris thunberg and its validation in vivo","volume":"2016","author":"Tabassum","year":"2016","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"35374","DOI":"10.1039\/C8RA07549B","article-title":"Novel caffeoylquinic acid derivatives from Lonicera japonica Thunb. flower buds exert pronounced anti-HBV activities","volume":"8","author":"Ge","year":"2018","journal-title":"RSC Adv."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1248\/cpb.53.800","article-title":"Staphylionosides A-K:megastigmane glucosides from the leaves of Staphylea bumalda DC","volume":"53","author":"Yu","year":"2005","journal-title":"Chem. Pharm. Bull."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13321-018-0283-x","article-title":"ADMETlab: A platform for systematic ADMET evaluation based on a comprehensively collected ADMET database","volume":"10","author":"Dong","year":"2018","journal-title":"J. Cheminform"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"W422","DOI":"10.1093\/nar\/gkae236","article-title":"ADMETlab 3.0: An updated comprehensive online ADMET prediction platform enhanced with broader coverage, improved performance, API functionality and decision support","volume":"52","author":"Fu","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ddtec.2004.11.007","article-title":"Lead-and drug-like compounds: The rule-of-five revolution","volume":"1","author":"Lipinski","year":"2004","journal-title":"Drug Discov. Today Technol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"bbae321","DOI":"10.1093\/bib\/bbae321","article-title":"DrugMetric: Quantitative drug-likeness scoring based on chemical space distance","volume":"25","author":"Li","year":"2024","journal-title":"Brief. Bioinform."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/hlca.200790035","article-title":"Phenolic compounds from Scorzonera tomentosa L.","volume":"90","author":"Zidorn","year":"2007","journal-title":"Helv. Chim. Acta"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s40011-012-0129-7","article-title":"Phytochemical composition and antioxidant activity of some Scorzonera species","volume":"83","author":"Erden","year":"2013","journal-title":"Proc. Natl. Acad. Sci. India Sect. B Biol. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Bahad\u0131r-Ac\u0131kara, \u00d6., \u00d6zbilgin, S., Saltan-\u0130\u015fcan, G., Dall\u2019Acqua, S., Rja\u0161kov\u00e1, V., \u00d6zg\u00f6k\u00e7e, F., Suchy, V., and \u0160mejkal, K. (2018). Phytochemical analysis of Podospermum and Scorzonera n-hexane extracts and the HPLC quantitation of triterpenes. Molecules, 23.","DOI":"10.3390\/molecules23071813"},{"key":"ref_43","first-page":"1","article-title":"Qualitative and quantitative analysis of phenolic acids in Scorzonera tometosa L.","volume":"10","year":"2013","journal-title":"Turk. J. Pharm. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.foodchem.2014.10.006","article-title":"Qualitative and quantitative analyses of secondary metabolites in aerial and subaerial of Scorzonera hispanica L. (black salsify)","volume":"173","author":"Granica","year":"2015","journal-title":"Food Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.bse.2009.09.006","article-title":"Flavonoids as chemo systematic markers in the tribe Cichorieae of the Asteraceae","volume":"38","author":"Sareedenchai","year":"2010","journal-title":"Biochem. Syst. Ecol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"125124","DOI":"10.1016\/j.foodchem.2019.125124","article-title":"Antiinflammatory effects of flavonoids","volume":"299","author":"Maleki","year":"2019","journal-title":"Food Chem."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1080\/13880209.2016.1190381","article-title":"In vivo anti-inflammatory activity of caffeoylquinic acid derivatives from Solidago virgaureat in rats","volume":"54","author":"Ezzat","year":"2016","journal-title":"Pharm. Biol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.fct.2019.01.011","article-title":"Anti-inflammatory effects of dicaffeoylquinic acids from Ilex kudingcha on lipopolysaccharide-treated RAW264.7 macrophages and potential mechanisms","volume":"126","author":"Wan","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Song, J., Li, P., Yu, Y., Kim, J., and Chun, H. (2023). Antioxidant and anti-inflammatory effects of 6,3\u2032,4\u2032- and 7,3\u2032,4\u2032-trihydroxyflavone on 2D and 3D RAW264.7 models. Antioxidants, 12.","DOI":"10.3390\/antiox12010204"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"115791","DOI":"10.1016\/j.ejmech.2023.115791","article-title":"Discovery of anti-inflammatory natural flavonoids: Diverse scaffolds and promising leads for drug discovery","volume":"256","author":"Li","year":"2023","journal-title":"Eur. J. Med. Chem."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Zheleva-Dimitrova, D., Simeonova, R., Kondeva-Burdina, M., Savov, Y., Balabanova, V., Zengin, G., Petrova, A., and Gevrenova, R. (2023). Antioxidant and Hepatoprotective Potential of Echinops ritro L. Extracts on Induced Oxidative Stress In Vitro\/In Vivo. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24129999"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Aidoo, D.B., Konja, D., Henneh, I.T., and Ekor, M. (2021). Protective Effect of Bergapten against Human Erythrocyte Hemolysis and Protein Denaturation In Vitro. Int. J. Inflamm., 1279359.","DOI":"10.1155\/2021\/1279359"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/2008-2231-20-76","article-title":"Membrane stabilization as a mechanism of the anti-inflammatory activity of some plants","volume":"20","author":"Anosike","year":"2012","journal-title":"DARU J. Pharm. Sci."},{"key":"ref_54","unstructured":"Yesmin, F., Paul, A., Naz, T., Atiqur Rahman, A.B.M., Akhter, S.F., Wahed, M.I.I., Emran, T.B., and Siddiqui, S.A. (2020). Membrane stabilization as a mechanism of anti-inflammatory action: A review. Clin. Phytosci., 59."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"14261","DOI":"10.1021\/acs.jmedchem.2c01147","article-title":"Hydrogen-bond donors in drug design","volume":"65","author":"Kenny","year":"2022","journal-title":"J. Med. Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1039\/D0RA09995C","article-title":"The importance of intramolecular hydrogen bonds on the translocation of the small drug piracetam through a lipid bilayer","volume":"11","author":"Coimbra","year":"2021","journal-title":"RSC Adv."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.drudis.2020.01.012","article-title":"Flexibility in early drug discovery: Focus on the beyond-Rule-of-5 chemical space","volume":"25","author":"Caron","year":"2020","journal-title":"Drug Discov. Today"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Asano, D., Takakusa, H., and Nakai, D. (2023). Oral absorption of middle-to-large molecules and its improvement, with a focus on new modality drugs. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16010047"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.drudis.2009.07.014","article-title":"The impact of aromatic ring count on compound developability\u2013are too many aromatic rings a liability in drug design?","volume":"14","author":"Ritchie","year":"2009","journal-title":"Drug Discov. Today"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.1021\/acs.jmedchem.7b01120","article-title":"Importance of rigidity in designing small molecule drugs to tackle protein\u2013protein interactions (PPIs) through stabilization of desired conformers: Miniperspective","volume":"61","author":"Lawson","year":"2017","journal-title":"J. Med. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Gunathilake, K.D.P.P., Ranaweera, K.K.D.S., and Rupasinghe, H.P. (2018). In vitro anti-inflammatory properties of selected green leafy vegetables. Biomedicine, 6.","DOI":"10.3390\/biomedicines6040107"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0367-326X(99)00030-1","article-title":"Membrane stabilizing activity\u2014A possible mechanism of action for the anti-inflammatory activity of Cedrus deodara wood oil","volume":"70","author":"Shinde","year":"1999","journal-title":"Fitoterapia"},{"key":"ref_63","unstructured":"(2024, April 10). PubChem Database; National Center for Biotechnology Information, Available online: https:\/\/pubchem.ncbi.nlm.nih.gov."},{"key":"ref_64","unstructured":"(2024, April 10). ChEMBL Database; European Bioinformatics Institute (EMBL-EBI). Available online: https:\/\/www.ebi.ac.uk\/chembl\/."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/s10593-014-1496-1","article-title":"Prediction of the biological activity spectra of organic compounds using the PASS online web resource","volume":"50","author":"Filimonov","year":"2014","journal-title":"Chem. Heterocycl. Compd."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1007\/s11172-019-2683-0","article-title":"Computer-aided prediction of biological activity spectra for organic compounds: The possibilities and limitations","volume":"68","author":"Poroikov","year":"2019","journal-title":"Russ. Chem. Bull."}],"container-title":["Molecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/1\/19\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T08:35:48Z","timestamp":1766392548000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1420-3049\/31\/1\/19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,20]]},"references-count":66,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["molecules31010019"],"URL":"https:\/\/doi.org\/10.3390\/molecules31010019","relation":{},"ISSN":["1420-3049"],"issn-type":[{"value":"1420-3049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,20]]}}}